{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:31:31Z","timestamp":1791199891649,"version":"4.2.0"},"reference-count":205,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrition and Cancer"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1207\/s15327914nc4802_2","type":"journal-article","created":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T19:28:39Z","timestamp":1088710119000},"page":"124-141","source":"Crossref","is-referenced-by-count":69,"title":["Colorectal Cancer and the Relationship Between Genes and the Environment"],"prefix":"10.1207","volume":"48","author":[{"given":"Patricia M.","family":"Heavey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","reference":[{"key":"p_1_97","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1079\/NRR19960012","volume":"9","author":"Bingham SA","year":"1996","journal-title":"Nutr Res Rev"},{"key":"p_2_98","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02234831","volume":"44","author":"Nagata C","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"p_3_99","unstructured":"Haenszel W: Cancer mortality among the foreign born in the U.S. JNCI 26, 37-132, 1961."},{"key":"p_4_100","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/1097-0142(196505)18:5<656::AID-CNCR2820180515>3.0.CO;2-3","volume":"18","author":"Buell P","year":"1965","journal-title":"Cancer"},{"key":"p_5_101","unstructured":"Staszewski J and Haenszel W: Cancer mortality among the Polish born in the U.S. JNCI 35, 291-297, 1965."},{"key":"p_6_102","unstructured":"Haenszel W and Kurihara M: Mortality from cancer and other diseases among Japanese in the United States. JNCI 40, 43-68, 1968."},{"key":"p_7_103","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200012000-00006"},{"key":"p_8_104","doi-asserted-by":"crossref","unstructured":"Potter JD. Colorectal cancer: Molecules and populations. JNCI 91, 916-932, 1999.","DOI":"10.1093\/jnci\/91.11.916"},{"key":"p_9_105","first-page":"S12","volume":"11","author":"Augenlicht LH","year":"2002","journal-title":"Eur J Cancer Prev"},{"key":"p_10_106","unstructured":"Bruce WR, Giacca A, and Medline A: Possible mechanisms relating diet to colorectal cancer risk. IARC Scientific Publications 156, 277-281, 2002."},{"key":"p_11_107","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601522"},{"key":"p_12_108","doi-asserted-by":"crossref","unstructured":"Shih M, Wang TL, Traverso G, Romans K, Hamilton SR, etal: Top-down morphogenesis of colorectal tumors. Proc Natl Acad Sci USA 98, 2640-2645, 2001.","DOI":"10.1073\/pnas.051629398"},{"key":"p_13_109","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90186-I"},{"key":"p_14_110","doi-asserted-by":"publisher","DOI":"10.1038\/359235a0"},{"key":"p_15_111","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1101\/gad.13.10.1309","volume":"13","author":"Smits R","year":"1999","journal-title":"Genes Dev"},{"key":"p_16_112","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5382.1509"},{"key":"p_17_113","doi-asserted-by":"publisher","DOI":"10.1038\/18884"},{"key":"p_18_114","first-page":"911","volume":"21","author":"Dimberg J","year":"2001","journal-title":"Anticancer Res"},{"key":"p_19_115","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3352"},{"key":"p_20_116","doi-asserted-by":"publisher","DOI":"10.1038\/327293a0"},{"key":"p_21_117","doi-asserted-by":"crossref","unstructured":"Vogelstein BER, Fearon SR, Hamilton SE, Kern AC, Preisinger M, etal: Genetic alterations during colorectal tumor development. N Engl J Med 319, 525-532, 1988.","DOI":"10.1056\/NEJM198809013190901"},{"key":"p_22_118","doi-asserted-by":"crossref","unstructured":"Cho KR, Vogelstein B: Suppressor gene alterations in the colorectal adenoma-carcinoma sequence. J Cell Biochem 16G, 137-141,1992.","DOI":"10.1002\/jcb.240501124"},{"key":"p_23_119","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1126\/science.2649981","volume":"244","author":"Baker SJ","year":"1989","journal-title":"Science"},{"key":"p_24_120","doi-asserted-by":"publisher","DOI":"10.1038\/358015a0"},{"key":"p_25_121","first-page":"4855","volume":"54","author":"Greenblatt MS","year":"1994","journal-title":"Cancer Res"},{"key":"p_26_122","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81336-7"},{"key":"p_27_123","doi-asserted-by":"publisher","DOI":"10.1038\/ng0796-343"},{"key":"p_28_124","doi-asserted-by":"crossref","unstructured":"Xu W, Angelis K, Danielpour D, Haddad MM, Bischof O, etal: Ski acts as a co-repressor with Smad 2 and Smad 3 to regulate the response to type beta transforming growth factor. Proc Natl Acad Sci USA 97, 5924-5929, 2000.","DOI":"10.1073\/pnas.090097797"},{"key":"p_29_125","doi-asserted-by":"publisher","DOI":"10.1038\/35043051"},{"key":"p_30_126","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(95)90059-4"},{"key":"p_31_127","unstructured":"Veale AMO: Intestinal Polyposis. Eugenics Laboratory Memoirs. Series no. 40. London: Cambridge University Press, 1965."},{"key":"p_32_128","doi-asserted-by":"publisher","DOI":"10.1038\/12511"},{"key":"p_33_129","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(85)90115-X"},{"key":"p_34_130","first-page":"801","volume":"36","author":"Lynch","year":"1999","journal-title":"J Med Genet"},{"key":"p_35_131","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199911)26:3<247::AID-GCC9>3.3.CO;2-8"},{"key":"p_36_132","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00376-7"},{"key":"p_37_133","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1126\/science.8484120","volume":"260","author":"Peltomaki P","year":"1993","journal-title":"Science"},{"key":"p_38_134","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2002.1399"},{"key":"p_39_135","first-page":"300","volume":"57","author":"Parsons R","year":"1995","journal-title":"Cancer Res"},{"key":"p_40_136","first-page":"3101","volume":"58","author":"Grady WH","year":"1998","journal-title":"Cancer Res"},{"key":"p_41_137","doi-asserted-by":"crossref","unstructured":"Hamilton SR: The adenoma-adenomacarcinoma sequence in the large bowel: variation on a theme. J Cell Biochem 16G, 41-46, 1992.","DOI":"10.1002\/jcb.240501108"},{"key":"p_42_138","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/bjc.1997.522","volume":"76","author":"Hiltunen MO","year":"1997","journal-title":"Br J Cancer"},{"key":"p_43_139","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.6254144","volume":"210","author":"Razin A","year":"1980","journal-title":"Science"},{"key":"p_44_140","doi-asserted-by":"publisher","DOI":"10.1038\/301089a0"},{"key":"p_45_141","doi-asserted-by":"crossref","unstructured":"Makos M, Nelkin B, Lerman M, Latif F, Zbar B, etal: Distinct hypermethylation patterns occur altered chromosome loci in human lung and colon cancer. Proc Natl Acad Sci USA 89, 1929-1933, 1992.","DOI":"10.1073\/pnas.89.5.1929"},{"key":"p_46_142","first-page":"1159","volume":"48","author":"Feinberg AP","year":"1988","journal-title":"Cancer Res"},{"key":"p_47_143","first-page":"5438","volume":"32","author":"Issa JP","year":"1999","journal-title":"Crit Rev Oncol Hematol"},{"key":"p_48_144","first-page":"4366","volume":"60","author":"Esteller M","year":"2000","journal-title":"Cancer Res"},{"key":"p_49_145","first-page":"6991","volume":"61","author":"Nakagawa H","year":"2001","journal-title":"Cancer Res"},{"key":"p_50_146","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600699"},{"key":"p_51_147","first-page":"513","volume":"8","author":"Slattery ML","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_52_148","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(99)00167-9"},{"key":"p_53_149","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1349-7006.1999.tb00805.x","volume":"90","author":"Murata M","year":"1999","journal-title":"Jpn J Cancer Res"},{"key":"p_54_150","first-page":"659","volume":"8","author":"Ulrich CM","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_55_151","first-page":"647","volume":"7","author":"Lin HJ","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_56_152","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008913619957"},{"key":"p_57_153","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91012-0"},{"key":"p_58_154","first-page":"3307","volume":"58","author":"Chen J","year":"1998","journal-title":"Cancer Res"},{"key":"p_59_155","first-page":"15","volume":"8","author":"Kampman E","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_60_156","unstructured":"Wagner C: Biochemical role of folate in cellular metabolism. In Folate in Health and Disease, Bailey LB (ed). New York: Marcel Dekker, 1995, pp 313-328."},{"key":"p_61_157","first-page":"382","volume":"3","author":"Baylin SB","year":"1991","journal-title":"Cancer Cells"},{"key":"p_62_158","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-111"},{"key":"p_63_159","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/oxfordjournals.aje.a010289","volume":"151","author":"Brockton N","year":"2000","journal-title":"Am J Epidemiol"},{"key":"p_64_160","doi-asserted-by":"crossref","unstructured":"Hein DW: N-acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis. Toxicol Lett 112-113, 349-356, 2000.","DOI":"10.1016\/S0378-4274(99)00226-X"},{"key":"p_65_161","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00027-3"},{"key":"p_66_162","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/oxfordjournals.aje.a010124","volume":"151","author":"Cotton SC","year":"2000","journal-title":"Am J Epidemiol"},{"key":"p_67_163","first-page":"289","volume":"8","author":"Welfare M","year":"1992","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_68_164","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.7.1053"},{"key":"p_69_165","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1289\/ehp.95103s8165","volume":"103","author":"Willett WC","year":"1995","journal-title":"Environ Health Perspect"},{"key":"p_70_166","unstructured":"World Cancer Research Fund\/American Institute for Cancer Research. Food, Nutrition and the Prevention of Cancer: A Global Perspective. Washington, DC: WCRF\/AICR, 1997."},{"key":"p_71_167","unstructured":"COMA Working Group on Diet and Cancer. Nutritional aspects of the development of cancer: UK Department of Health Report on Health and Social Subjects (No. 48). Norwich: HMSO, 1998."},{"key":"p_72_168","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.5-5-393"},{"key":"p_73_169","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005519920643"},{"key":"p_74_170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1753-4887.2001.tb06974.x","volume":"59","author":"Norat T","year":"2001","journal-title":"Nutr Rev"},{"key":"p_75_171","first-page":"439","volume":"10","author":"Sandhu MS","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_76_172","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2002402"},{"key":"p_77_173","doi-asserted-by":"publisher","DOI":"10.1006\/appe.1998.0187"},{"key":"p_78_174","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.1.199"},{"key":"p_79_175","first-page":"503","volume":"5","author":"Wurzemann JI","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_80_176","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/ajcn\/69.2.250","volume":"69","author":"Lund EK","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"p_81_177","first-page":"559","volume":"10","author":"Sinha R","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_82_178","first-page":"675","volume":"3","author":"Lang NP","year":"1994","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_83_179","first-page":"2100","volume":"51","author":"Ladero JM","year":"2098","journal-title":"Cancer Res"},{"key":"p_84_180","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1002\/1097-0142(19941215)74:12<3108::AID-CNCR2820741208>3.0.CO;2-M","volume":"74","author":"Shibuta K","year":"1994","journal-title":"Cancer"},{"key":"p_85_181","doi-asserted-by":"crossref","unstructured":"Marchand LL: Combined influence of genetic and dietary factors on colorectal cancer incidence in Japanese Americans. JNCI 26, 101-105, 1999.","DOI":"10.1093\/oxfordjournals.jncimonographs.a024220"},{"key":"p_86_182","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015700415808"},{"key":"p_87_183","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.1.38"},{"key":"p_88_184","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600845"},{"key":"p_89_185","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005432804902"},{"key":"p_90_186","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600846"},{"key":"p_91_187","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF01830239","volume":"5","author":"Jacobson JS","year":"1994","journal-title":"Cancer Causes Control"},{"key":"p_92_188","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1370"},{"key":"p_93_189","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/01635589209514210","volume":"18","author":"Kune GA","year":"1992","journal-title":"Nutr Cancer"},{"key":"p_94_190","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/00008469-199912001-00008","volume":"8","author":"Franceschi S","year":"1999","journal-title":"Eur J Cancer Prev"},{"key":"p_95_191","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018490212481"},{"key":"p_96_192","unstructured":"Bueno-De-Mesquita HB: Plant foods and colorectal cancer in the EPIC cohort. Proceedings of the European Conference on Nutrition and Cancer. 11 abstr, 2001."},{"key":"p_97_193","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.11.1081"},{"key":"p_98_194","unstructured":"Michels KB, Giovannucci E, Joshipura KJ, Rosner BA, Stampfer MJ, etal: Fruit and vegetable consumption and colorectal cancer incidence. IARC Sci Publications 156, 139-140, 2002."},{"key":"p_99_195","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/ijc.2910530502","volume":"53","author":"Steinmetz KA","year":"1993","journal-title":"Int J Cancer"},{"key":"p_100_196","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00195-7"},{"key":"p_101_197","first-page":"733","volume":"5","author":"Verhoeven DT","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_102_198","first-page":"17","volume":"10","author":"Jacobs EJ","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_103_199","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/BF02237131","volume":"42","author":"Whelan RL","year":"1999","journal-title":"Dis Colon Rectum"},{"key":"p_104_200","doi-asserted-by":"crossref","unstructured":"Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, etal: Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci USA 98, 3410-3415, 2001.","DOI":"10.1073\/pnas.051618798"},{"key":"p_105_201","doi-asserted-by":"publisher","DOI":"10.1021\/jf000191p"},{"key":"p_106_202","first-page":"647","volume":"7","author":"Lin HJ","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_107_203","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/oxfordjournals.aje.a010124","volume":"151","author":"Cotton SC","year":"2000","journal-title":"Am J Epidemiol"},{"key":"p_108_204","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1093\/carcin\/17.10.2125","volume":"17","author":"Probst-Hensch NM","year":"1996","journal-title":"Carcinogenesis"},{"key":"p_109_205","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91012-0"},{"key":"p_110_206","first-page":"6935","volume":"60","author":"Slattery ML","year":"2000","journal-title":"Cancer Res"},{"key":"p_111_207","doi-asserted-by":"crossref","unstructured":"Higginson J and Oettle AG: Cancer incidence in Bantu and \"Cape colored\" races of South Africa: report of a cancer survey of the Transvaal (1953-1955). JNCI 24, 589-671, 1960.","DOI":"10.1093\/jnci\/24.3.589"},{"key":"p_112_208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)90757-0"},{"key":"p_113_209","doi-asserted-by":"crossref","unstructured":"Trock B, Lanza E, and Greenwald P: Dietary fiber, vegetables, and colon cancer: critical review and meta-analysis of the epidemiologic evidence. JNCI 82, 650-661, 1990.","DOI":"10.1093\/jnci\/82.8.650"},{"key":"p_114_210","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12458-0"},{"key":"p_115_211","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13174-1"},{"key":"p_116_212","doi-asserted-by":"crossref","unstructured":"Fuchs CS, Giovannuci EL, Colditz GA, Hunter DJ, Stampfer MJ, etal: Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med 340, 169-176, 1999.","DOI":"10.1056\/NEJM199901213400301"},{"key":"p_117_213","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13219-9"},{"key":"p_118_214","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1079\/PNS19810003","volume":"40","author":"Cummings JH","year":"1981","journal-title":"Proc Nutr Soc"},{"key":"p_119_215","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.1999.00696.x"},{"key":"p_120_216","doi-asserted-by":"crossref","unstructured":"Edwards CA, Rowland IR: Bacterial fermentation in the colon and its measurement. In Dietary Fiber, A Component of Food, Nutritional Function in Health and Disease, Schweizer T and Edwards CA (eds). Europe: ILSI, 1991, pp 119-136.","DOI":"10.1007\/978-1-4471-1928-9_6"},{"key":"p_121_217","doi-asserted-by":"crossref","unstructured":"Rowland IR: Non-digestible carbohydrates and gut function: implications for carcinogenesis. In Advanced Dietary Fiber Technology, McCleary BV and Prosky L (eds). Oxford: Blackwell Science, 2000, pp 226-231.","DOI":"10.1002\/9780470999615.ch20"},{"key":"p_122_218","doi-asserted-by":"crossref","unstructured":"Roediger WE: The starved colon-diminished mucosal nutrition, diminished absorption, and colitis Dis Colon Rectum 33, 858-862, 1990.","DOI":"10.1007\/BF02051922"},{"key":"p_123_219","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1136\/gut.35.1_Suppl.S35","volume":"1","author":"Scheppach W","year":"1994","journal-title":"Gut Suppl."},{"key":"p_124_220","first-page":"523","volume":"8","author":"Heerdt BG","year":"1997","journal-title":"Cell Growth Differ"},{"key":"p_125_221","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.1.7"},{"key":"p_126_222","doi-asserted-by":"crossref","unstructured":"Chapkin RS, Fan Y, and Lupton JR: Effect of diet on colonic programmed cell death: molecular mechanism of action. Toxicol Lett 112-113, 411-414, 2000.","DOI":"10.1016\/S0378-4274(99)00263-5"},{"key":"p_127_223","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.10.1675"},{"key":"p_128_224","doi-asserted-by":"crossref","unstructured":"Richon VM, Sandhoff TW, Rifkind RA, and Marks PA: Histone deacetylase inhibitors selectively induces p21 super (WAF1) expression and gene associated histone acetylation. Proc Natl Acad Sci USA 97, 10014-10019, 2000.","DOI":"10.1073\/pnas.180316197"},{"key":"p_129_225","first-page":"5906","volume":"52","author":"Boffa LC","year":"1992","journal-title":"Cancer Res"},{"key":"p_130_226","unstructured":"Nigro ND, Bull AW, Klopfer BA, Paks MS, and Campbell RL: Effects of dietary fiber on azoxymethane-induced intestinal carcinogenesis in rats. JNCI 62, 1097-1102, 1979."},{"key":"p_131_227","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/carcin\/16.6.1425","volume":"16","author":"Hardman WE","year":"1995","journal-title":"Carcinogenesis"},{"key":"p_132_228","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1271\/bbb.61.1337","volume":"61","author":"Ishizuka S","year":"1997","journal-title":"Biosci Biotechnol Biochem"},{"key":"p_133_229","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.3.525"},{"key":"p_134_230","first-page":"25","volume":"1","author":"Bird AR","year":"2000","journal-title":"Curr Issues in Intest Microbiol"},{"key":"p_135_231","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1136\/gut.34.3.386","volume":"34","author":"McIntyre A","year":"1993","journal-title":"Gut"},{"key":"p_136_232","first-page":"124","volume":"57","author":"Mobarhan S","year":"1999","journal-title":"Nutr Rev"},{"key":"p_137_233","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008962219408"},{"key":"p_138_234","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/27.5.788"},{"key":"p_139_235","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.4.302"},{"key":"p_140_236","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/carcin\/4.9.1205","volume":"4","author":"Wargovich MJ","year":"1983","journal-title":"Carcinogenesis"},{"key":"p_141_237","first-page":"67","volume":"63","author":"Chakrabarty S","year":"2003","journal-title":"Cancer Res"},{"key":"p_142_238","doi-asserted-by":"crossref","unstructured":"Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, ColditzGA et al.: Alcohol, low-methionine -low folate diets, and risk of colon cancer in men. JNCI 87, 265-273, 1995.","DOI":"10.1093\/jnci\/87.4.265"},{"key":"p_143_239","doi-asserted-by":"crossref","first-page":"517","DOI":"10.7326\/0003-4819-129-7-199810010-00002","volume":"129","author":"Giovannucci E","year":"1998","journal-title":"Ann Intern Med"},{"key":"p_144_240","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ijc.2910550208","volume":"55","author":"Benito E","year":"1993","journal-title":"Int J Cancer"},{"key":"p_145_241","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/oxfordjournals.aje.a008871","volume":"144","author":"Tseng M","year":"1996","journal-title":"Am J Epidemiol"},{"key":"p_146_242","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(00)00188-5"},{"key":"p_147_243","first-page":"1098","volume":"57","author":"Chen J","year":"1996","journal-title":"Cancer Res"},{"key":"p_148_244","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.12.2261"},{"key":"p_149_245","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/20.12.2345"},{"key":"p_150_246","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1053\/gast.2000.8518","volume":"119","author":"Kim YI","year":"2000","journal-title":"Gastroenterology"},{"key":"p_151_247","first-page":"5181","volume":"59","author":"Martinez ME","year":"1999","journal-title":"Cancer Res"},{"key":"p_152_248","doi-asserted-by":"crossref","unstructured":"Logan RF, Little J, Hawtin PG, and Hardcastle JD: Effect of aspirin and non-steroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham fecal occult blood screening programme. Br Med J 307, 285-289, 1993.","DOI":"10.1136\/bmj.307.6899.285"},{"key":"p_153_249","doi-asserted-by":"crossref","unstructured":"Greenberg ER, Baron JA, Freeman DH Jr, Mandel JS, and Haile R: Reduced risk of large-bowel adenomas among aspirin users. The Polyp Prevention Study Group. JNCI 85, 912-916, 1993.","DOI":"10.1093\/jnci\/85.11.912"},{"key":"p_154_250","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7326\/0003-4819-121-4-199408150-00001","volume":"121","author":"Giovannucci E","year":"1994","journal-title":"Ann Intern Med"},{"key":"p_155_251","first-page":"1000","volume":"61","author":"Slattery ML","year":"2001","journal-title":"Cancer Res"},{"key":"p_156_252","first-page":"285","volume":"5","author":"Freedman AN","year":"1996","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_157_253","doi-asserted-by":"crossref","unstructured":"Gann PH, Manson JE, Glynn RJ, Buring JE, and Hennekens CH: Low-dose aspirin and incidence of colorectal tumors in a randomized trial. JNCI 85, 1220-1224, 1993.","DOI":"10.1093\/jnci\/85.15.1220"},{"key":"p_158_254","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200007000-00003"},{"key":"p_159_255","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008931708716"},{"key":"p_160_256","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.857"},{"key":"p_161_257","first-page":"217","volume":"16","author":"Shacter E","year":"2002","journal-title":"Oncology"},{"key":"p_162_258","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(01)01197-7"},{"key":"p_163_259","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-419X(00)00006-8"},{"key":"p_164_260","first-page":"3785","volume":"55","author":"Sano H","year":"1999","journal-title":"Cancer Res"},{"key":"p_165_261","first-page":"2556","volume":"55","author":"Kargman SL","year":"1995","journal-title":"Cancer Res"},{"key":"p_166_262","first-page":"6323","volume":"62","author":"Sun Y","year":"2002","journal-title":"Cancer Res"},{"key":"p_167_263","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)00011-4"},{"key":"p_168_264","first-page":"911","volume":"21","author":"Dimberg J","year":"2001","journal-title":"Anticancer Res"},{"key":"p_169_265","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204123"},{"key":"p_170_266","first-page":"6307","volume":"61","author":"Shureiqi I","year":"2001","journal-title":"Cancer Res"},{"key":"p_171_267","first-page":"2223","volume":"59","author":"Hong SH","year":"1999","journal-title":"Cancer Res"},{"key":"p_172_268","doi-asserted-by":"crossref","unstructured":"Steele VE, Hawk ET, Viner JL, and Lubert RA: Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer. Mutat Res 523-524, 137-144, 2003.","DOI":"10.1016\/S0027-5107(02)00329-9"},{"key":"p_173_269","first-page":"1995","volume":"20","author":"Shureiqi I","year":"1985","journal-title":"Carcinogenesis"},{"key":"p_174_270","doi-asserted-by":"crossref","unstructured":"Shureiqi I, Chen D, Lee JJ, Yang P, Newman RA, etal: 15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. JNCI 92, 1136-1142, 2000.","DOI":"10.1093\/jnci\/92.14.1136"},{"key":"p_175_271","first-page":"725","volume":"10","author":"Giovannucci E","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"p_176_272","doi-asserted-by":"crossref","unstructured":"Slattery ML, Curtin K, Anderson K, Ma KN, Ballard L, etal: Association between cigarette smoking, lifestyle factors, and microsatellite instability in colon cancers. JNCI 92, 1831-1836, 2000.","DOI":"10.1093\/jnci\/92.22.1831"},{"key":"p_177_273","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.10.1681"},{"key":"p_178_274","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF01830239","volume":"5","author":"Jacobson JS","year":"1994","journal-title":"Cancer Causes Control"},{"key":"p_179_275","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00424-4"},{"key":"p_180_276","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1089\/jwh.1.1999.8.1155","volume":"8","author":"Crandall CJ","year":"1999","journal-title":"J Womens Health Gend Based Med"},{"key":"p_181_277","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00008469-199812000-00002","volume":"7","author":"Franceschi S","year":"1998","journal-title":"Eur J Cancer Prev"},{"key":"p_182_278","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1097\/00008469-199912001-00009","volume":"8","author":"Giacosa A","year":"1999","journal-title":"Eur J Cancer Prev"},{"key":"p_183_279","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200010000-00004"},{"key":"p_184_280","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800561"},{"key":"p_185_281","doi-asserted-by":"crossref","first-page":"S530","DOI":"10.1097\/00005768-200106001-00025","volume":"33","author":"Thune I","year":"2001","journal-title":"Med Sci Sports Exerc"},{"key":"p_186_282","doi-asserted-by":"publisher","DOI":"10.1210\/er.15.1.80"},{"key":"p_187_283","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/bjc.1992.65","volume":"65","author":"Macauley VM","year":"1992","journal-title":"Br J Cancer"},{"key":"p_188_284","doi-asserted-by":"crossref","unstructured":"Ma J, Pollack MN, Giovannucci E, Chan JM, Tao Y etal: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF-I) and IGF-binding protein-3. JNCI 91, 620-625, 1999.","DOI":"10.1093\/jnci\/91.7.620"},{"key":"p_189_285","doi-asserted-by":"crossref","unstructured":"Kaaks R, Toniolo P, Akhmedkhanov A, Lukanova A, Biessy C, etal: Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women. JNCI 92, 1592-1600, 2000.","DOI":"10.1093\/jnci\/92.19.1592"},{"key":"p_190_286","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(99)00070-0"},{"key":"p_191_287","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1055\/s-2007-972626","volume":"18","author":"Roelen CA","year":"1997","journal-title":"Int J Sports Med"},{"key":"p_192_288","first-page":"1436","volume":"86","author":"Korizis LP","year":"1999","journal-title":"Jf App Psychol"},{"key":"p_193_289","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/00008469-199912000-00003","volume":"8","author":"Levi F","year":"1999","journal-title":"Eur J Cancer Prev"},{"key":"p_194_290","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/gerona\/52A.3.M149","volume":"52","author":"Vitiello MV","year":"1997","journal-title":"J Gerontol"},{"key":"p_195_291","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00007256-200232010-00001","volume":"32","author":"Consitt LA","year":"2002","journal-title":"Sports Med"},{"key":"p_196_292","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801021"},{"key":"p_197_293","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(01)02505-9"},{"key":"p_198_294","first-page":"4701","volume":"48","author":"McKeown-Eyssen GE","year":"1988","journal-title":"Cancer Res"},{"key":"p_199_295","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90299-2"},{"key":"p_200_296","doi-asserted-by":"crossref","unstructured":"MacLennan R, Macrae F, Bain C, Battistutta D, Chapuis P, etal: Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. JNCI 87, 1760-1766, 1995.","DOI":"10.1093\/jnci\/87.23.1760"},{"key":"p_201_297","doi-asserted-by":"publisher","DOI":"10.1159\/000007480"},{"key":"p_202_298","doi-asserted-by":"crossref","unstructured":"Baron JA, Beach M, Mandel JS, van Stolk RU, Haile RW, etal: Calcium supplements and colorectal adenomas. Polyp Prevention Study Group. Ann NY Acad Sci 889, 138-145, 1999.","DOI":"10.1111\/j.1749-6632.1999.tb08731.x"},{"key":"p_203_299","doi-asserted-by":"crossref","unstructured":"Schatzkin A, Lanza E, Corle D, Lance P, Iber F, etal: Lack of effect of a low-fat, high fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. N Engl J Med 342, 1149-1155, 2000.","DOI":"10.1056\/NEJM200004203421601"},{"key":"p_204_300","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1053\/gast.2000.19580","volume":"119","author":"Ahlquist AD","year":"2000","journal-title":"Gastroenterology"},{"key":"p_205_301","first-page":"55","volume":"25","author":"Lauschke H","year":"2001","journal-title":"Cancer Detect Prev"}],"container-title":["Nutrition and Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1207\/s15327914nc4802_2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T16:13:26Z","timestamp":1585844006000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/abs\/10.1207\/s15327914nc4802_2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":205,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["10.1207\/s15327914nc4802_2"],"URL":"https:\/\/doi.org\/10.1207\/s15327914nc4802_2","relation":{},"ISSN":["0163-5581","1532-7914"],"issn-type":[{"value":"0163-5581","type":"print"},{"value":"1532-7914","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}