{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:18:26Z","timestamp":1792696706645,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1208\/s12249-021-02053-3","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T13:03:10Z","timestamp":1625058190000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Design and Optimization of 3D-Printed Gastroretentive Floating Devices by Central Composite Design"],"prefix":"10.1208","volume":"22","author":[{"given":"Thapakorn","family":"Charoenying","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasopchai","family":"Patrojanasophon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanasait","family":"Ngawhirunpat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theerasak","family":"Rojanarata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasert","family":"Akkaramongkolporn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praneet","family":"Opanasopit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"issue":"1-2","key":"2053_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ijpharm.2017.05.021","volume":"527","author":"A Goyanes","year":"2017","unstructured":"Goyanes A, Fina F, Martorana A, Sedough D, Gaisford S, Basit AW. Development of modified release 3D printed tablets (printlets) with pharmaceutical excipients using additive manufacturing. Int J Pharm. 2017;527(1-2):21\u201330. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.05.021.","journal-title":"Int J Pharm"},{"issue":"1","key":"2053_CR2","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1038\/s41598-017-03097-x","volume":"7","author":"X Chai","year":"2017","unstructured":"Chai X, Chai H, Wang X, Yang J, Li J, Zhao Y, et al. Fused deposition modeling (FDM) 3D printed tablets for intragastric floating delivery of domperidone. Sci Rep. 2017;7(1):2829. https:\/\/doi.org\/10.1038\/s41598-017-03097-x.","journal-title":"Sci Rep"},{"issue":"1-2","key":"2053_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ijpharm.2014.09.044","volume":"476","author":"A Goyanes","year":"2014","unstructured":"Goyanes A, Buanz AB, Basit AW, Gaisford S. Fused-filament 3D printing (3DP) for fabrication of tablets. Int J Pharm. 2014;476(1-2):88\u201392. https:\/\/doi.org\/10.1016\/j.ijpharm.2014.09.044.","journal-title":"Int J Pharm"},{"issue":"5","key":"2053_CR4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ajps.2018.11.008","volume":"14","author":"S Lamichhane","year":"2019","unstructured":"Lamichhane S, Bashyal S, Keum T, Noh G, Seo JE, Bastola R, et al. Complex formulations, simple techniques: can 3D printing technology be the midas touch in pharmaceutical industry? Asian J Pharm Sci. 2019;14(5):465\u201379. https:\/\/doi.org\/10.1016\/j.ajps.2018.11.008.","journal-title":"Asian J Pharm Sci"},{"key":"2053_CR5","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.msec.2019.04.063","volume":"102","author":"SN Economidou","year":"2019","unstructured":"Economidou SN, Pere CPP, Reid A, Uddin MJ, Windmill JFC, Lamprou DA, et al. 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. Mater Sci Eng C Mater Biol Appl. 2019;102:743\u201355. https:\/\/doi.org\/10.1016\/j.msec.2019.04.063.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"2053_CR6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.procir.2016.02.194","volume":"42","author":"Z Ali","year":"2016","unstructured":"Ali Z, T\u00fcreyen EB, Karpat Y, \u00c7akmakc\u0131 M. Fabrication of polymer micro needles for transdermal drug delivery system using DLP based projection stereo-lithography. Procedia CIRP. 2016;42:87\u201390. https:\/\/doi.org\/10.1016\/j.procir.2016.02.194.","journal-title":"Procedia CIRP"},{"issue":"1-2","key":"2053_CR7","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.ijpharm.2017.06.085","volume":"529","author":"EA Clark","year":"2017","unstructured":"Clark EA, Alexander MR, Irvine DJ, Roberts CJ, Wallace MJ, Sharpe S, et al. 3D printing of tablets using inkjet with UV photoinitiation. Int J Pharm. 2017;529(1-2):523\u201330. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.06.085.","journal-title":"Int J Pharm"},{"key":"2053_CR8","doi-asserted-by":"publisher","first-page":"105555","DOI":"10.1016\/j.ejps.2020.105555","volume":"155","author":"T Charoenying","year":"2020","unstructured":"Charoenying T, Patrojanasophon P, Ngawhirunpat T, Rojanarata T, Akkaramongkolporn P, Opanasopit P. Three-dimensional (3D)-printed devices composed of hydrophilic cap and hydrophobic body for improving buoyancy and gastric retention of domperidone tablets. Eur J Pharm Sci. 2020;155:105555. https:\/\/doi.org\/10.1016\/j.ejps.2020.105555.","journal-title":"Eur J Pharm Sci"},{"issue":"5","key":"2053_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216875","volume":"14","author":"S Shin","year":"2019","unstructured":"Shin S, Kim TH, Jeong SW, Chung SE, Lee DY, Kim DH, et al. Development of a gastroretentive delivery system for acyclovir by 3D printing technology and its in vivo pharmacokinetic evaluation in Beagle dogs. PLoS One. 2019;14(5):e0216875. https:\/\/doi.org\/10.1371\/journal.pone.0216875.","journal-title":"PLoS One"},{"issue":"5","key":"2053_CR10","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.ajps.2016.04.007","volume":"11","author":"UK Mandal","year":"2016","unstructured":"Mandal UK, Chatterjee B, Senjoti FG. Gastro-retentive drug delivery systems and their in vivo success: a recent update. Asian J Pharm Sci. 2016;11(5):575\u201384. https:\/\/doi.org\/10.1016\/j.ajps.2016.04.007.","journal-title":"Asian J Pharm Sci"},{"issue":"2","key":"2053_CR11","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3109\/10717544.2010.520354","volume":"18","author":"VK Pawar","year":"2011","unstructured":"Pawar VK, Kansal S, Garg G, Awasthi R, Singodia D, Kulkarni GT. Gastroretentive dosage forms: a review with special emphasis on floating drug delivery systems. Drug Deliv. 2011;18(2):97\u2013110. https:\/\/doi.org\/10.3109\/10717544.2010.520354.","journal-title":"Drug Deliv"},{"issue":"2","key":"2053_CR12","first-page":"1","volume":"1","author":"A Nayak","year":"2010","unstructured":"Nayak A, Malakar J, Sen K. Gastroretentive drug delivery technologies: current approaches and future potential. J Pharm Educ Res. 2010;1(2):1\u201312.","journal-title":"J Pharm Educ Res"},{"issue":"1","key":"2053_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.ijpharm.2016.05.016","volume":"510","author":"CM Lopes","year":"2016","unstructured":"Lopes CM, Bettencourt C, Rossi A, Buttini F, Barata P. Overview on gastroretentive drug delivery systems for improving drug bioavailability. Int J Pharm. 2016;510(1):144\u201358. https:\/\/doi.org\/10.1016\/j.ijpharm.2016.05.016.","journal-title":"Int J Pharm"},{"key":"2053_CR14","doi-asserted-by":"publisher","unstructured":"Iglesias N, Galbis E, Romero-Azogil L, Benito E, Lucas R, Garcia-Martin MG, et al. In-depth study into polymeric materials in low-density gastroretentive formulations. Pharmaceutics. 2020;12(7). https:\/\/doi.org\/10.3390\/pharmaceutics12070636.","DOI":"10.3390\/pharmaceutics12070636"},{"issue":"1-2","key":"2053_CR15","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ijpharm.2017.10.037","volume":"535","author":"Q Li","year":"2018","unstructured":"Li Q, Guan X, Cui M, Zhu Z, Chen K, Wen H, et al. Preparation and investigation of novel gastro-floating tablets with 3D extrusion-based printing. Int J Pharm. 2018;535(1-2):325\u201332. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.10.037.","journal-title":"Int J Pharm"},{"issue":"1-2","key":"2053_CR16","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.ijpharm.2018.08.011","volume":"549","author":"J Fu","year":"2018","unstructured":"Fu J, Yin H, Yu X, Xie C, Jiang H, Jin Y, et al. Combination of 3D printing technologies and compressed tablets for preparation of riboflavin floating tablet-in-device (TiD) systems. Int J Pharm. 2018;549(1-2):370\u20139. https:\/\/doi.org\/10.1016\/j.ijpharm.2018.08.011.","journal-title":"Int J Pharm"},{"key":"2053_CR17","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ibiod.2017.01.010","volume":"117","author":"X Qi","year":"2017","unstructured":"Qi X, Ren Y, Wang X. New advances in the biodegradation of poly(lactic) acid. Int Biodeterior Biodegradation. 2017;117:215\u201323. https:\/\/doi.org\/10.1016\/j.ibiod.2017.01.010.","journal-title":"Int Biodeterior Biodegradation"},{"issue":"1526","key":"2053_CR18","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1098\/rstb.2008.0289","volume":"364","author":"JH Song","year":"2009","unstructured":"Song JH, Murphy RJ, Narayan R, Davies GB. Biodegradable and compostable alternatives to conventional plastics. Philos Trans R Soc Lond Ser B Biol Sci. 2009;364(1526):2127\u201339. https:\/\/doi.org\/10.1098\/rstb.2008.0289.","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"issue":"12","key":"2053_CR19","doi-asserted-by":"publisher","first-page":"4777","DOI":"10.1021\/ma2000948","volume":"44","author":"L Xu","year":"2011","unstructured":"Xu L, Crawford K, Gorman CB. Effects of temperature and pH on the degradation of poly(lactic acid) brushes. Macromolecules. 2011;44(12):4777\u201382. https:\/\/doi.org\/10.1021\/ma2000948.","journal-title":"Macromolecules."},{"key":"2053_CR20","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.jddst.2019.06.004","volume":"52","author":"K Huanbutta","year":"2019","unstructured":"Huanbutta K, Sangnim T. Design and development of zero-order drug release gastroretentive floating tablets fabricated by 3D printing technology. J Drug Deliv Sci Technol. 2019;52:831\u20137. https:\/\/doi.org\/10.1016\/j.jddst.2019.06.004.","journal-title":"J Drug Deliv Sci Technol"},{"key":"2053_CR21","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/B978-0-7020-4087-0.00043-7","volume":"120","author":"A Aggarwal","year":"2014","unstructured":"Aggarwal A, Bhatt M. Commonly used gastrointestinal drugs. Handb Clin Neurol. 2014;120:633\u201343. https:\/\/doi.org\/10.1016\/B978-0-7020-4087-0.00043-7.","journal-title":"Handb Clin Neurol"},{"issue":"9","key":"2053_CR22","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1111\/j.1572-0241.2007.01255.x","volume":"102","author":"SC Reddymasu","year":"2007","unstructured":"Reddymasu SC, Soykan I, McCallum RW. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007;102(9):2036\u201345. https:\/\/doi.org\/10.1111\/j.1572-0241.2007.01255.x.","journal-title":"Am J Gastroenterol"},{"key":"2053_CR23","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.msec.2017.03.219","volume":"77","author":"F Paulo","year":"2017","unstructured":"Paulo F, Santos L. Design of experiments for microencapsulation applications: a review. Mater Sci Eng C Mater Biol Appl. 2017;77:1327\u201340. https:\/\/doi.org\/10.1016\/j.msec.2017.03.219.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"issue":"5","key":"2053_CR24","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.talanta.2008.05.019","volume":"76","author":"MA Bezerra","year":"2008","unstructured":"Bezerra MA, Santelli RE, Oliveira EP, Villar LS, Escaleira LA. Response surface methodology (RSM) as a tool for optimization in analytical chemistry. Talanta. 2008;76(5):965\u201377. https:\/\/doi.org\/10.1016\/j.talanta.2008.05.019.","journal-title":"Talanta."},{"key":"2053_CR25","unstructured":"Pound J. British Pharmacopoeia Health Ministers of the United Kingdom; 2019."},{"key":"2053_CR26","doi-asserted-by":"publisher","first-page":"258","DOI":"10.4028\/www.scientific.net\/KEM.859.258","volume":"859","author":"T Charoenying","year":"2020","unstructured":"Charoenying T, Patrojanasophon P, Ngawhirunpat T, Rojanarata T, Akkaramongkolporn P, Opanasopit P. Effects of thermal crosslinking on the properties and release profiles of three-dimensional (3D)-printed poly vinyl alcohol (PVA) tablets. Key Eng Mater. 2020;859:258\u201364. https:\/\/doi.org\/10.4028\/www.scientific.net\/KEM.859.258.","journal-title":"Key Eng Mater"},{"key":"2053_CR27","doi-asserted-by":"publisher","first-page":"101393","DOI":"10.1016\/j.jddst.2019.101393","volume":"55","author":"T Charoenying","year":"2020","unstructured":"Charoenying T, Patrojanasophon P, Ngawhirunpat T, Rojanarata T, Akkaramongkolporn P, Opanasopit P. Fabrication of floating capsule-in-3D-printed devices as gastro-retentive delivery systems of amoxicillin. J Drug Deliv Sci Technol. 2020;55:101393. https:\/\/doi.org\/10.1016\/j.jddst.2019.101393.","journal-title":"J Drug Deliv Sci Technol"},{"key":"2053_CR28","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1248\/bpb.b16-00878","volume":"40","author":"T Tagami","year":"2017","unstructured":"Tagami T, Fukushige K, Ogawa E, Hayashi N, Ozeki T. 3D printing factors important for the fabrication of polyvinylalcohol filament-based tablets. Biol Pharm Bull. 2017;40:357\u201364. https:\/\/doi.org\/10.1248\/bpb.b16-00878.","journal-title":"Biol Pharm Bull"},{"key":"2053_CR29","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.ejpb.2014.12.003","volume":"89","author":"A Goyanes","year":"2015","unstructured":"Goyanes A, Buanz AB, Hatton GB, Gaisford S, Basit AW. 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. Eur J Pharm Biopharm. 2015;89:157\u201362. https:\/\/doi.org\/10.1016\/j.ejpb.2014.12.003.","journal-title":"Eur J Pharm Biopharm"},{"key":"2053_CR30","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4028\/www.scientific.net\/KEM.859.289","volume":"859","author":"K Singpanna","year":"2020","unstructured":"Singpanna K, Charoenying T, Patrojanasophon P, Rojanarata T, Sukma M, Opanasopit P. Fabrication of a floating device of domperidone tablets using 3D-printing technologies. Key Eng Mater. 2020;859:289\u201394. https:\/\/doi.org\/10.4028\/www.scientific.net\/KEM.859.289.","journal-title":"Key Eng Mater"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-021-02053-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-021-02053-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-021-02053-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T17:25:19Z","timestamp":1627320319000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-021-02053-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["2053"],"URL":"https:\/\/doi.org\/10.1208\/s12249-021-02053-3","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]},"assertion":[{"value":"3 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"197"}}