{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:50:07Z","timestamp":1773424207414,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1208\/s12249-008-9133-x","type":"journal-article","created":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T21:11:44Z","timestamp":1220389904000},"page":"1006-1015","source":"Crossref","is-referenced-by-count":28,"title":["Development of a Melting Tablet Containing Promethazine HCl Against Motion Sickness"],"prefix":"10.1208","volume":"9","author":[{"given":"Rahul V.","family":"Haware","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. D.","family":"Chaudhari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Parakh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bauer-Brandl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,9,3]]},"reference":[{"issue":"6","key":"9133_CR1","first-page":"52, 54, 56, 58","volume":"24","author":"R.-K. Chang","year":"2000","unstructured":"R.-K. Chang, X. Guo, B. A. Burnside, and R. A. Couch. Fast-dissolving tablets. Pharm. Technol.\n                  246:52, 54, 56, 58 (2000).","journal-title":"Pharm. Technol."},{"key":"9133_CR2","unstructured":"Guidance for Industry Orally Disintegrating Tablet. \n                    http:\/\/www.fda.gov\/cder\/guidance\/5909dft.htm\n                    \n                  . Accessed March 3, 2008."},{"key":"9133_CR3","first-page":"710","volume-title":"In Text Book Of Organic Medical and Pharmaceutical Chemistry","author":"J. N. Delgado","year":"1998","unstructured":"J. N. Delgado. Histaminics and Antihistaminics. In W. Grisvold (ed.), In Text Book Of Organic Medical and Pharmaceutical Chemistry, 11th ed., Lippincott, Philadelphia, 1998, pp. 710\u2013711.","edition":"11"},{"key":"9133_CR4","first-page":"221","volume-title":"European Pharmacopoeia","author":"Bitterness value","year":"2004","unstructured":"Bitterness value. European Pharmacopoeia, 5th ed., Council of Europe, Strasbourg, 2004, pp. 221\u2013223.","edition":"5"},{"key":"9133_CR5","unstructured":"GmbH R. Eudragit\n                  \u00ae\n                  : Polymethacrylate for phatmaceutical use, Technical literature. Darmstadt, Germany."},{"issue":"10","key":"9133_CR6","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1248\/cpb.47.1451","volume":"47","author":"T. Ishikawa","year":"1999","unstructured":"T. Ishikawa, Y. Watanabe, N. Utoguchi, and M. Matsumoto. Preparation and evaluation of tablets rapidly disintegrating in saliva containing bitter-taste-masked granules by the compression method. Chem. Pharm. Bull. (Tokyo). 4710:1451\u20131454 (1999)Oct.","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"issue":"2","key":"9133_CR7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1248\/cpb.44.399","volume":"44","author":"Y. Shirai","year":"1996","unstructured":"Y. Shirai, K. Sogo, H. Fujioka, and Y. Nakamura. Influence of heat treatment on dissolution and masking degree of bitter taste for a novel fine granule system. Chem. Pharm. Bul.\n                  442:399\u2013402 (1996).","journal-title":"Chem. Pharm. Bul."},{"key":"9133_CR8","unstructured":"W. A. Ritschel, and A. Bauer-Brandl. Herstellung verpre\u00dfbarer tablettiermessen. Die Tablette Handbuch der Entwicklung, Herstellung und Qualit\u00e4tssicherung. Editio Cantor, Aulendorf, 2002, p. 355."},{"key":"9133_CR9","unstructured":"Uniformity of mass of single dose preparations. European pharmacopoeia, 233 (2004)."},{"key":"9133_CR10","unstructured":"Friability of uncoated tablets. European Pharmacopoeia. 5th ed. Council of Europe, Strasbourg, 2004, p. 3103."},{"issue":"Suppl.","key":"9133_CR11","doi-asserted-by":"crossref","first-page":"195S","DOI":"10.1111\/j.2042-7158.1971.tb08789.x","volume":"23","author":"J. M. Newton","year":"1971","unstructured":"J. M. Newton, G. Rowley, J. T. Fell, D. G. Peacock, and K. Ridgway. Computer analysis of the relation between tablet strength and compaction pressure. J. Pharm. Pharmacol.\n                  23Suppl.:195S\u2013201S (1971).","journal-title":"J. Pharm. Pharmacol."},{"key":"9133_CR12","unstructured":"Uniformity of drug content. Indian Pharmacopoeia, vol 2. 4th ed. Controller of Publication, Government of India, New-Delhi, 1996, pp. 734\u2013736."},{"issue":"11","key":"9133_CR13","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1248\/cpb.44.2121","volume":"44","author":"Y. Bi","year":"1996","unstructured":"Y. Bi, H. Sunada, Y. Yonezawa, K. Danjo, A. Otsuka, and K. Iida. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem. Pharm. Bull. (Tokyo). 4411:2121\u20132127 (1996)Nov.","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"9133_CR14","unstructured":"Disintegration of tablets and capsules. European Pharmacopoeia. 5th ed. Council of Europe, Strasbourg, 2004, pp. 3351\u20133353."},{"key":"9133_CR15","unstructured":"The United States Pharmacopoeia-27\/National Formulary-22. Asia Edition ed. Rockville MD, 2000, pp. 1572\u20131573."},{"issue":"7","key":"9133_CR16","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1081\/DDC-100102245","volume":"25","author":"B. R. Matthews","year":"1999","unstructured":"B. R. Matthews. Regulatory aspects of stability testing in Europe. Drug Dev. Ind. Pharm.\n                  257:831\u2013856 (1999)Jul.","journal-title":"Drug Dev. Ind. Pharm."},{"key":"9133_CR17","first-page":"269","volume-title":"Encyclopedia of Pharmaceutical Technology, vol 20","author":"L. B. A. Augsburger","year":"2001","unstructured":"L. B. A. Augsburger, U. Shah, and H. Hahm. Super disintegrants: Characterization and function. In J. Swarbrick, and J. C. Boylan (eds.), Encyclopedia of Pharmaceutical Technology, vol 20, Marcel Dekker, New York, 2001, pp. 269\u2013290."},{"issue":"5","key":"9133_CR18","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1081\/DDC-100102211","volume":"25","author":"Y. X. Bi","year":"1999","unstructured":"Y. X. Bi, H. Sunada, Y. Yonezawa, and K. Danjo. Evaluation of rapidly disintegrating tablets prepared by a direct compression method. Drug Dev. Ind. Pharm.\n                  255:571\u2013581 (1999)May.","journal-title":"Drug Dev. Ind. Pharm."},{"key":"9133_CR19","volume-title":"Handbook of Pharmaceutical Excipients","author":"A. H. Kibbe","year":"2000","unstructured":"A. H. Kibbe. Handbook of Pharmaceutical Excipients, 3rd ed., Pharmaceutical, Washington, 2000.","edition":"3"},{"key":"9133_CR20","unstructured":"Phenergan. \n                    http:\/\/www.rxlist.com\/cgi\/generic\/prometh.htm\n                    \n                   Accessed March 3, 2007."},{"key":"9133_CR21","unstructured":"International Conference on Harmonisation of Technical Requirement for Registration of Pharmaceuticals for Human Use. \n                    http:\/\/www.ich.org\/LOB\/media\/MEDIA419.pdf\n                    \n                  . Accessed March 3, 2007."}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-008-9133-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-008-9133-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-008-9133-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-008-9133-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T03:48:12Z","timestamp":1559620092000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-008-9133-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["9133"],"URL":"https:\/\/doi.org\/10.1208\/s12249-008-9133-x","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}