{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:00:29Z","timestamp":1776369629740,"version":"3.51.2"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1208\/s12249-015-0296-y","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T23:02:16Z","timestamp":1423090936000},"page":"1041-1050","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Formulation of Eco-friendly Medicated Chewing Gum to Prevent Motion Sickness"],"prefix":"10.1208","volume":"16","author":[{"given":"Rahul B.","family":"Shete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vimalkumar J.","family":"Muniswamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashlesha P.","family":"Pandit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kishanchandra R.","family":"Khandelwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"296_CR1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0169-409X(94)90028-0","volume":"13","author":"MR Rassing","year":"1994","unstructured":"Rassing MR. Chewing gum as a drug delivery system. Adv Drug Delivery Rev. 1994;13:89\u2013121.","journal-title":"Adv Drug Delivery Rev"},{"key":"296_CR2","unstructured":"General monograph on dosage forms. Chewing gums, medicated, drug release. In: European Pharmacopoeia, 4th ed.; European directorate for the quality of medicines, Council of Europe: Strasbourg. France; 2002.p. 227."},{"key":"296_CR3","unstructured":"Barcelon SA. Chewing gum containing wheat gluten. Patent number WO1994017673 A1, Aug 18; 1994."},{"key":"296_CR4","first-page":"115","volume":"2","author":"Z Sramkova","year":"2009","unstructured":"Sramkova Z, Gregova E, Sturdik E. Chemical composition and nutritional quality of wheat grain. Acta Chimica Slovaca. 2009;2:115\u201338.","journal-title":"Acta Chimica Slovaca"},{"key":"296_CR5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2006.04.012","volume":"114","author":"AK Bandyopadhyay","year":"2006","unstructured":"Bandyopadhyay AK, Sudhakar Y, Kuotsu K. Buccal bioadhesive drug delivery\u2014a promising option for orally less efficient drugs. J Controlled Release. 2006;114:15\u201340.","journal-title":"J Controlled Release"},{"key":"296_CR6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ejps.2005.01.010","volume":"24","author":"L Maggi","year":"2005","unstructured":"Maggi L, Segale L, Conti S, Machist EO, Salini A, Conte U. Preparation and evaluation of release characteristics of 3TabGum, a novel chewing device. Eur J Pharm Sci. 2005;24:487\u201393.","journal-title":"Eur J Pharm Sci"},{"key":"296_CR7","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ijpharm.2013.04.082","volume":"452","author":"C Sander","year":"2013","unstructured":"Sander C, Neilsen HS, Sogaard SR, Stoving C, Rantanen J. Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum. Int J Pharm. 2013;452:434\u20137.","journal-title":"Int J Pharm"},{"key":"296_CR8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.18773\/austprescr.2009.032","volume":"32","author":"LV Graudins","year":"2009","unstructured":"Graudins LV. Preventing motion sickness in children. Aust Prescr. 2009;32:61\u20133.","journal-title":"Aust Prescr"},{"key":"296_CR9","unstructured":"Yajima M, Katahira R. Chewing gum composition containing gliadin and transglutaminase. U. S. Patent 5,858,423. 1999"},{"key":"296_CR10","unstructured":"Mukharjee PK. Quality control herbal drugs. 5th ed. Business horizons pharmaceutical; 2012."},{"key":"296_CR11","unstructured":"Kokare CR. Pharmaceutical microbiology experiments and techniques. 2nd ed. Career publication; 2008."},{"issue":"9","key":"296_CR12","first-page":"724","volume":"43","author":"AP Pandit","year":"2006","unstructured":"Pandit AP, Joshi SB. Formulation development of chewing gum as a novel drug delivery system for diltiazem hydrochloride. Indian Drugs. 2006;43(9):724\u20138.","journal-title":"Indian Drugs"},{"key":"296_CR13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-5173(98)00077-5","volume":"168","author":"M Salako","year":"1998","unstructured":"Salako M, Podczeck F, Newton JM. Investigations into the deformability and tensile strength of pellets. Int J Pharm. 1998;168:49\u201357.","journal-title":"Int J Pharm"},{"key":"296_CR14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.14227\/DT170310P15","volume":"2","author":"J Gajendran","year":"2010","unstructured":"Gajendran J, Kraemer J, Knudsen SR. Product performance test for medicated chewing gums. Dissolution Tech. 2010;2:15\u20138.","journal-title":"Dissolution Tech"},{"key":"296_CR15","unstructured":"Chewing gum, medicated release from, General Chapter 2.9.25. In: European Pharmacopoeia, 6th ed.; European directorate for the quality of medicines, Council of Europe: Strasbourg. France; 2008.p. 260."},{"key":"296_CR16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.14227\/DT180311P15","volume":"18","author":"MRC Marques","year":"2011","unstructured":"Marques MRC, Loebenberg R, Almukainzi M. Simulated biological fluids with possible application in dissolution testing. Dissolution Tech. 2011;18:15\u201328.","journal-title":"Dissolution Tech"},{"key":"296_CR17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0378-5173(91)90403-B","volume":"74","author":"MJ Rathbone","year":"1991","unstructured":"Rathbone MJ, Hadgraft J. Absorption of drugs from the human oral cavity. Int J Pharm. 1991;74:9\u201324.","journal-title":"Int J Pharm"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-015-0296-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-015-0296-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-015-0296-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T03:33:22Z","timestamp":1559619202000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-015-0296-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["296"],"URL":"https:\/\/doi.org\/10.1208\/s12249-015-0296-y","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}