{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:52:53Z","timestamp":1788774773897,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"DOI":"10.1208\/s12249-022-02473-9","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T22:03:21Z","timestamp":1674684201000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dissolving Microneedle Arrays as a Hepatitis B Vaccine Delivery System Adjuvanted by APC-Targeted Poly (Lactic-co-Glycolic Acid) (PLGA) Nanoparticles"],"prefix":"10.1208","volume":"24","author":[{"given":"Xiaoling","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuwa","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"2473_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119877","volume":"284","author":"M Dalvi","year":"2021","unstructured":"Dalvi M, Kharat P, Thakor P, Bhavana V, Singh S, Mehra NK. Panorama of dissolving microneedles for transdermal drug delivery. Life Sci. 2021;284: 119877. https:\/\/doi.org\/10.1016\/j.lfs.2021.119877.","journal-title":"Life Sci"},{"key":"2473_CR2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/B978-0-323-91811-4.00009-2","volume":"2022","author":"K Ita","year":"2022","unstructured":"Ita K. Dissolving microneedles. Microneedles. 2022;2022:49\u201372. https:\/\/doi.org\/10.1016\/B978-0-323-91811-4.00009-2.","journal-title":"Microneedles"},{"key":"2473_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118489","volume":"567","author":"DD Zhu","year":"2019","unstructured":"Zhu DD, Zhang XP, Yu HL, Liu RX, Shen CB, Zhang WF, Cui Y, Guo XD. Kinetic stability studies of HBV vaccine in a microneedle patch. Int J Pharm. 2019;567: 118489. https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118489.","journal-title":"Int J Pharm"},{"key":"2473_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1208\/s12249-019-1526-5","volume":"21","author":"J Zhu","year":"2019","unstructured":"Zhu J, Qin F, Ji Z, Fei W, Tan Z, Hu Y, Zheng C. Mannose-modified PLGA nanoparticles for sustained and targeted delivery in hepatitis B virus immunoprophylaxis. AAPS PharmSciTech. 2019;21:13. https:\/\/doi.org\/10.1208\/s12249-019-1526-5.","journal-title":"AAPS PharmSciTech"},{"key":"2473_CR5","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ijbiomac.2017.07.178","volume":"106","author":"Z Yin","year":"2018","unstructured":"Yin Z, Kuang D, Wang S, Zheng Z, Yadavalli VK, Lu S. Swellable silk fibroin microneedles for transdermal drug delivery. Int J Biol Macromol. 2018;106:48\u201356. https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.07.178.","journal-title":"Int J Biol Macromol"},{"issue":"11","key":"2473_CR6","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1007\/s11095-017-2223-2","volume":"34","author":"M Leone","year":"2017","unstructured":"Leone M, M\u00f6nk\u00e4re J, Bouwstra JA, Kersten G. Dissolving microneedle patches for dermal vaccination. Pharm Res. 2017;34(11):2223\u201340. https:\/\/doi.org\/10.1007\/s11095-017-2223-2.","journal-title":"Pharm Res"},{"issue":"46","key":"2473_CR7","doi-asserted-by":"publisher","first-page":"43588","DOI":"10.1021\/acsami.9b15668","volume":"11","author":"H Du","year":"2019","unstructured":"Du H, Liu P, Zhu J, Lan J, Li Y, Zhang L, Zhu J, Tao J. Hyaluronic acid-based dissolving microneedle patch loaded with methotrexate for improved treatment of psoriasis. ACS Appl Mater Interfaces. 2019;11(46):43588\u201398. https:\/\/doi.org\/10.1021\/acsami.9b15668.","journal-title":"ACS Appl Mater Interfaces"},{"key":"2473_CR8","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1002\/jbm.a.36423","volume":"106","author":"J Hajavi","year":"2018","unstructured":"Hajavi J, Ebrahimian M, Sankian M, Khakzad MR, Hashemi M. Optimization of PLGA formulation containing protein or peptide-based antigen: recent advances. J Biomed Mater Res, Part A. 2018;106:2540\u201351. https:\/\/doi.org\/10.1002\/jbm.a.36423.","journal-title":"J Biomed Mater Res, Part A"},{"issue":"9","key":"2473_CR9","doi-asserted-by":"publisher","first-page":"776","DOI":"10.2174\/1567201817666200804110003","volume":"17","author":"M Sardesai","year":"2020","unstructured":"Sardesai M, Shende P. Engineering of nanospheres dispersed microneedle system for antihypertensive action. Curr Drug Deliv. 2020;17(9):776\u201386. https:\/\/doi.org\/10.2174\/1567201817666200804110003.","journal-title":"Curr Drug Deliv"},{"key":"2473_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.eurpolymj.2018.09.026","volume":"108","author":"N Feiner-Gracia","year":"2018","unstructured":"Feiner-Gracia N, Dols-Perez A, Royo M, Solans C, Garcia-Celma MJ, Fornaguera C. Cell penetrating peptide grafting of PLGA nanoparticles to enhance cell uptake. Eur Polym J. 2018;108:429\u201338. https:\/\/doi.org\/10.1016\/j.eurpolymj.2018.09.026.","journal-title":"Eur Polym J"},{"key":"2473_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121393","volume":"613","author":"GK Braz","year":"2021","unstructured":"Braz GK, D\u2019Souza B, Vijayanand S, Menon I, D\u2019Souza MJ. A dual-delivery platform for vaccination using antigen-loaded nanoparticles in dissolving microneedles. Int J Pharm. 2021;613: 121393. https:\/\/doi.org\/10.1016\/j.ijpharm.2021.121393.","journal-title":"Int J Pharm"},{"key":"2473_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jconrel.2017.10.005","volume":"265","author":"LK Vora","year":"2017","unstructured":"Vora LK, Donnelly RF, Larra\u00f1eta E, Gonz\u00e1lez-V\u00e1zquez P, Thakur RRS, Vavia PR. Novel bilayer dissolving microneedle arrays with concentrated PLGA nano-microparticles for targeted intradermal delivery: Proof of concept. J Control Release. 2017;265:93\u2013101. https:\/\/doi.org\/10.1016\/j.jconrel.2017.10.005.","journal-title":"J Control Release"},{"issue":"3","key":"2473_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101664","volume":"3","author":"M Sauter","year":"2022","unstructured":"Sauter M, Sauter RJ, Nording H, Olbrich M, Emschermann F, Langer HF. Protocol to isolate and analyze mouse bone marrow derived dendritic cells (BMDC). STAR Protoc. 2022;3(3): 101664. https:\/\/doi.org\/10.1016\/j.xpro.2022.101664.","journal-title":"STAR Protoc"},{"issue":"2","key":"2473_CR14","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.intimp.2014.10.010","volume":"23","author":"X Chen","year":"2014","unstructured":"Chen X, Wang L, Liu Q, Jia J, Liu Y, Zhang W, Ma G, Su Z. Polycation-decorated PLA microspheres induce robust immune responses via commonly used parenteral administration routes. Int Immunopharmacol. 2014;23(2):592\u2013602. https:\/\/doi.org\/10.1016\/j.intimp.2014.10.010.","journal-title":"Int Immunopharmacol"},{"key":"2473_CR15","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1016\/j.bbrc.2004.09.007","volume":"323","author":"CH Zheng","year":"2004","unstructured":"Zheng CH, Gao JQ, Zhang YP, Liang WQ. A protein delivery system: biodegradable alginate-chitosan-poly(lactic-co-glycolic acid) composite microspheres. Biochem Biophys Res Commun. 2004;323:1321\u20137. https:\/\/doi.org\/10.1016\/j.bbrc.2004.09.007.","journal-title":"Biochem Biophys Res Commun"},{"key":"2473_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ijpharm.2019.03.033","volume":"563","author":"W Yao","year":"2019","unstructured":"Yao W, Tao C, Zou J, Zheng H, Zhu J, Zhu Z, Zhu Z, Zhu J, Liu L, Li F, Song X. Flexible two-layer dissolving and safing microneedle transdermal of neurotoxin: a biocomfortable attempt to treat Rheumatoid Arthritis. Int J Pharm. 2019;563:91\u2013100.","journal-title":"Int J Pharm"},{"key":"2473_CR17","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.ejps.2018.06.014","volume":"121","author":"H Zhan","year":"2018","unstructured":"Zhan H, Ma F, Huang Y, Zhang J, Jiang X, Qian Y. Application of composite dissolving microneedles with high drug loading ratio for rapid local anesthesia. Eur J Pharm Sci. 2018;121:330\u20137. https:\/\/doi.org\/10.1016\/j.ejps.2018.06.014.","journal-title":"Eur J Pharm Sci"},{"key":"2473_CR18","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ejpb.2018.05.031","volume":"129","author":"J M\u00f6nk\u00e4re","year":"2018","unstructured":"M\u00f6nk\u00e4re J, Pontier M, van Kampen EEM, Du G, Leone M, Romeijn S, Nejadnik MR, O\u2019Mahony C, Sl\u00fctter B, Jiskoot W, Bouwstra JA. Development of PLGA nanoparticle loaded dissolving microneedles and comparison with hollow microneedles in intradermal vaccine delivery. Eur J Pharm Biopharm. 2018;129:111\u201321. https:\/\/doi.org\/10.1016\/j.ejpb.2018.05.031.","journal-title":"Eur J Pharm Biopharm"},{"key":"2473_CR19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.colsurfa.2016.04.028","volume":"500","author":"Q Fan","year":"2016","unstructured":"Fan Q, Qi F, Miao C, Yue H, Gong F, Wu J, Ma G, Su Z. Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies. Colloids Surf A. 2016;500:177\u201385. https:\/\/doi.org\/10.1016\/j.colsurfa.2016.04.028.","journal-title":"Colloids Surf A"},{"key":"2473_CR20","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.3109\/10717544.2014.992497","volume":"23","author":"Y Qiu","year":"2016","unstructured":"Qiu Y, Guo L, Zhang S, Xu B, Gao Y, Hu Y, Hou J, Bai B, Shen H, Mao P. DNA-based vaccination against hepatitis B virus using dissolving microneedle arrays adjuvanted by cationic liposomes and CpG ODN. Drug Deliv. 2016;23:2391\u20138. https:\/\/doi.org\/10.3109\/10717544.2014.992497.","journal-title":"Drug Deliv"},{"issue":"22","key":"2473_CR21","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1016\/0142-9612(96)00049-x","volume":"17","author":"D Lemoine","year":"1996","unstructured":"Lemoine D, Francois C, Kedzierewicz F, Preat V, Hoffman M, Maincent P. Stability study of nanoparticles of poly(epsilon-caprolactone), poly(D, L-lactide) and poly(D, L-lactide-co-glycolide). Biomaterials. 1996;17(22):2191\u20137. https:\/\/doi.org\/10.1016\/0142-9612(96)00049-x.","journal-title":"Biomaterials"},{"issue":"1","key":"2473_CR22","doi-asserted-by":"publisher","first-page":"12270","DOI":"10.1038\/s41598-021-90792-5","volume":"11","author":"S Swetledge","year":"2021","unstructured":"Swetledge S, Carter R, Stout R, Astete CE, Jung JP, Sabliov CM. Stability and ocular biodistribution of topically administered PLGA nanoparticles. Sci Rep. 2021;11(1):12270. https:\/\/doi.org\/10.1038\/s41598-021-90792-5.","journal-title":"Sci Rep"},{"key":"2473_CR23","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1021\/nn304235j","volume":"7","author":"M Zaric","year":"2013","unstructured":"Zaric M, Lyubomska O, Touzelet O, Poux C, Al-Zahrani S, Fay F, Wallace L, Terhorst D, Malissen B, Henri S, Power UF, Scott CJ, Donnelly RF, Kissenpfennig A. Skin dendritic cell targeting via microneedle arrays laden with antigen-encapsulated Poly-d, l-lactide-co-glycolide nanoparticles induces efficient antitumor and antiviral immune responses. ACS Nano. 2013;7:2042\u201355. https:\/\/doi.org\/10.1021\/nn304235j.","journal-title":"ACS Nano"},{"key":"2473_CR24","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.immuni.2018.09.024","volume":"49","author":"CS Garris","year":"2018","unstructured":"Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-\u03b3 and IL-12. Immunity. 2018;49:1148\u201361. https:\/\/doi.org\/10.1016\/j.immuni.2018.09.024.","journal-title":"Immunity"},{"key":"2473_CR25","doi-asserted-by":"publisher","unstructured":"Elieh Ali Komi D, Grauwet K. Role of mast cells in regulation of T cell responses in experimental and clinical settings. Clin Rev Allerg Immunol. 2018;54:432\u2013445. https:\/\/doi.org\/10.1007\/s12016-017-8646-z","DOI":"10.1007\/s12016-017-8646-z"},{"issue":"22","key":"2473_CR26","doi-asserted-by":"publisher","first-page":"10423","DOI":"10.1128\/JVI.01467-16","volume":"90","author":"HA Prentice","year":"2016","unstructured":"Prentice HA, Lu H, Price MA, Kamali A, Karita E, Lakhi S, Sanders EJ, Anzala O, Allen S, Goepfert PA, Hunter E, Gilmour J, Tang J. Dynamics and correlates of CD8 T-cell counts in Africans with primary human immunodeficiency virus type 1 infection. J Virol. 2016;90(22):10423\u201330. https:\/\/doi.org\/10.1128\/JVI.01467-16.","journal-title":"J Virol"},{"issue":"17","key":"2473_CR27","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1056\/NEJMoa2106062","volume":"386","author":"EAF Sim\u00f5es","year":"2022","unstructured":"Sim\u00f5es EAF, Center KJ, Tita Alan TN, Swanson KA, Radley D, Houghton J, McGrory SB, Gomme E, Anderson M, Roberts JP, Scott DA, Jansen KU, Gruber WC, Dormitzer PR, Gurtman AC. Prefusion F protein-based respiratory syncytial virus immunization in pregnancy. N Engl J Med. 2022;386(17):1615\u201326. https:\/\/doi.org\/10.1056\/NEJMoa2106062.","journal-title":"N Engl J Med"},{"key":"2473_CR28","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.ejpb.2013.06.017","volume":"85","author":"D Pawar","year":"2013","unstructured":"Pawar D, Mangal S, Goswami R, Jaganathan KS. Development and characterization of surface modified PLGA nanoparticles for nasal vaccine delivery: effect of mucoadhesive coating on antigen uptake and immune adjuvant activity. Eur J Pharm Biopharm. 2013;85:550\u20139. https:\/\/doi.org\/10.1016\/j.ejpb.2013.06.017.","journal-title":"Eur J Pharm Biopharm"},{"key":"2473_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2020.108894","volume":"251","author":"P Gu","year":"2020","unstructured":"Gu P, Wusiman A, Zhang Y, Cai G, Xu S, Zhu S, Liu Z, Hu Y, Liu J, Wang D. Polyethylenimine-coated PLGA nanoparticles-encapsulated Angelica sinensis polysaccharide as an adjuvant for H9N2 vaccine to improve immune responses in chickens compared to Alum and oil-based adjuvants. Vet Microbiol. 2020;251: 108894. https:\/\/doi.org\/10.1016\/j.vetmic.2020.108894.","journal-title":"Vet Microbiol"},{"key":"2473_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.0105-2896.2004.00142.x","volume":"199","author":"WR Heath","year":"2004","unstructured":"Heath WR, Belz GT, Behrens GMN, Smith CM, Villadangos JA. Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens. Eur Heart J. 2004;199:9\u201326. https:\/\/doi.org\/10.1111\/j.0105-2896.2004.00142.x.","journal-title":"Eur Heart J"},{"issue":"42","key":"2473_CR31","doi-asserted-by":"publisher","first-page":"24505","DOI":"10.1039\/c9ra03831k","volume":"9","author":"E Shardlow","year":"2019","unstructured":"Shardlow E, Exley C. The size of micro-crystalline tyrosine (MCT\u00ae) influences its recognition and uptake by THP-1 macrophages in vitro. RSC Adv. 2019;9(42):24505\u201318. https:\/\/doi.org\/10.1039\/c9ra03831k.","journal-title":"RSC Adv."},{"issue":"4","key":"2473_CR32","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1021\/acs.chemrestox.9b00467","volume":"33","author":"M Cola\u00e7o","year":"2020","unstructured":"Cola\u00e7o M, Marques AP, Jesus S, Duarte A, Borges O. Safe-by-design of glucan nanoparticles: size matters when assessing the immunotoxicity. Chem Res Toxicol. 2020;33(4):915\u201332. https:\/\/doi.org\/10.1021\/acs.chemrestox.9b00467.","journal-title":"Chem Res Toxicol"},{"key":"2473_CR33","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/ijc.29402","volume":"137","author":"R Heidenreich","year":"2015","unstructured":"Heidenreich R, Jasny E, Kowalczyk A, Lutz J, Probst J, Baumhof P, Scheel B, Voss S, Kallen KJ, Fotin-Mleczek M. A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile. Int J Cancer. 2015;137:372\u201384. https:\/\/doi.org\/10.1002\/ijc.29402.","journal-title":"Int J Cancer"},{"key":"2473_CR34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1021\/acs.molpharmaceut.6b00434","volume":"14","author":"J Jia","year":"2016","unstructured":"Jia J, Zhang W, Liu Q, Yang T, Wang L, Ma G. Adjuvanticity regulation by biodegradable polymeric nano\/microparticle size. Mol Pharmaceutics. 2016;14:14\u201322. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.6b00434.","journal-title":"Mol Pharmaceutics"},{"issue":"42","key":"2473_CR35","doi-asserted-by":"publisher","first-page":"35745","DOI":"10.1021\/acsami.8b11556","volume":"10","author":"C Jia","year":"2018","unstructured":"Jia C, Yang T, Liu Y, Ali Z, Yin F, Wang Y, Xu L, Wang Y, Yan M, Cai Q, Liang X, Ju R, Chen J, Wang L. A novel human papillomavirus 16 l1 pentamer-loaded hybrid particles vaccine system: influence of size on immune responses. ACS Appl Mater Interfaces. 2018;10(42):35745\u201359. https:\/\/doi.org\/10.1021\/acsami.8b11556.","journal-title":"ACS Appl Mater Interfaces"},{"key":"2473_CR36","doi-asserted-by":"publisher","unstructured":"Edens C, Collins ML, Goodson JL, Rota PA, Prausnitz MR. A microneedle patch containing measles vaccine is immunogenic in non-human primates. 2015;33:4712\u20134718. https:\/\/doi.org\/10.1016\/j.vaccine.2015.02.074","DOI":"10.1016\/j.vaccine.2015.02.074"},{"key":"2473_CR37","doi-asserted-by":"publisher","first-page":"5437","DOI":"10.1021\/acs.molpharmaceut.8b00768","volume":"15","author":"AK Shakya","year":"2018","unstructured":"Shakya AK, Lee CH, Uddin MJ, Gill HS. Assessment of Th1\/Th2 bias of STING agonists coated on microneedles for possible use in skin allergen immunotherapy. Mol Pharm. 2018;15:5437\u201343. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.8b00768.","journal-title":"Mol Pharm"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-022-02473-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-022-02473-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-022-02473-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T14:09:17Z","timestamp":1714745357000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-022-02473-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["2473"],"URL":"https:\/\/doi.org\/10.1208\/s12249-022-02473-9","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,25]]},"assertion":[{"value":"23 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"42"}}