{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:10Z","timestamp":1787021230617,"version":"build-2736575974"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2003,6]]},"DOI":"10.1208\/pt040216","type":"journal-article","created":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T17:01:02Z","timestamp":1092762062000},"source":"Crossref","is-referenced-by-count":31,"title":["Implications of density correction in gravimetric method for water flux determination using rat single-pass intestinal perfusion technique: A technical note"],"prefix":"10.1208","volume":"4","author":[{"given":"Chayapathy","family":"Issa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyush","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind K.","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"4244_CR1","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1023\/A:1016212804288","volume":"12","author":"GL Amidon","year":"1995","unstructured":"Amidon GL, Lennernas H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res. 1995;12:413\u2013420.","journal-title":"Pharm Res"},{"key":"4244_CR2","first-page":"68","volume":"22","author":"J Devane","year":"1998","unstructured":"Devane J. Oral drug delivery technology: addressing the solubility\/permeability paradigm. Pharm Technol. 1998;22:68\u201380.","journal-title":"Pharm Technol"},{"key":"4244_CR3","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/j.1472-8206.1999.tb00334.x","volume":"13","author":"L Barthe","year":"1999","unstructured":"Barthe L, Woodley J, Houin G. Gastrointestinal absorption of drugs: methods and studies. Fundam Clin Pharmacol. 1999;13:154\u2013168.","journal-title":"Fundam Clin Pharmacol"},{"key":"4244_CR4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/med.2610150202","volume":"15","author":"KM Hillgren","year":"1995","unstructured":"Hillgren KM, Kato A, Borchardt RT. In vitro systems for studying intestinal drug absorption. Med Res Rev. 1995;15:83\u2013109.","journal-title":"Med Res Rev"},{"key":"4244_CR5","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1023\/A:1016207525186","volume":"12","author":"BH Stewart","year":"1995","unstructured":"Stewart BH, Chan OH, Lu RH, et al. Comparison of intestinal permeabilities determined in multiple in vitro and in situ models: relationship to absorption in humans. Pharm Res. 1995;12:693\u2013699.","journal-title":"Pharm Res"},{"key":"4244_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0169-409X(96)00424-3","volume":"23","author":"BH Stewart","year":"1997","unstructured":"Stewart BH, Chan OH, Jezyk N, Fleisher D. Discrimination between drug candidates using models for evaluation of intestinal absorption. Adv Drug Deliv Rev. 1997;23:27\u201345.","journal-title":"Adv Drug Deliv Rev"},{"key":"4244_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0378-5173(01)00848-1","volume":"229","author":"M Grassi","year":"2001","unstructured":"Grassi M, Cadelli G. Theoretical considerations on the in vivo intestinal permeability determination by means of the single pass and recirculation techniques. Int Pharm. 2001;229:95\u2013105.","journal-title":"Int Pharm"},{"key":"4244_CR8","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1211\/0022357011776252","volume":"53","author":"L Salphati","year":"2001","unstructured":"Salphati L, Childers K, Pan L, Tsutsui K, Takahashi L. Evaluation of a single-pass intestinal-perfusion method in rat for the prediction of absorption in man. J Pharm Pharmacol. 2001;53:1007\u20131013.","journal-title":"J Pharm Pharmacol"},{"key":"4244_CR9","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1023\/A:1015848815616","volume":"9","author":"HH Lu","year":"1992","unstructured":"Lu HH, Thomas JD, Tukker JJ, Fleisher D. Intestinal water and solute absorption studies: comparison of in situ perfusion with chronic isolated loops in rats. Pharm Res. 1992;9:894\u2013900.","journal-title":"Pharm Res"},{"key":"4244_CR10","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1023\/A:1015888813741","volume":"9","author":"H Lennernas","year":"1992","unstructured":"Lennernas H, Ahrenstedt O, Hallgren R, Knutson L, Ryde M, Paalzow LK. Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in man. Pharm Res. 1992;9:1243\u20131251.","journal-title":"Pharm Res"},{"key":"4244_CR11","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1023\/A:1016065715308","volume":"13","author":"U Fagerholm","year":"1996","unstructured":"Fagerholm U, Johansson M, Lennernas H. Comparison between permeability coefficients in rat and human jejunum. Pharm Res. 1996;13:1336\u20131342.","journal-title":"Pharm Res"},{"key":"4244_CR12","doi-asserted-by":"crossref","unstructured":"Sutton SC, Rinaldi MTS, Vukovinsky KE. Comparison of the gravimetric, phenol red and 14C-PEG-3350 methods to determine water absorption in the rat single-pass intestinal perfusion model. AAPS Pharm Sci. 2001;3(3) article 25.","DOI":"10.1208\/ps030325"},{"key":"4244_CR13","first-page":"3","volume":"50","author":"R Lobenberg","year":"2000","unstructured":"Lobenberg R, Amidon GL. Modern bioavailability, bioequivalence and biopharmaceutics classification system: new scientific approaches to international regulatory standards. Eur J Pharm Sci. 2000;50:3\u201312.","journal-title":"Eur J Pharm Sci"},{"key":"4244_CR14","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/0378-5173(80)90140-4","volume":"4","author":"I Komiya","year":"1980","unstructured":"Komiya I, Park JY, Kamani A, Ho NFH, Higuchi WI. Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes. Int J Pharm. 1980;4:249\u2013262.","journal-title":"Int J Pharm"},{"key":"4244_CR15","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1002\/jps.10081","volume":"91","author":"SC Sutton","year":"2002","unstructured":"Sutton SC, Rinaldi MTS, McCarthy JM, Vukovinsky KE. A statistical method for the determination of absorption rate constant estimated using the rat single pass intestinal perfusion model and multiple linear regression. J Pharm Sci. 2002;91:1046\u20131053.","journal-title":"J Pharm Sci"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt040216.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/pt040216\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt040216.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt040216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T23:42:01Z","timestamp":1559605321000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/pt040216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["4244"],"URL":"https:\/\/doi.org\/10.1208\/pt040216","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]},"article-number":"44"}}