{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T19:16:51Z","timestamp":1772565411772,"version":"3.50.1"},"reference-count":39,"publisher":"American Society of Clinical Oncology (ASCO)","issue":"2","content-domain":{"domain":["ascopubs.org"],"crossmark-restriction":true},"short-container-title":["JCO Glob Oncol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE<\/jats:title>\n                    <jats:p>Breast cancer (BC) is becoming a significant public health issue in Cape Verde. Understanding the profile of BC cases is crucial for improving patient outcomes and guiding public health initiatives. This study aimed to investigate the clinical and pathologic characteristics, treatment approaches, and outcomes of BC cases diagnosed and treated at Agostinho Neto University Hospital between January 2015 and July 2021 following implementation of an international treatment partnership.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 158 female patients with BC diagnosed during the study period. Data were collected on patient demographics, tumor characteristics, treatment protocols, and survival outcomes. Immunohistochemistry was performed on a subset of 114 patients to identify molecular subtypes. Descriptive statistics were used to summarize all variables. Overall survival was analyzed, and log-rank tests were performed to formally compare the survival curves and assess the statistical significance of any observed differences. Cox proportional hazard models were used to determine the independent effect of sociodemographic factors and clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The median age at diagnosis was 52.5 years, with patients ranging from 28 to 91 years. Most patients resided on Santiago Island. Invasive ductal carcinoma was the most common type, found in 93% of cases. Over half of the tumors were poorly differentiated, and 57% were diagnosed at advanced stages (III and IV). Subtype distribution mirrored sub-Saharan patterns, with 24% triple negative and 11% human epidermal growth factor receptor 2 positive. Among patients with potentially curable BC, 61.4% received adequate therapy that followed the National Comprehensive Cancer Network (NCCN) Harmonized Guidelines for sub-Saharan Africa (SSA), including radiotherapy treatment, although this was performed abroad. The median follow-up calculated by reverse Kaplan-Meier was 33.7 months (IQR, 20.5-52.8 months). Patients treated according to stage-appropriate and phenotype-specific recommendations achieved better outcomes (79.9% 3-year survival).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study emphasizes the importance of early diagnosis and adoption of the NCCN Harmonized Guidelines for SSA. Access to radiotherapy abroad, necessitated by the absence of local radiotherapy facilities, was correlated with improved survival. These findings underscore the feasibility of improving outcomes in low-resource settings through standardized treatment frameworks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1200\/go-25-00258","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:58:12Z","timestamp":1772225892000},"update-policy":"https:\/\/doi.org\/10.1200\/crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Breast Cancer in Cape Verde: Clinical-Molecular Profile and Impact of an International Treatment Partnership"],"prefix":"10.1200","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4491-9874","authenticated-orcid":true,"given":"Pamela","family":"Borges","sequence":"first","affiliation":[{"name":"Agostinho Neto University Hospital, Praia, Cabo Verde"}]},{"given":"Victor","family":"Costa","sequence":"additional","affiliation":[{"name":"Agostinho Neto University Hospital, Praia, Cabo Verde"}]},{"given":"Hirondina Borges","family":"Spencer","sequence":"additional","affiliation":[{"name":"Agostinho Neto University Hospital, Praia, Cabo Verde"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-242X","authenticated-orcid":true,"given":"Pedro","family":"Leite-Silva","sequence":"additional","affiliation":[{"name":"Group of Epidemiology, Results, Economy and Management in Oncology, IPO Porto Research Center (CI-IPOP), Instituto Portugu\u00eas de Oncologia do Porto, Francisco Gentil, Porto, Portugal"},{"name":"Department of Epidemiology, Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9493-7176","authenticated-orcid":true,"given":"Stefani","family":"Furtado","sequence":"additional","affiliation":[{"name":"Agostinho Neto University Hospital, Praia, Cabo Verde"}]},{"given":"Carla","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Agostinho Neto University Hospital, Praia, Cabo Verde"}]},{"given":"Cla\u00fadia","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Surgery, Garcia de Orta Hospital, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-8798","authenticated-orcid":true,"given":"Isabel","family":"Dos-Santos-Silva","sequence":"additional","affiliation":[{"name":"Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-5655","authenticated-orcid":true,"given":"L\u00facio Lara","family":"Santos","sequence":"additional","affiliation":[{"name":"Experimental Pathology and Therapeutics Research Group and Surgical Oncology Department, Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil, Porto, Portugal"}]}],"member":"233","reference":[{"key":"e_1_3_7_2_2","first-page":"1","article-title":"Breast cancer diagnostics, therapy, and outcomes in Sub-Saharan Africa: A population-based registry study","volume":"20","author":"Joko-Fru WY","year":"2021","unstructured":"Joko-Fru WY, Griesel M, Mezger NCS, et al: Breast cancer diagnostics, therapy, and outcomes in Sub-Saharan Africa: A population-based registry study. 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