{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:16:37Z","timestamp":1775664997420,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"DOI":"10.1208\/s12249-024-02937-0","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T16:01:41Z","timestamp":1727366501000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["HPMC-Zein Film-forming Gel Loaded with 5-Fluorouracil Coupled with CO2 Laser Dermabrasion for Managing Stable Vitiligo"],"prefix":"10.1208","volume":"25","author":[{"given":"Heba A.","family":"Abou-Taleb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed S.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamal M.","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamiaa N.","family":"Abdelaty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud A.","family":"Makki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazem L.","family":"Abdel-Aleem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"El-Mokhtar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helal F.","family":"Hetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidaa","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-7419","authenticated-orcid":false,"given":"Mohammed S.","family":"Saddik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"issue":"1","key":"2937_CR1","first-page":"57","volume":"145","author":"AR Hossani-Madani","year":"2010","unstructured":"Hossani-Madani AR, Halder RM. Topical treatment and combination approaches for vitiligo: new insights, new developments. G Ital Dermatol Venereol. 2010;145(1):57\u201378.","journal-title":"G Ital Dermatol Venereol"},{"issue":"8","key":"2937_CR2","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1001\/jamadermatol.2019.0696","volume":"155","author":"JH Lee","year":"2019","unstructured":"Lee JH, Kwon HS, Jung HM, Lee H, Kim GM, Yim HW, et al. Treatment outcomes of topical calcineurin inhibitor therapy for patients with vitiligo: a systematic review and meta-analysis. JAMA Dermatol. 2019;155(8):929\u201338.","journal-title":"JAMA Dermatol"},{"issue":"12","key":"2937_CR3","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1111\/j.1524-4725.2011.02127.x","volume":"37","author":"T Garg","year":"2011","unstructured":"Garg T, Chander R, Jain A. Combination of microdermabrasion and 5-fluorouracil to induce repigmentation in vitiligo: an observational study. Dermatol Surg. 2011;37(12):1763\u20136.","journal-title":"Dermatol Surg"},{"issue":"1","key":"2937_CR4","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.21608\/ejhm.2023.284771","volume":"90","author":"N Khafagy","year":"2023","unstructured":"Khafagy N, Hassen S, Ezat F, Elhawatky A. Comparing the efficacy of micro-needling alone versus micro-needling with topical 5-Fluorouracil in treating stable non-segmental vitiligo. Egypt J Hosp Med. 2023;90(1):1960\u20137.","journal-title":"Egypt J Hosp Med"},{"issue":"2","key":"2937_CR5","doi-asserted-by":"publisher","first-page":"797-","DOI":"10.3892\/etm.2021.10229","volume":"22","author":"DE Kubelis-L\u00f3pez","year":"2021","unstructured":"Kubelis-L\u00f3pez DE, Zapata-Salazar NA, Said-Fern\u00e1ndez SL, S\u00e1nchez-Dom\u00ednguez CN, Salinas-Santander MA, Mart\u00ednez-Rodr\u00edguez HG, et al. Updates and new medical treatments for vitiligo (Review). Exp Ther Med. 2021;22(2):797-.","journal-title":"Exp Ther Med."},{"key":"2937_CR6","doi-asserted-by":"publisher","first-page":"116038","DOI":"10.1016\/j.molliq.2021.116038","volume":"333","author":"S Akay","year":"2021","unstructured":"Akay S, Kayan B, Jouyban A, Mart\u00ednez F. Solubility and dissolution thermodynamics of 5-fluorouracil in (ethanol+ water) mixtures. J Mol Liq. 2021;333:116038.","journal-title":"J Mol Liq"},{"key":"2937_CR7","doi-asserted-by":"publisher","first-page":"107447","DOI":"10.1016\/j.pharmthera.2019.107447","volume":"206","author":"S Vodenkova","year":"2020","unstructured":"Vodenkova S, Buchler T, Cervena K, Veskrnova V, Vodicka P, Vymetalkova V. 5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future. Pharmacol Ther. 2020;206:107447.","journal-title":"Pharmacol Ther"},{"issue":"9","key":"2937_CR8","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1001\/archderm.1983.01650330014006","volume":"119","author":"T Tsuji","year":"1983","unstructured":"Tsuji T, Hamada T. Topically administered fluorouracil in vitiligo. Arch Dermatol. 1983;119(9):722\u20137.","journal-title":"Arch Dermatol"},{"issue":"8","key":"2937_CR9","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1111\/j.1365-4632.2007.03226.x","volume":"46","author":"S Sethi","year":"2007","unstructured":"Sethi S, Mahajan BB, Gupta RR, Ohri A. Comparative evaluation of the therapeutic efficacy of dermabrasion, dermabrasion combined with topical 5% 5-fluorouracil cream, and dermabrasion combined with topical placentrex gel in localized stable vitiligo. Int J Dermatol. 2007;46(8):875\u20139.","journal-title":"Int J Dermatol"},{"key":"2937_CR10","doi-asserted-by":"crossref","unstructured":"Handog EB, Enriquez-Macarayo MJ (eds.). Melasma and vitiligo in brown skin (No. 25188). Springer India; 2017.","DOI":"10.1007\/978-81-322-3664-1"},{"key":"2937_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2147\/CCID.S225881","volume":"13","author":"M Abdelwahab","year":"2020","unstructured":"Abdelwahab M, Salah M, Samy N, Rabie A, Farrag A. Effect of topical 5-Fluorouracil alone versus its combination with Erbium:YAG (2940 nm) laser in treatment of vitiligo. Clin Cosmet Investig Dermatol. 2020;13:77\u201385.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"6","key":"2937_CR12","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3109\/09546630902789326","volume":"20","author":"AY Moore","year":"2009","unstructured":"Moore AY. Clinical applications for topical 5-fluorouracil in the treatment of dermatological disorders. J Dermatolog Treat. 2009;20(6):328\u201335.","journal-title":"J Dermatolog Treat"},{"issue":"4","key":"2937_CR13","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1111\/j.1365-2133.2005.06779.x","volume":"153","author":"CC Lan","year":"2005","unstructured":"Lan CC, Yu HS, Wu CS, Kuo HY, Chai CY, Chen GS. FK506 inhibits tumour necrosis factor-\u03b1 secretion in human keratinocytes via regulation of nuclear factor-\u03baB. Br J Dermatol. 2005;153(4):725\u201332.","journal-title":"Br J Dermatol"},{"issue":"1","key":"2937_CR14","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/j.1365-2133.2011.10564.x","volume":"166","author":"W Bayoumi","year":"2012","unstructured":"Bayoumi W, Fontas E, Sillard L, Le Duff F, Ortonne JP, Bahadoran P, et al. Effect of a preceding laser dermabrasion on the outcome of combined therapy with narrowband ultraviolet B and potent topical steroids for treating nonsegmental vitiligo in resistant localizations. Br J Dermatol. 2012;166(1):208\u201311.","journal-title":"Br J Dermatol"},{"issue":"2","key":"2937_CR15","doi-asserted-by":"publisher","first-page":"e12447","DOI":"10.1111\/dth.12447","volume":"30","author":"M El Mofty","year":"2017","unstructured":"El Mofty M, Esmat S, Hunter N, Mashaly HM, Dorgham D, Shaker O, et al. Effect of different types of therapeutic trauma on vitiligo lesions. Dermatol Ther. 2017;30(2):e12447.","journal-title":"Dermatol Ther"},{"issue":"1","key":"2937_CR16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1600-0846.2010.00477.x","volume":"17","author":"D Helbig","year":"2011","unstructured":"Helbig D, Paasch U. Molecular changes during skin aging and wound healing after fractional ablative photothermolysis. Skin Res Technol. 2011;17(1):119\u201328.","journal-title":"Skin Res Technol"},{"issue":"4","key":"2937_CR17","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1111\/bjd.13511","volume":"172","author":"M Tembhre","year":"2015","unstructured":"Tembhre M, Parihar A, Sharma V, Sharma A, Chattopadhyay P, Gupta S. Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation. Br J Dermatol. 2015;172(4):940\u201350.","journal-title":"Br J Dermatol"},{"issue":"2","key":"2937_CR18","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1006\/excr.2000.4962","volume":"258","author":"E El Fahime","year":"2000","unstructured":"El Fahime E, Torrente Y, Caron N, Bresolin M, Tremblay J. In vivo migration of transplanted myoblasts requires matrix metalloproteinase activity. Exp Cell Res. 2000;258(2):279\u201387.","journal-title":"Exp Cell Res"},{"issue":"6","key":"2937_CR19","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1034\/j.1600-0749.2002.02044.x","volume":"15","author":"TC Lei","year":"2002","unstructured":"Lei TC, Vieira WD, Hearing VJ. In vitro migration of melanoblasts requires matrix metalloproteinase-2: implications to vitiligo therapy by photochemotherapy. Pigment Cell Res. 2002;15(6):426\u201332.","journal-title":"Pigment Cell Res"},{"issue":"2","key":"2937_CR20","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/j.1365-2133.2011.10324.x","volume":"165","author":"R Kumar","year":"2011","unstructured":"Kumar R, Parsad D, Kanwar A, Kaul D. Altered levels of Ets-1 transcription factor and matrix metalloproteinases in melanocytes from patients with vitiligo. Br J Dermatol. 2011;165(2):285\u201391.","journal-title":"Br J Dermatol"},{"issue":"5","key":"2937_CR21","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1111\/jocd.15616","volume":"22","author":"N Pazyar","year":"2023","unstructured":"Pazyar N, Hatami M, Yaghoobi R, Parvar SY, Radmanesh M, Hadibarhaghtalab M. The efficacy of adding topical 5-fluorouracil to micro-needling in the treatment of vitiligo: A randomized controlled trial. J Cosmet Dermatol. 2023;22(5):1513\u201320.","journal-title":"J Cosmet Dermatol"},{"issue":"11","key":"2937_CR22","doi-asserted-by":"publisher","first-page":"2956","DOI":"10.3390\/cancers15112956","volume":"15","author":"L Toffoli","year":"2023","unstructured":"Toffoli L, Dianzani C, Bonin S, Guarneri C, Guarneri F, Giuffrida R, et al. Actinic keratoses: a prospective pilot study on a novel formulation of 4% 5-fluorouracil cream and a review of other current topical treatment options. Cancers. 2023;15(11):2956.","journal-title":"Cancers"},{"issue":"Supplement_4","key":"2937_CR23","doi-asserted-by":"publisher","first-page":"ljad113. 74","DOI":"10.1093\/bjd\/ljad113.174","volume":"188","author":"MH Junejo","year":"2023","unstructured":"Junejo MH, Carucci M, Hurt C, Adams R, Matin R, Proby C, et al. BI06 Short sharp shock or slow burn: clinician perspectives on treatment of actinic keratoses with 5-fluorouracil 5% cream monotherapy vs. 5-fluorouracil\/calcipotriol ointment combination therapy. Br J Dermatol. 2023;188(Supplement_4):ljad113. 74.","journal-title":"Br J Dermatol"},{"issue":"4","key":"2937_CR24","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.joms.2020.07.215","volume":"79","author":"MF Caminiti","year":"2021","unstructured":"Caminiti MF, El-Rabbany M, Jeon J, Bradley G. 5-Fluorouracil is associated with a decreased recurrence risk in odontogenic keratocyst management: a retrospective cohort study. J Oral Maxillofac Surg. 2021;79(4):814\u201321.","journal-title":"J Oral Maxillofac Surg"},{"key":"2937_CR25","doi-asserted-by":"publisher","first-page":"103213","DOI":"10.1016\/j.jddst.2022.103213","volume":"70","author":"AS Han","year":"2022","unstructured":"Han AS, Kim J, Park JW, Jin SG. Novel acyclovir-loaded film-forming gel with enhanced mechanical properties and skin permeability. J Drug Deliv Sci Technol. 2022;70:103213.","journal-title":"J Drug Deliv Sci Technol"},{"key":"2937_CR26","doi-asserted-by":"publisher","first-page":"105167","DOI":"10.1016\/j.jddst.2023.105167","volume":"90","author":"MS Mohamed","year":"2023","unstructured":"Mohamed MS, El-Shenawy AA, Mahmoud EA, Amin MA, Mohammed HA, Shaldam MA, et al. Metolazone co-crystals-loaded oral fast dissolving films: Design, optimization, and in vivo evaluation. J Drug Deliv Sci Technol. 2023;90:105167.","journal-title":"J Drug Deliv Sci Technol"},{"key":"2937_CR27","doi-asserted-by":"publisher","first-page":"4277","DOI":"10.2147\/DDDT.S267317","volume":"14","author":"SA Mohamad","year":"2020","unstructured":"Mohamad SA, Salem H, Yassin HA, Mansour HF. Bucco-adhesive film as a pediatric proper dosage form for systemic delivery of propranolol hydrochloride: in-vitro and in-vivo evaluation. Drug Des Dev Ther. 2020;14:4277.","journal-title":"Drug Des Dev Ther"},{"issue":"2","key":"2937_CR28","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/1203475420972340","volume":"25","author":"AA Abdel Motaleb","year":"2021","unstructured":"Abdel Motaleb AA, Tawfik YM, El-Mokhtar MA, Elkady S, El-Gazzar AF, ElSayed SK, et al. Cutaneous JAK expression in vitiligo. J Cutan Med Surg. 2021;25(2):157\u201362.","journal-title":"J Cutan Med Surg"},{"issue":"12","key":"2937_CR29","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1080\/03639045.2019.1689993","volume":"45","author":"MS Mohamed","year":"2019","unstructured":"Mohamed MS, Abdelhafez WA, Zayed G, Samy AM. In vitro and in vivo characterization of fast dissolving tablets containing gliquidone\u2013pluronic solid dispersion. Drug Dev Ind Pharm. 2019;45(12):1973\u201381.","journal-title":"Drug Dev Ind Pharm"},{"issue":"6","key":"2937_CR30","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1001\/archdermatol.2009.97","volume":"145","author":"DL Sachs","year":"2009","unstructured":"Sachs DL, Kang S, Hammerberg C, Helfrich Y, Karimipour D, Orringer J, et al. Topical fluorouracil for actinic keratoses and photoaging: a clinical and molecular analysis. Arch Dermatol. 2009;145(6):659\u201366.","journal-title":"Arch Dermatol"},{"issue":"5","key":"2937_CR31","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1211\/0022357055957","volume":"57","author":"CL Li","year":"2005","unstructured":"Li CL, Martini LG, Ford JL, Roberts M. The use of hypromellose in oral drug delivery. J Pharm Pharmacol. 2005;57(5):533\u201346.","journal-title":"J Pharm Pharmacol"},{"key":"2937_CR32","doi-asserted-by":"publisher","unstructured":"Kariduraganavar MY, Heggannavar GB, Amado S, Mitchell GR. Protein Nanocarriers for Targeted Drug Delivery for Cancer Therapy. Nanocarriers for Drug Delivery. Elsevier; 2019. pp. 173-204. https:\/\/doi.org\/10.1016\/B978-0-12-814033-8.00006-0.","DOI":"10.1016\/B978-0-12-814033-8.00006-0"},{"key":"2937_CR33","doi-asserted-by":"publisher","first-page":"100922","DOI":"10.1016\/j.fochx.2023.100922","volume":"20","author":"SR Falsafi","year":"2023","unstructured":"Falsafi SR, Topuz F, Esfandiari Z, Karaca AC, Jafari SM, Rostamabadi H. Recent trends in the application of protein electrospun fibers for loading food bioactive compounds. Food Chem X. 2023;20:100922.","journal-title":"Food Chem X"},{"key":"2937_CR34","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.carbpol.2013.08.046","volume":"99","author":"MK Riekes","year":"2014","unstructured":"Riekes MK, Kuminek G, Rauber GS, de Campos CEM, Bortoluzzi AJ, Stulzer HK. HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions. Carbohyd Polym. 2014;99:474\u201382.","journal-title":"Carbohyd Polym"},{"issue":"1\u20132","key":"2937_CR35","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ijpharm.2016.09.023","volume":"513","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Cui L, Li F, Shi N, Li C, Yu X, et al. Design, fabrication and biomedical applications of zein-based nano\/micro-carrier systems. Int J Pharm. 2016;513(1\u20132):191\u2013210.","journal-title":"Int J Pharm"},{"issue":"41","key":"2937_CR36","doi-asserted-by":"publisher","first-page":"415102","DOI":"10.1088\/1361-6528\/ab2e29","volume":"30","author":"HV Ngo","year":"2019","unstructured":"Ngo HV, Tran PH, Lee B-J, Tran TT. Development of film-forming gel containing nanoparticles for transdermal drug delivery. Nanotechnology. 2019;30(41):415102.","journal-title":"Nanotechnology"},{"issue":"1","key":"2937_CR37","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1208\/s12249-011-9731-x","volume":"13","author":"K Karthikeyan","year":"2012","unstructured":"Karthikeyan K, Lakra R, Rajaram R, Korrapati PS. Development and characterization of zein-based micro carrier system for sustained delivery of aceclofenac sodium. AAPS PharmSciTech. 2012;13(1):143\u20139.","journal-title":"AAPS PharmSciTech"},{"issue":"7","key":"2937_CR38","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1002\/1520-6017(200007)89:7<850::AID-JPS2>3.0.CO;2-G","volume":"89","author":"JW Lee","year":"2000","unstructured":"Lee JW, Park JH, Robinson JR. Bioadhesive-based dosage forms: The next generation. J Pharm Sci. 2000;89(7):850\u201366.","journal-title":"J Pharm Sci"},{"key":"2937_CR39","first-page":"91","volume":"1","author":"S G\u00fcng\u00f6r","year":"2012","unstructured":"G\u00fcng\u00f6r S, Erdal MS, \u00d6zsoy Y. Plasticizers in transdermal drug delivery systems. Recent Adv Plasticizers. 2012;1:91\u20132.","journal-title":"Recent Adv Plasticizers"},{"issue":"4","key":"2937_CR40","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.3109\/10717544.2015.1124473","volume":"23","author":"A Hussain","year":"2016","unstructured":"Hussain A, Haque MW, Singh SK, Ahmed FJ. Optimized permeation enhancer for topical delivery of 5-fluorouracil-loaded elastic liposome using Design Expert: part II. Drug Delivery. 2016;23(4):1242\u201353.","journal-title":"Drug Delivery"},{"issue":"3","key":"2937_CR41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jconrel.2007.09.014","volume":"125","author":"A Vintiloiu","year":"2008","unstructured":"Vintiloiu A, Leroux J-C. Organogels and their use in drug delivery\u2014a review. J Control Release. 2008;125(3):179\u201392.","journal-title":"J Control Release"},{"key":"2937_CR42","doi-asserted-by":"crossref","unstructured":"Hiremath P, Nuguru K, Agrahari V. Material attributes and their impact on wet granulation process performance. In Handbook of pharmaceutical wet granulation. Academic Press; 2019. p. 263\u2013315.","DOI":"10.1016\/B978-0-12-810460-6.00012-9"},{"issue":"3","key":"2937_CR43","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jsps.2014.11.010","volume":"23","author":"S Tummala","year":"2015","unstructured":"Tummala S, Kumar MS, Prakash A. Formulation and characterization of 5-Fluorouracil enteric coated nanoparticles for sustained and localized release in treating colorectal cancer. Saudi Pharm J. 2015;23(3):308\u201314.","journal-title":"Saudi Pharm J"},{"issue":"4","key":"2937_CR44","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3390\/nano8040225","volume":"8","author":"P-H Wang","year":"2018","unstructured":"Wang P-H, Wang T-L, Lin W-C, Lin H-Y, Lee M-H, Yang C-H. Crosslinked polymer ionic liquid\/ionic liquid blends prepared by photopolymerization as solid-state electrolytes in supercapacitors. Nanomaterials. 2018;8(4):225.","journal-title":"Nanomaterials"},{"issue":"10","key":"2937_CR45","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3390\/pharmaceutics11100513","volume":"11","author":"A Berardi","year":"2019","unstructured":"Berardi A, Abdel Rahim S, Bisharat L, Cespi M. Swelling of zein matrix tablets benchmarked against HPMC and ethylcellulose: challenging the matrix performance by the addition of co-excipients. Pharmaceutics. 2019;11(10):513.","journal-title":"Pharmaceutics"},{"key":"2937_CR46","doi-asserted-by":"crossref","unstructured":"Gupta V, Gupta S. Future directions in the treatment of vitiligo: Medical and surgical\u00a0management. In book: Vitiligo. 2018. p. 475\u2013489.","DOI":"10.1002\/9781118937303.ch52"},{"issue":"1","key":"2937_CR47","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.yacs.2022.10.001","volume":"6","author":"JG Labadie","year":"2023","unstructured":"Labadie JG, Ibrahim O, Dover JS. Laser-assisted drug delivery. Adv Cosmet Surg. 2023;6(1):19\u201330.","journal-title":"Adv Cosmet Surg"},{"issue":"6","key":"2937_CR48","doi-asserted-by":"publisher","first-page":"474","DOI":"10.2340\/0001555566474478","volume":"66","author":"T Tsuji","year":"1986","unstructured":"Tsuji T, Karasek MA. Differential effects of 5-fluorouracil on human skin melanocytes and malignant melanoma cells in vitro. Acta Derm Venereol. 1986;66(6):474\u20138.","journal-title":"Acta Derm Venereol"},{"key":"2937_CR49","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/lsm.23663","volume":"55","author":"BC Carney","year":"2023","unstructured":"Carney BC, Oliver MA, Kurup S, Collins M, Keyloun JW, Moffatt LT, et al. Laser-assisted drug delivery of synthetic alpha melanocyte stimulating hormone and L-tyrosine leads to increased pigmentation area and expression of melanogenesis genes in a porcine hypertrophic scar model. Lasers Surg Med. 2023;55:490\u2013502.","journal-title":"Lasers Surg Med."},{"issue":"21","key":"2937_CR50","first-page":"343","volume":"3","author":"M Rashighi","year":"2015","unstructured":"Rashighi M, Harris JE. Interfering with the IFN-\u03b3\/CXCL10 pathway to develop new targeted treatments for vitiligo. Ann Transl Med. 2015;3(21):343.","journal-title":"Ann Transl Med"},{"issue":"1","key":"2937_CR51","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/09546634.2020.1735615","volume":"33","author":"K Phan","year":"2022","unstructured":"Phan K, Phan S, Shumack S, Gupta M. Repigmentation in vitiligo using janus kinase (JAK) inhibitors with phototherapy: systematic review and Meta-analysis. J Dermatol Treat. 2022;33(1):173\u20137.","journal-title":"J Dermatol Treat"},{"issue":"5","key":"2937_CR52","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41429-023-00603-4","volume":"76","author":"HA Mohammed","year":"2023","unstructured":"Mohammed HA, Amin MA, Zayed G, Hassan Y, El-Mokhtar M, Saddik MS. In vitro and in vivo synergistic wound healing and anti-methicillin-resistant Staphylococcus aureus (MRSA) evaluation of liquorice-decorated silver nanoparticles. J Antibiot (Tokyo). 2023;76(5):291\u2013300.","journal-title":"J Antibiot (Tokyo)"},{"issue":"18","key":"2937_CR53","doi-asserted-by":"publisher","first-page":"14259","DOI":"10.3390\/ijms241814259","volume":"24","author":"S Hosny","year":"2023","unstructured":"Hosny S, El-Baki RFA, El-Wahab ZHA, Gouda GA, Saddik MS, Aljuhani A, et al. Development of novel nano-sized imine complexes using Coriandrum sativum extract: structural elucidation, non-isothermal kinetic study, theoretical investigation and pharmaceutical applications. Int J Mol Sci. 2023;24(18):14259.","journal-title":"Int J Mol Sci."},{"key":"2937_CR54","first-page":"100245","volume":"7","author":"MS Saddik","year":"2024","unstructured":"Saddik MS, Al-Hakkani MF, Abu-Dief AM, Mohamed MS, Al-Fattah IA, Makki M, et al. Formulation and evaluation of azithromycin-loaded silver nanoparticles for the treatment of infected wounds. Int J Pharm X. 2024;7:100245.","journal-title":"Int J Pharm X"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-024-02937-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-024-02937-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-024-02937-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T15:09:18Z","timestamp":1729696158000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-024-02937-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,26]]},"references-count":54,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["2937"],"URL":"https:\/\/doi.org\/10.1208\/s12249-024-02937-0","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,26]]},"assertion":[{"value":"8 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research protocol was approved by the Ethics Committee of Minia University (HV04\/2020), and the US Clinical Trials Registry number (NCT06209138).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Board Statement"}},{"value":"Informed written consent was obtained from patients before enrollment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}],"article-number":"225"}}