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For somatic testing, we discuss the commonly prevalent somatic mutations and their impact on prognosis and treatment of patients with pNET. We also highlight the relevant genomic biomarkers that predict response to specific treatments. Previously, germline testing was only recommended for high-risk patients with syndromic features ( MEN1, VHL, TSC, and NF1), we review the evolving paradigm of germline testing in pNETs as recent studies have now shown that sporadic-appearing pNETs can also harbor germline variants. <\/jats:p>","DOI":"10.1200\/po.24.00221","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T19:59:38Z","timestamp":1725479978000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":7,"title":["Genomic Landscape of Pancreatic Neuroendocrine Tumors and Implications for Clinical Practice"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3225-3024","authenticated-orcid":true,"given":"Ana","family":"De Jesus-Acosta","sequence":"first","affiliation":[{"name":"Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, 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