{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:45:51Z","timestamp":1775695551274,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1208\/s12249-019-1496-7","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T16:03:19Z","timestamp":1566576199000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Preparation, Optimization, and Evaluation of Hyaluronic Acid-Based Hydrogel Loaded with Miconazole Self-Nanoemulsion for the Treatment of Oral Thrush"],"prefix":"10.1208","volume":"20","author":[{"given":"Khaled M.","family":"Hosny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hibah M.","family":"Aldawsari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahaf H","family":"Bahmdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal M.","family":"Sindi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mallesh","family":"Kurakula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majed M.","family":"Alrobaian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Y.","family":"Aldryhim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala M","family":"Alkhalidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiba Hisham","family":"Bahmdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha A.","family":"Khallaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amani M.","family":"El Sisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,23]]},"reference":[{"issue":"1","key":"1496_CR1","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.amjmed.2011.11.001","volume":"125","author":"MA Pfaller","year":"2012","unstructured":"Pfaller MA. Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment. Am J Med. 2012 Jan 1;125(1):S3\u201313.","journal-title":"Am J Med"},{"issue":"12","key":"1496_CR2","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/hed.10318","volume":"25","author":"C Scully","year":"2003","unstructured":"Scully C, Epstein J, Sonis S. Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis. Head Neck. 2003;25(12):1057\u201370.","journal-title":"Head Neck"},{"issue":"2","key":"1496_CR3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ijpharm.2011.09.034","volume":"421","author":"S Tsutsumi","year":"2011","unstructured":"Tsutsumi S, Iida M, Tada N, Kojima T, Ikeda Y, Moriwaki T, et al. Characterization and evaluation of miconazole salts and cocrystals for improved physicochemical properties. Int J Pharm. 2011;421(2):230\u20136.","journal-title":"Int J Pharm"},{"issue":"2","key":"1496_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0002-9343(76)90428-9","volume":"60","author":"DA Stevens","year":"1976","unstructured":"Stevens DA, Levine HB, Deresinski SC. Miconazole in coccidioidomycosis: II. Therapeutic and pharmacologic studies in man. Am J Med. 1976;60(2):191\u2013202.","journal-title":"Am J Med"},{"issue":"922","key":"1496_CR5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1136\/pmj.78.922.455","volume":"78","author":"A Akpan","year":"2002","unstructured":"Akpan A, Morgan R. Oral candidiasis. Postgrad Med J. 2002 Aug 1;78(922):455\u20139.","journal-title":"Postgrad Med J"},{"key":"1496_CR6","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1086\/516315","volume":"26","author":"RO Darouiche","year":"1998","unstructured":"Darouiche RO. Oropharyngeal and esophageal candidiasis in immunocompromised patients: treatment issues. Clin Infect Dis. 1998;26:259\u201372.","journal-title":"Clin Infect Dis"},{"issue":"10","key":"1496_CR7","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2217\/nnm.10.126","volume":"5","author":"AA Date","year":"2010","unstructured":"Date AA, Desai N, Dixit R, Nagarsenker M. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomedicine. 2010;5(10):1595\u2013616.","journal-title":"Nanomedicine"},{"issue":"1","key":"1496_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1208\/s12249-009-9359-2","volume":"11","author":"EA Mahmoud","year":"2010","unstructured":"Mahmoud EA, Bendas ER, Mohamed MI. Effect of formulation parameters on the preparation of superporous hydrogel self-nanoemulsifying drug delivery system (SNEDDS) of carvedilol. AAPS PharmSciTech. 2010;11(1):221\u20135.","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"1496_CR9","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jconrel.2013.06.030","volume":"171","author":"A Alexander","year":"2013","unstructured":"Alexander A, Khichariya A, Gupta S, Patel RJ, Giri TK, Tripathi DK. Recent expansions in an emergent novel drug delivery technology: Emulgel. J Control Release. 2013;171(2):122\u201332.","journal-title":"J Control Release"},{"issue":"3","key":"1496_CR10","doi-asserted-by":"publisher","first-page":"536","DOI":"10.2165\/00003495-199447030-00009","volume":"47","author":"KL Goa","year":"1994","unstructured":"Goa KL, Benfield P. Hyaluronic acid. Drugs. 1994 Mar 1;47(3):536\u201366.","journal-title":"Drugs."},{"issue":"6","key":"1496_CR11","first-page":"491","volume":"28","author":"PM Friedman","year":"2002","unstructured":"Friedman PM, Mafong EA, Kauvar AN, Geronemus RG. Safety data of injectable nonanimal stabilized hyaluronic acid gel for soft tissue augmentation. Dermatol Surg. 2002;28(6):491\u20134.","journal-title":"Dermatol Surg"},{"issue":"2","key":"1496_CR12","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jconrel.2011.01.027","volume":"153","author":"VF Patel","year":"2011","unstructured":"Patel VF, Liu F, Brown MB. Advances in oral transmucosal drug delivery. J Control Release. 2011;153(2):106\u201316.","journal-title":"J Control Release"},{"issue":"1\u20132","key":"1496_CR13","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ijpharm.2015.12.010","volume":"498","author":"E Gu\u00e9","year":"2016","unstructured":"Gu\u00e9 E, Since M, Ropars S, Herbinet R, Le Pluart L, Malzert-Fr\u00e9on A. Evaluation of the versatile character of a nanoemulsion formulation. Int J Pharm. 2016;498(1\u20132):49\u201365.","journal-title":"Int J Pharm"},{"issue":"8","key":"1496_CR14","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1007\/s11095-012-0746-0","volume":"29","author":"SS Patil","year":"2012","unstructured":"Patil SS, Venugopal E, Bhat S, Mahadik KR, Paradkar AR. Microstructural elucidation of self-emulsifying system: effect of chemical structure. Pharm Res. 2012;29(8):2180\u20138.","journal-title":"Pharm Res"},{"issue":"1","key":"1496_CR15","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1137\/140971129","volume":"3","author":"S Chen","year":"2015","unstructured":"Chen S, Reyes KR, Gupta MK, McAlpine MC, Powell WB. Optimal learning in experimental design using the knowledge gradient policy with application to characterizing nanoemulsion stability. SIAM\/ASA Journal on Uncertainty Quantification. 2015;3(1):320\u201345.","journal-title":"SIAM\/ASA Journal on Uncertainty Quantification"},{"issue":"1","key":"1496_CR16","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0169-409X(96)00490-5","volume":"25","author":"CW Pouton","year":"1997","unstructured":"Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev. 1997;25(1):47\u201358.","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"1496_CR17","doi-asserted-by":"publisher","first-page":"131","DOI":"10.22270\/jddt.v3i3.517","volume":"3","author":"M Venkatesh","year":"2013","unstructured":"Venkatesh M, Mallesh K. Self-nano emulsifying drug delivery system (SNEDDS) for oral delivery of atorvastatin-formulation and bioavailability studies. Journal of Drug Delivery and Therapeutics. 2013;3(3):131\u201340.","journal-title":"Journal of Drug Delivery and Therapeutics"},{"issue":"2","key":"1496_CR18","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3109\/10717544.2014.933284","volume":"23","author":"A Hussain","year":"2016","unstructured":"Hussain A, Samad A, Singh SK, Ahsan MN, Haque MW, Faruk A, et al. Nanoemulsion gel-based topical delivery of an antifungal drug: in vitro activity and in vivo evaluation. Drug Delivery. 2016;23(2):642\u201357.","journal-title":"Drug Delivery"},{"issue":"5","key":"1496_CR19","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1039\/b919944f","volume":"6","author":"Y Lee","year":"2010","unstructured":"Lee Y, Chung HJ, Yeo S, Ahn CH, Lee H, Messersmith PB, et al. Thermo-sensitive, injectable, and tissue adhesive sol\u2013gel transition hyaluronic acid\/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction. Soft Matter. 2010;6(5):977\u201383.","journal-title":"Soft Matter"},{"key":"1496_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/468456","volume":"2014","author":"Ritika Arora","year":"2014","unstructured":"Arora R, Aggarwal G, Harikumar SL, Kaur K. Nanoemulsion based hydrogel for enhanced transdermal delivery of ketoprofen. Adv Pharm. 2014;2014.","journal-title":"Advances in Pharmaceutics"},{"issue":"1","key":"1496_CR21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.ejpb.2008.04.025","volume":"70","author":"L MAYOL","year":"2008","unstructured":"Mayol L, Quaglia F, Borzacchiello A, Ambrosio L, La Rotonda MI. A novel poloxamers\/hyaluronic acid in situ forming hydrogel for drug delivery: rheological, mucoadhesive and in vitro release properties. Eur J Pharm Biopharm 2008;70(1):199\u2013206.","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"issue":"22","key":"1496_CR22","doi-asserted-by":"publisher","first-page":"12758","DOI":"10.1021\/la801685v","volume":"24","author":"TJ Wooster","year":"2008","unstructured":"Wooster TJ, Golding M, Sanguansri P. Impact of oil type on nanoemulsion formation and Ostwald ripening stability. Langmuir. 2008;24(22):12758\u201365.","journal-title":"Langmuir"},{"issue":"1\u20132","key":"1496_CR23","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.ijpharm.2015.05.030","volume":"490","author":"AO Abioye","year":"2015","unstructured":"Abioye AO, Issah S, Kola-Mustapha AT. Ex vivo skin permeation and retention studies on chitosan\u2013ibuprofen\u2013gellan ternary nanogel prepared by in situ ionic gelation technique\u2014a tool for controlled transdermal delivery of ibuprofen. Int J Pharm. 2015;490(1\u20132):112\u201330.","journal-title":"Int J Pharm"},{"issue":"1","key":"1496_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1208\/s12249-008-9178-x","volume":"10","author":"A Azeem","year":"2009","unstructured":"Azeem A, Rizwan M, Ahmad FJ, Iqbal Z, Khar RK, Aqil M, et al. Nanoemulsion components screening and selection: a technical note. AAPS PharmSciTech. 2009;10(1):69\u201376.","journal-title":"AAPS PharmSciTech"},{"issue":"54","key":"1496_CR25","first-page":"20","volume":"6","author":"P Patil Prashant","year":"2016","unstructured":"Patil Prashant P, Vaishali K, Santosh P. Potential investigation of peceol for formulation of ezetimibe self nano emulsifying drug delivery systems. Asian Journal of Biomedical and Pharmaceutical Sciences. 2016;6(54):20\u201347.","journal-title":"Asian Journal of Biomedical and Pharmaceutical Sciences"},{"issue":"2","key":"1496_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.2174\/157341309788185505","volume":"5","author":"A Azeem","year":"2009","unstructured":"Azeem A, Rizwan M, Ahmad FJ, Khar RK, Iqbal Z, Talegaonkar S. Components screening and influence of surfactant and cosurfactant on nanoemulsion formation. Curr Nanosci. 2009;5(2):220\u20136.","journal-title":"Curr Nanosci"},{"issue":"1\u20132","key":"1496_CR27","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ijpharm.2004.05.016","volume":"280","author":"K Bouchemal","year":"2004","unstructured":"Bouchemal K, Brian\u00e7on S, Perrier E, Fessi H. Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. Int J Pharm. 2004 Aug 6;280(1\u20132):241\u201351.","journal-title":"Int J Pharm"},{"issue":"3","key":"1496_CR28","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ejpb.2007.03.022","volume":"66","author":"DA Chiappetta","year":"2007","unstructured":"Chiappetta DA, Sosnik A. Poly (ethylene oxide)\u2013poly (propylene oxide) block copolymer micelles as drug delivery agents: improved hydrosolubility, stability and bioavailability of drugs. Eur J Pharm Biopharm. 2007;66(3):303\u201317.","journal-title":"Eur J Pharm Biopharm"},{"issue":"3","key":"1496_CR29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.biopha.2004.02.001","volume":"58","author":"RN Gursoy","year":"2004","unstructured":"Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother. 2004;58(3):173\u201382.","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"1496_CR30","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/j.1468-3083.2007.02564.x","volume":"22","author":"JH Lee","year":"2008","unstructured":"Lee JH, Jung JY, Bang D. The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Beh\u00e7et\u2019s disease. J Eur Acad Dermatol Venereol. 2008;22(5):590\u20135.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"6","key":"1496_CR31","doi-asserted-by":"publisher","first-page":"627","DOI":"10.3109\/10837450.2010.508074","volume":"16","author":"E Baloglu","year":"2011","unstructured":"Baloglu E, Karavana SY, Senyigit ZA, Guneri T. Rheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base. Pharm Dev Technol. 2011;16(6):627\u201336.","journal-title":"Pharm Dev Technol"},{"issue":"3","key":"1496_CR32","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0079-6700(97)00047-6","volume":"23","author":"GM Kavanagh","year":"1998","unstructured":"Kavanagh GM, Ross-Murphy SB. Rheological characterisation of polymer gels. Prog Polym Sci. 1998;23(3):533\u201362.","journal-title":"Prog Polym Sci"},{"key":"1496_CR33","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.colsurfb.2013.12.016","volume":"115","author":"B Gorain","year":"2014","unstructured":"Gorain B, Choudhury H, Kundu A, Sarkar L, Karmakar S, Jaisankar P, et al. Nanoemulsion strategy for olmesartan medoxomil improves oral absorption and extended antihypertensive activity in hypertensive rats. Colloids Surf B: Biointerfaces. 2014;115:286\u201394.","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"29","key":"1496_CR34","doi-asserted-by":"publisher","first-page":"5691","DOI":"10.1016\/j.biomaterials.2009.06.055","volume":"30","author":"L Yin","year":"2009","unstructured":"Yin L, Ding J, He C, Cui L, Tang C, Yin C. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials. 2009;30(29):5691\u2013700.","journal-title":"Biomaterials."},{"issue":"6","key":"1496_CR35","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/0142-9612(91)90056-G","volume":"12","author":"H Br\u00f8ndsted","year":"1991","unstructured":"Br\u00f8ndsted H, Kopec\u0306ek J. Hydrogels for site-specific oral drug delivery: synthesis and characterization. Biomaterials. 1991 Aug 1;12(6):584\u201392.","journal-title":"Biomaterials."},{"issue":"11","key":"1496_CR36","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1023\/A:1016268311867","volume":"12","author":"PP Constantinides","year":"1995","unstructured":"Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995;12(11):1561\u201372.","journal-title":"Pharm Res"},{"issue":"11","key":"1496_CR37","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1007\/s12272-013-0191-6","volume":"36","author":"TS Ahn","year":"2013","unstructured":"Ahn TS, Lee JP, Kim J, Oh SY, Chun MK, Choi HK. Effect of pressure sensitive adhesive and vehicles on permeation of terbinafine across porcine hoof membrane. Arch Pharm Res. 2013;36(11):1403\u20139.","journal-title":"Arch Pharm Res"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-019-1496-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-019-1496-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-019-1496-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T23:04:31Z","timestamp":1598051071000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-019-1496-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,23]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["1496"],"URL":"https:\/\/doi.org\/10.1208\/s12249-019-1496-7","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,23]]},"assertion":[{"value":"23 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"297"}}