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The natural history of multiple sclerosis: A geographically based study. II: Predictive value of the early clinical course. Brain 1989; 112: 1419\u20131428. 3. Weinshenker BG, Rice GPA, Noseworthy JH, et al. The natural history of multiple sclerosis: A geographically based study. III: Multivariate analysis of predictive factors and models of outcome. Brain 1991; 114:1045\u20131056. 4. Minimal Record of Disability for Multiple Sclerosis. New York: International Federation of Multiple Sclerosis Societies, 1985. 5. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS). Neurology 1983; 33:1114\u20131452. 6. Moskowitz E, McCann C. Classification of disability in the chronically ill and aging. J Chronic Dis 1957; 5:342\u2013346. 7. Mahoney FL, Barthel DW. Functional evaluation: The Barthel index. Maryland State Med J 1965; 14:61\u201365. 8. Granger CV. Assessment of functional status: A model for multiple sclerosis. Acta Neurol Scand 1981; 64(suppl 87):4047. 9. Mellerup E, Fog T. The socioeconomic scale. Acta Neurol Scand 1981;64(suppl 87):130\u2013 138. 10. Hauser SL, Dawson DM, Lehrich JR, et al. Intensive immunosuppression in progressive multiple sclerosis: A randomized three-armed study of high dose intravenous cyclophosphamide, plasma exchange, and ACTH. N Engl J Med 1983; 308:173\u2013180. 11. Rudick R, Antel J, Confavreux C, et al. Recommendations from the National Multiple Sclerosis Society Clinical Outcomes Assessment Task Force. Ann Neurol 1997; 42:379\u2013382. 12. Goodkin DE, Hertzgard D, Seminary J. Upper extremity function in multiple sclerosis: Improving assessment sensitivity with box-and-block and nine-hole-peg tests. Arch Phys Med Rehabil 1988; 69:850\u2013854. 13. Gronwall DMA. Paced auditory serial-addition task: A measure of recovery from concussion. Percept Mot Skills 1977; 44:367\u2013373. 14. Smith CR, LaRocca NG, Giesser BS, et al. High-dose oral baclofen: Experience in patients with multiple sclerosis. Neurology 1991; 41:1829\u20131831. 15. The United Kingdom Tizanidine Study Group. A double-blind placebo-controlled trial of tizanidine in the treatment of spasticity caused by multiple sclerosis. Neurology 1994; 44(suppl 9):70\u201379. 16. Davidoff RA. Antispasticity drugs: mechanisms of action. Ann Neurol 1985; 17:107\u2013116. 17. Dunevsky A, Perel A. gabapentin for relief of spasticity associated with multiple sclerosis. Am J Phys Med Rehabil 1998; 77:451\u2013454. 18. Moore CD. Regional block: A Handbook for Use in the Clinical Practice of Medicine and Surgery, 4th ed. Springfield, IL: Charles C Thomas, 1971. 19. Borg-Stein J, et al. Botulinum toxin for the treatment of spasticity in multiple sclerosis: New observation. Am J Phys Med Rehabil 1993; 72:364\u2013368. 20. Borodic GE, Ferrante R, Weigner AW, et al. Treatment of spasticity with botulinum toxin. Ann Neurol 1992; 31:113. 21. Petajan JH, Gappmaier E, White AT, et al. Impact of aerobic training on fitness and quality of life in multiple sclerosis. Ann Neurol 1996; 39:432\u2013441. 22. Penn RD, Savoy SM, Corcos D, et al. Intrathecal baclofen for severe spinal spasticity. N Engl J Med 1989; 320:1517\u20131521. 23. Redford JB. Principles of orthotic devices. In: Redford JB, ed. Orthotics Etcetera. Baltimore: Williams & Wilkins, 1985, pp 1\u201320. 24. Lehman JF. Lower limb orthotics. In: Redford JB, ed. Orthotics Etcetera. Baltimore: Williams & Wilkins, 1985, pp 278\u2013351. 25. Lehman JF, Esselman PC, Ko MJ, et al. Plastic ankle-foot orthoses: Evaluation of function. 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