{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:54:59Z","timestamp":1785786899755,"version":"3.56.0"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"5 Part 2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Res"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1203\/pdr.0b013e31819dbd0a","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T22:32:30Z","timestamp":1242945150000},"page":"38R-45R","source":"Crossref","is-referenced-by-count":67,"title":["An Integrated Classification of Pediatric Inflammatory Diseases, Based on the Concepts of Autoinflammation and the Immunological Disease Continuum"],"prefix":"10.1038","volume":"65","author":[{"given":"Dennis","family":"McGonagle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azad","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J","family":"Dickie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"pr2009121-bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/978-3-540-75203-5_8","volume":"321","author":"Ryan JG","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"key":"pr2009121-bib2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/01.inf.0000258777.86510.da","volume":"26","author":"Chitkara P","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"pr2009121-bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000143226","volume":"1","author":"Beutler B","year":"2009","journal-title":"J Innate Immun"},{"key":"pr2009121-bib4","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1371\/journal.pmed.0030297","volume":"3","author":"McGonagle D","year":"2006","journal-title":"PLoS Med"},{"key":"pr2009121-bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00281-007-0084-1","volume":"29","author":"McGonagle D","year":"2007","journal-title":"Semin Immunopathol"},{"key":"pr2009121-bib6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.molmed.2007.07.005","volume":"13","author":"McDermott MF","year":"2007","journal-title":"Trends Mol Med"},{"key":"pr2009121-bib7","first-page":"S79","volume":"24","author":"Galeazzi M","year":"2006","journal-title":"Clin Exp Rheumatol"},{"key":"pr2009121-bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0092-8674(00)80721-7","volume":"97","author":"McDermott MF","year":"1999","journal-title":"Cell"},{"key":"pr2009121-bib9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ncprheum0874","volume":"4","author":"Neven B","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"key":"pr2009121-bib10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0092-8674(00)80539-5","volume":"90","year":"1997","journal-title":"Cell"},{"key":"pr2009121-bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0997-25","volume":"17","year":"1997","journal-title":"Nat Genet"},{"key":"pr2009121-bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/9691","volume":"22","author":"Houten SM","year":"1999","journal-title":"Nat Genet"},{"key":"pr2009121-bib13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/9696","volume":"22","author":"Drenth JP","year":"1999","journal-title":"Nat Genet"},{"key":"pr2009121-bib14","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1067\/mai.2001.118790","volume":"108","author":"Hoffman HM","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"pr2009121-bib15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1086\/341357","volume":"71","author":"Feldmann J","year":"2002","journal-title":"Am J Hum Genet"},{"key":"pr2009121-bib16","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1002\/art.10509","volume":"46","author":"Aganna E","year":"2002","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib17","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/hmg\/11.8.961","volume":"11","author":"Wise CA","year":"2002","journal-title":"Hum Mol Genet"},{"key":"pr2009121-bib18","doi-asserted-by":"crossref","first-page":"13501","DOI":"10.1073\/pnas.2135380100","volume":"100","author":"Shoham NG","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"pr2009121-bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.it.2004.07.007","volume":"25","author":"McDermott MF","year":"2004","journal-title":"Trends Immunol"},{"key":"pr2009121-bib20","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/art.22491","volume":"56","author":"Aksentijevich I","year":"2007","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1074-7613(04)00046-9","volume":"20","author":"Agostini L","year":"2004","journal-title":"Immunity"},{"key":"pr2009121-bib22","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1002\/art.20494","volume":"50","author":"Janssen R","year":"2004","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib23","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jpeds.2008.01.038","volume":"152","author":"Takada H","year":"2008","journal-title":"J Pediatr"},{"key":"pr2009121-bib24","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/bor.0000174210.78449.6b","volume":"17","author":"Stojanov S","year":"2005","journal-title":"Curr Opin Rheumatol"},{"key":"pr2009121-bib25","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1002\/art.23604","volume":"58","author":"Day TG","year":"2008","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"Hugot JP","year":"2001","journal-title":"Nature"},{"key":"pr2009121-bib27","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Ogura Y","year":"2001","journal-title":"Nature"},{"key":"pr2009121-bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng720","volume":"29","author":"Miceli-Richard C","year":"2001","journal-title":"Nat Genet"},{"key":"pr2009121-bib29","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/j.1365-2133.2007.08210.x","volume":"157","author":"Coto-Segura P","year":"2007","journal-title":"Br J Dermatol"},{"key":"pr2009121-bib30","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.0022-202X.2004.22341.x","volume":"122","author":"Kanazawa N","year":"2004","journal-title":"J Invest Dermatol"},{"key":"pr2009121-bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-3083.2008.02114.x","volume":"68","author":"McGonagle D","year":"2008","journal-title":"Scand J Immunol"},{"key":"pr2009121-bib32","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1182\/blood-2005-09-3556","volume":"107","author":"Grosse J","year":"2006","journal-title":"Blood"},{"key":"pr2009121-bib33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s100380200067","volume":"47","author":"Yamazaki K","year":"2002","journal-title":"J Hum Genet"},{"key":"pr2009121-bib34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0952-7915(97)80180-X","volume":"9","author":"Romagnani P","year":"1997","journal-title":"Curr Opin Immunol"},{"key":"pr2009121-bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrg2203","volume":"9","author":"Mathew CG","year":"2008","journal-title":"Nat Rev Genet"},{"key":"pr2009121-bib36","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/ng.145","volume":"40","author":"Fisher SA","year":"2008","journal-title":"Nat Genet"},{"key":"pr2009121-bib37","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ng.221","volume":"40","author":"Franke A","year":"2008","journal-title":"Nat Genet"},{"key":"pr2009121-bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2006.05.017","volume":"25","author":"Uhlig HH","year":"2006","journal-title":"Immunity"},{"key":"pr2009121-bib39","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/ng1954","volume":"39","author":"Hampe J","year":"2007","journal-title":"Nat Genet"},{"key":"pr2009121-bib40","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1345\/aph.1G374","volume":"40","author":"Pham CQ","year":"2006","journal-title":"Ann Pharmacother"},{"key":"pr2009121-bib41","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.289.5483.1352","volume":"289","author":"Steidler L","year":"2000","journal-title":"Science"},{"key":"pr2009121-bib42","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10620-006-3192-1","volume":"51","author":"Giaglis S","year":"2006","journal-title":"Dig Dis Sci"},{"key":"pr2009121-bib43","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00431-007-0508-x","volume":"167","author":"Sari S","year":"2008","journal-title":"Eur J Pediatr"},{"key":"pr2009121-bib44","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/1098-1004(200009)16:3<271::AID-HUMU16>3.0.CO;2-A","volume":"16","author":"Touitou I","year":"2000","journal-title":"Hum Mutat"},{"key":"pr2009121-bib45","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0092-8674(95)90013-6","volume":"81","author":"Fisher GH","year":"1995","journal-title":"Cell"},{"key":"pr2009121-bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2249.2000.01275.x","volume":"121","author":"Pignata C","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"pr2009121-bib47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","volume":"27","author":"Bennett CL","year":"2001","journal-title":"Nat Genet"},{"key":"pr2009121-bib48","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-3-540-75203-5_7","volume":"321","author":"Appleby MW","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"key":"pr2009121-bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ng1297-393","volume":"17","author":"Nagamine K","year":"1997","journal-title":"Nat Genet"},{"key":"pr2009121-bib50","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1210\/jc.2008-0935","volume":"93","author":"Meloni A","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"pr2009121-bib51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1055\/s-0029-1211924","volume":"105","author":"Krude H","year":"1997","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"pr2009121-bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00007611-199202000-00006","volume":"85","author":"Giacoia GP","year":"1992","journal-title":"South Med J"},{"key":"pr2009121-bib53","unstructured":""},{"key":"pr2009121-bib54","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrg1944","volume":"7","author":"Gregersen PK","year":"2006","journal-title":"Nat Rev Genet"},{"key":"pr2009121-bib55","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJMoa073003","volume":"357","author":"Remmers EF","year":"2007","journal-title":"N Engl J Med"},{"key":"pr2009121-bib56","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/ng.102","volume":"40","author":"Hunt KA","year":"2008","journal-title":"Nat Genet"},{"key":"pr2009121-bib57","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/ard.2007.080283","volume":"67","author":"Rueda B","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"pr2009121-bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.gene.6364351","volume":"8","author":"Liu Y","year":"2007","journal-title":"Genes Immun"},{"key":"pr2009121-bib59","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/511051","volume":"80","author":"Cargill M","year":"2007","journal-title":"Am J Hum Genet"},{"key":"pr2009121-bib60","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1002\/art.23492","volume":"58","author":"Chang M","year":"2008","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib61","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1136\/ard.2004.032060","volume":"64","author":"Alexander T","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"pr2009121-bib62","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00467-007-0500-8","volume":"22","author":"Dalgic B","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"pr2009121-bib63","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jbspin.2007.01.032","volume":"74","author":"Gerard S","year":"2007","journal-title":"Joint Bone Spine"},{"key":"pr2009121-bib64","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/art.20033","volume":"50","author":"Hawkins PN","year":"2004","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib65","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/rheumatology\/kem318","volume":"47","author":"Maksimovic L","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"pr2009121-bib66","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.21807","volume":"54","author":"Mirault T","year":"2006","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib67","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/ard.2005.038091","volume":"65","author":"Rynne M","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"pr2009121-bib68","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/art.23261","volume":"58","author":"Yamazaki T","year":"2008","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib69","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/S0140-6736(04)17401-1","volume":"364","author":"Hoffman HM","year":"2004","journal-title":"Lancet"},{"key":"pr2009121-bib70","first-page":"2085","volume":"33","author":"Metyas SK","year":"2006","journal-title":"J Rheumatol"},{"key":"pr2009121-bib71","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1525-1470.2007.00343.x","volume":"24","author":"O'Connell SM","year":"2007","journal-title":"Pediatr Dermatol"},{"key":"pr2009121-bib72","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2310\/7750.2008.07050","volume":"12","author":"Ross JB","year":"2008","journal-title":"J Cutan Med Surg"},{"key":"pr2009121-bib73","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1053\/j.ajkd.2006.10.026","volume":"49","author":"Thornton BD","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"pr2009121-bib74","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJMoa055137","volume":"355","author":"Goldbach-Mansky R","year":"2006","journal-title":"N Engl J Med"},{"key":"pr2009121-bib75","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/art.22561","volume":"56","author":"Goldbach-Mansky R","year":"2007","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib76","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/art.20953","volume":"52","author":"Lovell DJ","year":"2005","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib77","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/art.23620","volume":"58","author":"Goldbach-Mansky R","year":"2008","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib78","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/art.23687","volume":"58","author":"Hoffman HM","year":"2008","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib79","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1136\/ard.2005.045245","volume":"65","author":"de Koning HD","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"pr2009121-bib80","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/art.23119","volume":"58","author":"McGonagle D","year":"2008","journal-title":"Arthritis Rheum"},{"key":"pr2009121-bib81","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","volume":"9","author":"So A","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"pr2009121-bib82","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jaad.2005.08.047","volume":"55","author":"McGinness JL","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"pr2009121-bib83","doi-asserted-by":"crossref","first-page":"13009","DOI":"10.1073\/pnas.0806874105","volume":"105","author":"Gavanescu I","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"pr2009121-bib84","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1046\/j.1365-2141.2002.03753.x","volume":"118","author":"Heelan BT","year":"2002","journal-title":"Br J Haematol"},{"key":"pr2009121-bib85","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1600-0609.2007.00924.x","volume":"79","author":"Wei A","year":"2007","journal-title":"Eur J Haematol"},{"key":"pr2009121-bib86","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0006-291X(03)00221-3","volume":"302","author":"Dowds TA","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"pr2009121-bib87","first-page":"390","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"}],"container-title":["Pediatric Research"],"original-title":[],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T02:53:13Z","timestamp":1684896793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/doifinder\/10.1203\/PDR.0b013e31819dbd0a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":87,"journal-issue":{"issue":"5 Part 2","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["pr2009121"],"URL":"https:\/\/doi.org\/10.1203\/pdr.0b013e31819dbd0a","relation":{},"ISSN":["0031-3998","1530-0447"],"issn-type":[{"value":"0031-3998","type":"print"},{"value":"1530-0447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}