{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T14:09:37Z","timestamp":1770646177500,"version":"3.49.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1208\/pt050455","type":"journal-article","created":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T19:45:23Z","timestamp":1109965523000},"page":"30-35","source":"Crossref","is-referenced-by-count":25,"title":["Agglomeration of ibuprofen with talc by novel crystallo-co-agglomeration technique"],"prefix":"10.1208","volume":"5","author":[{"given":"Atmaram","family":"Pawar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anant","family":"Paradkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivajirao","family":"Kadam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kakasaheb","family":"Mahadik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"5455_CR1","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.3109\/03639048909052536","volume":"14\u201315","author":"K Lovgren","year":"1989","unstructured":"Lovgren K, Lundberg PJ. Determination of sphericity of pellets prepared by extrusion\/spheronization and the impact of some process parameters.Drug Dev Ind Pharm. 1989; 14\u201315:2375\u20132392.","journal-title":"Drug Dev Ind Pharm"},{"key":"5455_CR2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3109\/03639049409050183","volume":"20","author":"SR Gokonda","year":"1994","unstructured":"Gokonda SR, Hileman GA, Upadrastha SM. Development of matrix controlled release beads by extrusion-spheronization techniques technology using a statistical screening design.Drug Dev Ind Pharm. 1994; 20:279\u2013292.","journal-title":"Drug Dev Ind Pharm"},{"key":"5455_CR3","unstructured":"Hideji O, Kiyoji K, Masayuki H, Takao G, Chikanori T. inventors. Ibuprofen-containing granule: its preparation, and internal medicine comprising it. JP patent 56-120616. Nov. 22, 1981."},{"key":"5455_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0378-5173(03)00081-4","volume":"255","author":"AR Paradkar","year":"2003","unstructured":"Paradkar AR, Maheshwari M, Ketkar AR, Chauhan B. Preparation and evaluation of ibuprofen beads by melt solidification technique.Int J Pharm. 2003; 255:33\u201342.","journal-title":"Int J Pharm"},{"issue":"4","key":"5455_CR5","doi-asserted-by":"publisher","first-page":"E65","DOI":"10.1208\/pt040465","volume":"4","author":"AR Paradkar","year":"2003","unstructured":"Paradkar AR, Maheshwari M, Tygi AK, Chauhan B, Kadam SS. Preparation and characterization of flurbiprofen beads by melt solidification technique.AAPS PharmSciTech. 2003; 4(4):E65.","journal-title":"AAPS PharmSciTech"},{"key":"5455_CR6","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.3109\/03639049009115960","volume":"16","author":"T Schaefer","year":"1990","unstructured":"Schaefer T, Holm P, Kristensen HG. Melt granulation in a laboratory scale high shear mixer.Drug Dev Ind Pharm. 1990; 16:1249\u20131277.","journal-title":"Drug Dev Ind Pharm"},{"key":"5455_CR7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0378-5173(99)00093-9","volume":"183","author":"A Johansen","year":"1999","unstructured":"Johansen A, Schaefer T, Kristensen HG. Evaluation of melt agglomeration properties of polyethylene glycols using a mixer torque rheometer.Int J Pharm. 1999; 183:155\u2013164.","journal-title":"Int J Pharm"},{"key":"5455_CR8","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1002\/adv.1987.060070306","volume":"7","author":"JL White","year":"1987","unstructured":"White JL, Szdlowski W, Min K, Kim MH. Twin screw extruders: development of technology analysis of flow.Adv Polym Technol. 1987; 7:295\u2013332.","journal-title":"Adv Polym Technol"},{"key":"5455_CR9","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0378-5173(97)00165-8","volume":"155","author":"OL Sprockel","year":"1997","unstructured":"Sprockel OL, Sen M, Shivanand P, Prapaitrakul W. A melt extrusion process for manufacturing matrix drug delivery systems.Int J Pharm. 1997; 155:191\u2013199.","journal-title":"Int J Pharm"},{"key":"5455_CR10","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1248\/cpb.30.1837","volume":"30","author":"Y Kawashima","year":"1982","unstructured":"Kawashima Y, Lin SY, Naito M, Takenama H. Direct agglomeration of sodium theophylline crystals produced by salting out in liquid.Chem Pharm Bull (Tokyo). 1982; 30:1837\u20131843.","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"5455_CR11","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/jps.2600760612","volume":"76","author":"A Sano","year":"1987","unstructured":"Sano A, Kuruki T, Handa T, Takeuchi H, Kawashima Y. Particle design of tolbutamide in the presence of soluble polymer or surfactant by the spherical crystallization technique: improvement of dissolution rate.J Pharm Sci. 1987; 76:471\u2013474.","journal-title":"J Pharm Sci"},{"key":"5455_CR12","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1081\/DDC-120015354","volume":"28","author":"AR Paradkar","year":"2002","unstructured":"Paradkar AR, Pawar AP, Chordiya JK, Patil VB, Ketkar AR. Spherical crystallization of celecoxib.Drug Dev Ind Pharm. 2002; 28:1213\u20131220.","journal-title":"Drug Dev Ind Pharm"},{"issue":"3","key":"5455_CR13","doi-asserted-by":"publisher","first-page":"E44","DOI":"10.1208\/pt050344","volume":"5","author":"AP Pawar","year":"2004","unstructured":"Pawar AP, Paradkar AR, Kadam SS, Mahadik KR. Crystallo-co-agglomeration: a novel process to obtain ibuprofen-paracetamol agglomerates.AAPS PharmSciTech. 2004; 5(3):E44.","journal-title":"AAPS PharmSciTech"},{"key":"5455_CR14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3109\/03639049509048101","volume":"21","author":"K Lin","year":"1995","unstructured":"Lin K, Peck GE. Development of agglomerated talc. I. Evaluation of fluidized bed granulation parameters on the physical properties of agglomerated talc.Drug Dev Ind Pharm. 1995; 21:159\u2013173.","journal-title":"Drug Dev Ind Pharm"},{"key":"5455_CR15","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3109\/03639049509026634","volume":"21","author":"K Lin","year":"1995","unstructured":"Lin K, Peck GE. Development of agglomerated talc. II. Optimization of the processing parameters for the preparation of granulated talc.Drug Dev Ind Pharm. 1995; 21:447\u2013460.","journal-title":"Drug Dev Ind Pharm"},{"key":"5455_CR16","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0168-3659(89)90059-X","volume":"10","author":"R Bodmeier","year":"1989","unstructured":"Bodmeier R, Chen H. Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen and ketoprofen.J Control Release. 1989; 10:167\u2013175.","journal-title":"J Control Release"},{"key":"5455_CR17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1248\/cpb.40.196","volume":"40","author":"Y Kawashima","year":"1992","unstructured":"Kawashima Y, Niwa T, Takeuchi H, Hino T, Ito Y. Control of prolonged release and compression properties of ibuprofen microspheres with acrylic polymer, Eudragit RS, by changing their intraparticle porosity.Chem Pharm Bull. 1992; 40:196\u2013201.","journal-title":"Chem Pharm Bull"},{"key":"5455_CR18","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1021\/js970052v","volume":"86","author":"T Durig","year":"1997","unstructured":"Durig T, Fassihi R. Mechanistic evaluation of binary effects of magnesium stearate and talc as dissolution retardants at 85% drug loading in an experimental extended release formulation.J Pharm Sci. 1997; 86:1092\u20131098.","journal-title":"J Pharm Sci"},{"key":"5455_CR19","unstructured":"Kadam SS, Mahadik KR, Paradkar AR inventors. A process for making agglomerates for use as or in a drug delivery system. Indian Patent 183036. Feb. 14, 1997."},{"key":"5455_CR20","unstructured":"Kadam SS, Mahadik KR, Paradkar AR. inventors. A process for making agglomerates for use as or in a drug delivery system. Indian Patent 183481. Feb. 14, 1997."},{"key":"5455_CR21","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0032-5910(93)80041-8","volume":"76","author":"K Morishima","year":"1993","unstructured":"Morishima K, Kawashima Y, Kawashima Y, Takeuchi H, Niwa T, Hino T. Micromeritic characteristics and agglomeration mechanisms in the spherical crystallization of bucillamine by the spherical agglomeration and the emulsion solvent diffusion methods.Powder Technol. 1993; 76:57\u201364.","journal-title":"Powder Technol"},{"key":"5455_CR22","volume-title":"Quantitative Analysis of Drugs in Pharmaceutical Formulations","author":"PD Sethi","year":"1993","unstructured":"Sethi PD. Paracetamol, Ibuprofen. In:Quantitative Analysis of Drugs in Pharmaceutical Formulations. 2nd ed. Delhi, India: CBS Publication; 1993.","edition":"2nd ed"},{"key":"5455_CR23","unstructured":"United States Pharmacopeial Convention.United States Pharmacopoeia. Rockville, MD: United States Pharmacopeia; 1975."},{"key":"5455_CR24","doi-asserted-by":"publisher","first-page":"471","DOI":"10.3109\/03639049109044257","volume":"17","author":"O Shirakura","year":"1991","unstructured":"Shirakura O, Yamada M, Hashimoto M, Ishimaru S, Takayama K, Nagai T. Particle size design using computer optimization technique.Drug Dev Ind Pharm. 1991; 17:471\u2013483.","journal-title":"Drug Dev Ind Pharm"},{"key":"5455_CR25","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/jps.2600720513","volume":"72","author":"PJ Jarosz","year":"1983","unstructured":"Jarosz PJ, Parrot EJ. Comparison of granule strength and tablet strength.J Pharm Sci. 1983; 72:530\u2013535.","journal-title":"J Pharm Sci"},{"key":"5455_CR26","first-page":"24","volume":"60","author":"PH Pawar","year":"1998","unstructured":"Pawar PH, Pawar AP, Mahadik KR, Paradkar AR. Evaluation of tableting properties of agglomerates obtained by spherical crystallisation of trimethoprim.Indian J Pharm Sci. 1998; 60:24\u201328.","journal-title":"Indian J Pharm Sci"},{"key":"5455_CR27","first-page":"125","volume":"53","author":"MH Rubinstein","year":"1978","unstructured":"Rubinstein MH, Musikabhumma P. A universal friability test for tablet granules.Pharm Acta Helv. 1978; 53:125\u2013129.","journal-title":"Pharm Acta Helv"},{"key":"5455_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0378-5173(82)90132-6","volume":"12","author":"H Leuenberger","year":"1982","unstructured":"Leuenberger H. The compressibility and compactibility of powder systems.Int J Pharm. 1982; 12:41\u201355.","journal-title":"Int J Pharm"},{"key":"5455_CR29","first-page":"116","volume":"41","author":"NM Sanghavi","year":"1979","unstructured":"Sanghavi NM, Sivanand R, Kotwaney HN. Dissolution pattern of miniscular sulfisoxazole.Ind J Pharm Sci. 1979; 41:116\u2013117.","journal-title":"Ind J Pharm Sci"},{"key":"5455_CR30","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3109\/03639049809085635","volume":"24","author":"SM Alsaidan","year":"1998","unstructured":"Alsaidan SM, Abdulhakeem AA, Eshra AG. Improved dissolution rate of indomethacin by adsorbents.Drug Dev Ind Pharm. 1998; 24:389\u2013394.","journal-title":"Drug Dev Ind Pharm"},{"key":"5455_CR31","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1248\/cpb.34.3376","volume":"34","author":"Y Kawashima","year":"1986","unstructured":"Kawashima Y, Handa T, Tekeuchi H, Okumara M, Katou H, Nagata O. Crystal modification of phenytoin with polyethylene glycol for improving mechanical strength, dissolution rate and bioavailability by spherical crystallization technique.Chem Pharm Bull (Tokyo). 1986; 34:3376\u20133383.","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"5455_CR32","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1248\/cpb.34.3403","volume":"34","author":"Y Kawashima","year":"1986","unstructured":"Kawashima Y, Handa T, Takeuchi H, Okumura M. Effects of polyethylene glycol on size of agglomerated crystals of phenytoin prepared by the spherical crystallization technique.Chem Pharm Bull (Tokyo). 1986; 34:3403\u20133407.","journal-title":"Chem Pharm Bull (Tokyo)"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt050455.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/pt050455\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt050455.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt050455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T03:42:03Z","timestamp":1559619723000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/pt050455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["5455"],"URL":"https:\/\/doi.org\/10.1208\/pt050455","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}