{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:10:31Z","timestamp":1774260631546,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T00:00:00Z","timestamp":1412208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1208\/s12249-014-0219-3","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T18:38:23Z","timestamp":1412188703000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Roller Compaction of Hydrophilic Extended Release Tablets\u2014Combined Effects of Processing Variables and Drug\/Matrix Former Particle Size"],"prefix":"10.1208","volume":"16","author":[{"given":"Johanna","family":"Heiman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Tajarobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindhumadhavan","family":"Gururajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Juppo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Abrahms\u00e9n-Alami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,10,2]]},"reference":[{"key":"219_CR1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/jps.2600550818","volume":"55","author":"H Lapidus","year":"1966","unstructured":"Lapidus H, Lordi NG. Some factors affecting the release of a water-soluble drug from a compressed hydrophilic matrix. J Pharm Sci. 1966;55:840\u20133. doi: 10.1002\/jps.2600550818 .","journal-title":"J Pharm Sci"},{"key":"219_CR2","first-page":"1","volume":"5","author":"DA Alderman","year":"1984","unstructured":"Alderman DA. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Int J Pharm Technol Prod. 1984;5:1\u20139.","journal-title":"Int J Pharm Technol Prod"},{"key":"219_CR3","doi-asserted-by":"crossref","unstructured":"Larsson A, Abrahms\u00e9n-Alami S, Juppo A. Oral extended-release formulations. In: Gad S C, editors. Pharmaceutical manufacturing handbook: production and processes. John Wiley & Sons Inc; 2008. p. 1191\u2013222.","DOI":"10.1002\/9780470259818.ch30"},{"key":"219_CR4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ejpb.2004.04.014","volume":"58","author":"P Kleinebudde","year":"2004","unstructured":"Kleinebudde P. Roll compaction\/dry granulation: pharmaceutical applications. Eur J Pharm Biopharm. 2004;58:317\u201326. doi: 10.1016\/j.ejpb.2004.04.014 .","journal-title":"Eur J Pharm Biopharm"},{"key":"219_CR5","first-page":"7","volume-title":"Theory of granulation. Book: handbook of pharmaceutical granulation technology, 2nd ed","author":"LL Augsburger","year":"1997","unstructured":"Augsburger LL, Vuppala MK. In: Parikh DM, editor. Theory of granulation. Book: handbook of pharmaceutical granulation technology, 2nd ed. New York: Marcel Dekker Inc; 1997. p. 7\u201324."},{"key":"219_CR6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0939-6411(01)00199-0","volume":"52","author":"H Leuenberger","year":"2001","unstructured":"Leuenberger H. New trends in the production of pharmaceutical granules: batch versus continuous processing. Eur J Pharm Biopharm. 2001;52:289\u201396. doi: 10.1016\/S0939-6411(01)00199-0 .","journal-title":"Eur J Pharm Biopharm"},{"key":"219_CR7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1211\/0022357055957","volume":"57","author":"CL Li","year":"2005","unstructured":"Li CL, Martini LG, Ford JL, Roberts M. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005;57:533\u201346. doi: 10.1211\/0022357055957 .","journal-title":"J Pharm Pharmacol"},{"key":"219_CR8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijpharm.2006.01.024","volume":"313","author":"J Herder","year":"2006","unstructured":"Herder J, Adolfsson \u00c5, Larsson A. Initial studies of water granulation of eight grades of hypromellose (HPMC). Int J Pharm. 2006;313:57\u201365. doi: 10.1016\/j.ijpharm.2006.01.024 .","journal-title":"Int J Pharm"},{"key":"219_CR9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/10837450701369253","volume":"12","author":"MT Am Ende","year":"2007","unstructured":"Am Ende MT, Moses SK, Carella AJ, Gadkari RA, Graul TW, Otano AL. Improving the content uniformity of a low-dose tablet formulation through roller compaction optimization. Pharm Dev Technol. 2007;12:391\u2013404. doi: 10.1080\/10837450701369253 .","journal-title":"Pharm Dev Technol"},{"key":"219_CR10","first-page":"90","volume":"23","author":"PJ Sheskey","year":"1999","unstructured":"Sheskey PJ, Hendren J. The effects of roll compaction equipment variables, granulation technique, and HPMC polymer level on a controlled-release matrix model drug formulation. Pharm Technol. 1999;23:90\u2013106.","journal-title":"Pharm Technol"},{"key":"219_CR11","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1248\/cpb.51.978","volume":"51","author":"M Saravanan","year":"2003","unstructured":"Saravanan M, Sri Nataraj K, Ganesh KS. Hydroxypropyl methylcellulose based cephalexin extended release tablets: influence of tablet formulation, hardness and storage on invitro release kinetics. Chem Pharm Bull. 2003;51:978\u201383. doi: 10.1248\/cpb.51.978 .","journal-title":"Chem Pharm Bull"},{"key":"219_CR12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1081\/DDC-120037487","volume":"30","author":"M Hariharan","year":"2004","unstructured":"Hariharan M, Wowchuk C, Nkansah P, Gupta VK. Effect of formulation composition on the properties of controlled release tablets prepared by roller compaction. Drug Dev Ind Pharm. 2004;30:565\u201372. doi: 10.1081\/DDC-120037487 .","journal-title":"Drug Dev Ind Pharm"},{"key":"219_CR13","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/03639048309044678","volume":"9","author":"S Malkowska","year":"1983","unstructured":"Malkowska S, Khan K. Effect of re-compression on the properties of tablets preprared by dry granulation. Drug Dev Ind Pharm. 1983;9:331\u201347. doi: 10.3109\/03639048309044678 .","journal-title":"Drug Dev Ind Pharm"},{"key":"219_CR14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/jps.20531","volume":"95","author":"C Sun","year":"2006","unstructured":"Sun C, Himmelspach MW. Reduced tabletability of roller compacted granules as a result of granule size enlargement. J Pharm Sci. 2006;95:200\u20136. doi: 10.1002\/jps.20531 .","journal-title":"J Pharm Sci"},{"key":"219_CR15","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/03639040500215784","volume":"31","author":"LR Shaw","year":"2005","unstructured":"Shaw LR, Irwin WJ, Grattan TJ, Conway BR. The effect of selected water-soluble excipients on the dissolution of paracetamol and ibuprofen. Drug Dev Ind Pharm. 2005;31:515\u201325. doi: 10.1080\/03639040500215784 .","journal-title":"Drug Dev Ind Pharm"},{"key":"219_CR16","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1002\/jps.20414","volume":"94","author":"A Gupta","year":"2005","unstructured":"Gupta A, Peck GE, Miller RW, Morris KR. Effect of the variation in the ambient moisture on the compaction behavior of powder undergoing roller-compaction and on the characteristics of tablets produced from the post-milled granules. J Pharm Sci. 2005;94:2314\u201326. doi: 10.1002\/jps.20414 .","journal-title":"J Pharm Sci"},{"key":"219_CR17","first-page":"283","volume-title":"Mechanical properties in pharmaceutical powder compaction technology","author":"RC Rowe","year":"1996","unstructured":"Rowe RC, Roberts RJ. In: Alderborn G, Nystr\u00f6m C, editors. Mechanical properties in pharmaceutical powder compaction technology. New York: Marcel Dekker; 1996. p. 283\u2013322."},{"key":"219_CR18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0378-5173(94)00354-8","volume":"118","author":"A Nokhodchi","year":"1995","unstructured":"Nokhodchi A, Rubinstein MH, Larhrib H, Guyot JC. The effect of moisture on the properties of ibuprofen tablets. Int J Pharm. 1995;118:191\u20137. doi: 10.1016\/0378-5173(94)00354-8 .","journal-title":"Int J Pharm"},{"key":"219_CR19","volume-title":"Design of experiments: principles and applications","author":"L Eriksson","year":"2008","unstructured":"Eriksson L, Johansson E, Kettaneh-Wold N, Wikstr\u00f6m C, Wold S. Design of experiments: principles and applications. 3rd ed. Ume\u00e5: MKS Umetrics AB; 2008.","edition":"3"},{"key":"219_CR20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejpb.2009.04.008","volume":"73","author":"Y Teng","year":"2009","unstructured":"Teng Y, Qiu Z, Wen H. Systematical approach of formulation and process development using roller compaction. Eur J Pharm Biopharm. 2009;73:219\u201329. doi: 10.1016\/j.ejpb.2009.04.008 .","journal-title":"Eur J Pharm Biopharm"},{"key":"219_CR21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.powtec.2004.08.003","volume":"146","author":"K Thalberg","year":"2004","unstructured":"Thalberg K, Lindholm D, Axelsson A. Comparison of different flowability tests for powders for inhalation. Powder Technol. 2004;146:206\u201313. doi: 10.1016\/j.powtec.2004.08.003 .","journal-title":"Powder Technol"},{"key":"219_CR22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ijpharm.2007.12.012","volume":"355","author":"X Cao","year":"2008","unstructured":"Cao X, Leyva N, Anderson SR, Hancock BC. Use of prediction methods to estimate true density of active pharmaceutical ingredients. Int J Pharm. 2008;355:231\u20137. doi: 10.1016\/j.ijpharm.2007.12.012 .","journal-title":"Int J Pharm"},{"key":"219_CR23","first-page":"64","volume":"27","author":"BC Hancock","year":"2003","unstructured":"Hancock BC, Colvin JT, Mullarney MP, Zinchuk AV. The relative densities of pharmaceutical powders, blends, dry granulations, and immediate-release tablets. Pharm Technol. 2003;27:64\u201380.","journal-title":"Pharm Technol"},{"key":"219_CR24","volume-title":"Handbook of pharmaceutical excipients","author":"RC Rowe","year":"2006","unstructured":"Rowe RC, Sheskey PJ, Owen SC. Handbook of pharmaceutical excipients. 5th ed. USA: Pharmaceutical Press; 2006.","edition":"5"},{"key":"219_CR25","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1007\/BF00547442","volume":"23","author":"KG Pitt","year":"1988","unstructured":"Pitt KG, Newton MJ, Stanley P. Tensile fracture of doubly-convex cylindrical discs under diametral loading. J Mater Sci. 1988;23:2723\u20138. doi: 10.1007\/BF00547442 .","journal-title":"J Mater Sci"},{"key":"219_CR26","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1002\/jps.2600590523","volume":"59","author":"JT Fell","year":"1970","unstructured":"Fell JT, Newton JM. Determination of tablet strength by the diametrical compression test. J Pharm Sci. 1970;59:688\u201391. doi: 10.1002\/jps.2600590523 .","journal-title":"J Pharm Sci"},{"key":"219_CR27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijpharm.2013.02.036","volume":"477","author":"N Souihi","year":"2013","unstructured":"Souihi N, Dumarey M, Wikstr\u00f6m H, Tajarobi P, Fransson M, Svensson O, et al. A quality by design approach to investigate the effect of mannitol and dicalcium phosphate qualities on roll compaction. Int J Pharm. 2013;477:47\u201361. doi: 10.1016\/j.ijpharm.2013.02.036 .","journal-title":"Int J Pharm"},{"key":"219_CR28","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ejpb.2008.04.003","volume":"70","author":"MG Herting","year":"2008","unstructured":"Herting MG, Kleinebudde P. Studies on the reduction of tensile strength of tablets after roll compaction\/dry granulation. Eur J Pharm Biopharm. 2008;70:372\u20139. doi: 10.1016\/j.ejpb.2008.04.003 .","journal-title":"Eur J Pharm Biopharm"},{"key":"219_CR29","first-page":"60","volume":"24","author":"JK Prescott","year":"2000","unstructured":"Prescott JK, Barnum RA. On powder flowability. Pharm Technol. 2000;24:60\u201385.","journal-title":"Pharm Technol"},{"key":"219_CR30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.2042-7158.1982.tb04727.x","volume":"34","author":"A McKenna","year":"1982","unstructured":"McKenna A, McCafferty D. Effect of particle size on the compaction mechanism and tensile strength of tablets. J Pharm Pharmacol. 1982;34:347\u201351. doi: 10.1111\/j.2042-7158.1982.tb04727.x .","journal-title":"J Pharm Pharmacol"},{"key":"219_CR31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5173(95)04122-2","volume":"126","author":"A Nokhodchi","year":"1995","unstructured":"Nokhodchi A, Rubinstein MH, Ford JL. The effect of particle size and viscosity grade on the compaction properties of hydroxypropylmethylcellulose 2208. Int J Pharm. 1995;126:189\u201397. doi: 10.1016\/0378-5173(95)04122-2 .","journal-title":"Int J Pharm"},{"key":"219_CR32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ijpharm.2008.02.013","volume":"358","author":"C Bacher","year":"2008","unstructured":"Bacher C, Olsen PM, Bertelsen P, Sonnergaard JM. Compressibility and compactibility of granules produced by wet and dry granulation. Int J Pharm. 2008;358:69\u201374. doi: 10.1016\/j.ijpharm.2008.02.013 .","journal-title":"Int J Pharm"},{"key":"219_CR33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0378-5173(92)90059-B","volume":"84","author":"M Wikberg","year":"1992","unstructured":"Wikberg M, Alderborn G. Compression characteristics of granulated materials: VI. pore size distributions, assessed by mercury penetration, of compacts of two lactose granulations with different fragmentation propensities. Int J Pharm. 1992;84:191\u20135.","journal-title":"Int J Pharm"},{"key":"219_CR34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijpharm.2010.02.022","volume":"391","author":"CY Wu","year":"2010","unstructured":"Wu CY, Hung WL, Migu\u00e9lez-Mor\u00e1n AM, Gururajan B, Seville JPK. Roller compaction of moist pharmaceutical powders. Int J Pharm. 2010;391:90\u20137. doi: 10.1016\/j.ijpharm.2010.02.022 .","journal-title":"Int J Pharm"},{"key":"219_CR35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejpb.2004.09.012","volume":"59","author":"W Weyenberg","year":"2005","unstructured":"Weyenberg W, Vermeire A, Vandervoort J, Remon JP, Ludwig A. Effects of roller compaction settings on the preparation of bioadhesive granules and ocular minitablets. Eur J Pharm Biopharm. 2005;59:527\u201336. doi: 10.1016\/j.ejpb.2004.09.012 .","journal-title":"Eur J Pharm Biopharm"},{"key":"219_CR36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0378-5173(95)04203-2","volume":"127","author":"A Juppo","year":"1996","unstructured":"Juppo A. Relationship between breaking force and pore structure of lactose, glucose and mannitol tablets. Int J Pharm. 1996;127:95\u2013102. doi: 10.1016\/0378-5173(95)04203-2 .","journal-title":"Int J Pharm"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-014-0219-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-014-0219-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-014-0219-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T18:52:48Z","timestamp":1565895168000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-014-0219-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["219"],"URL":"https:\/\/doi.org\/10.1208\/s12249-014-0219-3","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,2]]}}}