{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:01:56Z","timestamp":1769299316560,"version":"3.49.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1208\/s12249-021-02033-7","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T20:11:32Z","timestamp":1622146292000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Novel Gellan Gum-Based In Situ Nanovesicle Formulation of Docetaxel for Its Localized Delivery Using Depot Formation"],"prefix":"10.1208","volume":"22","author":[{"given":"Amrinder","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shubham","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narpinder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satwinderjeet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-941X","authenticated-orcid":false,"given":"Subheet Kumar","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"issue":"12","key":"2033_CR1","doi-asserted-by":"publisher","first-page":"6769","DOI":"10.21873\/anticanres.14700","volume":"40","author":"EE DE BREE","year":"2020","unstructured":"DE BREE EE, Katsougkri D, Polioudaki H, Tsangaridou E, Michelakis D, Zoras O, et al. Hyperthermia during intraperitoneal chemotherapy with paclitaxel or docetaxel for ovarian cancer: is there any benefit? Anticancer Res. 2020;40(12):6769\u201380.","journal-title":"Anticancer Res"},{"issue":"8","key":"2033_CR2","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.3109\/10717544.2015.1049720","volume":"23","author":"X Tang","year":"2016","unstructured":"Tang X, Wang G, Shi R, Jiang K, Meng L, Ren H, et al. Enhanced tolerance and antitumor efficacy by docetaxel-loaded albumin nanoparticles. Drug Deliv. 2016;23(8):2686\u201396.","journal-title":"Drug Deliv"},{"key":"2033_CR3","unstructured":"EUROPEAN MEDICINES AGENCY Information for the package leaflet regarding 5 polysorbates used as excipients in medicinal products for 6 human use https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/draft-information-package-leaflet-regarding-polysorbates-used-excipients-medicinal-products-human_en.pdf. Accessed on 21\/10\/2020."},{"issue":"3","key":"2033_CR4","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jconrel.2011.12.001","volume":"158","author":"G Bajaj","year":"2012","unstructured":"Bajaj G, Kim MR, Mohammed SI, Yeo Y. Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors. J Control Release. 2012;158(3):386\u201392.","journal-title":"J Control Release"},{"key":"2033_CR5","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3389\/fchem.2019.00675","volume":"7","author":"DY Fan","year":"2019","unstructured":"Fan DY, Liu Z, Tian Y. Injectable hydrogels for localized cancer therapy. Front chem. 2019;7:675.","journal-title":"Front chem"},{"issue":"7","key":"2033_CR6","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1158\/0008-5472.CAN-16-1536","volume":"77","author":"S Tohme","year":"2017","unstructured":"Tohme S, Simmons RL, Tsung A. Surgery for cancer: a trigger for metastases. Cancer Res. 2017;77(7):1548\u201352.","journal-title":"Cancer Res"},{"issue":"4","key":"2033_CR7","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1177\/153303460500400405","volume":"4","author":"JK Vasir","year":"2005","unstructured":"Vasir JK, Labhasetwar V. Targeted drug delivery in cancer therapy. Tech Canc Res & Treat. 2005;4(4):363\u201374.","journal-title":"Tech Canc Res & Treat"},{"key":"2033_CR8","unstructured":"LABEL FDA https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2010\/020449s059lbl.pdf. Accessed on 08\/12\/2020."},{"key":"2033_CR9","unstructured":"National Drug Code List DOCETAXEL (https:\/\/ndclist.com\/ndc\/16729-267) Accessed on 15\/10\/2020."},{"issue":"1","key":"2033_CR10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.18433\/J3QW26","volume":"14","author":"P Zahedi","year":"2011","unstructured":"Zahedi P, De Souza R, Piquette-Miller M, Allen C. Docetaxel distribution following intraperitoneal administration in mice. J Pharm Pharmaceutical Sci. 2011;14(1):90\u20139.","journal-title":"J Pharm Pharmaceutical Sci"},{"issue":"6","key":"2033_CR11","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3109\/1061186X.2013.776055","volume":"21","author":"JK Cho","year":"2013","unstructured":"Cho JK, Hong JM, Han T, Yang HK, Song SC. Injectable and biodegradable poly (organophosphazene) hydrogel as a delivery system of docetaxel for cancer treatment. J Drug Target. 2013;21(6):564\u201373.","journal-title":"J Drug Target"},{"key":"2033_CR12","first-page":"7291","volume":"10","author":"R Fan","year":"2015","unstructured":"Fan R, Tong A, Li X, Gao X, Mei L, Zhou L, et al. Enhanced antitumor effects by docetaxel\/LL37-loaded thermosensitive hydrogel nanoparticles in peritoneal carcinomatosis of colorectal cancer. Int J Nanomedicine. 2015;10:7291.","journal-title":"Int J Nanomedicine"},{"key":"2033_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.colsurfb.2015.12.057","volume":"140","author":"L Gao","year":"2016","unstructured":"Gao L, Wang X, Ma J, Hao D, Wei P, Zhou L, et al. Evaluation of TPGS-modified thermo-sensitive Pluronic PF127 hydrogel as a potential carrier to reverse the resistance of P-gp-overexpressing SMMC-7721 cell lines. Colloids Surf B: Biointerfaces. 2016;140:307\u201316.","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"2033_CR14","doi-asserted-by":"crossref","unstructured":"Mahajan M, Utreja P, Kumar Jain S. Paclitaxel loaded nanoliposomes in thermosensitive hydrogel: a dual approach for sustained and localized delivery. Anti-Cancer Agents Med. Chem. (Formerly Current Medicinal Chemistry-Anti-Cancer Agents) 2016; 16(3): 365-376.","DOI":"10.2174\/1871520615666150807103910"},{"key":"2033_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.jmbbm.2016.08.005","volume":"65","author":"VM de Oliveira Cardoso","year":"2017","unstructured":"de Oliveira Cardoso VM, Cury BS, Evangelista RC, Gremi\u00e3o MP. Development and characterization of cross-linked gellan gum and retrograded starch blend hydrogels for drug delivery applications. J Mech Behave Biomed Mat. 2017;65:317\u201333.","journal-title":"J Mech Behave Biomed Mat"},{"issue":"1","key":"2033_CR16","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1111\/j.1365-2621.1994.tb06934.x","volume":"59","author":"J Tang","year":"1994","unstructured":"Tang J, Lelievre J, Ma T, Zeng Y. Polymer and ion concentration effects on gellan gel strength and strain. J Food Sci. 1994;59(1):216\u201320.","journal-title":"J Food Sci"},{"issue":"1","key":"2033_CR17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.ejpb.2013.11.001","volume":"87","author":"G D\u2019Arrigo","year":"2014","unstructured":"D\u2019Arrigo G, Navarro G, Di Meo C, Matricardi P, Torchilin V. Gellan gum nanohydrogel containing anti-inflammatory and anti-cancer drugs: a multi-drug delivery system for a combination therapy in cancer treatment. Eur J Pharm Biopharm. 2014;87(1):208\u201316.","journal-title":"Eur J Pharm Biopharm"},{"issue":"5","key":"2033_CR18","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1517\/17425247.2016.1146673","volume":"13","author":"U Posadowska","year":"2016","unstructured":"Posadowska U, Brzychczy-W\u0142och M, Dro\u017cd\u017c A, Krok-Borkowicz M, W\u0142odarczyk-Biegun M, Dobrzy\u0144ski P, et al. Injectable hybrid delivery system composed of gellan gum, nanoparticles and gentamicin for the localized treatment of bone infections. Exp Op drug deliv. 2016;13(5):613\u201320.","journal-title":"Exp Op drug deliv"},{"issue":"7","key":"2033_CR19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3109\/10611860903508788","volume":"18","author":"H Gupta","year":"2010","unstructured":"Gupta H, Velpandian T, Jain S. Ion-and pH-activated novel in-situ gel system for sustained ocular drug delivery. J Drug Target. 2010;18(7):499\u2013505.","journal-title":"J Drug Target"},{"issue":"14","key":"2033_CR20","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1039\/b818090c","volume":"19","author":"Y Gong","year":"2009","unstructured":"Gong Y, Wang C, Lai RC, Su K, Zhang F, Wang DA. An improved injectable polysaccharide hydrogel: modified gellan gum for long-term cartilage regeneration in vitro. J Mater Chem. 2009;19(14):1968\u201377.","journal-title":"J Mater Chem"},{"key":"2033_CR21","doi-asserted-by":"crossref","unstructured":"Singh A, Thakur S, Singh H, Singh H, Kaur S, Kaur S, Dudi R, Mondhe DM, Jain SK. Novel Vitamin E TPGS based docetaxel nanovesicle formulation for its safe and effective parenteral delivery: toxicological, pharmacokinetic and pharmacodynamic evaluation. 2020; J Lipo Res. 1-38.","DOI":"10.1080\/08982104.2020.1835955"},{"issue":"8","key":"2033_CR22","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1590\/S0100-40422013000800008","volume":"36","author":"GG Pereira","year":"2013","unstructured":"Pereira GG, Dimer FA, Guterres SS, Kechinski CP, Granada JE, Cardozo NS. Formulation and characterization of poloxamer 407\u00ae: thermoreversible gel containing polymeric microparticles and hyaluronic acid. Qu\u00edmica Nova. 2013;36(8):1121\u20135.","journal-title":"Qu\u00edmica Nova"},{"issue":"6","key":"2033_CR23","doi-asserted-by":"publisher","first-page":"663","DOI":"10.3109\/02652049409051117","volume":"11","author":"V Labhasetwar","year":"1994","unstructured":"Labhasetwar V, Mohan MS, Dorle AK. A study on zeta potential and dielectric constant of liposomes. J Microencapsul. 1994;11(6):663\u20138.","journal-title":"J Microencapsul"},{"issue":"2","key":"2033_CR24","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.jpba.2006.01.011","volume":"41","author":"BM Rao","year":"2006","unstructured":"Rao BM, Chakraborty A, Srinivasu MK, Devi ML, Kumar PR, Chandrasekhar KB, et al. A stability-indicating HPLC assay method for docetaxel. J Pharm Biomed Anal. 2006;41(2):676\u201381.","journal-title":"J Pharm Biomed Anal"},{"key":"2033_CR25","first-page":"101","volume":"5","author":"P Panwar","year":"2010","unstructured":"Panwar P, Pandey B, Lakhera PC, Singh KP. Preparation, characterization, and in vitro release study of albendazole-encapsulated nanosize liposomes. Int J Nanomedicine. 2010;5:101.","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"2033_CR26","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s10971-006-9007-1","volume":"42","author":"F Ganji","year":"2007","unstructured":"Ganji F, Abdekhodaie MJ, SA, AR. Gelation time and degradation rate of chitosan-based injectable hydrogel. J Sol-Gel Sci Tech. 2007;42(1):47\u201353.","journal-title":"J Sol-Gel Sci Tech"},{"issue":"1","key":"2033_CR27","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/app.35414","volume":"125","author":"J Hurler","year":"2012","unstructured":"Hurler J, Engesland A, Poorahmary Kermany B, \u0160kalko-Basnet N. Improved texture analysis for hydrogel characterization: gel cohesiveness, adhesiveness, and hardness. J Appl Polym Sci. 2012;125(1):180\u20138.","journal-title":"J Appl Polym Sci"},{"key":"2033_CR28","doi-asserted-by":"publisher","first-page":"289","DOI":"10.2147\/IJN.S187918","volume":"14","author":"X Liu","year":"2019","unstructured":"Liu X, Gan H, Hu C, Sun W, Zhu X, Meng Z, et al. Silver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent. Int J Nanomedicine. 2019;14:289.","journal-title":"Int J Nanomedicine"},{"issue":"4","key":"2033_CR29","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1039\/C7FO01391D","volume":"9","author":"H Singh","year":"2018","unstructured":"Singh H, Kumar C, Singh N, Paul S, Jain SK. Nanoencapsulation of docosahexaenoic acid (DHA) using a combination of food grade polymeric wall materials and its application for improvement in bioavailability and oxidative stability. Food Funct. 2018;9(4):2213\u201327.","journal-title":"Food Funct"},{"key":"2033_CR30","doi-asserted-by":"crossref","unstructured":"Thakur S, Singh H, Singh A, Kaur S, Sharma A, Singh SK, Kaur G, Jain SK. Thermosensitive injectable hydrogel containing carboplatin loaded nanoparticles: a dual approach for sustained and localized delivery with improved safety and therapeutic efficacy. J Drug Deliv Sci Tech. 2020; 101817.","DOI":"10.1016\/j.jddst.2020.101817"},{"key":"2033_CR31","unstructured":"Material Safety Data Sheet DOCETAXEL (https:\/\/pfe-pfizercom-d8- prod.s3.amazonaws.com\/products\/material_safety_data\/Docetaxel_Injection_1-March-2016.pdf) Accessed on 15\/10\/2020."},{"key":"2033_CR32","unstructured":"Y\u0131lmaz S, Tokp\u0131nar A, Avnio\u011flu S Experimental cancer models"},{"issue":"3","key":"2033_CR33","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.3892\/ol.2017.6484","volume":"14","author":"MS Rahman","year":"2017","unstructured":"Rahman MS, Alam MB, Choi YH, Yoo JC. Anticancer activity and antioxidant potential of Aponogeton undulatus against Ehrlich ascites carcinoma cells in Swiss albino mice. Oncol Lett. 2017;14(3):3169\u201376.","journal-title":"Oncol Lett"},{"issue":"1","key":"2033_CR34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3109\/10717544.2011.621990","volume":"19","author":"P Utreja","year":"2012","unstructured":"Utreja P, Jain S, Tiwary AK. Evaluation of biosafety and intracellular uptake of Cremophor EL free paclitaxel elastic liposomal formulation. Drug Deliv. 2012;19(1):11\u201320.","journal-title":"Drug Deliv"},{"issue":"3","key":"2033_CR35","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1080\/713840402","volume":"10","author":"J Balasubramaniam","year":"2003","unstructured":"Balasubramaniam J, Pandit JK. Ion-activated in situ gelling systems for sustained ophthalmic delivery of ciprofloxacin hydrochloride. Drug Deliv. 2003;10(3):185\u201391.","journal-title":"Drug Deliv"},{"issue":"12","key":"2033_CR36","first-page":"1","volume":"1","author":"J Li","year":"2016","unstructured":"Li J, Mooney DJ. Designing hydrogels for controlled drug delivery. Nature Rev Mat. 2016;1(12):1\u20137.","journal-title":"Nature Rev Mat"},{"issue":"6","key":"2033_CR37","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1007\/s11095-017-2135-1","volume":"34","author":"NI Hammadi","year":"2017","unstructured":"Hammadi NI, Abba Y, Hezmee MN, Razak IS, Jaji AZ, Isa T, et al. Formulation of a sustained release docetaxel loaded cockle shell-derived calcium carbonate nanoparticles against breast cancer. Pharm Res. 2017;34(6):1193\u2013203.","journal-title":"Pharm Res"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-021-02033-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-021-02033-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-021-02033-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T17:09:39Z","timestamp":1627319379000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-021-02033-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,27]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["2033"],"URL":"https:\/\/doi.org\/10.1208\/s12249-021-02033-7","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,27]]},"assertion":[{"value":"22 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"165"}}