{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T19:53:49Z","timestamp":1778270029865,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"DOI":"10.1208\/s12249-024-02966-9","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T22:01:41Z","timestamp":1728943301000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Surfactant-Assisted Wet Granulation-Based Matrix Tablets without Exceptional Additives: Prolonging Systemic Exposure of Model BCS Class II Ketoprofen"],"prefix":"10.1208","volume":"25","author":[{"given":"Rahat","family":"Shamim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Shafique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasir","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Ijaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5710-9574","authenticated-orcid":false,"given":"Nadeem Irfan","family":"Bukhari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"issue":"3","key":"2966_CR1","first-page":"1","volume":"2","author":"N Rao","year":"2013","unstructured":"Rao N, Raj K, Nayak BS. Review on matrix tablet as sustained release. Int J Pharm Res. 2013;2(3):1\u201317.","journal-title":"Int J Pharm Res"},{"key":"2966_CR2","unstructured":"Gwen M, Joseph R. In Banker GS and Rhodes CT, Eds., Modern Pharmaceutics, 3rd Edn, Vol. 72. Marcel Dekker Inc. New York; 1996."},{"issue":"3","key":"2966_CR3","first-page":"143","volume":"1","author":"H Patel","year":"2011","unstructured":"Patel H, Panchal DR, Patel U, Brahmbhatt T, Suthar M. Matrix type drug delivery system: A review. J Pharm Sci Res. 2011;1(3):143\u201351.","journal-title":"J Pharm Sci Res"},{"key":"2966_CR4","unstructured":"Venkateswarlu V. Biopharmaceutics and pharmacokinetics: PharmaMed Press; 2008."},{"issue":"2","key":"2966_CR5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2165\/00044011-200424020-00003","volume":"24","author":"D Getsios","year":"2004","unstructured":"Getsios D, Caro J, Ishak K, El-Hadi W, Payne K, O\u2019connel M, et al. Oxybutynin extended release and tolterodine immediate release. Clin Drug Investig. 2004;24(2):81\u20138.","journal-title":"Clin Drug Investig"},{"key":"2966_CR6","doi-asserted-by":"crossref","unstructured":"Qiu Y. Rational design of oral modified-release drug delivery systems. Developing Solid Oral Dosage Forms: Elsevier; 2009. p. 469-99.","DOI":"10.1016\/B978-0-444-53242-8.00020-5"},{"issue":"3","key":"2966_CR7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jconrel.2006.05.004","volume":"113","author":"P Borgquist","year":"2006","unstructured":"Borgquist P, K\u00f6rner A, Piculell L, Larsson A, Axelsson A. A model for the drug release from a polymer matrix tablet\u2014effects of swelling and dissolution. J Control Release. 2006;113(3):216\u201325.","journal-title":"J Control Release"},{"issue":"1","key":"2966_CR8","first-page":"67","volume":"4","author":"MM Nafady","year":"2013","unstructured":"Nafady MM, Attala KM, Sayed MA. Improvement of the solubility and dissolution of ketoprofen using lanatural bile salts. Der Pharm Sin. 2013;4(1):67\u201376.","journal-title":"Der Pharm Sin"},{"issue":"1","key":"2966_CR9","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0378-5173(02)00230-2","volume":"241","author":"A Roda","year":"2002","unstructured":"Roda A, Sabatini L, Mirasoli M, Baraldini M, Roda E. Bioavailability of a new ketoprofen formulation for once-daily oral administration. Int J Pharm. 2002;241(1):165\u201372.","journal-title":"Int J Pharm"},{"issue":"3","key":"2966_CR10","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/bdd.2510050302","volume":"5","author":"G Houghton","year":"1984","unstructured":"Houghton G, Dennis M, Rigler E, Parsons R. Comparative pharmacokinetics of ketoprofen derived from single oral doses of ketoprofen capsules or a novel sustained-release pellet formulation. Biopharm Drug Dispos. 1984;5(3):203\u20139.","journal-title":"Biopharm Drug Dispos"},{"issue":"2","key":"2966_CR11","first-page":"281","volume":"38","author":"R Shamim","year":"2019","unstructured":"Shamim R, Shafique S, Kanwal U, Hussain K, Asif N, Ijaz S, et al. Surfactant-Assisted Wet Granulation: A Simpler Approach to Improve Solubility and Sustain Ketoprofen Release. Lat Am J Pharm. 2019;38(2):281\u201390.","journal-title":"Lat Am J Pharm"},{"key":"2966_CR12","doi-asserted-by":"crossref","unstructured":"Vittal GV, Deveswaran R, Bharath S, Basavaraj B, Madhavan VJIjopi. Formulation and characterization of ketoprofen liquisolid compacts by Box-Behnken design. 2012;2(3):150.","DOI":"10.4103\/2230-973X.104398"},{"issue":"3","key":"2966_CR13","first-page":"001","volume":"3","author":"A Kumar","year":"2011","unstructured":"Kumar A, Sahoo SK, Padhee K, Kochar P, Sathapathy A, Pathak N. Review on solubility enhancement techniques for hydrophobic drugs. Pharm Globale. 2011;3(3):001\u20137.","journal-title":"Pharm Globale"},{"key":"2966_CR14","unstructured":"Singh Y. Martin\u2019s physical pharmacy and pharmaceutical sciences: Rutgers, The State University of New Jersey; 2006."},{"key":"2966_CR15","unstructured":"Aulton M, Summer M. Tablet and Compaction in: Pharmacutic The Science of Dosage Forms Design. Churchill Livingstone. Philadelphia; 2002."},{"issue":"6","key":"2966_CR16","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S1461-5347(00)00269-8","volume":"3","author":"P Colombo","year":"2000","unstructured":"Colombo P, Bettini R, Santi P, Peppas NA. Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance. Pharm Sci Technol Today. 2000;3(6):198\u2013204.","journal-title":"Pharm Sci Technol Today"},{"issue":"1\u20132","key":"2966_CR17","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0169-409X(93)90026-Z","volume":"11","author":"P Colombo","year":"1993","unstructured":"Colombo P. Swelling-controlled release in hydrogel matrices for oral route. Adv Drug Deliv Rev. 1993;11(1\u20132):37\u201357.","journal-title":"Adv Drug Deliv Rev"},{"key":"2966_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.addr.2012.09.028","volume":"64","author":"J Siepmann","year":"2012","unstructured":"Siepmann J, Peppas N. Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC). Adv Drug Deliv Rev. 2012;64:163\u201374.","journal-title":"Adv Drug Deliv Rev"},{"issue":"9","key":"2966_CR19","first-page":"24","volume":"20","author":"SB Tiwari","year":"2008","unstructured":"Tiwari SB, Rajabi-Siahboomi AR. Modulation of drug release from hydrophilic matrices. Pharm Technol Eur. 2008;20(9):24\u201332.","journal-title":"Pharm Technol Eur"},{"key":"2966_CR20","first-page":"33","volume":"1","author":"G Prajapati","year":"2010","unstructured":"Prajapati G, Patel R. Design and in vitro evaluation of novel nicorandil sustained release matrix tablets based on combination of hydrophillic and hydrophobic matrix systems. Int J Pharm Sci Rev Res. 2010;1:33\u20135.","journal-title":"Int J Pharm Sci Rev Res"},{"issue":"2","key":"2966_CR21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0378-5173(93)90151-5","volume":"90","author":"J Johnson","year":"1993","unstructured":"Johnson J, Holinej J, Williams M. Influence of ionic strength on matrix integrity and drug release from hydroxypropyl cellulose compacts. Int J Pharm. 1993;90(2):151\u20139.","journal-title":"Int J Pharm"},{"issue":"3","key":"2966_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0168-3659(93)90154-W","volume":"27","author":"JW Skoug","year":"1993","unstructured":"Skoug JW, Mikelsons MV, Vigneron CN, Stemm NL. Qualitative evaluation of the mechanism of release of matrix sustained release dosage forms by measurement of polymer release. J Control Release. 1993;27(3):227\u201345.","journal-title":"J Control Release"},{"issue":"10","key":"2966_CR23","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1002\/jps.23233","volume":"101","author":"IE Shohin","year":"2012","unstructured":"Shohin IE, Kulinich JI, Ramenskaya GV, Abrahamsson B, Kopp S, Langguth P, et al. Biowaiver monographs for immediate-release solid oral dosage forms: ketoprofen. J Pharm Sci. 2012;101(10):3593\u2013603.","journal-title":"J Pharm Sci"},{"issue":"1656","key":"2966_CR24","doi-asserted-by":"publisher","first-page":"20130583","DOI":"10.1098\/rstb.2013.0583","volume":"369","author":"TH Hutchinson","year":"2014","unstructured":"Hutchinson TH, Madden JC, Naidoo V, Walker CH. Comparative metabolism as a key driver of wildlife species sensitivity to human and veterinary pharmaceuticals. Philos Trans R Soc B. 2014;369(1656):20130583.","journal-title":"Philos Trans R Soc B"},{"issue":"3","key":"2966_CR25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","volume":"12","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Huo M, Zhou J, Zou A, Li W, Yao C, et al. DDSolver: an add-in program for modeling and comparison of drug dissolution profiles. AAPS J. 2010;12(3):263\u201371.","journal-title":"AAPS J"},{"key":"2966_CR26","unstructured":"Farheen S, Sappori S, Kethavath M, Kalpana G. Formulation and evaluation of metformin hydrochloride sustained release tablets. Pharma Sci Monit. 2017;8(1):252\u201362."},{"key":"2966_CR27","unstructured":"USP. The United States Pharmacopeia. US Pharmacopeial Convention Inc., Rockville, MD,USA: 2748\u201327512005."},{"issue":"58","key":"2966_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-019-1606-6","volume":"21","author":"T Hussain","year":"2020","unstructured":"Hussain T, Ijaz M, Shamim R, Hussain K, Abbas N, Hussain A, et al. In Vivo Evaluation of a Novel Chitosan-Polycaprolactone Based Mucoadhesive Gastro-Retentive Sustained Release Drug Delivery System for Milnacipran HCl. AAPS PharmSciTech. 2020;21(58):1\u201311. https:\/\/doi.org\/10.1208\/s12249-019-1606-6.","journal-title":"AAPS PharmSciTech"},{"key":"2966_CR29","doi-asserted-by":"crossref","unstructured":"Abd-Elbary A, Aboelwafa AA, Al Sharabi IM. Once daily, high-dose mesalazine controlled-release tablet for colonic delivery: optimization of formulation variables using Box\u2013Behnken design. AAPSPharmSciTech. 2011;12:1454\u201364.","DOI":"10.1208\/s12249-011-9708-9"},{"issue":"2","key":"2966_CR30","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jchromb.2004.03.063","volume":"806","author":"C Puozzo","year":"2004","unstructured":"Puozzo C, Filaquier C, Zorza G. Determination of milnacipran, a serotonin and noradrenaline reuptake inhibitor, in human plasma using liquid chromatography with spectrofluorimetric detection. J Chromatogr, B: Anal Technol Biomed Life Sci. 2004;806(2):221\u20138. https:\/\/doi.org\/10.1016\/j.jchromb.2004.03.063.","journal-title":"J Chromatogr, B: Anal Technol Biomed Life Sci"},{"issue":"1","key":"2966_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4155\/bio.13.298","volume":"6","author":"D Zimmer","year":"2014","unstructured":"Zimmer D, New US. FDA draft guidance on bioanalytical method validation versus current FDA and EMA guidelines: chromatographic methods and ISR. J Bioanalysis. 2014;6(1):13\u20139.","journal-title":"J Bioanalysis"},{"key":"2966_CR32","first-page":"165","volume":"1","author":"P Rabindranath","year":"2009","unstructured":"Rabindranath P, Chakraborty M, Rabindra D, Gupta BK. In-vitro In-vivo correlation (IVIVC) study of leflunomide loaded microspheres. Int J Pharm Pharm Sci. 2009;1:165\u201370.","journal-title":"Int J Pharm Pharm Sci"},{"issue":"4","key":"2966_CR33","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1208\/pt0804106","volume":"8","author":"IA Attia","year":"2007","unstructured":"Attia IA, El-Gizawy SA, Fouda MA, Donia AM. Influence of a niosomal formulation on the oral bioavailability of acyclovir in rabbits. AAPS PharmSciTech. 2007;8(4):206\u201312.","journal-title":"AAPS PharmSciTech"},{"issue":"Suppl 1","key":"2966_CR34","first-page":"165","volume":"1","author":"R Pal","year":"2009","unstructured":"Pal R, Chakraborty M, Debnath R, Gupta BK. In Vitro-In Vivo Correlation (IVIVC) Study of Leflunomide Loaded Microspheres. Int J Pharm Pharm Sci. 2009;1(Suppl 1):165\u201370.","journal-title":"Int J Pharm Pharm Sci"},{"issue":"1","key":"2966_CR35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2478\/v10007-009-0010-2","volume":"59","author":"P Kumar","year":"2009","unstructured":"Kumar P, Singh S, Mishra B. Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology. Acta Pharm. 2009;59(1):15\u201330.","journal-title":"Acta Pharm"},{"key":"2966_CR36","unstructured":"USP. The United States Pharmacopeia 39 and National Formulary (USP39-NF34). US Pharmacopeial Convention Inc., Rockville, MD, USA. 2015."},{"key":"2966_CR37","unstructured":"USP. The United States Pharmacopeia 29 and National Formulary 24 (USP29-NF24) Tablet Friability. US Pharmacopeial Convention Inc., Rockville, MD, USA. 2006. p. 3046"},{"key":"2966_CR38","unstructured":"USP. The United States Pharmacopeia 35 and National Formulary 30 (USP 35-NF 30). The US Pharmacopeial Convention Inc., Rockville, MD, USA. 2012."},{"issue":"4","key":"2966_CR39","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1081\/DDC-100102199","volume":"25","author":"B-J Lee","year":"1999","unstructured":"Lee B-J, Ryu S-G, Cui J-H. Formulation and release characteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin. J Drug Dev Ind Pharm. 1999;25(4):493\u2013501.","journal-title":"J Drug Dev Ind Pharm"},{"issue":"3","key":"2966_CR40","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0928-0987(97)00072-9","volume":"6","author":"J Sujja-Areevath","year":"1998","unstructured":"Sujja-Areevath J, Munday D, Cox P, Khan K. Relationship between swelling, erosion and drug release in hydrophillic natural gum mini-matrix formulations. Eur J Pharm Sci. 1998;6(3):207\u201317.","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"2966_CR41","first-page":"277","volume":"50","author":"RS Bhuptani","year":"2016","unstructured":"Bhuptani RS, Jain AS, Makhija DT, Jagtap AG, Hassan PAR, Nagarsenker MS. Soluplus Based Polymeric Micelles and Mixed Micelles of Lornoxicam: Design, Characterization and In vivo Efficacy Studies in Rats. Indian J Pharm Educ Res. 2016;50(2):277.","journal-title":"Indian J Pharm Educ Res"},{"issue":"1","key":"2966_CR42","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/jps.22731","volume":"101","author":"ZK Nagy","year":"2012","unstructured":"Nagy ZK, Balogh A, Vajna B, Farkas A, Patyi G, Kramarics \u00c1, et al. Comparison of electrospun and extruded Soluplus\u00ae-based solid dosage forms of improved dissolution. J Pharm Sci. 2012;101(1):322\u201332.","journal-title":"J Pharm Sci"},{"key":"2966_CR43","doi-asserted-by":"crossref","unstructured":"Abd-Elbary A, Tadros MI, Alaa-Eldin AA. Sucrose stearate-enriched lipid matrix tablets of etodolac: modulation of drug release, diffusional modeling and structure elucidation studies. AAPS PharmSciTech. 2013;14(2):656\u201368.","DOI":"10.1208\/s12249-013-9951-3"},{"issue":"1","key":"2966_CR44","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/03639040701580572","volume":"34","author":"R Yang","year":"2008","unstructured":"Yang R, Wang Y, Zheng X, Meng J, Tang X, Zhang X. Preparation and evaluation of ketoprofen hot-melt extruded enteric and sustained-release tablets. Drug Dev Ind Pharm. 2008;34(1):83\u20139.","journal-title":"Drug Dev Ind Pharm"},{"issue":"1","key":"2966_CR45","first-page":"1001","volume":"5","author":"SS Gupta","year":"2016","unstructured":"Gupta SS, Meena A, Parikh T, Serajuddin AT. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion-I: Polyvinylpyrrolidone and related polymers. J Excipients Food Chem. 2016;5(1):1001.","journal-title":"J Excipients Food Chem"},{"issue":"1","key":"2966_CR46","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.farmac.2004.08.008","volume":"60","author":"M \u00dcner","year":"2005","unstructured":"\u00dcner M, G\u00f6n\u00fcll\u00fc \u00dc, Yener G, Alt\u0131nkurt T. A new approach for preparing a controlled release ketoprofen tablets by using beeswax. Il Farmaco. 2005;60(1):27\u201331.","journal-title":"Il Farmaco"},{"issue":"1","key":"2966_CR47","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3109\/10837450.2014.949269","volume":"20","author":"J Lu","year":"2015","unstructured":"Lu J, Shah S, Jo S, Majumdar S, Gryczke A, Kolter K, et al. Investigation of phase diagrams and physical stability of drug\u2013polymer solid dispersions. Pharm Dev Technol. 2015;20(1):105\u201317.","journal-title":"Pharm Dev Technol"},{"issue":"1","key":"2966_CR48","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.ijpharm.2014.11.060","volume":"478","author":"DH Lee","year":"2015","unstructured":"Lee DH, Yeom DW, Song YS, Cho HR, Choi YS, Kang MJ, et al. Improved oral absorption of dutasteride via Soluplus\u00ae-based supersaturable self-emulsifying drug delivery system (S-SEDDS). Int J Pharm. 2015;478(1):341\u20137.","journal-title":"Int J Pharm"},{"key":"2966_CR49","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1017\/S143192761401407X","volume":"21","author":"CIC Crucho","year":"2015","unstructured":"Crucho CIC. Synthesis of Polymeric Nanoparticles for biomedical delivery applications. Microsc Microanal. 2015;21:74.","journal-title":"Microsc Microanal"},{"issue":"1\u20132","key":"2966_CR50","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ijpharm.2017.10.056","volume":"535","author":"MA Repka","year":"2018","unstructured":"Repka MA, Bandari S, Kallakunta VR, Vo AQ, McFall H, Pimparade MB, et al. Melt extrusion with poorly soluble drugs\u2013An integrated review. Int J Pharm. 2018;535(1\u20132):68\u201385.","journal-title":"Int J Pharm"},{"issue":"3","key":"2966_CR51","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.ejpb.2013.03.002","volume":"85","author":"K Zhang","year":"2013","unstructured":"Zhang K, Yu H, Luo Q, Yang S, Lin X, Zhang Y, et al. Increased dissolution and oral absorption of itraconazole\/Soluplus extrudate compared with itraconazole nanosuspension. Eur J Pharm Biopharm. 2013;85(3):1285\u201392.","journal-title":"Eur J Pharm Biopharm"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-024-02966-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-024-02966-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-024-02966-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T15:11:17Z","timestamp":1729696277000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-024-02966-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["2966"],"URL":"https:\/\/doi.org\/10.1208\/s12249-024-02966-9","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"27 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicting interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"241"}}