{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:33:09Z","timestamp":1778394789967,"version":"3.51.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T00:00:00Z","timestamp":1554768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1208\/s12249-019-1366-3","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T17:01:27Z","timestamp":1554829287000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of Hydrogenated Soybean Phosphatidylcholine Matrices Prepared by Hot Melt Extrusion for Oral Controlled Delivery of Water-Soluble Drugs"],"prefix":"10.1208","volume":"20","author":[{"given":"Marina","family":"Kolbina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Schulte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"van Hoogevest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"K\u00f6rber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Bodmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,9]]},"reference":[{"issue":"1","key":"1366_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ijpharm.2014.04.033","volume":"469","author":"J Grund","year":"2014","unstructured":"Grund J, Koerber M, Walther M, Bodmeier R. The effect of polymer properties on direct compression and drug release from water-insoluble controlled release matrix tablets. Int J Pharm. 2014;469(1):94\u2013101.","journal-title":"Int J Pharm"},{"issue":"1","key":"1366_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.jconrel.2011.04.002","volume":"154","author":"C Maderuelo","year":"2011","unstructured":"Maderuelo C, Zarzuelo A, Lanao JM. Critical factors in the release of drugs from sustained release hydrophilic matrices. J Control Release. 2011;154(1):2\u201319.","journal-title":"J Control Release"},{"issue":"4","key":"1366_CR3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3109\/10837450.2013.871035","volume":"20","author":"M Roberts","year":"2015","unstructured":"Roberts M, Pulcini L, Mostafa S, Cuppok-Rosiaux Y, Marchaud D. Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained release of diclofenac sodium. Pharm Dev Technol. 2015;20(4):507\u201312.","journal-title":"Pharm Dev Technol"},{"key":"1366_CR4","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ejps.2017.07.017","volume":"108","author":"M Kolbina","year":"2017","unstructured":"Kolbina M, Bodmeier R, K\u00f6rber M. Saturated phosphatidylcholine as matrix former for oral extended release dosage forms. Eur J Pharm Sci. 2017;108:86\u201392.","journal-title":"Eur J Pharm Sci"},{"key":"1366_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejps.2017.07.008","volume":"108","author":"P Hoogevest van","year":"2017","unstructured":"van Hoogevest P. Review\u2014an update on the use of oral phospholipid excipients. Eur J Pharm Sci. 2017;108:1\u201312.","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"1366_CR6","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ijpharm.2003.09.037","volume":"269","author":"MM Crowley","year":"2004","unstructured":"Crowley MM, Schroeder B, Fredersdorf A, Obara S, Talarico M, Kucera S, et al. Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion. Int J Pharm. 2004;269(2):509\u201322.","journal-title":"Int J Pharm"},{"issue":"9","key":"1366_CR7","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1080\/00914037.2013.854218","volume":"63","author":"L Grehan","year":"2014","unstructured":"Grehan L, Killion JA, Devine DM, Kenny EK, Devery S, Higginbotham CL, et al. The development of hot melt extruded biocompatible controlled release drug delivery devices. Int J Polym Mater Polym Biomater. 2014;63(9):476\u201385.","journal-title":"Int J Polym Mater Polym Biomater"},{"issue":"1\u20132","key":"1366_CR8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ijpharm.2015.11.021","volume":"497","author":"T Kipping","year":"2016","unstructured":"Kipping T, Rein H. Continuous production of controlled release dosage forms based on hot-melt extruded gum arabic: formulation development, in vitro characterization and evaluation of potential application fields. Int J Pharm. 2016;497(1\u20132):36\u201353.","journal-title":"Int J Pharm"},{"key":"1366_CR9","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejps.2018.05.007","volume":"121","author":"VR Kallakunta","year":"2018","unstructured":"Kallakunta VR, Tiwari R, Sarabu S, Bandari S, Repka MA. Effect of formulation and process variables on lipid based sustained release tablets via continuous twin screw granulation: a comparative study. Eur J Pharm Sci. 2018;121:126\u201338.","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"1366_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.ijpharm.2006.03.006","volume":"317","author":"F Siepmann","year":"2006","unstructured":"Siepmann F, Muschert S, Flament MP, Leterme P, Gayot A, Siepmann J. Controlled drug release from Gelucire-based matrix pellets: experiment and theory. Int J Pharm. 2006;317(2):136\u201343.","journal-title":"Int J Pharm"},{"issue":"1","key":"1366_CR11","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ejpb.2011.10.002","volume":"80","author":"S G\u00fcres","year":"2012","unstructured":"G\u00fcres S, Siepmann F, Siepmann J, Kleinebudde P. Drug release from extruded solid lipid matrices: theoretical predictions and independent experiments. Eur J Pharm Biopharm. 2012;80(1):122\u20139.","journal-title":"Eur J Pharm Biopharm"},{"issue":"8","key":"1366_CR12","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1021\/js960221w","volume":"86","author":"H Sato","year":"1997","unstructured":"Sato H, Miyagawa Y, Okabe T, Miyajima M, Sunada H. Dissolution mechanism of diclofenac sodium from wax matrix granules. J Pharm Sci. 1997;86(8):929\u201334.","journal-title":"J Pharm Sci"},{"issue":"2","key":"1366_CR13","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0378-5173(00)00383-5","volume":"199","author":"C Brabander De","year":"2000","unstructured":"De Brabander C, Vervaet C, Fiermans L, Remon JP. Matrix mini-tablets based on starch\/microcrystalline wax mixtures. Int J Pharm. 2000;199(2):195\u2013203.","journal-title":"Int J Pharm"},{"issue":"2","key":"1366_CR14","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0939-6411(01)00162-X","volume":"52","author":"J Liu","year":"2001","unstructured":"Liu J, Zhang F, McGinity JW. Properties of lipophilic matrix tablets containing phenylpropanolamine hydrochloride prepared by hot-melt extrusion. Eur J Pharm Biopharm. 2001;52(2):181\u201390.","journal-title":"Eur J Pharm Biopharm"},{"issue":"3","key":"1366_CR15","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.ejpb.2011.07.004","volume":"79","author":"E Roblegg","year":"2011","unstructured":"Roblegg E, J\u00e4ger E, Hodzic A, Koscher G, Mohr S, Zimmer A, et al. Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion. Eur J Pharm Biopharm. 2011;79(3):635\u201345.","journal-title":"Eur J Pharm Biopharm"},{"key":"1366_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ejpb.2014.12.027","volume":"89","author":"EJ Laukamp","year":"2015","unstructured":"Laukamp EJ, Vynckier A-K, Voorspoels J, Thommes M, Breitkreutz J. Development of sustained and dual drug release co-extrusion formulations for individual dosing. Eur J Pharm Biopharm. 2015;89:357\u201364.","journal-title":"Eur J Pharm Biopharm"},{"issue":"3","key":"1366_CR17","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.ejpb.2011.07.012","volume":"79","author":"D Hasa","year":"2011","unstructured":"Hasa D, Perissutti B, Grassi M, Zacchigna M, Pagotto M, Lenaz D, et al. Melt extruded helical waxy matrices as a new sustained drug delivery system. Eur J Pharm Biopharm. 2011;79(3):592\u2013600.","journal-title":"Eur J Pharm Biopharm"},{"issue":"5","key":"1366_CR18","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3109\/10837450.2013.805775","volume":"19","author":"K Vithani","year":"2014","unstructured":"Vithani K, Cuppok Y, Mostafa S, Slipper IJ, Snowden MJ, Douroumis D. Diclofenac sodium sustained release hot melt extruded lipid matrices. Pharm Dev Technol. 2014;19(5):531\u20138.","journal-title":"Pharm Dev Technol"},{"issue":"1","key":"1366_CR19","first-page":"158","volume":"512","author":"T Monteyne","year":"2016","unstructured":"Monteyne T, Adriaensens P, Brouckaert D, Remon J-P, Vervaet C, De Beer T. Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation. Int J. 2016;512(1):158\u201367.","journal-title":"Int J"},{"issue":"1","key":"1366_CR20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ajps.2016.08.005","volume":"12","author":"P Vaingankar","year":"2017","unstructured":"Vaingankar P, Amin P. Continuous melt granulation to develop high drug loaded sustained release tablet of metformin HCl. Asian J Pharm Sci. 2017;12(1):37\u201350.","journal-title":"Asian J Pharm Sci"},{"key":"1366_CR21","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.msec.2016.07.070","volume":"70","author":"V Nart","year":"2017","unstructured":"Nart V, Beringhs AO, Fran\u00e7a MT, de Esp\u00edndola B, Pezzini BR, Stulzer HK. Carnauba wax as a promising excipient in melt granulation targeting the preparation of mini-tablets for sustained release of highly soluble drugs. Mater Sci Eng C. 2017;70:250\u20137.","journal-title":"Mater Sci Eng C"},{"issue":"5","key":"1366_CR22","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0009-3084(67)90023-0","volume":"1","author":"D Chapman","year":"1967","unstructured":"Chapman D, Williams RM, Ladbrooke BD. Physical studies of phospholipids. VI. Thermotropic and lyotropic mesomorphism of some 1,2-diacyl-phosphatidylcholines (lecithins). Chem Phys Lipids. 1967;1(5):445\u201375.","journal-title":"Chem Phys Lipids"},{"issue":"2","key":"1366_CR23","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s11095-009-0033-x","volume":"27","author":"Z Ghalanbor","year":"2010","unstructured":"Ghalanbor Z, K\u00f6rber M, Bodmeier R. Improved lysozyme stability and release properties of poly (lactide-co-glycolide) implants prepared by hot-melt extrusion. Pharm Res. 2010;27(2):371\u20139.","journal-title":"Pharm Res"},{"issue":"6","key":"1366_CR24","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1023\/A:1011976615750","volume":"15","author":"VP Shah","year":"1998","unstructured":"Shah VP, Tsong Y, Sathe P, Liu J. In vitro dissolution profile comparison\u2014statistics and analysis of the similarity factor, f2. Pharm Res. 1998;15(6):889\u201396.","journal-title":"Pharm Res"},{"issue":"1","key":"1366_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0304-4157(98)00006-9","volume":"1376","author":"R Koynova","year":"1998","unstructured":"Koynova R, Caffrey M. Phases and phase transitions of the phosphatidylcholines. Biochim Biophys Acta Rev Biomembr. 1998;1376(1):91\u2013145.","journal-title":"Biochim Biophys Acta Rev Biomembr"},{"key":"1366_CR26","doi-asserted-by":"crossref","unstructured":"Chapman D. Liquid crystalline nature of phospholipids. In: Porter RS, Johnson JF, editors. Ordered Fluids and Liquid Crystals: American Chemical Society; 1967. p. 157\u201366.","DOI":"10.1021\/ba-1967-0063.ch012"},{"key":"1366_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0079-6832(71)90003-6","volume":"11","author":"RM Williams","year":"1971","unstructured":"Williams RM, Chapman D. Phospholipids, liquids crystals and cell membranes. Prog Chem Fats Other Lipids. 1971;11:1\u201379.","journal-title":"Prog Chem Fats Other Lipids"},{"issue":"4936","key":"1366_CR28","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/202987a0","volume":"202","author":"P Byrne","year":"1964","unstructured":"Byrne P, Chapman D. Liquid crystalline nature of phospholipids. Nature. 1964;202(4936):987\u20138.","journal-title":"Nature."},{"issue":"4","key":"1366_CR29","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/0009-3084(69)90040-1","volume":"3","author":"BD Ladbrooke","year":"1969","unstructured":"Ladbrooke BD, Chapman D. Thermal analysis of lipids, proteins and biological membranes a review and summary of some recent studies. Chem Phys Lipids. 1969;3(4):304\u201356.","journal-title":"Chem Phys Lipids"},{"issue":"1","key":"1366_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1021\/js9601896","volume":"86","author":"BC Hancock","year":"1997","unstructured":"Hancock BC, Zografi G. Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci. 1997;86(1):1\u201312.","journal-title":"J Pharm Sci"},{"issue":"1","key":"1366_CR31","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.ejpb.2006.08.003","volume":"66","author":"I Bravo-Osuna","year":"2007","unstructured":"Bravo-Osuna I, Ferrero C, Jim\u00e9nez-Castellanos MR. Influence of moisture content on the mechanical properties of methyl methacrylate\u2013starch copolymers. Eur J Pharm Biopharm. 2007;66(1):63\u201372.","journal-title":"Eur J Pharm Biopharm"},{"key":"1366_CR32","unstructured":"Massing U, Bauer-Brandl A. Tablet containing hydrogenated phospholipids. EP1952805A1, 2008."},{"issue":"5146","key":"1366_CR33","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/2181031a0","volume":"218","author":"V Luzzati","year":"1968","unstructured":"Luzzati V, Gulik-Krzywicki T, Tardieu A. Polymorphism of lecithins. Nature. 1968;218(5146):1031\u20134.","journal-title":"Nature."},{"key":"1366_CR34","doi-asserted-by":"publisher","DOI":"10.1201\/9781482267358","volume-title":"Controlled drug release of oral dosage forms","author":"JM Vergnaud","year":"1993","unstructured":"Vergnaud JM. Controlled drug release of oral dosage forms. Boca Raton: CRC Press; 1993."},{"issue":"2","key":"1366_CR35","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ijpharm.2005.08.030","volume":"314","author":"C Guse","year":"2006","unstructured":"Guse C, Koennings S, Kreye F, Siepmann F, Goepferich A, Siepmann J. Drug release from lipid-based implants: elucidation of the underlying mass transport mechanisms. Int J Pharm. 2006;314(2):137\u201344.","journal-title":"Int J Pharm"},{"issue":"1","key":"1366_CR36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ijpharm.2011.07.015","volume":"418","author":"J Siepmann","year":"2011","unstructured":"Siepmann J, Siepmann F. Mathematical modeling of drug release from lipid dosage forms. Int J Pharm. 2011;418(1):42\u201353.","journal-title":"Int J Pharm"},{"issue":"3 Pt A","key":"1366_CR37","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.ejpb.2013.08.007","volume":"85","author":"J Grund","year":"2013","unstructured":"Grund J, K\u00f6rber M, Bodmeier R. Predictability of drug release from water-insoluble polymeric matrix tablets. Eur J Pharm Biopharm. 2013;85(3 Pt A):650\u20135.","journal-title":"Eur J Pharm Biopharm"},{"issue":"2","key":"1366_CR38","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0378-5173(97)00164-6","volume":"155","author":"L Yang","year":"1997","unstructured":"Yang L, Fassihi R. Examination of drug solubility, polymer types, hydrodynamics and loading dose on drug release behavior from a triple-layer asymmetric configuration delivery system. Int J Pharm. 1997;155(2):219\u201329.","journal-title":"Int J Pharm"},{"issue":"8","key":"1366_CR39","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1023\/A:1015913207052","volume":"05","author":"RS Harland","year":"1988","unstructured":"Harland RS, Gazzaniga A, Sangalli ME, Colombo P, Peppas NA. Drug\/polymer matrix swelling and dissolution. Pharm Res. 1988;05(8):488\u201394.","journal-title":"Pharm Res"},{"issue":"1","key":"1366_CR40","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0168-3659(00)00200-5","volume":"67","author":"A Streubel","year":"2000","unstructured":"Streubel A, Siepmann J, Dashevsky A, Bodmeier R. pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets. J Control Release. 2000;67(1):101\u201310.","journal-title":"J Control Release"},{"issue":"5","key":"1366_CR41","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/pen.760230505","volume":"23","author":"Y Ide","year":"1983","unstructured":"Ide Y, Ophir Z. Orientation development in thermotropic liquid crystal polymers. Polym Eng Sci. 1983;23(5):261\u20135.","journal-title":"Polym Eng Sci"},{"issue":"9","key":"1366_CR42","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1002\/pen.760270913","volume":"27","author":"RA Weiss","year":"1987","unstructured":"Weiss RA, Huh W, Nicolais L. Novel reinforced polymers based on blends of polystyrene and a thermotropic liquid crystalline polymer. Polym Eng Sci. 1987;27(9):684\u201391.","journal-title":"Polym Eng Sci"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-019-1366-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-019-1366-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-019-1366-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T23:06:06Z","timestamp":1586300766000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-019-1366-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,9]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1366"],"URL":"https:\/\/doi.org\/10.1208\/s12249-019-1366-3","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,9]]},"assertion":[{"value":"1 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"159"}}