{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:22:43Z","timestamp":1791948163697,"version":"4.3.4"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chrysin is a natural flavonoid with a wide range of bioactivities. Only a few investigations have assessed the analgesic activity of chrysin. The lipophilicity of chrysin reduces its aqueous solubility and bioavailability. Hence, self-nanoemulsifying drug delivery systems (SNEDDS) were designed to overcome this problem. Kollisolv GTA, Tween 80, and Transcutol HP were selected as oil, surfactant, and cosurfactant, respectively. SNEDDS A, B, and C were prepared, loaded with chrysin (0.1%w\/w), and extensively evaluated. The optimized formula (B) encompasses 25% Kollisolv GTA, 18.75% Tween 80, and 56.25% Transcutol HP was further assessed. TEM, <jats:italic>in vitro<\/jats:italic> release, and biocompatibility towards the normal oral epithelial cell line (OEC) were estimated. Brain targeting and acetic acid-induced writhing in a mouse model were studied. After testing several adsorbents, powdered SNEDDS B was formulated and evaluated. The surfactant\/cosurfactant (S\/CoS) ratio of 1:3 w\/w was appropriate for the preparation of SNEDDS. Formula B exhibited instant self-emulsification, spherical nanoscaled droplets of 155.4 \u00b1 32.02 nm, and a zeta potential of \u2212 12.5 \u00b1 3.40 mV. The <jats:italic>in vitro<\/jats:italic> release proved the superiority of formula B over chrysin suspension (56.16 \u00b1 10.23 and 9.26 \u00b1 1.67%, respectively). The biocompatibility of formula B towards OEC was duplicated (5.69 \u00b1 0.03 \u00b5g\/mL). The nociceptive pain was mitigated by formula B more efficiently than chrysin suspension as the writhing numbers reduced from 8.33 \u00b1 0.96 to 0 after 60 min of oral administration. Aerosil R972 was selected as an adsorbent, and its chemical compatibility was confirmed. In conclusion, our findings prove the therapeutic efficacy of chrysin self-nanoemulsion as a potential targeting platform to combat pain.<\/jats:p>\n                <jats:p><jats:bold>Graphical Abstract<\/jats:bold><\/jats:p>","DOI":"10.1208\/s12249-024-02767-0","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T19:02:19Z","timestamp":1709665339000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Self-Nanoemulsion Intrigues the Gold Phytopharmaceutical Chrysin: In Vitro Assessment and Intrinsic Analgesic Effect"],"prefix":"10.1208","volume":"25","author":[{"given":"Samar Mohamed","family":"Elhoseny","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-5528","authenticated-orcid":false,"given":"Noha Mohamed","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahasen Mohamed","family":"Meshali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2767_CR1","doi-asserted-by":"crossref","first-page":"116797","DOI":"10.1016\/j.lfs.2019.116797","volume":"235","author":"S Naz","year":"2019","unstructured":"Naz S, Imran M, Rauf A, Orhan IE, Shariati MA, Iahtisham Ul H, et al. Chrysin: pharmacological and therapeutic properties. Life Sci. 2019;235:116797.","journal-title":"Life Sci."},{"issue":"2","key":"2767_CR2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2125.2001.01317.x","volume":"51","author":"T Walle","year":"2001","unstructured":"Walle T, Otake Y, Brubaker JA, Walle UK, Halushka PV. Disposition and metabolism of the flavonoid chrysin in normal volunteers. Br J Clin Pharmacol. 2001;51(2):143\u20136.","journal-title":"Br J Clin Pharmacol."},{"key":"2767_CR3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2014.01.065","volume":"728","author":"EM Mantawy","year":"2014","unstructured":"Mantawy EM, El-Bakly WM, Esmat A, Badr AM, El-Demerdash E. Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Eur J Pharmacol. 2014;728:107\u201318.","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"2767_CR4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3390\/app12010477","volume":"12","author":"IMDM Ramalho","year":"2022","unstructured":"Ramalho IMDM, Bezerra GS, Ostrosky EA, Ferrari M, Oliveira VDS, Wanderley Neto ADO, et al. Chrysin-loaded microemulsion: formulation design, evaluation and antihyperalgesic activity in mice. Appl Sci. 2022;12(1):477.","journal-title":"Appl Sci."},{"issue":"1","key":"2767_CR5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/molecules23010067","volume":"23","author":"JJ Ram\u00edrez-Espinosa","year":"2018","unstructured":"Ram\u00edrez-Espinosa JJ, Salda\u00f1a-R\u00edos J, Garc\u00eda-Jim\u00e9nez S, Villalobos-Molina R, \u00c1vila-Villarreal G, Rodr\u00edguez-Ocampo AN, et al. Chrysin induces antidiabetic, antidyslipidemic and anti-inflammatory effects in athymic nude diabetic mice. Molecules. 2018;23(1):67.","journal-title":"Molecules."},{"key":"2767_CR6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.procbio.2017.05.024","volume":"60","author":"M Sabzichi","year":"2017","unstructured":"Sabzichi M, Mohammadian J, Bazzaz R, Pirouzpanah MB, Shaaker M, Hamishehkar H, et al. Chrysin loaded nanostructured lipid carriers (NLCs) triggers apoptosis in MCF-7 cancer cells by inhibiting the Nrf2 pathway. Proc Biochem. 2017;60:84\u201391.","journal-title":"Proc Biochem."},{"key":"2767_CR7","doi-asserted-by":"crossref","first-page":"112590","DOI":"10.1016\/j.bbr.2020.112590","volume":"386","author":"J Cueto-Escobedo","year":"2020","unstructured":"Cueto-Escobedo J, Andrade-Soto J, Lima-Maximino M, Maximino C, Hern\u00e1ndez-L\u00f3pez F, Rodr\u00edguez-Landa JF. Involvement of GABAergic system in the antidepressant-like effects of chrysin (5,7-dihydroxyflavone) in ovariectomized rats in the forced swim test: comparison with neurosteroids. Behav Brain Res. 2020;386:112590.","journal-title":"Behav Brain Res"},{"issue":"10","key":"2767_CR8","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/0006-2952(90)90716-X","volume":"40","author":"JH Medina","year":"1990","unstructured":"Medina JH, Paladini AC, Wolfman C, de Levi SM, Calvo D, Diaz LE, et al. Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol. 1990;40(10):2227\u201331.","journal-title":"Biochem Pharmacol"},{"key":"2767_CR9","doi-asserted-by":"crossref","first-page":"104612","DOI":"10.1016\/j.neuint.2019.104612","volume":"132","author":"E Angelopoulou","year":"2020","unstructured":"Angelopoulou E, Pyrgelis ES, Piperi C. Neuroprotective potential of chrysin in Parkinson\u2019s disease: molecular mechanisms and clinical implications. Neurochem Int. 2020;132:104612.","journal-title":"Neurochem Int"},{"key":"2767_CR10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuint.2015.09.006","volume":"90","author":"SF Nabavi","year":"2015","unstructured":"Nabavi SF, Braidy N, Habtemariam S, Orhan IE, Daglia M, Manayi A, et al. Neuroprotective effects of chrysin: from chemistry to medicine. Neurochem Int. 2015;90:224\u201331.","journal-title":"Neurochem Int."},{"key":"2767_CR11","doi-asserted-by":"crossref","first-page":"111906","DOI":"10.1016\/j.biopha.2021.111906","volume":"141","author":"M Talebi","year":"2021","unstructured":"Talebi M, Talebi M, Farkhondeh T, Kopustinskiene DM, Simal-Gandara J, Bernatoniene J, et al. An updated review on the versatile role of chrysin in neurological diseases: chemistry, pharmacology, and drug delivery approaches. Biomed Pharmacother. 2021;141:111906.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"2767_CR12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/19768354.2020.1765019","volume":"24","author":"J-S Hong","year":"2020","unstructured":"Hong J-S, Feng J-H, Park J-S, Lee H-J, Lee J-Y, Lim S-S, et al. Antinociceptive effect of chrysin in diabetic neuropathy and formalin-induced pain models. Animal Cells Syst. 2020;24(3):143\u201350.","journal-title":"Animal Cells Syst."},{"issue":"3","key":"2767_CR13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4103\/ijabmr.IJABMR_58_19","volume":"10","author":"RK Rayiti","year":"2020","unstructured":"Rayiti RK, Munnangi SR, Bandarupalli R, Chakka V, Nimmagadda SL, Sk LS, et al. Effect of chrysin on mechanical hyperalgesia in chronic constriction injury-induced neuropathic pain in rat model. Int J Appl Basic Med. 2020;10(3):189.","journal-title":"Int J Appl Basic Med."},{"key":"2767_CR14","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1136\/rapm-2020-101472","volume":"45","author":"J Wu","year":"2020","unstructured":"Wu J, Wang Y, Cui W, Zhou W, Zhao X. 5-HT1A receptor-mediated attenuation of heat hyperalgesia and mechanical allodynia by chrysin in mice with experimental mononeuropathy. Reg Anesth Pain Med. 2020;45:610\u20139.","journal-title":"Reg Anesth Pain Med."},{"issue":"23","key":"2767_CR15","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.3390\/molecules28237862","volume":"28","author":"K Sa\u0142at","year":"2023","unstructured":"Sa\u0142at K, Zar\u0119ba P, Awtoniuk M, Sa\u0142at R. Naturally inspired molecules for neuropathic pain inhibition\u2014effect of mirogabalin and cebranopadol on mechanical and thermal nociceptive threshold in mice. Molecules. 2023;28(23):7862.","journal-title":"Molecules."},{"issue":"3","key":"2767_CR16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.spen.2016.10.004","volume":"23","author":"E Mathew","year":"2016","unstructured":"Mathew E, Kim E, Zempsky W. Pharmacologic treatment of pain. Sem Pediatr Neurol. 2016;23(3):209\u201319.","journal-title":"Sem Pediatr Neurol"},{"issue":"1","key":"2767_CR17","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s12951-022-01473-y","volume":"20","author":"S Babaie","year":"2022","unstructured":"Babaie S, Taghvimi A, Hong J-H, Hamishehkar H, An S, Kim KH. Recent advances in pain management based on nanoparticle technologies. J Nanobiotechnol. 2022;20(1):290.","journal-title":"J Nanobiotechnol."},{"issue":"3","key":"2767_CR18","first-page":"217","volume":"58","author":"KP Grichnik","year":"1991","unstructured":"Grichnik KP, Ferrante FM. The difference between acute and chronic pain. MT SINAI J MED. 1991;58(3):217\u201320.","journal-title":"MT SINAI J MED"},{"issue":"12","key":"2767_CR19","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3390\/pharmaceutics12121194","volume":"12","author":"AB Buya","year":"2020","unstructured":"Buya AB, Beloqui A, Memvanga PB, Pr\u00e9at V. Self-nano-emulsifying drug-delivery systems: from the development to the current applications and challenges in oral drug delivery. Pharmaceutics. 2020;12(12):1194.","journal-title":"Pharmaceutics"},{"issue":"5","key":"2767_CR20","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1080\/03639045.2019.1576726","volume":"45","author":"D Baidya","year":"2019","unstructured":"Baidya D, Kushwaha J, Mahadik K, Patil S. Chrysin-loaded folate conjugated PF127-F68 mixed micelles with enhanced oral bioavailability and anticancer activity against human breast cancer cells. Drug Dev Ind Pharm. 2019;45(5):852\u201360.","journal-title":"Drug Dev Ind Pharm"},{"issue":"null","key":"2767_CR21","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.2147\/IJN.S132043","volume":"12","author":"KM Kim","year":"2017","unstructured":"Kim KM, Lim HK, Shim SH, Jung J. Improved chemotherapeutic efficacy of injectable chrysin encapsulated by copolymer nanoparticles. Int J Nanomed. 2017;12(null):1917\u201325.","journal-title":"Int J Nanomed."},{"issue":"2","key":"2767_CR22","doi-asserted-by":"crossref","first-page":"e22634","DOI":"10.1002\/jbt.22634","volume":"35","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Zhao J, Afzal O, Kazmi I, Al-Abbasi FA, Altamimi ASA, et al. Neuroprotective role of chrysin-loaded poly(lactic-co-glycolic acid) nanoparticle against kindling-induced epilepsy through Nrf2\/ARE\/HO-1 pathway. J Biochem Mol Toxicol. 2021;35(2):e22634.","journal-title":"J Biochem Mol Toxicol."},{"issue":"10","key":"2767_CR23","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.3390\/nu11102549","volume":"11","author":"S-M Kim","year":"2019","unstructured":"Kim S-M, Jung J-I, Chai C, Imm J-Y. Characteristics and glucose uptake promoting effect of chrysin-loaded phytosomes prepared with different phospholipid matrices. Nutrients. 2019;11(10):2549.","journal-title":"Nutrients."},{"key":"2767_CR24","doi-asserted-by":"crossref","unstructured":"Dong D, Quan E, Yuan X, Xie Q, Li Z, Wu BJM. Sodium oleate-based nanoemulsion enhances oral absorption of chrysin through inhibition of UGT-mediated metabolism. Mol Pharm. 2017;14(9):2864-74.","DOI":"10.1021\/acs.molpharmaceut.6b00851"},{"issue":"8","key":"2767_CR25","first-page":"1912","volume":"10","author":"P Ting","year":"2021","unstructured":"Ting P, Srinuanchai W, Suttisansanee U, Tuntipopipat S, Charoenkiatkul S, Praengam K, et al. Development of chrysin loaded oil-in-water nanoemulsion for improving bioaccessibility. Foods (Basel, Switzerland). 2021;10(8):1912.","journal-title":"Foods (Basel, Switzerland)."},{"issue":"1","key":"2767_CR26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/17425247.2023.2153831","volume":"20","author":"MY George","year":"2023","unstructured":"George MY, El-Derany MO, Ahmed Y, Zaher M, Ibrahim C, Waleed H, et al. Design and evaluation of chrysin-loaded nanoemulsion against lithium\/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK\/SIRT-1\/PGC-1\u03b1 pathway. Expert Opin Drug Deliv. 2023;20(1):159\u201374.","journal-title":"Expert Opin Drug Deliv."},{"issue":"6","key":"2767_CR27","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/02652048.2018.1559369","volume":"35","author":"S Komath","year":"2018","unstructured":"Komath S, Garg A, Wahajuddin MJJ. Development and evaluation of chrysin-phospholipid complex loaded solid lipid nanoparticles-storage stability and in vitro anti-cancer activity. J Microencapsul. 2018;35(6):600\u201317.","journal-title":"J Microencapsul"},{"key":"2767_CR28","doi-asserted-by":"crossref","first-page":"111429","DOI":"10.1016\/j.colsurfb.2020.111429","volume":"197","author":"T Sharma","year":"2021","unstructured":"Sharma T, Katare O, Jain A, Jain S, Chaudhari D, Borges B, et al. QbD-steered development of biotin-conjugated nanostructured lipid carriers for oral delivery of chrysin: role of surface modification for improving biopharmaceutical performance. Colloids Surf B Biointerfaces. 2021;197:111429.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"7","key":"2767_CR29","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3109\/03639045.2015.1107089","volume":"42","author":"R Puri","year":"2016","unstructured":"Puri R, Mahajan M, Sahajpal NS, Singh H, Singh H, Jain SK. Self-nanoemulsifying drug delivery system of docosahexanoic acid: development, in vitro, in vivo characterization. Drug Dev Ind Pharm. 2016;42(7):1032\u201341.","journal-title":"Drug Dev Ind Pharm"},{"issue":"11","key":"2767_CR30","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.3390\/pharmaceutics14112395","volume":"14","author":"L Corrie","year":"2022","unstructured":"Corrie L, Kaur J, Awasthi A, Vishwas S, Gulati M, Saini S, et al. Multivariate data analysis and central composite design-oriented optimization of solid carriers for formulation of curcumin-loaded solid SNEDDS: Dissolution and Bioavailability Assessment. Pharmaceutics. 2022;14(11):2395.","journal-title":"Pharmaceutics."},{"key":"2767_CR31","doi-asserted-by":"crossref","first-page":"102320","DOI":"10.1016\/j.jddst.2021.102320","volume":"61","author":"MB Zewail","year":"2021","unstructured":"Zewail MB, El-Gizawy SA, Osman MA, Haggag YA. Preparation and In vitro characterization of a novel self-nano emulsifying drug delivery system for a fixed-dose combination of candesartan cilexetil and hydrochlorothiazide. J Drug Deliv Sci Technol. 2021;61:102320.","journal-title":"J Drug Deliv Sci Technol"},{"key":"2767_CR32","doi-asserted-by":"crossref","unstructured":"Kassem AA, Abd El-Alim SH, Salman AM, Mohammed MA, Hassan NS, El-Gengaihi SEJDD, et al. Improved hepatoprotective activity of Beta vulgaris L. leaf extract loaded self-nanoemulsifying drug delivery system (SNEDDS): in vitro and in vivo evaluation. Drug Dev Ind Pharm 2020;46(10):1589-603.","DOI":"10.1080\/03639045.2020.1811303"},{"key":"2767_CR33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.molliq.2016.02.081","volume":"218","author":"AA Kassem","year":"2016","unstructured":"Kassem AA, Mohsen AM, Ahmed RS, Essam TMJJ. Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: design, optimization, in vitro and in vivo evaluation. J Mol Liq. 2016;218:219\u201332.","journal-title":"J Mol Liq."},{"key":"2767_CR34","doi-asserted-by":"crossref","first-page":"101646","DOI":"10.1016\/j.jddst.2020.101646","volume":"57","author":"A Khattab","year":"2020","unstructured":"Khattab A, Mohamed M. Basalious EBJJODDS, Technology Design of self-nanoemulsifying system to enhance absorption and bioavailability of poorly permeable Aliskiren hemi-fumarate. J Drug Deliv Sci Technol. 2020;57:101646.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"3","key":"2767_CR35","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3390\/pharmaceutics14030482","volume":"14","author":"M Ashfaq","year":"2022","unstructured":"Ashfaq M, Shah S, Rasul A, Hanif M, Khan HU, Khames A, et al. Enhancement of the solubility and bioavailability of pitavastatin through a self-nanoemulsifying drug delivery system (SNEDDS). Pharmaceutics. 2022;14(3):482.","journal-title":"Pharmaceutics"},{"issue":"1","key":"2767_CR36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.xphs.2020.10.020","volume":"110","author":"DA Bhagwat","year":"2021","unstructured":"Bhagwat DA, Swami PA, Nadaf SJ, Choudhari PB, Kumbar VM, More HN, et al. Capsaicin loaded solid SNEDDS for enhanced bioavailability and anticancer activity: in-vitro, in-silico, and in-vivo characterization. J Pharm Sci. 2021;110(1):280\u201391.","journal-title":"J Pharm Sci."},{"issue":"5","key":"2767_CR37","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.3390\/nano11051086","volume":"11","author":"R Arshad","year":"2021","unstructured":"Arshad R, Tabish TA, Kiani MH, Ibrahim IM, Shahnaz G, Rahdar A, et al. A hyaluronic acid functionalized self-nano-emulsifying drug delivery system (SNEDDS) for enhancement in ciprofloxacin targeted delivery against intracellular infection. Nanomaterials. 2021;11(5):1086.","journal-title":"Nanomaterials."},{"issue":"5","key":"2767_CR38","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3390\/polym14051055","volume":"14","author":"A Zafar","year":"2022","unstructured":"Zafar A, Yasir M, Alruwaili NK, Imam SS, Alsaidan OA, Alshehri S, et al. Formulation of self-nanoemulsifying drug delivery system of cephalexin: physiochemical characterization and antibacterial evaluation. Polymers. 2022;14(5):1055.","journal-title":"Polymers."},{"issue":"2","key":"2767_CR39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/08982104.2017.1295990","volume":"28","author":"HF Salem","year":"2018","unstructured":"Salem HF, Kharshoum RM, Halawa AKA, Naguib DMJJ. Preparation and optimization of tablets containing a self-nano-emulsifying drug delivery system loaded with rosuvastatin. J Liposome Res. 2018;28(2):149\u201360.","journal-title":"J Liposome Res."},{"key":"2767_CR40","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.2147\/IJN.S324171","volume":"16","author":"A AbuElfadl","year":"2021","unstructured":"AbuElfadl A, Boughdady M, Meshali M. New Peceol\u2122\/Span\u2122 60 niosomes coated with chitosan for candesartan cilexetil: perspective increase in absolute bioavailability in rats. Int J Nanomedicine. 2021;16:5581\u2013601.","journal-title":"Int J Nanomedicine."},{"key":"2767_CR41","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s40242-017-7096-8","volume":"33","author":"Z Xu","year":"2017","unstructured":"Xu Z, Lian X, Li M, Zhang X, Wang Y, Tao Z, et al. Effects of inclusion of chrysin in cucurbit [8] uril on its stability, solubility and antioxidant potential. Chem Res Chin Univ. 2017;33:736\u201341.","journal-title":"Chem Res Chin Univ."},{"issue":"3","key":"2767_CR42","first-page":"217","volume":"67","author":"S Dash","year":"2010","unstructured":"Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010;67(3):217\u201323.","journal-title":"Acta Pol Pharm"},{"key":"2767_CR43","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jps.2600521210","volume":"52","author":"T Higuchi","year":"1963","unstructured":"Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 1963;52:1145\u20139.","journal-title":"J Pharm Sci."},{"issue":"1","key":"2767_CR44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","volume":"15","author":"RW Korsmeyer","year":"1983","unstructured":"Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA. Mechanisms of solute release from porous hydrophilic polymers. Int J Pharm. 1983;15(1):25\u201335.","journal-title":"Int J Pharm."},{"issue":"1","key":"2767_CR45","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.aoas.2022.06.004","volume":"67","author":"NY Fawzi","year":"2022","unstructured":"Fawzi NY, Abdelghani DY, Abdel-azim MA, Shokier CG, Youssef MW, Gad El-Rab MK, et al. The ability of probiotic lactic acid bacteria to ferment Egyptian broken rice milk and produce rice-based yoghurt. Annals Agric Sci. 2022;67(1):107\u201318.","journal-title":"Annals Agric Sci."},{"issue":"3","key":"2767_CR46","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/fft2.44","volume":"1","author":"S Kamiloglu","year":"2020","unstructured":"Kamiloglu S, Sari G, Ozdal T, Capanoglu E. Guidelines for cell viability assays. Food Front. 2020;1(3):332\u201349.","journal-title":"Food Front."},{"key":"2767_CR47","doi-asserted-by":"crossref","unstructured":"Baba M, Oishi R, Saeki KJN-S. Enhancement of blood-brain barrier permeability to sodium fluorescein by stimulation of \u00b5 opioid receptors in mice. Naunyn Schmiedebergs Arch Pharmacol. 1988;337:423-8.","DOI":"10.1007\/BF00169534"},{"issue":"3","key":"2767_CR48","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1208\/pt0803065","volume":"8","author":"H Abdelkader","year":"2007","unstructured":"Abdelkader H, Abdallah OY, Salem HS. Comparison of the effect of tromethamine and polyvinylpyrrolidone on dissolution properties and analgesic effect of nimesulide. AAPS PharmSciTech. 2007;8(3):65.","journal-title":"AAPS PharmSciTech."},{"issue":"3","key":"2767_CR49","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3390\/ijms21030760","volume":"21","author":"FL Fagundes","year":"2020","unstructured":"Fagundes FL, de Morais PG, P\u00e9rico LL, Rodrigues VP, Hiruma-Lima CA, Dos Santos RC. Chrysin modulates genes related to inflammation, tissue remodeling, and cell proliferation in the gastric ulcer healing. Int J Mol Sci. 2020;21(3):760.","journal-title":"Int J Mol Sci."},{"key":"2767_CR50","doi-asserted-by":"crossref","first-page":"8553","DOI":"10.2147\/IJN.S274352","volume":"15","author":"RH Awadeen","year":"2020","unstructured":"Awadeen RH, Boughdady MF, Meshali MM. Quality by design approach for preparation of zolmitriptan\/chitosan nanostructured lipid carrier particles \u2013 formulation and pharmacodynamic assessment. Int J Nanomedicine. 2020;15:8553\u201368.","journal-title":"Int J Nanomedicine"},{"key":"2767_CR51","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ijbiomac.2021.08.170","volume":"189","author":"R Khursheed","year":"2021","unstructured":"Khursheed R, Singh SK, Wadhwa S, Gulati M, Kapoor B, Jain SK, et al. Development of mushroom polysaccharide and probiotics based solid self-nanoemulsifying drug delivery system loaded with curcumin and quercetin to improve their dissolution rate and permeability: state of the art. Int J Biol Macromol. 2021;189:744\u201357.","journal-title":"Int J Biol Macromol."},{"key":"2767_CR52","doi-asserted-by":"crossref","first-page":"109980","DOI":"10.1016\/j.msec.2019.109980","volume":"104","author":"Y-G Na","year":"2019","unstructured":"Na Y-G, Byeon J-J, Wang M, Huh HW, Kim M-K, Bang K-H, et al. Statistical approach for solidifying ticagrelor loaded self-microemulsifying drug delivery system with enhanced dissolution and oral bioavailability. Mater Sci Eng C Mater Biol Appl. 2019;104:109980.","journal-title":"Mater Sci Eng C Mater Biol Appl."},{"key":"2767_CR53","doi-asserted-by":"crossref","unstructured":"Awadeen RH, Boughdady MF, Meshali MMJPD, Technology. New in-situ gelling biopolymer-based matrix for bioavailability enhancement of glimepiride; in-vitro\/in-vivo x-ray imaging and pharmacodynamic evaluations. Pharm Dev Technol. 2019;24(5):539-49.","DOI":"10.1080\/10837450.2018.1517366"},{"key":"2767_CR54","unstructured":"Pharmacopeia US. USP. Powder Flow. Twinbrook parkway, Rockville, MD 20852.2022."},{"key":"2767_CR55","unstructured":"Mohamed MI, Mahmoud HA, Mohamed AI, Nabil NM, Kasssem MA, Elsherif YAJPJPS. Formulation, in-vitro evaluation and optimization of valsartan nano-lipid complex by Box-Behnken design. Pak J Pharm Sci. 2023;36(4):1249-60."},{"issue":"1","key":"2767_CR56","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1080\/10717544.2022.2127974","volume":"29","author":"DS Ghataty","year":"2022","unstructured":"Ghataty DS, Amer RI, Wasfi R, Shamma RN. Novel linezolid loaded bio-composite films as dressings for effective wound healing: experimental design, development, optimization, and antimicrobial activity. Drug Deliv. 2022;29(1):3168\u201385.","journal-title":"Drug Deliv."},{"issue":"12","key":"2767_CR57","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.3390\/pharmaceutics14122592","volume":"14","author":"HSM Ali","year":"2022","unstructured":"Ali HSM, Ahmed SA, Alqurshi AA, Alalawi AM, Shehata AM, Alahmadi YM. Boosting tadalafil bioavailability via sono-assisted nano-emulsion-based oral jellies: Box-Behnken optimization and assessment. Pharmaceutics. 2022;14(12):2592.","journal-title":"Pharmaceutics."},{"key":"2767_CR58","doi-asserted-by":"crossref","unstructured":"Mobarak D, Salah S, Ghorab MJJodds, technology. Improvement of dissolution of a class II poorly water-soluble drug, by developing a five-component self-nanoemulsifying drug delivery system. J Drug Deliv Sci Technol. 2019;50:99-106.","DOI":"10.1016\/j.jddst.2018.12.018"},{"issue":"3","key":"2767_CR59","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ejpb.2012.10.007","volume":"83","author":"C McConville","year":"2013","unstructured":"McConville C, Friend D. Development and characterisation of a self-microemulsifying drug delivery systems (SMEDDSs) for the vaginal administration of the antiretroviral UC-781. Eur J Pharm Biopharm. 2013;83(3):322\u20139.","journal-title":"Eur J Pharm Biopharm."},{"issue":"8","key":"2767_CR60","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1208\/s12249-018-1180-3","volume":"19","author":"SM Etman","year":"2018","unstructured":"Etman SM, Elnaggar YSR, Abdelmonsif DA, Abdallah OY. Oral brain-targeted microemulsion for enhanced piperine delivery in Alzheimer\u2019s disease therapy: in vitro appraisal, in vivo activity, and nanotoxicity. AAPS PharmSciTech. 2018;19(8):3698\u2013711.","journal-title":"AAPS PharmSciTech."},{"key":"2767_CR61","first-page":"86","volume":"12","author":"T Sastri","year":"2020","unstructured":"Sastri T, Gadela R. Development of self nano-emulsifying drug delivery system for an anti-hypertensive agent felodipine: a systematic approach for lipid nano-formulation with improved oral bioavailability in rats. Int J Pharm Sci. 2020;12:86\u201394.","journal-title":"Int J Pharm Sci."},{"key":"2767_CR62","doi-asserted-by":"crossref","unstructured":"Patel MH, Sawant KKJEJ. Self microemulsifying drug delivery system of lurasidone hydrochloride for enhanced oral bioavailability by lymphatic targeting: in vitro, Caco-2 cell line and in vivo evaluation. Eur J Pharm Sci. 2019;138:105027.","DOI":"10.1016\/j.ejps.2019.105027"},{"key":"2767_CR63","doi-asserted-by":"crossref","first-page":"119180","DOI":"10.1016\/j.ijpharm.2020.119180","volume":"580","author":"AB Buya","year":"2020","unstructured":"Buya AB, Ucakar B, Beloqui A, Memvanga PB, Pr\u00e9at V. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDSs) for senicapoc. Int J Pharm. 2020;580:119180.","journal-title":"Int J Pharm."},{"issue":"9","key":"2767_CR64","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1211\/jpp.58.9.0004","volume":"58","author":"H Shen","year":"2010","unstructured":"Shen H, Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J Pharm Pharmacol. 2010;58(9):1183\u201391.","journal-title":"J Pharm Pharmacol."},{"key":"2767_CR65","doi-asserted-by":"crossref","unstructured":"Miao Y, Zhao S, Zuo J, Sun J, Wang JJDD, Development, therapy. reduced the food effect and enhanced the oral bioavailability of ivacaftor by self-nanoemulsifying drug delivery system (SNEDDS) using a new oil phase. Drug Des Devel Ther. 2022;16:1531-46.","DOI":"10.2147\/DDDT.S356967"},{"key":"2767_CR66","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1208\/s12249-018-0991-6","volume":"19","author":"X Xue","year":"2018","unstructured":"Xue X, Cao M, Ren L, Qian Y, Chen GJAP. Preparation and optimization of rivaroxaban by self-nanoemulsifying drug delivery system (SNEDDS) for enhanced oral bioavailability and no food effect. AAPS PharmSciTech. 2018;19:1847\u201359.","journal-title":"AAPS PharmSciTech."},{"issue":"3","key":"2767_CR67","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/pharmaceutics8030020","volume":"8","author":"A Nasr","year":"2016","unstructured":"Nasr A, Gardouh A, Ghorab M. Novel solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of olmesartan medoxomil: design, formulation, pharmacokinetic and bioavailability evaluation. Pharmaceutics. 2016;8(3):20.","journal-title":"Pharmaceutics."},{"issue":"4","key":"2767_CR68","doi-asserted-by":"crossref","first-page":"85","DOI":"10.26554\/sti.2017.2.4.85-88","volume":"2","author":"NA Fithri","year":"2017","unstructured":"Fithri NA, Mardiyanto M, Novita RP, Andrean V. Furosemide self nano emulsifying drug delivery system (SNEDDS) formulation comprising of capryol-90, polysorbate-80, and peg-400 with simplex-lattice-design. Sci Technol Indones. 2017;2(4):85\u20138.","journal-title":"Sci Technol Indones"},{"issue":"6","key":"2767_CR69","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3390\/pharmaceutics13060902","volume":"13","author":"S Nagaraja","year":"2021","unstructured":"Nagaraja S, Basavarajappa GM, Attimarad M, Pund S. Topical nanoemulgel for the treatment of skin cancer: proof-of-technology. Pharmaceutics. 2021;13(6):902.","journal-title":"Pharmaceutics."},{"issue":"8","key":"2767_CR70","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3390\/pharmaceutics12080699","volume":"12","author":"E Kontogiannidou","year":"2020","unstructured":"Kontogiannidou E, Meikopoulos T, Gika H, Panteris E, Vizirianakis IS, M\u00fcllertz A, et al. In vitro evaluation of self-nano-emulsifying drug delivery systems (SNEDDS) containing room temperature ionic liquids (RTILs) for the oral delivery of amphotericin B. Pharmaceutics. 2020;12(8):699.","journal-title":"Pharmaceutics."},{"issue":"8","key":"2767_CR71","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/pharmaceutics13081142","volume":"13","author":"KC Baral","year":"2021","unstructured":"Baral KC, Song J-G, Lee SH, Bajracharya R, Sreenivasulu G, Kim M, et al. Enhanced bioavailability of AC1497, a novel anticancer drug candidate, via a self-nanoemulsifying drug delivery system. Pharmaceutics. 2021;13(8):1142.","journal-title":"Pharmaceutics."},{"issue":"1","key":"2767_CR72","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s13346-022-01193-8","volume":"13","author":"C Rathore","year":"2022","unstructured":"Rathore C, Hemrajani C, Sharma AK, Gupta PK, Jha NK, Aljabali AAA, et al. Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies. Drug Del Transl Res. 2022;13(1):292\u2013307.","journal-title":"Drug Del Transl Res."},{"key":"2767_CR73","doi-asserted-by":"crossref","first-page":"103117","DOI":"10.1016\/j.jddst.2022.103117","volume":"68","author":"A Chaudhuri","year":"2022","unstructured":"Chaudhuri A, Shrivastava N, Kumar S, Singh AK, Ali J, Baboota S. Designing and development of omega-3 fatty acid based self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel with enhanced biopharmaceutical attributes for management of breast cancer. J Drug Del Sci Technol. 2022;68:103117.","journal-title":"J Drug Del Sci Technol"},{"key":"2767_CR74","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.toxrep.2022.04.017","volume":"9","author":"S Mahalanobish","year":"2022","unstructured":"Mahalanobish S, Kundu M, Ghosh S, Das J, Sil PC. Fabrication of phenyl boronic acid modified pH-responsive zinc oxide nanoparticles as targeted delivery of chrysin on human A549 cells. Toxicol Rep. 2022;9:961\u20139.","journal-title":"Toxicol Rep."},{"key":"2767_CR75","doi-asserted-by":"crossref","first-page":"e18070","DOI":"10.1590\/s2175-97902019000418070","volume":"56","author":"HR Trivedi","year":"2020","unstructured":"Trivedi HR, Siriah TM, Puranik PK. Experimental design approach for development of novel microemulsion system and immediate release self microemulsifying tablet of nebivolol HCl. Braz J Pharm Sci. 2020;56:e18070.","journal-title":"Braz J Pharm Sci."},{"issue":"7","key":"2767_CR76","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1021\/acs.langmuir.8b03364","volume":"35","author":"N Pal","year":"2019","unstructured":"Pal N, Kumar N, Mandal A. Stabilization of dispersed oil droplets in nanoemulsions by synergistic effects of the gemini surfactant, phpa polymer, and silica nanoparticle. Langmuir. 2019;35(7):2655\u201367.","journal-title":"Langmuir."},{"key":"2767_CR77","doi-asserted-by":"crossref","unstructured":"Mona Ebrahim Elmoghayer NMS, Randa Ahmed Zaghloul, Wael M. Elsaed, Irhan Ibrahim Abu Hashim. The fundamental efficacy of hesperidin-loaded\/chitosan-coated hybrid nanoparticles as a prospective regimen in wound healing amendment: in vitro and in vivo comprehensive study. J Drug Deliv Sci Technol. 2024;92:105302.","DOI":"10.1016\/j.jddst.2023.105302"},{"issue":"1","key":"2767_CR78","doi-asserted-by":"crossref","first-page":"012039","DOI":"10.1088\/1742-6596\/733\/1\/012039","volume":"733","author":"TGF Souza","year":"2016","unstructured":"Souza TGF, Ciminelli VST, Mohallem NDS. A comparison of TEM and DLS methods to characterize size distribution of ceramic nanoparticles. J Phys Conf Series. 2016;733(1):012039.","journal-title":"J Phys Conf Series."},{"issue":"4","key":"2767_CR79","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/08853282231198948","volume":"38","author":"A Naseri","year":"2023","unstructured":"Naseri A, Taymouri S, Hosseini Sharifabadi A, Varshosaz J. Chrysin loaded bilosomes improve the hepatoprotective effects of chrysin against CCl4 induced hepatotoxicity in mice. J Biomater Appl. 2023;38(4):509\u201326.","journal-title":"J Biomater Appl."},{"issue":"19","key":"2767_CR80","first-page":"1026","volume":"7","author":"A Anthrayose","year":"2018","unstructured":"Anthrayose A, George NJWJ. Formulation and evaluation of phytosomal nanocarriers for enhanced chrysin delivery. World J Pharm Res. 2018;7(19):1026\u201341.","journal-title":"World J Pharm Res."},{"issue":"1","key":"2767_CR81","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3390\/pharmaceutics13010109","volume":"13","author":"E Halevas","year":"2021","unstructured":"Halevas E, Kokotidou C, Zaimai E, Moschona A, Lialiaris E, Mitraki A, et al. Evaluation of the hemocompatibility and anticancer potential of poly (\u03b5-Caprolactone) and poly (3-Hydroxybutyrate) microcarriers with encapsulated chrysin. Pharmaceutics. 2021;13(1):109.","journal-title":"Pharmaceutics."},{"key":"2767_CR82","doi-asserted-by":"crossref","first-page":"100109","DOI":"10.1016\/j.talo.2022.100109","volume":"5","author":"R Pastres","year":"2022","unstructured":"Pastres R, Panzeri AL, Visentin D, Causin V. Determination by infrared spectroscopy of triacetin content in diesel: a tool for countering designer fuel frauds. Talanta Open. 2022;5:100109.","journal-title":"Talanta Open."},{"key":"2767_CR83","unstructured":"Kumar R, Mishra RK, Jain PJWJPR. Formulation and evaluation of nanoemulsion vaginal suppositories of progesterone for Pcos. World J Pharm Res. 2019;8:1068-103."},{"issue":"1","key":"2767_CR84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40543-015-0073-2","volume":"6","author":"K Pramod","year":"2015","unstructured":"Pramod K, Suneesh CV, Shanavas S, Ansari SH, Ali J. Technology Unveiling the compatibility of eugenol with formulation excipients by systematic drug-excipient compatibility studies. J Anal Sci Technol. 2015;6(1):1\u201314.","journal-title":"J Anal Sci Technol."},{"issue":"1","key":"2767_CR85","doi-asserted-by":"crossref","first-page":"17068","DOI":"10.1038\/s41598-021-96199-6","volume":"11","author":"Y Bide","year":"2021","unstructured":"Bide Y, Fashapoyeh MA, Shokrollahzadeh S. Structural investigation and application of Tween 80-choline chloride self-assemblies as osmotic agent for water desalination. Sci Rep. 2021;11(1):17068.","journal-title":"Sci Rep."},{"issue":"9","key":"2767_CR86","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3390\/ph15091064","volume":"15","author":"FU Rehman","year":"2022","unstructured":"Rehman FU, Farid A, Shah SU, Dar MJ, Rehman AU, Ahmed N, et al. Self-emulsifying drug delivery systems (SEDDS): measuring energy dynamics to determine thermodynamic and kinetic stability. Pharmaceuticals (Basel). 2022;15(9):1064.","journal-title":"Pharmaceuticals (Basel)."},{"key":"2767_CR87","doi-asserted-by":"crossref","unstructured":"Castro G, Ferretti F, Blanco SJSAPAM, Spectroscopy B. Determination of the overlapping pKa values of chrysin using UV\u2013vis spectroscopy and ab initio methods. Spectrochim Acta A Mol Biomol Spectrosc. 2005;62(1-3):657-65.","DOI":"10.1016\/j.saa.2005.02.013"},{"issue":"7","key":"2767_CR88","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1080\/03639045.2021.1988092","volume":"47","author":"Y Qu","year":"2021","unstructured":"Qu Y, Mu S, Song C, Zheng G. Preparation and in vitro\/in vivo evaluation of a self-microemulsifying drug delivery system containing chrysin. Drug Dev Ind Pharm. 2021;47(7):1127\u201339.","journal-title":"Drug Dev Ind Pharm."},{"key":"2767_CR89","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jddst.2018.05.006","volume":"46","author":"S Jabbari","year":"2018","unstructured":"Jabbari S, Ghamkhari A, Javadzadeh Y, Salehi R, Davaran S. Doxorubicin and chrysin combination chemotherapy with novel pH-responsive poly [(lactide-co-glycolic acid)-block-methacrylic acid] nanoparticle. J Drug Del Sci Technol. 2018;46:129\u201337.","journal-title":"J Drug Del Sci Technol."},{"key":"2767_CR90","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ijbiomac.2018.06.026","volume":"117","author":"H Nosrati","year":"2018","unstructured":"Nosrati H, Abbasi R, Charmi J, Rakhshbahar A, Aliakbarzadeh F, Danafar H, et al. Folic acid conjugated bovine serum albumin: an efficient smart and tumor targeted biomacromolecule for inhibition folate receptor positive cancer cells. Int J Biol Macromol. 2018;117:1125\u201332.","journal-title":"Int J Biol Macromol."},{"key":"2767_CR91","doi-asserted-by":"crossref","first-page":"8379","DOI":"10.2147\/IJN.S219577","volume":"14","author":"IA Abdel Raheem","year":"2019","unstructured":"Abdel Raheem IA, Abdul Razek A, Elgendy AA, Saleh NM, Shaaban MI, Abd El-Hady FK. Design, evaluation and antimicrobial activity of Egyptian propolis-loaded nanoparticles: intrinsic role as a novel and naturally based root canal nanosealer. Int J Nanomedicine. 2019;14:8379\u201398.","journal-title":"Int J Nanomedicine."},{"issue":"16","key":"2767_CR92","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.3390\/ma13163618","volume":"13","author":"F Fenyvesi","year":"2020","unstructured":"Fenyvesi F, Nguyen TLP, Haimhoffer \u00c1, Ruszny\u00e1k \u00c1, Vasv\u00e1ri G, B\u00e1cskay I, et al. Cyclodextrin complexation improves the solubility and Caco-2 permeability of chrysin. Materials (Basel, Switzerland). 2020;13(16):3618.","journal-title":"Materials (Basel, Switzerland)."},{"issue":"1","key":"2767_CR93","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cbi.2007.08.007","volume":"171","author":"PA Tsuji","year":"2008","unstructured":"Tsuji PA, Walle T. Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. Chem-Biol Interact. 2008;171(1):37\u201344.","journal-title":"Chem-Biol Interact"},{"issue":"7","key":"2767_CR94","doi-asserted-by":"crossref","first-page":"e68595","DOI":"10.1371\/journal.pone.0068595","volume":"8","author":"LF Yen","year":"2013","unstructured":"Yen LF, Wei VC, Kuo EY, Lai TW. Distinct patterns of cerebral extravasation by Evans blue and sodium fluorescein in rats. PloS one. 2013;8(7):e68595.","journal-title":"PloS one."},{"key":"2767_CR95","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-1-61779-191-8_25","volume":"763","author":"M Kaya","year":"2011","unstructured":"Kaya M, Ahishali B. Assessment of permeability in barrier type of endothelium in brain using tracers: Evans blue, sodium fluorescein, and horseradish peroxidase. Methods Mol Biol. 2011;763:369\u201382.","journal-title":"Methods Mol Biol."},{"issue":"7","key":"2767_CR96","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3390\/pharmaceutics14071487","volume":"14","author":"S Meirinho","year":"2022","unstructured":"Meirinho S, Rodrigues M, Santos AO, Falc\u00e3o A, Alves G. Self-emulsifying drug delivery systems: an alternative approach to improve brain bioavailability of poorly water-soluble drugs through intranasal administration. Pharmaceutics. 2022;14(7):1487.","journal-title":"Pharmaceutics."},{"issue":"1","key":"2767_CR97","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-2999(99)00790-6","volume":"387","author":"RA Ribeiro","year":"2000","unstructured":"Ribeiro RA, Vale ML, Thomazzi SM, Paschoalato ABP, Poole S, Ferreira SH, et al. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur J Pharmacol. 2000;387(1):111\u20138.","journal-title":"Eur J Pharmacol."},{"key":"2767_CR98","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.biopha.2017.06.003","volume":"92","author":"M Zeinali","year":"2017","unstructured":"Zeinali M, Rezaee SA, Hosseinzadeh H. An overview on immunoregulatory and anti-inflammatory properties of chrysin and flavonoids substances. Biomed Pharmacother. 2017;92:998\u20131009.","journal-title":"Biomed Pharmacother."},{"issue":"4","key":"2767_CR99","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bcp.2014.03.016","volume":"89","author":"X Feng","year":"2014","unstructured":"Feng X, Qin H, Shi Q, Zhang Y, Zhou F, Wu H, et al. Chrysin attenuates inflammation by regulating M1\/M2 status via activating PPAR\u03b3. Biochem Pharmacol. 2014;89(4):503\u201314.","journal-title":"Biochem Pharmacol."},{"key":"2767_CR100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neuroscience.2014.01.004","volume":"262","author":"J Xiao","year":"2014","unstructured":"Xiao J, Zhai H, Yao Y, Wang C, Jiang W, Zhang C, et al. Chrysin attenuates experimental autoimmune neuritis by suppressing immuno-inflammatory responses. Neuroscience. 2014;262:156\u201364.","journal-title":"Neuroscience."},{"issue":"7","key":"2767_CR101","doi-asserted-by":"crossref","first-page":"12270","DOI":"10.3390\/ijms150712270","volume":"15","author":"Y Jiang","year":"2014","unstructured":"Jiang Y, Gong F-L, Zhao G-B, Li J. Chrysin suppressed inflammatory responses and the inducible nitric oxide synthase pathway after spinal cord injury in rats. Int J Mol Sci. 2014;15(7):12270\u20139.","journal-title":"Int J Mol Sci."},{"issue":"3","key":"2767_CR102","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.apsb.2017.02.002","volume":"7","author":"F Li","year":"2017","unstructured":"Li F, Hu R, Wang B, Gui Y, Cheng G, Gao S, et al. Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake. Acta Pharm Sin B. 2017;7(3):353\u201360.","journal-title":"Acta Pharm Sin B"},{"key":"2767_CR103","doi-asserted-by":"crossref","first-page":"106159","DOI":"10.1016\/j.ejps.2022.106159","volume":"174","author":"DY Usta","year":"2022","unstructured":"Usta DY, Timur B, Teksin ZS. Formulation development, optimization by Box-Behnken design, characterization, in vitro, ex-vivo, and in vivo evaluation of bosentan-loaded self-nanoemulsifying drug delivery system: a novel alternative dosage form for pulmonary arterial hypertension treatment. Eur J Pharm Sci. 2022;174:106159.","journal-title":"Eur J Pharm Sci."},{"key":"2767_CR104","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejpb.2015.11.019","volume":"100","author":"K Netsomboon","year":"2016","unstructured":"Netsomboon K, Laffleur F, Suchaoin W, Bernkop-Schn\u00fcrch A. Novel in vitro transport method for screening the reversibility of P-glycoprotein inhibitors. Eur J Pharm Biopharm. 2016;100:9\u201314.","journal-title":"Eur J Pharm Biopharm."},{"issue":"11","key":"2767_CR105","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1021\/acs.molpharmaceut.8b00482","volume":"15","author":"R Gurjar","year":"2018","unstructured":"Gurjar R, Chan CYS, Curley P, Sharp J, Chiong J, Rannard S, et al. Inhibitory effects of commonly used excipients on P-glycoprotein in vitro. Mol Pharm. 2018;15(11):4835\u201342.","journal-title":"Mol Pharm."},{"key":"2767_CR106","doi-asserted-by":"crossref","unstructured":"Nguyen T-T-L, Duong V-A, Maeng H-J. Pharmaceutical formulations with P-glycoprotein inhibitory effect as promising approaches for enhancing oral drug absorption and bioavailability. Pharmaceutics. 2021;13(7):1103.","DOI":"10.3390\/pharmaceutics13071103"},{"key":"2767_CR107","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.colsurfb.2013.06.001","volume":"111","author":"LM Negi","year":"2013","unstructured":"Negi LM, Tariq M, Talegaonkar S. Nano scale self-emulsifying oil based carrier system for improved oral bioavailability of camptothecin derivative by P-glycoprotein modulation. Colloids Surf B: Biointerfaces. 2013;111:346\u201353.","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"3","key":"2767_CR108","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3109\/10837450.2010.535825","volume":"17","author":"P Mura","year":"2012","unstructured":"Mura P, Valleri M, Cirri M, Mennini N. New solid self-microemulsifying systems to enhance dissolution rate of poorly water soluble drugs. Pharm Dev Technol. 2012;17(3):277\u201384.","journal-title":"Pharm Dev Technol."},{"issue":"4","key":"2767_CR109","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1039\/C5RA21796B","volume":"6","author":"S Verma","year":"2016","unstructured":"Verma S, Singh SK, Verma PRP. Solidified SNEDDS of loratadine: formulation using hydrophilic and hydrophobic grades of Aerosil\u00ae, pharmacokinetic evaluations and in vivo\u2013in silico predictions using GastroPlus\u2122. RSC Advances. 2016;6(4):3099\u2013116.","journal-title":"RSC Advances."},{"issue":"3","key":"2767_CR110","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2174\/2213476X07666200827102951","volume":"7","author":"S Bhattacharya","year":"2020","unstructured":"Bhattacharya S. Self-emulsifying drug delivery system (SEDDS) and its pharmaceutical applications. Appl Clin Res Clin Trials Reg Affairs. 2020;7(3):206\u201324.","journal-title":"Appl Clin Res Clin Trials Reg Affairs."},{"issue":"9","key":"2767_CR111","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1016\/j.apsusc.2009.11.030","volume":"256","author":"M Parvinzadeh","year":"2010","unstructured":"Parvinzadeh M, Moradian S, Rashidi A, Yazdanshenas M-E. Surface characterization of polyethylene terephthalate\/silica nanocomposites. Appl Surf Sci. 2010;256(9):2792\u2013802.","journal-title":"Appl Surf Sci."},{"key":"2767_CR112","doi-asserted-by":"crossref","first-page":"108099","DOI":"10.1016\/j.cep.2020.108099","volume":"156","author":"A \u00c7alhan","year":"2020","unstructured":"\u00c7alhan A, Deniz S, Kujawski W, Kujawa J, Knozowska K, Hasano\u011flu A. silica filled polyphenylsulfone\/polydimethylsiloxane composite membranes for pervaporation separation of biobutanol from ABE mixtures. Chem Eng Process: Process Intensif. 2020;156:108099.","journal-title":"Chem Eng Process: Process Intensif."},{"issue":"1","key":"2767_CR113","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijpharm.2007.05.010","volume":"343","author":"T Limnell","year":"2007","unstructured":"Limnell T, Riikonen J, Salonen J, Kaukonen AM, Laitinen L, Hirvonen J, et al. Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles. Int J Pharm. 2007;343(1):141\u20137.","journal-title":"Int J Pharm."},{"issue":"2","key":"2767_CR114","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1208\/s12249-014-0078-y","volume":"15","author":"Y Weerapol","year":"2014","unstructured":"Weerapol Y, Limmatvapirat S, Nunthanid J, Sriamornsak P. Self-nanoemulsifying drug delivery system of nifedipine: impact of hydrophilic\u2013lipophilic balance and molecular structure of mixed surfactants. AAPS PharmSciTech. 2014;15(2):456\u201364.","journal-title":"AAPS PharmSciTech."},{"issue":"2","key":"2767_CR115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ijpharm.2017.05.036","volume":"533","author":"J Mandi\u0107","year":"2017","unstructured":"Mandi\u0107 J, Zvonar Pobirk A, Vre\u010der F, Ga\u0161perlin M. Overview of solidification techniques for self-emulsifying drug delivery systems from industrial perspective. Int J Pharm. 2017;533(2):335\u201345.","journal-title":"Int J Pharm."},{"issue":"4","key":"2767_CR116","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1208\/s12249-022-02267-z","volume":"23","author":"PV Dangre","year":"2022","unstructured":"Dangre PV, Gurram NJ, Surana SJ, Chalikwar SS. Development and optimization of vitamin D3 solid self-microemulsifying drug delivery system: investigation of flowability and shelf life. AAPS PharmSciTech. 2022;23(4):110.","journal-title":"AAPS PharmSciTech."},{"issue":"14","key":"2767_CR117","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.3390\/polym13142272","volume":"13","author":"BK Almutairy","year":"2021","unstructured":"Almutairy BK, Alshetaili A, Alali AS, Ahmed MM, Anwer MK, Aboudzadeh MAJP. Design of olmesartan medoxomil-loaded nanosponges for hypertension and lung cancer treatments. Polymers (Basel). 2021;13(14):2272.","journal-title":"Polymers (Basel)."},{"issue":"1","key":"2767_CR118","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ijpharm.2015.09.011","volume":"495","author":"RB Chavan","year":"2015","unstructured":"Chavan RB, Modi SR, Bansal AK. Role of solid carriers in pharmaceutical performance of solid supersaturable SEDDS of celecoxib. Int J Pharm. 2015;495(1):374\u201384.","journal-title":"Int J Pharm."},{"key":"2767_CR119","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.colsurfb.2012.06.031","volume":"101","author":"S Beg","year":"2013","unstructured":"Beg S, Jena SS, Patra CN, Rizwan M, Swain S, Sruti J, et al. Development of solid self-nanoemulsifying granules (SSNEGs) of ondansetron hydrochloride with enhanced bioavailability potential. Colloids Surf B: Biointerfaces. 2013;101:414\u201323.","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"5","key":"2767_CR120","first-page":"1169","volume":"15","author":"S Miyamoto","year":"2006","unstructured":"Miyamoto S, Kohno H, Suzuki R, Sugie S, Murakami A, Ohigashi H, et al. Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats. Oncol Rep. 2006;15(5):1169\u201373.","journal-title":"Oncol Rep"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-024-02767-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-024-02767-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-024-02767-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T21:49:23Z","timestamp":1711403363000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-024-02767-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,5]]},"references-count":120,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["2767"],"URL":"https:\/\/doi.org\/10.1208\/s12249-024-02767-0","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,5]]},"assertion":[{"value":"26 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"54"}}