{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:49:12Z","timestamp":1788580152764,"version":"build-2803163510"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1208\/s12249-017-0866-2","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T15:36:25Z","timestamp":1505230585000},"page":"36-47","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Stability of Organoleptic Agents in Pharmaceuticals and Cosmetics"],"prefix":"10.1208","volume":"19","author":[{"given":"Akash","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Bhide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Bookwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavik","family":"Soneta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaykumar","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Almotairy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mashan","family":"Almutairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Narasimha Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"866_CR1","unstructured":"US Pharmacopeia [Internet]. US Pharmacopeia, Excipients. 2007 [cited 2016 Oct 20]. 1\u201311 p. Available from: http:\/\/www.usp.org\/sites\/default\/files\/usp_pdf\/EN\/USPNF\/chapter3.pdf"},{"issue":"5 Suppl","key":"866_CR2","first-page":"11","volume":"27","author":"MG Jacobs","year":"2009","unstructured":"Jacobs MG, Klug DB, Moreton RC, Silverstein I. Qualification of excipients for use in pharmaceuticals. Chim Oggi. 2009;27(5 Suppl):11\u20133.","journal-title":"Chim Oggi"},{"key":"866_CR3","doi-asserted-by":"crossref","unstructured":"Loftsson T. Excipient pharmacokinetics and profiling. Int J Pharm [Internet]. 2015 Mar 1 [cited 2017 may 4];480(1\u20132):48\u201354. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25596414 .","DOI":"10.1016\/j.ijpharm.2015.01.022"},{"key":"866_CR4","unstructured":"Mohanta G, Parimalakrishnan S, Manna P. An overview of organoleptic excipients [Internet]. Pharmabiz.com . 2011. p. 1\u20136. Available from: http:\/\/www.pharmabiz.com\/NewsDetails.aspx?aid=65654&sid=21"},{"key":"866_CR5","unstructured":"Gennaro AR. Remington: the science and practice of pharmacy. 21st ed. Lippincott Williams and Wilkins:1060 p."},{"key":"866_CR6","doi-asserted-by":"crossref","unstructured":"Weerawatanakorn M, Wu J, Pan M, Ho C. Reactivity and stability of selected flavor compounds. J Food Drug Anal. 2015. p. 176\u201390.","DOI":"10.1016\/j.jfda.2015.02.001"},{"key":"866_CR7","doi-asserted-by":"crossref","unstructured":"Lenik J, Weso\u0142y M, Ciosek P, Wr\u00f3blewski W. Evaluation of taste masking effect of diclofenac using sweeteners and cyclodextrin by a potentiometric electronic tongue. J Electroanal Chem [Internet]. 2016 [cited 2017 May 4];780:153\u20139 Available from: http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1572665716304751","DOI":"10.1016\/j.jelechem.2016.09.017"},{"key":"866_CR8","unstructured":"Allen L, Popovich N, Ansel H. Pharmaceutical dosage forms and drug delivery systems [internet]. 9th ed. Allen L, Popovich N, Ansel H, editors. Pharmaceutical dosage forms and drug delivery systems. MD and PA: Lippincott Williams & Wilkins; 2011. 130 p. Available from: http:\/\/pharmachitchat.com\/wp-content\/uploads\/2015\/05\/ansel-drug-delivery-system.pdf"},{"key":"866_CR9","unstructured":"Classen C, Howes D, Synnott A. Aroma: the cultural history of smell [Internet]. 18th ed. London and New York: Routledge; 1994. 1\u201320 p. Available from: file:\/\/\/C:\/Users\/akash\/Downloads\/1440494494.Constan Classen, David Howes, Anthony Synnott Aroma The Cultural History of Smell 1994.pdf."},{"key":"866_CR10","unstructured":"US patent for odor-masking coating for a pharmaceutical preparation Patent (Patent # 6,667,059 issued December 23, 2003) - Justia Patents Search [Internet]. Available from: http:\/\/patents.justia.com\/patent\/6667059"},{"key":"866_CR11","unstructured":"US Pharmacopeia USP29-NF 24. 2006. 2994 p."},{"key":"866_CR12","unstructured":"The IPEC Excipient stability program guide [Internet]. International Pharmaceutical Excipients Council 2010 p. 1\u201314. Available from: http:\/\/ipec-europe.org\/UPLOADS\/100311_IPECStabilityGuide-Final.pdf"},{"key":"866_CR13","unstructured":"Allam K, Kumar G. Colorants\u2014the cosmetics for the pharmaceutical dosage forms. Int J Pharm Pharm Sci. 2011. p. 13\u201321."},{"key":"866_CR14","unstructured":"Schoneker D. Coloring Agents for use in pharmaceuticals. In: Swarbrick J, editor. Encylopedia of Pharmaceutical Technology [Internet]. 3rd ed. New York: Informa Healthcare; 2007. p. 648. Available from: http:\/\/www.gmpua.com\/Process\/EncyclopediaPT.pdf"},{"key":"866_CR15","unstructured":"Peck B. Pharmaceutical dosage forms\u2014tablets. 2nd ed. 116\u2013117 p."},{"key":"866_CR16","doi-asserted-by":"crossref","unstructured":"Rowe RC. The opacity of tablet film coatings. J Pharm Pharmacol [Internet]. 1984 Sep [cited 2016 Oct 20];36(9):569\u201372. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6149277 .","DOI":"10.1111\/j.2042-7158.1984.tb04899.x"},{"issue":"5","key":"866_CR17","first-page":"365","volume":"3","author":"H Kanekar","year":"2014","unstructured":"Kanekar H, Khale A. Coloring agents: current regulatory perspective for coloring agents intended for pharmaceutical and cosmetic use. Int J Pharm Phytopharm Res. 2014;3(5):365\u201373.","journal-title":"Int J Pharm Phytopharm Res"},{"key":"866_CR18","unstructured":"US Pharmacopeia USP39-NF 34. 2016."},{"key":"866_CR19","unstructured":"US FDA. Summary of color additives for use in the United States in foods, drugs, cosmetics, and medical devices. [Internet]. Center for Food Safety and Applied Nutrition; [cited 2016 Oct 20] Available from: http:\/\/www.fda.gov\/forindustry\/coloradditiv https:\/\/www.fda.gov\/forindustry\/coloradditives\/coloradditiveinventories\/ucm115641.htm#table3A"},{"key":"866_CR20","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1111\/j.1365-2621.2007.01668.x","volume":"44","author":"H Azeredo","year":"2009","unstructured":"Azeredo H. Betalains: properties, sources, applications, and stability\u2014a review. Int J Food Sci Technol. 2009;44:2365\u20137.","journal-title":"Int J Food Sci Technol"},{"issue":"10","key":"866_CR21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.tifs.2007.04.012","volume":"18","author":"F Stintzing","year":"2007","unstructured":"Stintzing F, Carle R. Betalains\u2014emerging prospects for food scientists. Trends Food Sci Technol. 2007;18(10):514\u201325.","journal-title":"Trends Food Sci Technol"},{"issue":"9","key":"866_CR22","doi-asserted-by":"crossref","first-page":"4937","DOI":"10.1021\/acs.chemrev.5b00507","volume":"116","author":"P Trouillas","year":"2016","unstructured":"Trouillas P, Sancho-Garc\u00eda J, De Freitas V, Gierschner J, Otyepka M, Dangles O. Stabilizing and modulating color by copigmentation: insights from theory and experiment. Chem Rev. 2016;116(9):4937\u201382.","journal-title":"Chem Rev"},{"key":"866_CR23","doi-asserted-by":"crossref","unstructured":"Khan M. Stabilization of betalains: a review. Food Chemistry. 2016. p. 1280\u20135.","DOI":"10.1016\/j.foodchem.2015.11.043"},{"key":"866_CR24","doi-asserted-by":"publisher","unstructured":"Menon V, Sudheer A. Antioxidant and anti-inflammatory properties of curcumin [Internet]. Advances in Experimental Medicine and Biology. Boston, MA: Springer US; 2007 [cited 2016 Nov 3]. p. 105\u201325. Available from: http:\/\/link.springer.com\/10.1007\/978-0-387-46401-5_3","DOI":"10.1007\/978-0-387-46401-5_3"},{"key":"866_CR25","unstructured":"Maing I, Miller I. Curcumin-metal color complexes [Internet]. US; US 4263333 A, 1979 [cited 2016 Oct 20]. Available from: https:\/\/www.google.com\/patents\/US4263333"},{"key":"866_CR26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1201\/9781482270518","volume-title":"Natural food colorants\u2014science and technology","author":"G Lauro","year":"2000","unstructured":"Lauro G, Francis J. Natural food colorants\u2014science and technology. 1st ed. New York: Marcel Dekker; 2000. p. 205\u201323.","edition":"1"},{"key":"866_CR27","doi-asserted-by":"publisher","unstructured":"He J, Giusti MM. Anthocyanins: Natural colorants with health-promoting properties. Annu Rev Food Sci Technol [Internet]. 2010 Apr [cited 2016 Nov 3];1(1):163\u201387 Available from: http:\/\/www.annualreviews.org\/doi\/10.1146\/annurev.food.080708.100754","DOI":"10.1146\/annurev.food.080708.100754"},{"key":"866_CR28","doi-asserted-by":"publisher","unstructured":"Francis F. Carotenoids as food colorants [Internet]. Cereal Foods World. 2000 [cited 2016 Nov 3]. p. 198\u2013203. Available from: http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10408398209527357","DOI":"10.1080\/10408398209527357"},{"key":"866_CR29","unstructured":"Frank J. Beta carotene: a work-horse colorant & pro-vitamin A [internet]. PRO 2015. Available from: http:\/\/knowledge.ulprospector.com\/2838\/fbn-beta-carotene-work-horse-colorant-pro-vitamin-a\/"},{"key":"866_CR30","doi-asserted-by":"publisher","unstructured":"Peica N, Kiefer W. Characterization of indigo carmine with surface-enhanced resonance Raman spectroscopy (SERRS) using silver colloids and island films, and theoretical calculations. J Raman Spectrosc [Internet]. 2008 Jan [cited 2016 Nov 3];39(1):47\u201360 Available from: http:\/\/doi.wiley.com\/10.1002\/jrs.1813","DOI":"10.1002\/jrs.1813"},{"key":"866_CR31","doi-asserted-by":"crossref","unstructured":"Thorngate J. Synthetic food colorants, food additives. In: Thorngate J, Salminen S, Branen L, Davidson M, editors. Food Additives. 2nd ed. Marcel Dekker; 2002. p. 477\u2013500.","DOI":"10.1201\/9780824741709.ch16"},{"key":"866_CR32","doi-asserted-by":"publisher","unstructured":"Anderson M, Opawale F, Rao D, Delmarre D, Anyarambhatla G. Excipients for oral liquid formulations. In: Katdare A, Chaubal M, editors. Excipient Development for Pharmaceutical, Biotechnology, and Drug Delivery Systems [Internet]. New York London: Informa Healthcare USA, Inc; 2006 [cited 2016 Oct 20]. p. 174. Available from: http:\/\/www.crcnetbase.com\/doi\/book\/10.1201\/9781420004137","DOI":"10.1201\/9781420004137"},{"key":"866_CR33","doi-asserted-by":"crossref","unstructured":"Abramsson-Zetterberg L, Ilb\u00e4ck NG. The synthetic food colouring agent Allura Red AC (E129) is not genotoxic in a flow cytometry-based micronucleus assay in vivo. Food Chem Toxicol [Internet]. 2013 Sep [cited 2016 Nov 3];59:86\u20139. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23748052 .","DOI":"10.1016\/j.fct.2013.05.047"},{"key":"866_CR34","unstructured":"Knehr E. Maintaining color stability [internet]. Natura Products Insider, Informa Health. 2006. p. 1\u20134. Available from: http:\/\/www.naturalproductsinsider.com\/articles\/2006\/08\/maintaining-color-stability.aspx#"},{"issue":"1","key":"866_CR35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0308-8146(80)90064-3","volume":"5","author":"AM Humphrey","year":"1980","unstructured":"Humphrey AM. Chlorophyll. Food Chem Elsevier. 1980;5(1):57\u201367.","journal-title":"Food Chem Elsevier"},{"key":"866_CR36","doi-asserted-by":"crossref","unstructured":"\u00d6zkan G, Ersus Bilek S. Enzyme-assisted extraction of stabilized chlorophyll from spinach. Food Chem [Internet]. 2015 Jun 1 [cited 2016 Oct 20];176:152\u20137. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25624218 .","DOI":"10.1016\/j.foodchem.2014.12.059"},{"issue":"1","key":"866_CR37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.etap.2014.11.021","volume":"39","author":"V Periasamy","year":"2015","unstructured":"Periasamy V, Athinarayanan J, Al-Hadi A, Juhaimi F, Mahmoud M, Alshatwi A. Identification of titanium dioxide nanoparticles in food products: induce intracellular oxidative stress mediated by TNF and CYP1A genes in human lung fibroblast cells. Environ Toxicol Pharmacol. 2015;39(1):176\u201386.","journal-title":"Environ Toxicol Pharmacol"},{"key":"866_CR38","unstructured":"Rowe R, Sheskey P, Quinn M. Handbook of pharmaceutical excipients [internet]. 6th ed. Rowe R, Sheskey P, Quinn M, editors. Pharmaceutical press. London Chicago: APhA\/Pharmaceutical Press.; 2009. Available from: http:\/\/www.pharmpress.com\/product\/9780857110275\/excipients"},{"key":"866_CR39","doi-asserted-by":"crossref","unstructured":"Cornell R, Schwertmann U. Introduction to the iron oxides. In: Cornell R, Schwertmann U, editors. The iron oxides: structure, properties, reactions, occurrences and uses. 2nd ed. Wiley VCH; 2004. p. 1\u20137.","DOI":"10.1002\/3527602097"},{"key":"866_CR40","doi-asserted-by":"crossref","unstructured":"Sengar G, Sharma H. Food caramels: a review [internet]. Journal of food science and technology. Springer; 2012 [cited 2016 Nov 3]. p. 1686\u201396. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25190825 .","DOI":"10.1007\/s13197-012-0633-z"},{"key":"866_CR41","doi-asserted-by":"crossref","unstructured":"Hagiwara A, Imai N, Ichihara T, Sano M, Tamano S, Aoki H, et al. A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats. Food Chem Toxicol [Internet]. 2003 Aug [cited 2016 Nov 3];41(8):1157\u201364. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12842184 .","DOI":"10.1016\/S0278-6915(03)00104-2"},{"key":"866_CR42","doi-asserted-by":"crossref","unstructured":"Britton J. Carotenoids. In: Houghton J, Henry G, editors. Natural Food Colorants. 1996. p. 197\u2013243.","DOI":"10.1007\/978-1-4615-2155-6_7"},{"key":"866_CR43","volume-title":"Iodine and iodine compounds","author":"P Lyday","year":"2005","unstructured":"Lyday P. Iodine and iodine compounds. Wiley VCH: Ullmann\u2019s Encyclopedia of Industrial Chemistry; 2005."},{"key":"866_CR44","doi-asserted-by":"crossref","unstructured":"Pawar S, Kumar A. Issues in the formulation of drugs for oral use in children: role of excipients. Paediatr Drugs [Internet]. 2002 [cited 2016 Oct 20];4(6):371\u20139. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12038873 .","DOI":"10.2165\/00148581-200204060-00004"},{"issue":"10","key":"866_CR45","first-page":"1573","volume":"4","author":"D Basu","year":"2015","unstructured":"Basu D, Sen D. Organoleptic agents: adaptability, acceptability and palatability in formulations to make it lucrative. World J Pharm Pharm Sci. 2015;4(10):1573\u201386.","journal-title":"World J Pharm Pharm Sci"},{"key":"866_CR46","doi-asserted-by":"publisher","unstructured":"Graves D, Luo S. Decomposition of aspartame caused by heat in the acidified and dried state. J Agric Food Chem [Internet]. American Chemical Society; 1987 May [cited 2016 Oct 20];35(3):439\u201342 Available from: http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf00075a038","DOI":"10.1021\/jf00075a038"},{"key":"866_CR47","unstructured":"Klug C, Lipinski G. Sweeteners and sugar alternatives in food technology. 2nd ed. O\u2019Donnell K, Kearsley M, editors. West Sussex, UK: Wiley Blackwell; 2012. 93\u2013112 p."},{"key":"866_CR48","doi-asserted-by":"crossref","unstructured":"Prakash I, DuBois G, Clos J, Wilkens K, Fosdick L. Development of rebiana, a natural, non-caloric sweetener. Food Chem Toxicol [Internet]. 2008 Jul [cited 2017 may 17];46(7):S75\u201382. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18554769 .","DOI":"10.1016\/j.fct.2008.05.004"},{"key":"866_CR49","doi-asserted-by":"crossref","unstructured":"Sharma V, Sharma P. Flavouring agents in pharmaceutical formulations. Anc Sci Life [Internet]. 1988 [cited 2016 Oct 20];8(1):38\u201340 Available from: http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3331350&tool=pmcentrez&rendertype=abstract","DOI":"10.4103\/asl.ASL_195_17"},{"key":"866_CR50","first-page":"177","volume-title":"Patient-centered pharmacology: learning system for the conscientious prescribe","author":"M Sedrak","year":"2013","unstructured":"Sedrak M, Patel D. Drugs used in the treatment of common disorders of the gastrointestinal system. In: Tindall W, Sedrak M, Boltri J, editors. Patient-centered pharmacology: learning system for the conscientious prescribe. Philadelphia: FA Davis; 2013. p. 177\u201396."},{"key":"866_CR51","doi-asserted-by":"crossref","first-page":"ii32","DOI":"10.1136\/tobaccocontrol-2016-053192","volume":"25","author":"A Hoffman","year":"2016","unstructured":"Hoffman A, Salgado R, Dresler C, Faller R, Bartlett C. Flavour preferences in youth versus adults: a review. Tob Control. 2016;25:ii32\u20139.","journal-title":"Tob Control"},{"key":"866_CR52","doi-asserted-by":"crossref","unstructured":"Mennella J, Beauchamp G. Optimizing oral medications for children. Clin Ther [Internet]. NIH Public Access; 2008 Nov [cited 2017 may 17];30(11):2120\u201332. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19108800 .","DOI":"10.1016\/j.clinthera.2008.11.018"},{"key":"866_CR53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jsfa.2740480107","volume":"48","author":"J Burri","year":"1989","unstructured":"Burri J, Graf M, Lambelet P, L\u00f6liger J. Vanillin: more than a flavouring agent\u2014a potent antioxidant. J Sci Food Agric. 1989;48:49\u201356.","journal-title":"J Sci Food Agric"},{"key":"866_CR54","doi-asserted-by":"publisher","unstructured":"Schieberle P, Grosch W. Identification of potent flavor compounds formed in an aqueous lemon oil\/citric acid emulsion. J Agric Food Chem [Internet]. American Chemical Society; 1988 Jul [cited 2016 Oct 20];36(4):797\u2013800 Available from: http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf00082a031","DOI":"10.1021\/jf00082a031"},{"key":"866_CR55","doi-asserted-by":"publisher","unstructured":"Kimura K, Iwata I, Nishimura H. Relationship between acid-catalyzed cyclization of citral and deterioration of lemon flavor. Agric Biol Chem [Internet]. 1982 May 9 [cited 2016 Oct 20];46(5):1387\u20139 Available from: http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/00021369.1982.10865253","DOI":"10.1080\/00021369.1982.10865253"},{"issue":"96","key":"866_CR56","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1021\/jf960100h","volume":"8561","author":"Y Iwanami","year":"1997","unstructured":"Iwanami Y, Tateba H, Kodama N, Kishino K. Changes of lemon flavor components in an aqueous solution during UV irradiation. J Agric Food Chem Am Chem Soc. 1997;8561(96):463\u20136.","journal-title":"J Agric Food Chem Am Chem Soc"},{"key":"866_CR57","doi-asserted-by":"publisher","unstructured":"Rouseff R, Naim M. Citrus flavor stability. Flavor Chem [Internet]. 2000 Mar 23 [cited 2016 Oct 20];756(3):101\u201321 Available from: http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/bk-2000-0756.ch008","DOI":"10.1021\/bk-2000-0756.ch008"},{"key":"866_CR58","first-page":"23","volume":"19","author":"E Freeburg","year":"1994","unstructured":"Freeburg E, Mistry B, Reineccius G. Stability of citral-containing and citralless lemon oils in flavor emulsions and beverages. Perfum Flavorist [Internet]. 1994;19:23\u201332. Available from: http:\/\/www.perfumerflavorist.com\/flavor\/application\/citrus\/Stability-of-Citral-Containing-and-Citralless-Lemon-Oils-in-Flavor-Emulsions-and-Beverages-370512591.html#sthash.BRCIOdHl.dpuf","journal-title":"Perfum Flavorist [Internet]"},{"key":"866_CR59","doi-asserted-by":"publisher","unstructured":"Choi S, Decker E, Henson L, Popplewell L, McClements D. Influence of droplet charge on the chemical stability of citral in oil-in-water emulsions. J Food Sci [Internet]. Blackwell Publishing Inc; 2010 Aug [cited 2016 Oct 20];75(6):C536\u201340 Available from: http:\/\/doi.wiley.com\/10.1111\/j.1750-3841.2010.01693.x","DOI":"10.1111\/j.1750-3841.2010.01693.x"},{"issue":"4","key":"866_CR60","first-page":"1234","volume":"1","author":"P Mishra","year":"2009","unstructured":"Mishra P. Kinetics and mechanisms of oxidation of 4-hydroxy -3-methoxy benzaldehyde (vanillin) by bi (V) in aqueous alkaline medium. Int J PharmTech Res. 2009;1(4):1234\u201340.","journal-title":"Int J PharmTech Res"},{"issue":"3","key":"866_CR61","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.foodchem.2008.10.014","volume":"114","author":"I Mourtzinos","year":"2009","unstructured":"Mourtzinos I, Konteles S, Kalogeropoulos N, Karathanos V. Thermal oxidation of vanillin affects its antioxidant and antimicrobial properties. Food Chem. 2009;114(3):791\u20137.","journal-title":"Food Chem"},{"key":"866_CR62","doi-asserted-by":"publisher","unstructured":"Li Z, Grun I, Fernando L. Interaction of vanillin with soy and dairy proteins in aqueous model systems: a thermodynamic study. J Food Sci [Internet]. Blackwell Publishing Ltd; 2000 Sep [cited 2016 Oct 20];65(6):997\u20131001 Available from: http:\/\/doi.wiley.com\/10.1111\/j.1365-2621.2000.tb09406.x","DOI":"10.1111\/j.1365-2621.2000.tb09406.x"},{"key":"866_CR63","doi-asserted-by":"publisher","unstructured":"Mcneill V, Schmidt K. Vanillin interaction with milk protein isolates in sweetened drinks. J Food Sci [Internet]. Blackwell Publishing Ltd; 1993 Sep [cited 2016 Oct 20];58(5):1142\u20137 Available from: http:\/\/doi.wiley.com\/10.1111\/j.1365-2621.1993.tb06133.x","DOI":"10.1111\/j.1365-2621.1993.tb06133.x"},{"key":"866_CR64","first-page":"B2","volume":"8236970","author":"I Kenya","year":"2012","unstructured":"Kenya I, Takashi A. Vanillin acetals. US. 2012;8236970:B2.","journal-title":"US"},{"key":"866_CR65","doi-asserted-by":"publisher","unstructured":"Roscher R, Schwab W, Schreier P. Stability of naturally occurring 2,5-dimethyl-4-hydroxy-3[2H]-furanone derivatives. Food Res Technol [Internet]. Springer-Verlag; 1997 Jun 10 [cited 2016 Oct 20];204(6):438\u201341 Available from: http:\/\/link.springer.com\/10.1007\/s002170050109","DOI":"10.1007\/s002170050109"},{"issue":"8","key":"866_CR66","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1021\/jf960030e","volume":"44","author":"C Chen","year":"1996","unstructured":"Chen C, Shu C, Ho C. Photosensitized oxidative reaction of 2,5-Dimethyl-4-hydroxy-3(2H)-furanone. J Agric Food Chem Am Chem Soc. 1996;44(8):2361\u20135.","journal-title":"J Agric Food Chem Am Chem Soc"},{"key":"866_CR67","doi-asserted-by":"crossref","unstructured":"El Hadi M, Zhang F, Wu F, Zhou C, Tao J. Advances in fruit aroma volatile research [internet]. Molecules. 2013 [cited 2016 Oct 20]. p. 8200\u201329. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23852166 .","DOI":"10.3390\/molecules18078200"},{"key":"866_CR68","doi-asserted-by":"publisher","unstructured":"Shu C, Mookherjee B, Ho C. Volatile components of the thermal degradation of 2,5-Dimethyl-4-hydroxy-3(2H)-furanone. J Agric Food Chem [Internet]. American Chemical Society; 1985 May [cited 2016 Oct 20];33(3):446 Available from: http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/jf00063a030","DOI":"10.1021\/jf00063a030"},{"key":"866_CR69","doi-asserted-by":"publisher","unstructured":"Antipova I, Mukha S, Medvedeva S. Determination of composition and instability constants of maltol complexes with iron(III) ions. Russ Chem Bull [Internet]. Kluwer Academic Publishers-Plenum Publishers; 2004 Apr [cited 2016 Oct 20];53(4):780\u20134 Available from: http:\/\/link.springer.com\/10.1023\/B:RUCB.0000037841.67079.2b","DOI":"10.1023\/B:RUCB.0000037841.67079.2b"},{"key":"866_CR70","doi-asserted-by":"crossref","unstructured":"Rovira D. Dictionary of flavors. 3rd ed. John Wiley & Sons; 2008. 113\u2013114. p.","DOI":"10.1002\/9780470385067.ch1"},{"key":"866_CR71","doi-asserted-by":"publisher","unstructured":"Gholivand M, Ahmadi F. Simultaneous determination of trans-cinnamaldehyde and benzaldehyde in different real samples by differential pulse polarography and study of heat stability of trans-cinnamaldehyde. Anal Lett [Internet]. Taylor & Francis Group; 2008 Dec 10 [cited 2016 Oct 20];41(18):3324\u201341 Available from: http:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/00032710802507893","DOI":"10.1080\/00032710802507893"},{"key":"866_CR72","unstructured":"Gilmore L. Process for preparing a caramel butterscotch flavor syrup. US 4753814 A, 1987."},{"issue":"44","key":"866_CR73","first-page":"12204","volume":"110","author":"C B\u00e4cktorp","year":"2006","unstructured":"B\u00e4cktorp C, Wass J, Panas I, Sk\u00f6ld M, B\u00f6rje A, Nyman G. Theoretical investigation of linalool oxidation. J Phys Chem A Am Chem Soc. 2006;110(44):12204\u201312.","journal-title":"J Phys Chem A Am Chem Soc"},{"key":"866_CR74","unstructured":"MSDS - W236012 [Internet]. Available from: http:\/\/www.sigmaaldrich.com\/MSDS\/MSDS\/DisplayMSDSPage.do?country=US&language=en&productNumber=W236012&brand=ALDRICH&PageToGoToURL=http%3A%2F%2Fwww.sigmaaldrich.com%2Fcatalog%2Fproduct%2Faldrich%2Fw236012%3Flang%3Den"},{"key":"866_CR75","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1021\/ie50505a050","volume":"44","author":"R Reitsema","year":"1952","unstructured":"Reitsema R, Frederick J. Oxidation of peppermint oil. Ind Eng Chem. 1952;44:176\u201380.","journal-title":"Ind Eng Chem"},{"key":"866_CR76","unstructured":"Marketsandmarkets.com . Food texture market by applications, functionalities &amp; geography - 2018 [Internet]. 2013. Available from: http:\/\/www.marketsandmarkets.com\/Market-Reports\/texturizing-agents-market-1224.html"},{"key":"866_CR77","unstructured":"Diamante C. Cosmetic Ingredient Review 2008;1\u201331."},{"key":"866_CR78","doi-asserted-by":"crossref","unstructured":"Becker K, Salar-Behzadi S, Zimmer A. Solvent-free melting techniques for the preparation of lipid-based solid oral formulations. Pharm Res [Internet]. 2015 May [cited 2016 Oct 20];32(5):1519\u201345. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25788447 .","DOI":"10.1007\/s11095-015-1661-y"},{"key":"866_CR79","unstructured":"Texturizers and emulsifiers. https:\/\/www.gattefosse.com\/cosmetic-texturizers-emulsifiers ."},{"key":"866_CR80","doi-asserted-by":"publisher","unstructured":"Porter N, Wolf R, Weenen H. The free radical oxidation of polyunsaturated lecithins. Lipids [Internet]. Springer-Verlag; 1980 Mar [cited 2016 Oct 20];15(3):163\u20137 Available from: http:\/\/link.springer.com\/10.1007\/BF02540963","DOI":"10.1007\/BF02540963"},{"key":"866_CR81","doi-asserted-by":"crossref","unstructured":"Pichot R, Watson R, Norton I. Phospholipids at the interface: current trends and challenges. Int J Mol Sci [Internet]. Multidisciplinary Digital Publishing Institute; 2013 Jun 3 [cited 2016 Oct 20];14(6):11767\u201394 Available from: http:\/\/www.mdpi.com\/1422-0067\/14\/6\/11767\/","DOI":"10.3390\/ijms140611767"},{"key":"866_CR82","doi-asserted-by":"publisher","unstructured":"Ghosh A, Bandyopadhyay P. Polysaccharide-protein interactions and their relevance in food colloids. In: Karunaratne D, editor. The Complex World of Polysaccharides [Internet]. 2012 [cited 2016 Oct 20]. Available from: https:\/\/doi.org\/10.5772\/50561","DOI":"10.5772\/50561"},{"key":"866_CR83","doi-asserted-by":"publisher","unstructured":"Leal-Calderon F. Emulsified lipids: formulation and control of end-use properties. Ol\u00e9agineux, Corps gras, Lipides [Internet]. John Libbey Eurotext; 2012 Mar 15 [cited 2016 Oct 20];19(2):111\u20139 Available from: http:\/\/www.ocl-journal.org\/10.1051\/ocl.2012.0438","DOI":"10.1051\/ocl.2012.0438"},{"key":"866_CR84","doi-asserted-by":"publisher","unstructured":"Votano J, Parham M, Hall L. PEG stability: a look at pH and conductivity changes over time in polyethylene glycols. Chem\u2026 [Internet]. 2004;577\u201382. Available from: http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.200490137\/abstract","DOI":"10.1002\/cbdv.200490137\/abstract"},{"issue":"3","key":"866_CR85","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0141-3910(95)00225-1","volume":"52","author":"J Glastrup","year":"1996","unstructured":"Glastrup J. Degradation of polyethylene glycol. A study of the reaction mechanism in a model molecule: tetraethylene glycol. Polym Degrad Stab Elsevier. 1996;52(3):217\u201322.","journal-title":"Polym Degrad Stab Elsevier"},{"key":"866_CR86","unstructured":"Propylene glycol stability and storage [Internet]. DowChemicals.com . 2016. Available from: http:\/\/dowac.custhelp.com\/app\/answers\/detail\/a_id\/7485\/~\/propylene-glycols---stability-%26-storage"},{"key":"866_CR87","unstructured":"Neobee\u00ae Medium chain triglycerides brochure, Stepan Lipid Nutrition Pharmaceutical. 2012."},{"key":"866_CR88","unstructured":"Lipocire\u2122 A SG [Internet]. Available from: http:\/\/www.gattefosse.com\/en\/products\/lipocire-a-sg.html?textures-kys,texturizing-specialties-kh6 ."},{"key":"866_CR89","doi-asserted-by":"crossref","unstructured":"Piccolo J, Tawashi R, Saad HY, Higuchi WI, Buckley HE, Ives MB, et al. Inhibited dissolution of drug crystals by a certified water-soluble dye. J Pharm Sci [Internet]. Elsevier; 1970 Jan [cited 2016 Nov 3];59(1):56\u20139. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/5411326 .","DOI":"10.1002\/jps.2600590108"},{"key":"866_CR90","doi-asserted-by":"crossref","unstructured":"Cooper J, Ansel H, Cadwallader D. Liquid and solid solution interactions of primary certified colorants with pharmaceutical gelatins. J Pharm Sci [Internet]. Wiley Subscription Services, Inc., A Wiley Company; 1973 Jul [cited 2016 Nov 3];62(7):1156\u201364 Available from: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915411359","DOI":"10.1002\/jps.2600620721"},{"key":"866_CR91","doi-asserted-by":"crossref","unstructured":"Prillig E. Effect of colorants on the solubility of modified cellulose polymers. J Pharm Sci [Internet]. Wiley Subscription Services, Inc., A Wiley Company; 1969 Oct [cited 2016 Nov 3];58(10):1245\u20139 Available from: http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354915370271","DOI":"10.1002\/jps.2600581019"},{"issue":"3","key":"866_CR92","first-page":"3","volume":"1","author":"S Bharate","year":"2010","unstructured":"Bharate S, Bharate S, Bajaj A. Incompatibilities of pharmaceutical excipients with active pharmaceutical ingredients: a comprehensive review. J Excipients Food Chem. 2010;1(3):3\u201326.","journal-title":"J Excipients Food Chem"},{"key":"866_CR93","unstructured":"Excipient guide [Internet]. Available from: http:\/\/www.excipientsguide.com\/excipient_details.aspx?Id=151"},{"key":"866_CR94","unstructured":"US FDA. Guidance for industry Q1A(R2) stability testing of new drug substances and products. ICH [Internet]. 2003 [cited 2016 Oct 20];(November):1\u201322 Available from: http:\/\/www.fda.gov\/cder\/guidance\/index.htm"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-017-0866-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-017-0866-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-017-0866-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:37:29Z","timestamp":1692988649000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-017-0866-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,12]]},"references-count":94,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["866"],"URL":"https:\/\/doi.org\/10.1208\/s12249-017-0866-2","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,12]]}}}