{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:10:23Z","timestamp":1791227423587,"version":"4.1.0"},"reference-count":49,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"8","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Precis Oncol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>\n              The clinical and research FPG500 program (ClinicalTrials.gov identifier:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT06020625\">NCT06020625<\/jats:ext-link>\n              ) is currently ongoing at the Fondazione Policlinico Universitario Agostino Gemelli IRCCS to tailor matched targeted therapies (MTTs) according to biomarkers predictive of response identified by comprehensive genome profiling (CGP).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>The non\u2013small cell lung cancer (NSCLC) cohort results from the FPG500 program are outlined. CGP was performed by TruSight Oncology 500 High Throughput (TSO500HT) assay or Oncomine Focus Assay plus Archer's FusionPlex Lung Panel according to tumor cell content and DNA\/RNA quantity. Relevant issues for Molecular Tumor Board (MTB) evaluation included uncommon genomic findings, evaluation for off-label therapies, uncertain result confirmation, and variants of suspect germline origin requiring genetic counseling. Progression-free survival (PFS) and overall survival (OS) for the enrolled patients were assessed using Kaplan-Meier analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>In 2022, 283 patients with NSCLC were considered for sequencing, with 93% meeting eligibility criteria. TSO500HT sequencing was conducted in 76% of patients. Follow-up data were obtained for 187 patients, among whom 81% received treatment. Potential driver alterations were identified in 59% of patients, with 41% receiving MTT: 25% were prescribed approved MTTs, whereas 16% gained access to experimental drugs post-MTB evaluation; of note, 18% did not receive any MTT because the regimen was not yet reimbursed in our country. Median PFS and OS varied among treatment groups, with standard chemotherapy\/immunotherapy at 7.7 and 10.7 months, approved tyrosine kinase inhibitors at 18.8 and 23.9 months, and MTT post-MTB discussion at 14 and 23.4 months, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>The early data of the FPG program (NSCLC cohort) support the implementation of CGP and MTB in clinical practice to grant access to patients harboring actionable molecular alterations to the most effective and individualized available treatment options, thus improving their survival outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/po.24.00297","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T20:00:30Z","timestamp":1728331230000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Comprehensive Genome Profiling on the Management of Advanced Non\u2013Small Cell Lung Cancer: Preliminary Results From the Lung Cancer Cohort of the FPG500 Program"],"prefix":"10.1200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1582-8006","authenticated-orcid":true,"given":"Antonio","family":"Vitale","sequence":"first","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1853-4927","authenticated-orcid":true,"given":"Luca","family":"Mastrantoni","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Russo","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Giacomini","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Scientific Directorate, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Giannarelli","sequence":"additional","affiliation":[{"name":"Biostatistical Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-238X","authenticated-orcid":true,"given":"Simona","family":"Duranti","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Scientific Directorate, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-547X","authenticated-orcid":true,"given":"Emanuele","family":"Vita","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4442-4046","authenticated-orcid":true,"given":"Camilla","family":"Nero","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Women, Children and Public Health Sciences Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"D'Argento","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Pasciuto","sequence":"additional","affiliation":[{"name":"Data Collection Core Facility, Gemelli Science and Technology Park (G-STeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-4323","authenticated-orcid":true,"given":"Luciano","family":"Giaco\u0300","sequence":"additional","affiliation":[{"name":"Bioinformatics Core Facility, Gemelli Science and Technology Park (G-STeP), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariantonietta","family":"Di Salvatore","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Panfili","sequence":"additional","affiliation":[{"name":"Scientific Directorate, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-4484","authenticated-orcid":true,"given":"Alessio","family":"Stefani","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cancellieri","sequence":"additional","affiliation":[{"name":"Pathology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9383-5554","authenticated-orcid":true,"given":"Filippo","family":"Lococo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Thoracic Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0780-0153","authenticated-orcid":true,"given":"Elisa","family":"De Paolis","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Molecular and Personalized Diagnostics, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7364-0696","authenticated-orcid":true,"given":"Vanina","family":"Livi","sequence":"additional","affiliation":[{"name":"Interventional Pulmonology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5360-1895","authenticated-orcid":true,"given":"Gennaro","family":"Daniele","sequence":"additional","affiliation":[{"name":"Phase 1 Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Trisolini","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Interventional Pulmonology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0833-4334","authenticated-orcid":true,"given":"Angelo","family":"Minucci","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Molecular and Personalized Diagnostics, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Margaritora","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Thoracic Surgery Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-0598","authenticated-orcid":true,"given":"Domenica","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Humanitas San Pio X, Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-2605","authenticated-orcid":true,"given":"Nicola","family":"Normanno","sequence":"additional","affiliation":[{"name":"Scientific Directorate, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori,\u201d Meldola, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-9041","authenticated-orcid":true,"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Women, Children and Public Health Sciences Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-4962","authenticated-orcid":false,"given":"Giampaolo","family":"Tortora","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-704X","authenticated-orcid":true,"given":"Emilio","family":"Bria","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Medical Oncology Department, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"},{"name":"Faculty of Medicine and Surgery, Universita\u0300 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Medical Oncology, Ospedale Isola Tiberina\u2014Gemelli Isola, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"233","reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.05.008"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102019"},{"key":"e_1_3_6_4_2","first-page":"CD010383","article-title":"First-line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non-squamous non-small cell lung cancer","volume":"3","author":"Greenhalgh J","year":"2021","unstructured":"Greenhalgh J, Boland A, Bates V, et al: First-line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non-squamous non-small cell lung cancer. Cochrane Database Syst Rev 3:CD010383, 2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_6_5_2","first-page":"CD013453","article-title":"Targeted therapy for advanced anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer","volume":"1","author":"Cameron LB","year":"2022","unstructured":"Cameron LB, Hitchen N, Chandran E, et al: Targeted therapy for advanced anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer. Cochrane Database Syst Rev 1:CD013453, 2022","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz131"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30679-4"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002787"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2004407"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00247-3"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309457"},{"key":"e_1_3_6_12_2","first-page":"CD011395","article-title":"PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer","volume":"2021","author":"Taylor AM","year":"2021","unstructured":"Taylor AM, Chan DLH, Tio M, et al: PARP (Poly ADP-Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer. Cochrane Database Syst Rev 2021:CD011395, 2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02105"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-1044-x"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30691-6"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00541-1"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.3501"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2112431"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02005"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02767"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.014"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2021.103567"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.05.008"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.56"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051196"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0659"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.12.009"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246152"},{"key":"e_1_3_6_29_2","volume-title":"Nomenclature. Version 20.05","author":"Human Genome Variation Society (HGVS)","unstructured":"Human Genome Variation Society (HGVS): Nomenclature. Version 20.05. http:\/\/varnomen.hgvs.org\/"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.10.002"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.04.005"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-22-0985"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00857"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-840629"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.3009"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1303785"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.239244.118"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy263"},{"key":"e_1_3_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.09.1343"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12101746"},{"key":"e_1_3_6_41_2","article-title":"Molecular tumor board as a clinical tool for converting molecular data into real-world patient care","author":"Vingiani A","unstructured":"Vingiani A, Agnelli L, Duca M, et al: Molecular tumor board as a clinical tool for converting molecular data into real-world patient care. JCO Precis Oncol 10.1200\/PO.23.00067","journal-title":"JCO Precis Oncol"},{"key":"e_1_3_6_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2018-000339"},{"key":"e_1_3_6_43_2","article-title":"Personalized medicine in the oncology clinic: Implementation and outcomes of the Johns Hopkins molecular tumor board","author":"Dalton WB","unstructured":"Dalton WB, Forde PM, Kang H, et al: Personalized medicine in the oncology clinic: Implementation and outcomes of the Johns Hopkins molecular tumor board. JCO Precis Oncol 10.1200\/PO.16.00046","journal-title":"JCO Precis Oncol"},{"key":"e_1_3_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.01.019"},{"key":"e_1_3_6_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.03.027"},{"key":"e_1_3_6_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00221-0"},{"key":"e_1_3_6_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204619"},{"key":"e_1_3_6_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.792385"},{"key":"e_1_3_6_49_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12050749"},{"key":"e_1_3_6_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.06.001"}],"container-title":["JCO Precision Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/PO.24.00297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T20:00:35Z","timestamp":1728331235000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/PO.24.00297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1200\/PO.24.00297"],"URL":"https:\/\/doi.org\/10.1200\/po.24.00297","relation":{},"ISSN":["2473-4284"],"issn-type":[{"value":"2473-4284","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-05-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2400297"}}