{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:40:54Z","timestamp":1794271254720,"version":"4.9.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,3,24]],"date-time":"2010-03-24T00:00:00Z","timestamp":1269388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1208\/s12249-010-9411-2","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T19:15:41Z","timestamp":1269371741000},"page":"528-537","source":"Crossref","is-referenced-by-count":45,"title":["Drug-Cyclodextrin-Vesicles Dual Carrier Approach for Skin Targeting of Anti-acne Agent"],"prefix":"10.1208","volume":"11","author":[{"given":"Navjot","family":"Kaur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subheet Kumar","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,3,24]]},"reference":[{"key":"9411_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.2165\/00003495-198428010-00002","volume":"28","author":"A Ward","year":"1984","unstructured":"Ward A, Brogden RN, Heel RC, Speight TM, Avery GS. Isotretinoin. A review of its pharmacological properties and therapeutic efficacy in acne and other skin disorders. Drugs. 1984;28:6\u201337.","journal-title":"Drugs"},{"key":"9411_CR2","doi-asserted-by":"publisher","first-page":"4172","DOI":"10.1200\/JCO.2005.07.114","volume":"23","author":"N Aass","year":"2005","unstructured":"Aass N, De Mulder PH, Mickisch GH, Mulders P, van Oosterom AT, van Poppel H et al. Randomized phase II\/III trial of interferon Alfa-2a with and without 13-cis-retinoic acid in patients with progressive metastatic renal cell carcinoma: the European Organisation for Research and Treatment of Cancer Genito-Urinary Tract Cancer Group (EORTC 30951). J Clin Oncol. 2005;23:4172\u201378.","journal-title":"J Clin Oncol"},{"key":"9411_CR3","doi-asserted-by":"publisher","first-page":"S187","DOI":"10.1067\/mjd.2001.113719","volume":"45","author":"J McLane","year":"2001","unstructured":"McLane J. Analysis of common side effects of isotretinoin. J Am Acad Dermatol. 2001;45:S187\u201394.","journal-title":"J Am Acad Dermatol"},{"key":"9411_CR4","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0076-6879(90)90034-X","volume":"190","author":"H Gollnick","year":"1990","unstructured":"Gollnick H, Ehlert R, Rinck G, Orfanos CE. Retinoids: an overview of pharmacokinetics and therapeutic value. Methods Enzymol. 1990;190:291\u2013304.","journal-title":"Methods Enzymol"},{"key":"9411_CR5","first-page":"17","volume":"2","author":"C Peinni","year":"1991","unstructured":"Peinni C, Vigolti M. Drug and cosmetics in relation to the topical treatment of acne: data from a nationwide enquiry. Cosmet Dermatol. 1991;2:17\u201326.","journal-title":"Cosmet Dermatol"},{"key":"9411_CR6","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/S0190-9622(08)80252-6","volume":"27","author":"AM Layton","year":"1992","unstructured":"Layton AM, Cunlife WJ. Guidelines for optimal use of isotretinoin in acne. J Am Acad Dermatol. 1992;27:S2\u20137.","journal-title":"J Am Acad Dermatol"},{"key":"9411_CR7","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1016\/S0190-9622(88)70202-9","volume":"19","author":"DJ Elbaum","year":"1988","unstructured":"Elbaum DJ. Comparison of the stability of topical isotretinoin and topical tretinoin and their efficacy in acne. J Am Acad Dermatol. 1988;19:486\u201391.","journal-title":"J Am Acad Dermatol"},{"key":"9411_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/1523-1747.ep12463289","volume":"91","author":"PA Lehman","year":"1990","unstructured":"Lehman PA, John JT, Franz TJ. Percutaneous absorption of retinoids: influence of vehicle, light exposure and dose. J Invest Dermatol. 1990;91:56\u201361.","journal-title":"J Invest Dermatol"},{"key":"9411_CR9","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/jps.2600820104","volume":"82","author":"V Masini","year":"1990","unstructured":"Masini V, Bonte F, Meybeck A, Wepierre J. Cutaneous bioavailability in hairless rats of tretinoin in liposomes or gel. J Pharm Sci. 1990;82:17\u201321.","journal-title":"J Pharm Sci"},{"key":"9411_CR10","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0378-5173(01)00971-1","volume":"234","author":"M Manconi","year":"2002","unstructured":"Manconi M, Sinico C, Valenti D, Loy G, Fadda AM. Niosomes as carrier for tretinoin I. Preparation and properties. Int J Pharm. 2002;234:237\u201348.","journal-title":"Int J Pharm"},{"key":"9411_CR11","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ijpharm.2007.05.061","volume":"345","author":"KA Shah","year":"2007","unstructured":"Shah KA, Date AA, Joshi MD, Patravale VB. Solid lipid nanoparticle (SLN) of tretinoin: potential in topical delivery. Int J Pharm. 2007;345:163\u201371.","journal-title":"Int J Pharm"},{"key":"9411_CR12","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1081\/DDC-120025458","volume":"29","author":"S Jain","year":"2003","unstructured":"Jain S, Jain P, Umamaheshwari RB, Jain NK. Transfersomes\u2014a novel vesicular carrier for enhanced transdermal delivery: development, characterization, and performance evaluation. Drug Dev Ind Pharm. 2003;29:1013\u201326.","journal-title":"Drug Dev Ind Pharm"},{"key":"9411_CR13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.2174\/1567201054368020","volume":"2","author":"S Jain","year":"2005","unstructured":"Jain S, Jain N, Bhadra D, Tiwary AK, Jain NK. Transdermal delivery of an analgesic agent using elastic liposomes: preparation, characterization and performance evaluation. Curr Drug Deliv. 2005;2:223\u201333.","journal-title":"Curr Drug Deliv"},{"issue":"10","key":"9411_CR14","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1080\/03639040801965079","volume":"34","author":"T Garg","year":"2008","unstructured":"Garg T, Jain S, Singh HP, Sharma S, Tiwary AK. Elastic liposomal formulation for sustained delivery of anti-migraine drug: In vitro characterization and biological evaluation. Drug Dev Ind Pharm. 2008;34(10):1100\u201310.","journal-title":"Drug Dev Ind Pharm"},{"issue":"1","key":"9411_CR15","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1208\/s12248-008-9078-8","volume":"11","author":"HP Singh","year":"2009","unstructured":"Singh HP, Utreja P, Tiwary AK, Jain S. Elastic liposomal formulation for sustained delivery of colchicine: in vitro characterization and in vivo evaluation of anti-gout activity. AAPS J. 2009;11(1):54\u201364.","journal-title":"AAPS J"},{"key":"9411_CR16","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.ejpb.2007.08.002","volume":"68","author":"K Cal","year":"2008","unstructured":"Cal K, Centkowska K. Use of cyclodextrins in topical formulations: practical aspects. Eur J Pharm Biopharm. 2008;68:467\u201378.","journal-title":"Eur J Pharm Biopharm"},{"key":"9411_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ijpharm.2005.12.047","volume":"312","author":"F Maestrelli","year":"2006","unstructured":"Maestrelli F, Gonz\u00e1lez-Rodr\u00edguez ML, Rabasco AM, Mura P. Effect of preparation technique on the properties of liposomes encapsulating ketoprofen\u2013cyclodextrin complexes aimed for transdermal delivery. Int J Pharm. 2006;312:53\u201360.","journal-title":"Int J Pharm"},{"key":"9411_CR18","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ejps.2005.01.021","volume":"25","author":"KL Yap","year":"2005","unstructured":"Yap KL, Liu X, Thenmozhiyal JC, Ho PC. Characterization of the 13-cis-retinoic acid\/cyclodextrin inclusion complexs by phase solubility, photostability, physicochemical and computational analysis. Eur J Pharm Sci. 2005;25:49\u201356.","journal-title":"Eur J Pharm Sci"},{"key":"9411_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0168-3659(96)01566-0","volume":"45","author":"G Cevc","year":"1997","unstructured":"Cevc G, Blume G, Schatzlein A. Transfersomes mediated transepidermal delivery improves the regiospecificity and biological activity of corticosteroids in vivo. J Control Release. 1997;45:211\u201326.","journal-title":"J Control Release"},{"key":"9411_CR20","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.jpba.2006.08.027","volume":"43","author":"BM Tashtoush","year":"2007","unstructured":"Tashtoush BM, Jacobson EL, Jacobson MK. A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations. J Pharm Biomed Anal. 2007;43:859\u201364.","journal-title":"J Pharm Biomed Anal"},{"key":"9411_CR21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0022-3565(25)08751-8","volume":"8","author":"JH Draize","year":"1944","unstructured":"Draize JH, Woodward G, Calvery HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther. 1944;8:377\u201390.","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"9411_CR22","doi-asserted-by":"publisher","first-page":"276","DOI":"10.2174\/156720107782151250","volume":"4","author":"K Kaur","year":"2007","unstructured":"Kaur K, Jain S, Sapra B, Tiwary AK. Niosomal gel for site specific sustained delivery of anti-arthritic drug: in vitro in vivo evaluation. Curr Drug Deliv. 2007;4(4):276\u201382.","journal-title":"Curr Drug Deliv"},{"key":"9411_CR23","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1211\/0022357991776813","volume":"51","author":"GMM Maghraby El","year":"1999","unstructured":"El Maghraby GMM, Williams AC, Barry BW. Skin delivery from ultradeformable liposomes: refinement of surfactant concentration. J Pharm Pharmacol. 1999;51:1123\u201334.","journal-title":"J Pharm Pharmacol"},{"issue":"2","key":"9411_CR24","doi-asserted-by":"publisher","first-page":"157","DOI":"10.2174\/156720106776359221","volume":"3","author":"S Jain","year":"2006","unstructured":"Jain S, Tiwary AK, Jain NK. Sustained and targeted delivery of an anti-HIV agent using elastic liposomal formulation: mechanism of action. Curr Drug Deliv. 2006;3(2):157\u201366.","journal-title":"Curr Drug Deliv"},{"key":"9411_CR25","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3109\/10837459809009856","volume":"3","author":"AC Williams","year":"1998","unstructured":"Williams AC, Shatri SR, Barry BW. Transdermal permeation modulation by cyclodextrins: a mechanistic study. Pharm Dev Technol. 1998;3:283\u201396.","journal-title":"Pharm Dev Technol"},{"key":"9411_CR26","unstructured":"Rowe RC, Sheskey PJ, Owen SC (2006) Handbook of pharmaceutical excipients, 5th ed., American Pharmaceutical Association. 217\u201321."},{"key":"9411_CR27","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s10847-007-9326-z","volume":"59","author":"C Caddeo","year":"2007","unstructured":"Caddeo C, Manconi M, Valenti D, Pini E, Sinico C. Photostability and solubility improvement of \u03b2-cyclodextrin-included tretinoin. J Incl Phenom Macrocycl Chem. 2007;59:293\u2013300.","journal-title":"J Incl Phenom Macrocycl Chem"},{"key":"9411_CR28","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0378-5173(97)00104-X","volume":"153","author":"P Montassier","year":"1997","unstructured":"Montassier P, Duchene D, Poieman MC. Inclusion complex of tretinoin with cyclodextrins. Int J Pharm. 1997;153:199\u2013209.","journal-title":"Int J Pharm"},{"key":"9411_CR29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0378-5173(01)00692-5","volume":"222","author":"ME Dalmora","year":"2001","unstructured":"Dalmora ME, Dalmora SL, Oliveira AG. Inclusion complex of piroxicam with beta-cyclodextrin and incorporation in cationic microemulsion. In vitro drug release and in vivo topical anti-inflammatory effect. Int J Pharm. 2001;222:45\u201355.","journal-title":"Int J Pharm"},{"key":"9411_CR30","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1016\/0190-9622(90)70154-A","volume":"22","author":"SH Dromgoole","year":"1990","unstructured":"Dromgoole SH, Maibach HI. Sunscreening agent intolerance: contact and photocontact sensitization and contact urticaria. J Am Acad Dermatol. 1990;22:1068\u201378.","journal-title":"J Am Acad Dermatol"},{"key":"9411_CR31","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0731-7085(93)80074-B","volume":"11","author":"X Tan","year":"1993","unstructured":"Tan X, Meltzer N, Lindenbaum S. Determination of the kinetics of degradation of 13-cis retinoic acid and all-trans retinoic acid in solution. J Pharm Biomed Anal. 1993;11:817\u201322.","journal-title":"J Pharm Biomed Anal"},{"key":"9411_CR32","unstructured":"Code of Federal Regulation (1976) Title 16, Part 173.210."},{"key":"9411_CR33","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jconrel.2004.11.036","volume":"104","author":"Y Yamaguchi","year":"2005","unstructured":"Yamaguchi Y, Nagasawa T, Nakamura N, Takenaga M, Mizoguchi M, Kawai S et al. Successful treatment of photo-damaged skin of nano-scale at RA particles using a novel transdermal delivery. J Control Release. 2005;104:29\u201340.","journal-title":"J Control Release"},{"key":"9411_CR34","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/00039896.1975.10666669","volume":"30","author":"KI Campbell","year":"1975","unstructured":"Campbell KI, George EL, Hall LL, Stara JF. Dermal irritancy of metal compounds. Studies with palladium, platinum, lead, and manganese compounds. Arch Enviorn Health. 1975;30:168\u201370.","journal-title":"Arch Enviorn Health"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-010-9411-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-010-9411-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-010-9411-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-010-9411-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T17:30:53Z","timestamp":1739986253000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-010-9411-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3,24]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["9411"],"URL":"https:\/\/doi.org\/10.1208\/s12249-010-9411-2","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3,24]]}}}