{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:01:18Z","timestamp":1793721678442,"version":"4.6.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"DOI":"10.1208\/s12249-025-03129-0","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T21:01:40Z","timestamp":1747429300000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Development and Evaluation of Cyclosporine a Mixed Micelle Eye Drops for Enhanced Ocular Drug Delivery"],"prefix":"10.1208","volume":"26","author":[{"given":"Yue","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daquan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9586-7373","authenticated-orcid":false,"given":"Dilei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"3129_CR1","doi-asserted-by":"crossref","unstructured":"Goyal S, Dwivedi P, Kaushik J, Jhanwar M, Singh A, M AC. Innovations in ocular drug delivery. South Asian J Health Prof. 2024;7:59\u201364.","DOI":"10.18231\/j.sajhp.2024.015"},{"key":"3129_CR2","doi-asserted-by":"crossref","unstructured":"Liu L-C, Chen Y-H, Lu D-W. Overview of recent advances in nano-based ocular drug delivery. Int J Mol Sci. 2023;24:15352.","DOI":"10.3390\/ijms242015352"},{"key":"3129_CR3","doi-asserted-by":"crossref","unstructured":"Dosmar E, Walsh J, Doyel M, Bussett K, Oladipupo A, Amer S, et al. Targeting ocular drug delivery: an examination of local anatomy and current approaches. Bioeng. 2022;9:41.","DOI":"10.3390\/bioengineering9010041"},{"key":"3129_CR4","doi-asserted-by":"publisher","first-page":"e2414548","DOI":"10.1002\/advs.202414548","volume":"12","author":"X Jiang","year":"2025","unstructured":"Jiang X, Liu S, Chen J, Lei J, Meng W, Wang X, et al. A transformative wearable corneal microneedle patch for efficient therapy of ocular injury and infection. Adv Sci (Weinh). 2025;12:e2414548.","journal-title":"Adv Sci (Weinh)."},{"key":"3129_CR5","doi-asserted-by":"publisher","first-page":"e41881","DOI":"10.1016\/j.heliyon.2025.e41881","volume":"11","author":"MF Tafti","year":"2025","unstructured":"Tafti MF, Fayyaz Z, Aghamollaei H, Jadidi K, Faghihi S. Drug delivery strategies to improve the treatment of corneal disorders. Heliyon. 2025;11:e41881.","journal-title":"Heliyon"},{"key":"3129_CR6","doi-asserted-by":"publisher","first-page":"107638","DOI":"10.1016\/j.phrs.2025.107638","volume":"213","author":"Q Zhao","year":"2025","unstructured":"Zhao Q, Wei L, Chen Y. From bench to bedside: developing CRISPR\/Cas-based therapy for ocular diseases. Pharmacol Res. 2025;213:107638.","journal-title":"Pharmacol Res."},{"key":"3129_CR7","doi-asserted-by":"publisher","first-page":"e2413962","DOI":"10.1002\/advs.202413962","volume":"12","author":"F Yu","year":"2025","unstructured":"Yu F, Zhao X, Wang Q, Niu Y, Xiao P, Zhang J, et al. Photothermal-responsive soluble microneedle patches for meibomian gland dysfunction therapy. Adv Sci (Weinh). 2025;12:e2413962.","journal-title":"Adv Sci (Weinh)."},{"key":"3129_CR8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3390\/pharmaceutics17010085","volume":"17","author":"SM Martinez","year":"2025","unstructured":"Martinez SM, Inda A, R\u00edos MN, Bessone CDV, Bruera Bossio A, Guido ME, et al. Neuroprotective effect of melatonin loaded in human serum albumin nanoparticles applied subconjunctivally in a retinal degeneration animal model. Pharmaceutics. 2025;17:85.","journal-title":"Pharmaceutics"},{"key":"3129_CR9","first-page":"e77","volume":"3","author":"AC Bisen","year":"2024","unstructured":"Bisen AC, Biswas A, Dubey A, Sanap SN, Agrawal S, Yadav KS, et al. A review on polymers in ocular drug delivery systems. MedComm Biomater Appl. 2024;3:e77.","journal-title":"MedComm Biomater Appl."},{"key":"3129_CR10","doi-asserted-by":"crossref","unstructured":"Pelusi L, Mandatori D, Mastropasqua L, Agnifili L, Allegretti M, Nubile M, et al. Innovation in the development of synthetic and natural ocular drug delivery systems for eye diseases treatment: focusing on drug-loaded ocular inserts, contacts, and intraocular lenses. Pharm. 2023;15:625.","DOI":"10.3390\/pharmaceutics15020625"},{"key":"3129_CR11","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/17425247.2024.2323208","volume":"21","author":"V Paganini","year":"2024","unstructured":"Paganini V, Chetoni P, Gangi MD, Monti D, Tampucci S, Burgalassi S. Nanomicellar eye drops: a review of recent advances. Expert Opin Drug Deliv. 2024;21:381\u201397.","journal-title":"Expert Opin Drug Deliv"},{"key":"3129_CR12","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1124\/jpet.119.256933","volume":"370","author":"V Gote","year":"2019","unstructured":"Gote V, Sikder S, Sicotte J, Pal D. Ocular drug delivery: present innovations and future challenges. J Pharmacol Exp Ther. 2019;370:602\u201324.","journal-title":"J Pharmacol Exp Ther"},{"key":"3129_CR13","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.jconrel.2024.11.050","volume":"377","author":"Q Wei","year":"2025","unstructured":"Wei Q, Zhu C, Yuan G, Jin J, Zhang J, Fan W, et al. Active trans-corneal drug delivery with ocular adhesive micelles for efficient glaucoma therapy. J Control Release. 2025;377:578\u201390.","journal-title":"J Control Release"},{"key":"3129_CR14","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00210-024-03376-1","volume":"398","author":"A Das","year":"2025","unstructured":"Das A, Shahriar TG, Zehravi M, Sweilam SH, Alshehri MA, Ahmad I, et al. Clinical management of eye diseases: carotenoids and their nanoformulations as choice of therapeutics. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:329\u201349.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3129_CR15","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41467-024-55721-w","volume":"16","author":"Z Zhou","year":"2025","unstructured":"Zhou Z, Feng Y, Jiang M, Yao Z, Wang J, Pan F, et al. Ionizable polymeric micelles (IPMs) for efficient siRNA delivery. Nat Commun. 2025;16:360.","journal-title":"Nat Commun"},{"key":"3129_CR16","doi-asserted-by":"publisher","first-page":"e2407043","DOI":"10.1002\/advs.202407043","volume":"11","author":"X Zhou","year":"2024","unstructured":"Zhou X, Rong R, Liang G, Wu Y, Xu C, Xiao H, et al. Self-assembly hypoxic and ROS dual response nano prodrug as a new therapeutic approach for glaucoma treatments. Adv Sci (Weinh). 2024;11:e2407043.","journal-title":"Adv Sci (Weinh)"},{"key":"3129_CR17","doi-asserted-by":"publisher","first-page":"3730","DOI":"10.1016\/j.apsb.2024.05.004","volume":"14","author":"Q Zheng","year":"2024","unstructured":"Zheng Q, Ge C, Li K, Wang L, Xia X, Liu X, et al. Remote-controlled dexamethasone-duration on eye-surface with a micelle-magnetic nanoparticulate co-delivery system for dry eye disease. Acta Pharm Sin B. 2024;14:3730\u201345.","journal-title":"Acta Pharm Sin B"},{"key":"3129_CR18","doi-asserted-by":"crossref","unstructured":"Terreni E, Chetoni P, Burgalassi S, Tampucci S, Zucchetti E, Chipala E, et al. A hybrid ocular delivery system of cyclosporine-A comprising nanomicelle-laden polymeric inserts with improved efficacy and tolerability. Biomater Sci. 2021;9:8235\u201348.","DOI":"10.1039\/D1BM01453F"},{"key":"3129_CR19","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3390\/bioengineering8080115","volume":"8","author":"TR Bjerk","year":"2021","unstructured":"Bjerk TR, Severino P, Jain S, Marques C, Silva AM, Pashirova T, et al. Biosurfactants: properties and applications in drug delivery, biotechnology and ecotoxicology. Bioengineering (Basel). 2021;8:115.","journal-title":"Bioengineering (Basel)"},{"key":"3129_CR20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1089\/jop.2013.0157","volume":"30","author":"AD Vadlapudi","year":"2014","unstructured":"Vadlapudi AD, Cholkar K, Vadlapatla RK, Mitra AK. Aqueous nanomicellar formulation for topical delivery of biotinylated lipid prodrug of acyclovir: formulation development and ocular biocompatibility. J Ocul Pharmacol Ther. 2014;30:49\u201358.","journal-title":"J Ocul Pharmacol Ther"},{"key":"3129_CR21","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s11095-018-2556-5","volume":"36","author":"A Mandal","year":"2019","unstructured":"Mandal A, Gote V, Pal D, Ogundele A, Mitra AK. Ocular pharmacokinetics of a topical ophthalmic nanomicellar solution of cyclosporine (Cequa\u00ae) for dry eye disease. Pharm Res. 2019;36:36.","journal-title":"Pharm Res"},{"key":"3129_CR22","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ijpharm.2015.12.037","volume":"498","author":"K Cholkar","year":"2016","unstructured":"Cholkar K, Gilger BC, Mitra AK. Topical delivery of aqueous micellar resolvin E1 analog (RX-10045). Int J Pharm. 2016;498:326\u201334.","journal-title":"Int J Pharm"},{"key":"3129_CR23","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1208\/s12249-014-0244-2","volume":"16","author":"K Cholkar","year":"2015","unstructured":"Cholkar K, Gunda S, Earla R, Pal D, Mitra AK. Nanomicellar topical aqueous drop formulation of rapamycin for back-of-the-eye delivery. AAPS PharmSciTech. 2015;16:610\u201322.","journal-title":"AAPS PharmSciTech"},{"key":"3129_CR24","doi-asserted-by":"publisher","first-page":"140123","DOI":"10.1016\/j.ijbiomac.2025.140123","volume":"299","author":"D Gu","year":"2025","unstructured":"Gu D, Zhou L, Zhang Y, Jin H, Nie W, Zhang M, et al. N-acetylcysteine and chitosan conjugate modified dexamethasone nanostructured lipid carriers: Enhanced permeability, precorneal retention and lower inflammation for the treatment of dry eye syndrome. Int J Biol Macromol. 2025;299:140123.","journal-title":"Int J Biol Macromol."},{"key":"3129_CR25","doi-asserted-by":"publisher","first-page":"125313","DOI":"10.1016\/j.saa.2024.125313","volume":"327","author":"S Roya Alizadeh","year":"2025","unstructured":"Roya Alizadeh S, Biparva P, Hashemi Z, Ali EM. A colorimetric sensor based on 2,3-bis(6-chloropyridin-2-yl)-6-fluoroquinoxaline for naked-eye detection of Iron (III) and its application in real sample analysis. Spectrochim Acta A Mol Biomol Spectrosc. 2025;327:125313.","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"3129_CR26","doi-asserted-by":"publisher","first-page":"114206","DOI":"10.1016\/j.colsurfb.2024.114206","volume":"245","author":"L Yu","year":"2025","unstructured":"Yu L, Meng Q, Li M, Tian L, Wu X, Jie Y. Heating-driven self-assembled glycyrrhizin nanomicelles loading bisdemethoxycurcumin: preparation, characterization, and efficacy evaluation on experimental dry eye. Colloids Surf B Biointerfaces. 2025;245:114206.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"3129_CR27","doi-asserted-by":"publisher","first-page":"2372279","DOI":"10.1080\/10717544.2024.2372279","volume":"31","author":"K Krzeminska","year":"2024","unstructured":"Krzeminska K, Sznitowska M, Wroblewska M, Wolska E, Winnicka K. Suspensions of antibiotics in self-emulsifying oils as a novel approach to formulate eye drops with substances which undergo hydrolysis in aqueous environment. Drug Deliv. 2024;31:2372279.","journal-title":"Drug Deliv"},{"issue":"25","key":"3129_CR28","first-page":"00101","volume":"S0168\u20133659","author":"F Abdelrahman","year":"2025","unstructured":"Abdelrahman F, Makky S, Teba HE, Agwa MM, Abd ElAziz MM, Awad R, et al. Potential of vB_Pa_ZCPS1 phage embedded in situ gelling formulations as an ocular delivery system to attenuate Pseudomonas aeruginosa keratitis in a rabbit model. J Control Release. 2025;S0168\u20133659(25):00101\u20134.","journal-title":"J Control Release"},{"key":"3129_CR29","doi-asserted-by":"publisher","first-page":"177323","DOI":"10.1016\/j.ejphar.2025.177323","volume":"991","author":"F Conti","year":"2025","unstructured":"Conti F, Lazzara F, Thermos K, Zingale E, Spyridakos D, Romano GL, et al. Retinal pharmacodynamic and pharmacokinetics profile of cannabidiol in an in vivo model of retinal excitotoxicity. Eur J Pharmacol. 2025;991:177323.","journal-title":"Eur J Pharmacol."},{"key":"3129_CR30","doi-asserted-by":"crossref","unstructured":"Elnaggar YSR, Othman AMM, Farahat A, Essawy M, Omar SI. Formulation and clinical evaluation of hyaluronic acid nanogel in treatment of tear trough: nano-flipping from injectable fillers to topical nanofillers. Pharm Dev Technol. 2025;30:150\u20139.","DOI":"10.1080\/10837450.2025.2459908"},{"key":"3129_CR31","doi-asserted-by":"publisher","first-page":"136","DOI":"10.3390\/pharmaceutics17010136","volume":"17","author":"S Jacob","year":"2025","unstructured":"Jacob S, Kather FS, Boddu SHS, Attimarad M, Nair AB. Nanosuspension innovations: expanding horizons in drug delivery techniques. Pharmaceutics. 2025;17:136.","journal-title":"Pharmaceutics"},{"key":"3129_CR32","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/gels11010019","volume":"11","author":"MM Badran","year":"2024","unstructured":"Badran MM, Alsubaie A, Bekhit MMS, Alomrani AH, Almomen A. Layer-by-layer biopolymer-coated deformable liposomes-in situ gel: a hybrid strategy for enhanced ocular delivery of itraconazole: in vitro and in vivo appraisal. Gels. 2024;11:19.","journal-title":"Gels"},{"key":"3129_CR33","doi-asserted-by":"publisher","first-page":"200","DOI":"10.3390\/biomedicines13010200","volume":"13","author":"A Karami","year":"2025","unstructured":"Karami A, Mirzaeei S, Rezaei L, Nokhodchi A. Development and evaluation of polymethacrylate-based ophthalmic nanofiber inserts containing dual drug-loaded dorzolamide and timolol: in vivo study in rabbit\u2019s eye. Biomedicines. 2025;13:200.","journal-title":"Biomedicines."},{"key":"3129_CR34","first-page":"263300402513141","volume":"6","author":"TA Shalwani","year":"2025","unstructured":"Shalwani TA, Khowaja A, Punjwani N. Behcet\u2019s disease in a tertiary eye hospital in Pakistan. Ther Adv Rare Dis. 2025;6:26330040251314130.","journal-title":"Ther Adv Rare Dis"},{"key":"3129_CR35","doi-asserted-by":"publisher","first-page":"e202402441","DOI":"10.1002\/chem.202402441","volume":"31","author":"Z Ren","year":"2025","unstructured":"Ren Z, Liu X, Lv G, Wang X, Wang J, Wu W, et al. Mitochondrial localization of antioxidant nanodrug suppresses ocular inflammation by alleviating oxidative stress on cells. Chemistry. 2025;31:e202402441.","journal-title":"Chemistry."},{"key":"3129_CR36","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.2174\/0113816128350573241202105210","volume":"31","author":"A Kishore","year":"2025","unstructured":"Kishore A, Jain A, Asthana N, Milan R, Lakshmi SM, Gupta M, et al. Selection criteria for oils, surfactants, and co-surfactants in ocular nanoemulsion formulation: a mini review. Curr Pharm Des. 2025;31:1259\u201369.","journal-title":"Curr Pharm Des."},{"key":"3129_CR37","doi-asserted-by":"publisher","first-page":"112076","DOI":"10.1016\/j.msec.2021.112076","volume":"124","author":"J Fardous","year":"2021","unstructured":"Fardous J, Omoso Y, Joshi A, Yoshida K, Patwary MKA, Ono F, et al. Development and characterization of gel-in-water nanoemulsion as a novel drug delivery system. Mater Sci Eng C Mater Biol Appl. 2021;124:112076.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"3129_CR38","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/j.xphs.2019.01.016","volume":"108","author":"SS Ibrahim","year":"2019","unstructured":"Ibrahim SS. The role of surface active agents in ophthalmic drug delivery: a comprehensive review. J Pharm Sci. 2019;108:1923\u201333.","journal-title":"J Pharm Sci"},{"key":"3129_CR39","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3390\/ma9090761","volume":"9","author":"J-T Lo","year":"2016","unstructured":"Lo J-T, Lee T-M, Chen B-H. Nonionic microemulsions as solubilizers of hydrophobic drugs: solubilization of paclitaxel. Materials. 2016;9:761.","journal-title":"Materials"},{"key":"3129_CR40","doi-asserted-by":"crossref","unstructured":"Shannigrahi M, Bagchi S. Novel fluorescent probe as aggregation predictor and micro-polarity reporter for micelles and mixed micelles. Spectrochim Acta A Mol Biomol Spectrosc. 2005;61:2131\u20138.","DOI":"10.1016\/j.saa.2004.08.012"},{"key":"3129_CR41","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0039-6257(01)00211-9","volume":"45","author":"KR Wilhelmus","year":"2001","unstructured":"Wilhelmus KR. The Draize eye test. Surv Ophthalmol. 2001;45:493\u2013515.","journal-title":"Surv Ophthalmol"},{"key":"3129_CR42","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0021-9797(02)00082-6","volume":"258","author":"J Aguiar","year":"2003","unstructured":"Aguiar J, Carpena P, Molina-Bol\u0131\u0301var JA, Carnero Ruiz C. On the determination of the critical micelle concentration by the pyrene 1:3 ratio method. J Colloid Interface Sci. 2003;258:116\u201322.","journal-title":"J Colloid Interface Sci"},{"key":"3129_CR43","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1016\/j.xphs.2018.08.002","volume":"107","author":"K Wu","year":"2018","unstructured":"Wu K, Gore A, Graham R. A new hydrate of cyclosporine: structural and physicochemical characterization. J Pharm Sci. 2018;107:3070\u20139.","journal-title":"J Pharm Sci"},{"key":"3129_CR44","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ejpb.2017.10.001","volume":"122","author":"M Doreth","year":"2018","unstructured":"Doreth M, L\u00f6bmann K, Priemel P, Grohganz H, Taylor R, Holm R, et al. Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin. Eur J Pharm Biopharm. 2018;122:62\u20139.","journal-title":"Eur J Pharm Biopharm"},{"key":"3129_CR45","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1039\/D4OB01685H","volume":"23","author":"ED Sultanova","year":"2025","unstructured":"Sultanova ED, Bogdanov IM, Gromova NI, Astrakhantseva AV, Kapralov MA, Nizamutdinov AS, et al. Synthesis of zwitterionic asymmetric and symmetric carboxy-imidazolium derivatives and their use in molecular interactions with bovine serum albumin. Org Biomol Chem. 2025;23:1981\u201394.","journal-title":"Org Biomol Chem."},{"key":"3129_CR46","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1021\/acs.molpharmaceut.1c00650","volume":"18","author":"A Gawin-Miko\u0142ajewicz","year":"2021","unstructured":"Gawin-Miko\u0142ajewicz A, Nartowski KP, Dyba AJ, Go\u0142kowska AM, Malec K, Karolewicz B. Ophthalmic nanoemulsions: from composition to technological processes and quality control. Mol Pharm. 2021;18:3719\u201340.","journal-title":"Mol Pharm"},{"key":"3129_CR47","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.3390\/polym13183038","volume":"13","author":"C Ponnusamy","year":"2021","unstructured":"Ponnusamy C, Sugumaran A, Krishnaswami V, Palanichamy R, Velayutham R, Natesan S. Development and evaluation of Polyvinylpyrrolidone K90 and Poloxamer 407 self-assembled nanomicelles: enhanced topical ocular delivery of artemisinin. Polymers (Basel). 2021;13:3038.","journal-title":"Polymers (Basel)"},{"key":"3129_CR48","doi-asserted-by":"crossref","unstructured":"Dong S, Zhang N, Yi M, Zhang J, Di D, Deng J, et al. Slug-flow microextraction mass spectrometry for enhanced detection of analytes in human tear fluids using noninvasive microsampling and nanoelectrospray ionization via a capillary. Anal Chem. 2023;95:16054\u20138.","DOI":"10.1021\/acs.analchem.3c03683"},{"key":"3129_CR49","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1097\/ICO.0000000000003330","volume":"43","author":"T Saito","year":"2023","unstructured":"Saito T, Suzuki T, Nakayama C, Kato Y, Kakisu K, Itokawa T, et al. Measurement of anions in tear fluid using ion chromatography. Cornea. 2023;43:172\u20137.","journal-title":"Cornea"},{"key":"3129_CR50","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.carbpol.2019.03.103","volume":"215","author":"AY Meliko\u011flu","year":"2019","unstructured":"Meliko\u011flu AY, Bilek SE, Cesur S. Optimum alkaline treatment parameters for the extraction of cellulose and production of cellulose nanocrystals from apple pomace. Carbohydr Polym. 2019;215:330\u20137.","journal-title":"Carbohydr Polym"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-025-03129-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-025-03129-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-025-03129-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T17:03:08Z","timestamp":1751907788000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-025-03129-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":50,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["3129"],"URL":"https:\/\/doi.org\/10.1208\/s12249-025-03129-0","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]},"assertion":[{"value":"6 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"136"}}