{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:52:27Z","timestamp":1753883547904,"version":"3.41.2"},"reference-count":46,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"11","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n            <jats:title>PURPOSE<\/jats:title>\n            <jats:p>Genome-wide association studies have identified several single-nucleotide polymorphisms (SNPs) linked to colorectal cancer (CRC) risk in European and Asian populations, but studies in admixed populations, like Brazilians, remain scarce. We aimed to replicate 45 SNPs associated with CRC risk and explore their correlation with genetic ancestry in a large Brazilian cohort.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>A case-control study included 990 CRC cases and 1,027 controls in Brazil. We genotyped 45 SNPs using SNPtype assays and assessed ancestry with 46 ancestry informative markers. After matching cases and controls by sex and age, 906 cases and 906 controls were analyzed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>\n              Genotyping succeeded for 35 SNPs, and nine showed significant CRC associations. Multivariate analysis confirmed two SNPs linked to increased CRC risk, rs10795668 (odds ratio [OR], 1.98;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .003) and rs6066825 (OR, 1.50;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .008), and two SNPs with protective effects: rs4939827 (OR, 0.61;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .001) and rs6983267 (OR, 0.65;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .013). Low Asian (lowest tercile, OR, 1.48;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .001) and low African (lowest tercile, OR, 1.22;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              = .025) ancestry increased CRC risk.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>\n              Our findings validated rs10795668 (\n              <jats:italic toggle=\"yes\">LOC10537640<\/jats:italic>\n              ), rs4939827 (\n              <jats:italic toggle=\"yes\">SMAD7<\/jats:italic>\n              ), rs6066825 (\n              <jats:italic toggle=\"yes\">PREX1<\/jats:italic>\n              ), and rs6983267 (\n              <jats:italic toggle=\"yes\">CCAT2<\/jats:italic>\n              ) polymorphisms in CRC risk among Brazilians and suggest that lower Asian and African ancestries might influence CRC susceptibility.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1200\/go-24-00512","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T19:59:20Z","timestamp":1749239960000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Association of Genetic Ancestry and Colorectal Cancer Risk in a Large Brazilian Cohort: Replication of Single-Nucleotide Polymorphisms Identified by Genome-Wide Association Studies"],"prefix":"10.1200","author":[{"given":"Ana Carolina","family":"de Carvalho","sequence":"first","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"given":"Ana Carolina","family":"Laus","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8447-8463","authenticated-orcid":true,"given":"Howard Ribeiro","family":"Lopes Junior","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-4203","authenticated-orcid":true,"given":"Jun","family":"Porto","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3899-9633","authenticated-orcid":true,"given":"D\u00e9bora","family":"Sant'Anna Silva","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0568-7038","authenticated-orcid":true,"given":"Adeylson Guimar\u00e3es","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-7517","authenticated-orcid":true,"given":"Jos\u00e9 Guilherme","family":"Datorre","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9492-2650","authenticated-orcid":true,"given":"Rosielly Melo","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Barretos Cancer Hospital, Rua Antenor Duarte Vilela, Barretos, SP, Brazil"}]},{"given":"Anne Beatriz","family":"Sousa Carlos","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Barretos Cancer Hospital, Rua Antenor Duarte Vilela, Barretos, SP, Brazil"}]},{"given":"Tulio","family":"Furquim","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Barretos Cancer Hospital, Rua Antenor Duarte Vilela, Barretos, SP, Brazil"}]},{"given":"Miyuki","family":"Uno","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Translacional em Oncologia- CTO. Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo-ICESP, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0342-8726","authenticated-orcid":true,"given":"Roger","family":"Chammas","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Translacional em Oncologia- CTO. Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo-ICESP, SP, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-2385","authenticated-orcid":true,"given":"Priscilla","family":"Villela","sequence":"additional","affiliation":[{"name":"ESALQ-USP, Piraciacaba, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-7940","authenticated-orcid":true,"given":"Mariana Bisarro","family":"dos Reis","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"given":"Marcus","family":"de Medeiros Matsushita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"given":"Marco Ant\u00f4nio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Department, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"given":"Welinton Yoshio","family":"Hirai","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Department, Barretos Cancer Hospital, Barretos, SP, Brazil"}]},{"given":"Denise Peixoto","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"},{"name":"Department of Prevention, Barretos Cancer Hospital, Rua Antenor Duarte Vilela, Barretos, Brazil"}]},{"given":"Florinda Almeida","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Barretos Cancer Hospital, Rua Antenor Duarte Vilela, Barretos, SP, Brazil"}]},{"given":"Rui Manuel","family":"Reis","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, SP, Brazil"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal"}]}],"member":"233","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_3_5_4_2","first-page":"e213700","article-title":"Estimativa de Incid\u00eancia de C\u00e2ncer no Brasil, 2023-2025","volume":"69","author":"de Oliveira Santos M","year":"2023","unstructured":"de Oliveira Santos M, da Silva de Lima FC, Leite Martins LF, et al: Estimativa de Incid\u00eancia de C\u00e2ncer no Brasil, 2023-2025. 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