{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:57:57Z","timestamp":1791475077160,"version":"4.3.4"},"reference-count":54,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>PURPOSE<\/jats:title><jats:p> African American\/Black (AA\/B) individuals are under-represented in genomic databases and thus less likely to receive definitive information from germline genetic testing (GGT) than non-Hispanic White (NHW) individuals. With nearly 500,000 AA\/B and NHW individuals having undergone multigene panel testing (MGPT) for hereditary cancer risk at a single commercial laboratory, to our knowledge, we present the largest study to date investigating cancer GGT results in AA\/B and NHW individuals. <\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p> MGPT results from a retrospective cohort of AA\/B (n = 48,684) and NHW (n = 444,831) patients were evaluated. Frequencies of pathogenic germline variants (PGVs) and variants of uncertain significance (VUS) were compared between AA\/B and NHW individuals. Changes in frequency of VUS over time were determined. Pearson's chi-squared test was used to compare categorical variables among groups. All significance tests were two-tailed, and P &lt; .05 was considered statistically significant. <\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p> Between 2015 and 2022, rates of VUS decreased 2.3-fold in AA\/B and 1.8-fold in NHW individuals; however, frequencies of VUS and PGV remained significantly higher (46% v 32%; P &lt; .0001) and lower (9% v 13%; P &lt; .0001) in AA\/B compared with NHW individuals. Rates of VUS in ATM, BRCA1, BRCA2, PALB2, and PMS2 were significantly higher in AA\/B compared with NHW individuals, whereas rates of PGV in BRCA1, BRCA2, and PALB2 were higher in AA\/B compared with NHW individuals ( P &lt; .001). <\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p> Despite reductions in VUS frequencies over time, disparities in definitive GGT results persist. Increasing inclusion of AA\/B populations in both testing and research will further increase knowledge of genetic variants across these racial groups. <\/jats:p><\/jats:sec>","DOI":"10.1200\/po.23.00715","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T19:59:18Z","timestamp":1720727958000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Disparate Rates of Germline Variants in Cancer Predisposition Genes in African American\/Black Compared With Non-Hispanic White Individuals Between 2015 and 2022"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-5358","authenticated-orcid":true,"given":"Rachel B.","family":"Wyatt Castillo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, UT Health San Antonio, San Antonio, TX"},{"name":"Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, 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