{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T22:10:36Z","timestamp":1759702236229},"reference-count":0,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCO"],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:p> Four patients with Philadelphia chromosome (Ph1)-positive chronic granulocytic leukemia (CGL) in blast phase received cyclophosphamide, total body irradiation, and autologous marrow transplants using cryopreserved marrow from the stable phase. Two patients fully reestablished stable-phase leukemia that lasted for 26 and six months; the first patient developed transient Ph1-negative hematopoiesis after transplantation. Three patients eventually died of recurrent blast-phase leukemia. Previous studies using autologous marrow for CGL have reported an occasional long survivor, but incomplete engraftment and especially the rapid recurrence of blast-phase leukemia have been responsible for the overall poor results. The latter problem complicates even normal marrow transplantation, indicating the inadequacy of the current therapeutic regimens used for treating blast-phase leukemia and the possibility of improving results with more effective regimens and autologous marrow transplantation. Although it is unknown whether the reestablishment of Ph1-negative hematopoiesis after transplantation contributes to improved survival, this interesting phenomenon must be investigated further. <\/jats:p>","DOI":"10.1200\/jco.1984.2.5.379","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T12:48:40Z","timestamp":1487854120000},"page":"379-384","source":"Crossref","is-referenced-by-count":10,"title":["Intensive chemotherapy, total body irradiation, and autologous marrow transplantation for chronic granulocytic leukemia-blast phase: report of four additional cases."],"prefix":"10.1200","volume":"2","author":[{"given":"G L","family":"Phillips","sequence":"first","affiliation":[]},{"given":"G P","family":"Herzig","sequence":"additional","affiliation":[]}],"member":"233","container-title":["Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascopubs.org\/doi\/pdfdirect\/10.1200\/JCO.1984.2.5.379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T22:21:47Z","timestamp":1653517307000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascopubs.org\/doi\/10.1200\/JCO.1984.2.5.379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1984,5]]}},"alternative-id":["10.1200\/JCO.1984.2.5.379"],"URL":"https:\/\/doi.org\/10.1200\/jco.1984.2.5.379","relation":{},"ISSN":["0732-183X","1527-7755"],"issn-type":[{"value":"0732-183X","type":"print"},{"value":"1527-7755","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}