{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T03:58:30Z","timestamp":1780804710371,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1208\/s12249-018-1031-2","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T15:38:47Z","timestamp":1528731527000},"page":"2767-2777","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A Simplified Geometric Model to Predict Nasal Spray Deposition in Children and Adults"],"prefix":"10.1208","volume":"19","author":[{"given":"Mow Yee","family":"Foo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Sawant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Overholtzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen D.","family":"Donovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"1031_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/oxfordjournals.rpd.a081070","volume":"38","author":"YS Cheng","year":"1991","unstructured":"Cheng YS, Yeh HC, Swift DL. Aerosol deposition in human nasal airway for particles 1 nm to 20 \u03bcm: a model study. Radiat Prot Dosim. 1991;38:41\u20137.","journal-title":"Radiat Prot Dosim"},{"issue":"1","key":"1031_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1089\/jam.2006.0531","volume":"20","author":"JS Kimbell","year":"2007","unstructured":"Kimbell JS, Segal RA, Asgharian B, Wong BA, Schroeter JD, Southall JP, et al. Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages. J Aerosol Med. 2007;20(1):59\u201374.","journal-title":"J Aerosol Med"},{"issue":"2","key":"1031_CR3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1177\/0194599811427519","volume":"146","author":"DO Frank","year":"2012","unstructured":"Frank DO, Kimbell JS, Pawar S, Rhee JS. Effects of anatomy and particle size on nasal sprays and nebulizers. Otolaryngol Head Neck Surg. 2012;146(2):313\u20139.","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"1031_CR4","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jaerosci.2010.12.004","volume":"42","author":"J Xi","year":"2011","unstructured":"Xi J, Si X, Kim JW, Berlinski A. Simulation of airflow and aerosol deposition in the nasal cavity of a 5-year-old child. J Aerosol Sci. 2011;42(3):156\u201373.","journal-title":"J Aerosol Sci"},{"issue":"8","key":"1031_CR5","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1007\/s11095-011-0417-6","volume":"28","author":"V Kundoor","year":"2011","unstructured":"Kundoor V, Dalby RN. Effect of formulation and administration related variables on deposition pattern of nasal spray pumps evaluated using a nasal cast. Pharm Res. 2011;28(8):1895\u2013904.","journal-title":"Pharm Res"},{"issue":"4","key":"1031_CR6","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1089\/jam.2007.0638","volume":"20","author":"MY Foo","year":"2007","unstructured":"Foo MY, Cheng YS, Su WC, Donovan MD. The influence of spray properties on intranasal deposition. J Aerosol Med. 2007;20(4):495\u2013508.","journal-title":"J Aerosol Med"},{"issue":"1","key":"1031_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1023\/A:1013643912335","volume":"19","author":"JD Suman","year":"2002","unstructured":"Suman JD, Laube BL, Lin T, Brouet G, Dalby R. Validity of in vitro tests on aqueous spray pumps as surrogates for nasal deposition. Pharm Res. 2002;19(1):1\u20136.","journal-title":"Pharm Res"},{"issue":"5","key":"1031_CR8","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1089\/jamp.2014.1174","volume":"28","author":"BL Laube","year":"2015","unstructured":"Laube BL, Sharpless G, Vikani AR, Harrand V, Zinreich SJ, Sedberry K, et al. Intranasal deposition of Accuspray\u2122 aerosol in anatomically correct models of 2-, 5-, and 12-year-old children. J Aerosol Med Pulm Drug Deliv. 2015;28(5):320\u201333.","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"1031_CR9","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.compbiomed.2016.08.002","volume":"77","author":"X Tong","year":"2016","unstructured":"Tong X, Dong J, Shang Y, Inthavong K, Tu J. Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity. Comput Biol Med. 2016;77:40\u20138.","journal-title":"Comput Biol Med"},{"issue":"2","key":"1031_CR10","first-page":"111","volume":"26","author":"SP Newman","year":"1988","unstructured":"Newman SP, Moren F, Clarke SW. Deposition pattern of nasal sprays in man. Rhinology. 1988;26(2):111\u201320.","journal-title":"Rhinology"},{"issue":"6","key":"1031_CR11","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s11095-016-1896-2","volume":"33","author":"J Xi","year":"2016","unstructured":"Xi J, Yuan JE, Zhang Y, Nevorski D, Wang Z, Zhou Y. Visualization and quantification of nasal and olfactory deposition in a sectional adult nasal airway cast. Pharm Res. 2016;33(6):1527\u201341.","journal-title":"Pharm Res"},{"issue":"5","key":"1031_CR12","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s11095-018-2385-6","volume":"35","author":"NA Sawant","year":"2018","unstructured":"Sawant NA, Donovan MD. In vitro assessment of spray deposition patterns in a pediatric (12 year-old) nasal cavity model. Pharm Res. 2018;35(5):108.","journal-title":"Pharm Res"},{"issue":"1","key":"1031_CR13","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0169-409X(97)00067-7","volume":"29","author":"H Kublik","year":"1998","unstructured":"Kublik H, Vidgren MT. Nasal delivery systems and their effect on deposition and absorption. Adv Drug Deliv Rev. 1998;29(1):157\u201377.","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"1031_CR14","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1365-2273.2004.00797.x","volume":"29","author":"R Aggarwal","year":"2004","unstructured":"Aggarwal R, Cardozo A, Homer J. The assessment of topical nasal drug distribution. Clin Otolaryngol. 2004;29(3):201\u20135.","journal-title":"Clin Otolaryngol"},{"issue":"2","key":"1031_CR15","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S0091-6749(86)80116-6","volume":"77","author":"GW Hallworth","year":"1986","unstructured":"Hallworth GW, Padfield JM. A comparison of the regional deposition in a model nose of a drug discharged from metered serosel and metered-pump nasal delivery systems. J Allergy Clin Immunol. 1986;77(2):348\u201353.","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"1031_CR16","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1080\/02786820600924978","volume":"40","author":"K Inthavong","year":"2006","unstructured":"Inthavong K, Tian Z, Li H, Tu J, Yang W, Xue C, et al. A numerical study of spray particle deposition in a human nasal cavity. Aerosol Sci Technol. 2006;40(11):1034\u201345.","journal-title":"Aerosol Sci Technol"},{"issue":"6","key":"1031_CR17","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.xphs.2016.03.033","volume":"105","author":"A Rygg","year":"2016","unstructured":"Rygg A, Hindle M, Longest PW. Linking suspension nasal spray drug deposition patterns to pharmacokinetic profiles: a proof-of-concept study using computational fluid dynamics. J Pharm Sci. 2016;105(6):1995\u20132004.","journal-title":"J Pharm Sci"},{"issue":"6","key":"1031_CR18","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1007\/s11095-016-1875-7","volume":"33","author":"L Engelhardt","year":"2016","unstructured":"Engelhardt L, R\u00f6hm M, Mavoungou C, Schindowski K, Schafmeister A, Simon U. First steps to develop and validate a CFPD model in order to support the design of nose-to-brain delivered biopharmaceuticals. Pharm Res. 2016;33(6):1337\u201350.","journal-title":"Pharm Res"},{"key":"1031_CR19","unstructured":"Abd El-Shafy MA PJ, Bommareddy GSP, Dondeti P, Egbaria K. Plume geometry and spray pattern tests as tools to predict nasal deposition. AAPS PharmSci. 2000;2(2):Abstract 297. \n                    http:\/\/abstracts.aaps.org\/SecureView\/AAPSJournal\/radzmy0fbng.htm"},{"key":"1031_CR20","volume-title":"Deposition pattern of nasal sprays in the human nasal airway\u2014interactions among formulation, device, anatomy and administration techniques: University of Iowa","author":"MY Foo","year":"2007","unstructured":"Foo MY. Deposition pattern of nasal sprays in the human nasal airway\u2014interactions among formulation, device, anatomy and administration techniques: University of Iowa; 2007."},{"key":"1031_CR21","first-page":"959","volume-title":"Calculus with analytical geometry","author":"RE Larson","year":"1990","unstructured":"Larson RE, Hostetler RP, Edwards BH. Multiple integration. In: Calculus with analytical geometry. Lexington: D. C. Heath and Company; 1990. p. 959."},{"key":"1031_CR22","first-page":"641","volume-title":"Calculus and analytic geometry","author":"P Gillett","year":"1981","unstructured":"Gillett P. Calculus and analytic geometry. Lexington: D. C. Heath and Company; 1981. p. 641\u20135."},{"issue":"23","key":"1031_CR23","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.1016\/j.ijheatmasstransfer.2008.04.037","volume":"51","author":"J Xi","year":"2008","unstructured":"Xi J, Longest PW. Numerical predictions of submicrometer aerosol deposition in the nasal cavity using a novel drift flux approach. Int J Heat Mass Transf. 2008;51(23):5562\u201377.","journal-title":"Int J Heat Mass Transf"},{"key":"1031_CR24","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.jaerosci.2013.12.008","volume":"69","author":"A Dastan","year":"2014","unstructured":"Dastan A, Abouali O, Ahmadi G. CFD simulation of total and regional fiber deposition in human nasal cavities. J Aerosol Sci. 2014;69:132\u201349.","journal-title":"J Aerosol Sci"},{"issue":"1","key":"1031_CR25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1089\/jam.1998.11.27","volume":"11","author":"J Kesavanathan","year":"1998","unstructured":"Kesavanathan J, Bascom R, Swift DL. The effect of nasal passage characteristics on particle deposition. J Aerosol Med. 1998;11(1):27\u201339.","journal-title":"J Aerosol Med."},{"issue":"4","key":"1031_CR26","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1365-2273.1993.tb00846.x","volume":"18","author":"H Riechelmann","year":"1993","unstructured":"Riechelmann H, Rheinheimer M, Wolfensberger M. Acoustic rhinometry in pre-school children. Clin Otolaryngol. 1993;18(4):272\u20137.","journal-title":"Clin Otolaryngol"},{"issue":"8","key":"1031_CR27","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1288\/00005537-199408000-00019","volume":"104","author":"O Pedersen","year":"1994","unstructured":"Pedersen O, Hilberg O, Berkowitz R, Yamagiwa M. Nasal cavity dimensions in the newborn measured by acoustic reflections. Laryngoscope. 1994;104(8):1023\u20138.","journal-title":"Laryngoscope"},{"key":"1031_CR28","first-page":"134","volume":"6","author":"D Warren","year":"1969","unstructured":"Warren D, Duany L, Fischer N. Nasal pathway resistance in normal and cleft lip and palate subjects. Cleft Palate Craniofac J. 1969;6:134\u201340.","journal-title":"Cleft Palate Craniofac J"},{"key":"1031_CR29","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jaerosci.2013.09.004","volume":"67","author":"E Ghahramani","year":"2014","unstructured":"Ghahramani E, Abouali O, Emdad H, Ahmadi G. Numerical analysis of stochastic dispersion of micro-particles in turbulent flows in a realistic model of human nasal\/upper airway. J Aerosol Sci. 2014;67:188\u2013206.","journal-title":"J Aerosol Sci"},{"issue":"2","key":"1031_CR30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1089\/jamp.2014.1205","volume":"29","author":"JA Keeler","year":"2016","unstructured":"Keeler JA, Patki A, Woodard CR, Frank-Ito DO. A computational study of nasal spray deposition pattern in four ethnic groups. J Aerosol Med Pulm Drug Deliv. 2016;29(2):153\u201366.","journal-title":"J Aerosol Med Pulm Drug Deliv."}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-018-1031-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-018-1031-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-018-1031-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T23:02:38Z","timestamp":1560207758000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-018-1031-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,11]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["1031"],"URL":"https:\/\/doi.org\/10.1208\/s12249-018-1031-2","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,11]]},"assertion":[{"value":"3 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}