{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:33:36Z","timestamp":1787697216025,"version":"build-2784847793"},"reference-count":90,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIBAA 28720210100113CO"],"award-info":[{"award-number":["PIBAA 28720210100113CO"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agencia Nacional de Laboratorios P\u00fablicos","award":["EX-2020-50428127-APN-ANLAP#MS"],"award-info":[{"award-number":["EX-2020-50428127-APN-ANLAP#MS"]}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2021-GRT-TI-00524"],"award-info":[{"award-number":["PICT-2021-GRT-TI-00524"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005740","name":"Universidad Nacional del Sur","doi-asserted-by":"publisher","award":["PGI 24\/B339"],"award-info":[{"award-number":["PGI 24\/B339"]}],"id":[{"id":"10.13039\/501100005740","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005740","name":"Universidad Nacional del Sur","doi-asserted-by":"publisher","award":["PGI 24\/B306"],"award-info":[{"award-number":["PGI 24\/B306"]}],"id":[{"id":"10.13039\/501100005740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"DOI":"10.1208\/s12249-025-03208-2","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T16:33:53Z","timestamp":1755102833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Palatable Orally Disintegrating Tablets of Losartan Potassium Developed by Spray-drying Technique and Direct Compression Intended for Pediatric Use"],"prefix":"10.1208","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0299-9041","authenticated-orcid":false,"given":"Candela","family":"Juan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0687-0096","authenticated-orcid":false,"given":"Noelia","family":"Gonzalez Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-9620","authenticated-orcid":false,"given":"Loreana","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,13]]},"reference":[{"key":"3208_CR1","unstructured":"Pediam\u00e9cum. Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Espa\u00f1a. 2015. https:\/\/www.aeped.es\/comite-medicamentos\/pediamecum\/losartan. Accessed 25 Mar 2025."},{"key":"3208_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2017-1904","volume":"140","author":"JT Flynn","year":"2017","unstructured":"Flynn JT, Kaelber DC, Baker-Smith CM, Blowey D, Carroll AE, Daniels SR, et al. Clinical practice guideline for screening and management of high blood pressure in children and adolescents. Pediatrics. 2017;140:1\u201372. https:\/\/doi.org\/10.1542\/peds.2017-1904.","journal-title":"Pediatrics"},{"key":"3208_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biopha.2021.112576","volume":"146","author":"J Johannesson","year":"2022","unstructured":"Johannesson J, Hansson P, Bergstr\u00f6m CAS, Paulsson M. Manipulations and age-appropriateness of oral medications in pediatric oncology patients in Sweden: need for personalized dosage forms. Biomed Pharmacother. 2022;146:1\u201311. https:\/\/doi.org\/10.1016\/j.biopha.2021.112576.","journal-title":"Biomed Pharmacother"},{"key":"3208_CR4","unstructured":"Formulario farmacoterap\u00e9utico online del Hospital de Pediatr\u00eda Garrahan https:\/\/farmacia.garrahan.gov.ar\/Vademecum\/Busqueda. Accessed 8 Mar 2025."},{"key":"3208_CR5","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1080\/10837450.2019.1615090","volume":"24","author":"T Comoglu","year":"2019","unstructured":"Comoglu T, Dilek OE. Orally disintegrating tablets and orally disintegrating mini tablets\u2013novel dosage forms for pediatric use. Pharm Dev Technol. 2019;24:902\u201314. https:\/\/doi.org\/10.1080\/10837450.2019.1615090.","journal-title":"Pharm Dev Technol"},{"issue":"4","key":"3208_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy8040186","volume":"8","author":"M Chinwala","year":"2020","unstructured":"Chinwala M. Recent formulation advances and therapeutic usefulness of orally disintegrating tablets (ODTs). Pharmacy (Basel). 2020;8(4): 186:1\u201311. https:\/\/doi.org\/10.3390\/pharmacy8040186.","journal-title":"Pharmacy (Basel)"},{"key":"3208_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-019-1579-5","volume":"21","author":"J Concei\u00e7\u00e3o","year":"2020","unstructured":"Concei\u00e7\u00e3o J, Adeoye O, Cabral-Marques H, Concheiro A, Alvarez-Lorenzo C, Sousa Lobo JM. Orodispersible carbamazepine\/hydroxypropyl-\u03b2-cyclodextrin tablets obtained by direct compression with five-in-one co-processed excipients. AAPS PharmSciTech. 2020;21:1\u201310. https:\/\/doi.org\/10.1208\/s12249-019-1579-5.","journal-title":"AAPS PharmSciTech"},{"key":"3208_CR8","doi-asserted-by":"publisher","unstructured":"Tranov\u00e1 T, Loskot J, Navr\u00e1til O, Brniak W, Mu\u017e\u00edkov\u00e1 J. Effect of co-processed excipient type on properties of orodispersible tablets containing captopril, tramadol, and domperidone. Int J Pharm. 2023;636:122838. https:\/\/doi.org\/10.1016\/j.ijpharm.2023.122838. 1-10.","DOI":"10.1016\/j.ijpharm.2023.122838"},{"key":"3208_CR9","first-page":"2294","volume":"4","author":"RR Thakur","year":"2011","unstructured":"Thakur RR, Sharma A, Kashiv M. Formulation, evaluation and optimization of mouth dissolving tablet of losartan potassium: a cost effective antihypertensive drug. J Pharm Res. 2011;4:2294\u20136.","journal-title":"J Pharm Res"},{"key":"3208_CR10","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.ijpharm.2013.07.054","volume":"457","author":"A Ferrarini","year":"2013","unstructured":"Ferrarini A, Bianchetti AA, Fossali EF, Far\u00e9 PB, Simonetti GD, Lava SAG, et al. What can we do to make antihypertensive medications taste better for children? Int J Pharm. 2013;457:333\u20136. https:\/\/doi.org\/10.1016\/j.ijpharm.2013.07.054.","journal-title":"Int J Pharm"},{"key":"3208_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pharmaceutics14030570","volume":"14","author":"V Elezaj","year":"2022","unstructured":"Elezaj V, Lura A, Canha L, Breitkreutz J. Pharmaceutical development of film-coated mini-tablets with losartan potassium for epidermolysis bullosa. Pharmaceutics. 2022;14:1\u201317. https:\/\/doi.org\/10.3390\/pharmaceutics14030570.","journal-title":"Pharmaceutics"},{"key":"3208_CR12","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1021\/acs.molpharmaceut.2c00199","volume":"19","author":"J Yu","year":"2022","unstructured":"Yu J, Xie J, Xie H, Hu Q, Wu Z, Cai X, et al. Strategies for taste masking of orodispersible dosage forms: time, concentration, and perception. Mol Pharm. 2022;19:3007\u201325. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.2c00199.","journal-title":"Mol Pharm"},{"key":"3208_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ejpb.2017.03.017","volume":"126","author":"NT Tung","year":"2018","unstructured":"Tung NT, Tran CS, Nguyen TL, Hoang T, Trinh TD, Nguyen TN. Formulation and biopharmaceutical evaluation of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. Eur J Pharm Biopharm. 2018;126:187\u2013200. https:\/\/doi.org\/10.1016\/j.ejpb.2017.03.017.","journal-title":"Eur J Pharm Biopharm"},{"key":"3208_CR14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1248\/bpb.b14-00467","volume":"38","author":"R Matsui","year":"2015","unstructured":"Matsui R, Uchida S, Namiki N. Combination effect of physical and gustatory taste masking for propiverine hydrochloride orally disintegrating tablets on palatability. Biol Pharm Bull. 2015;38:17\u201322. https:\/\/doi.org\/10.1248\/bpb.b14-00467.","journal-title":"Biol Pharm Bull"},{"key":"3208_CR15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/10837450.2019.1687521","volume":"25","author":"II Soliman","year":"2020","unstructured":"Soliman II, Kandil SM, Abdou EM. Gabapentin\u2013saccharin co-crystals with enhanced physicochemical properties and in vivo absorption formulated as oro-dispersible tablets. Pharm Dev Technol. 2020;25:227\u201336. https:\/\/doi.org\/10.1080\/10837450.2019.1687521.","journal-title":"Pharm Dev Technol"},{"key":"3208_CR16","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1248\/cpb.59.920","volume":"59","author":"R Sheshala","year":"2011","unstructured":"Sheshala R, Khan N, Darwis Y. Formulation and optimization of orally disintegrating tablets of sumatriptan succinate. Chem Pharm Bull. 2011;59:920\u20138. https:\/\/doi.org\/10.1248\/cpb.59.920.","journal-title":"Chem Pharm Bull"},{"key":"3208_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119807","volume":"589","author":"S Farias","year":"2020","unstructured":"Farias S, Boateng JS. In vitro, ex vivo and in vivo evaluation of taste masked low dose acetylsalicylic acid loaded composite wafers as platforms for buccal administration in geriatric patients with dysphagia. Int J Pharm. 2020;589: 119807. https:\/\/doi.org\/10.1016\/j.ijpharm.2020.119807.","journal-title":"Int J Pharm"},{"key":"3208_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pharmaceutics11010011","volume":"11","author":"HA Al-Gethmy","year":"2019","unstructured":"Al-Gethmy HA, Fahmy UA, Alhakamy NA, Ahmed OAA, El-Say KM. Optimization of the factors affecting the absorption of vardenafil from oral disintegrating tablets: a clinical pharmacokinetic investigation. Pharmaceutics. 2019;11:1\u201313. https:\/\/doi.org\/10.3390\/pharmaceutics11010011.","journal-title":"Pharmaceutics"},{"key":"3208_CR19","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3109\/03639045.2013.789907","volume":"40","author":"H Lou","year":"2014","unstructured":"Lou H, Liu M, Qu W, Hu Z, Brunson E, Johnson J, et al. Evaluation of chlorpheniramine maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics. Drug Dev Ind Pharm. 2014;40:910\u20138. https:\/\/doi.org\/10.3109\/03639045.2013.789907.","journal-title":"Drug Dev Ind Pharm"},{"key":"3208_CR20","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.msec.2016.03.086","volume":"64","author":"JM Nadal","year":"2016","unstructured":"Nadal JM, Gomes MLS, Borsato DM, Almeida MA, Barboza FM, Zawadzki SF, et al. Spray-dried Eudragit\u00ae L100 microparticles containing ferulic acid: formulation, in vitro cytoprotection and in vivo anti-platelet effect. Materials Science and Engineering: C. 2016;64:318\u201328. https:\/\/doi.org\/10.1016\/j.msec.2016.03.086.","journal-title":"Materials Science and Engineering: C"},{"key":"3208_CR21","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.powtec.2018.10.041","volume":"342","author":"L Gallo","year":"2019","unstructured":"Gallo L, Ver\u00f3nica Ram\u00edrez-Rigo M, Bucal\u00e1 V. Development of porous spray-dried inhalable particles using an organic solvent-free technique. Powder Technol. 2019;342:642\u201352. https:\/\/doi.org\/10.1016\/j.powtec.2018.10.041.","journal-title":"Powder Technol"},{"key":"3208_CR22","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1080\/07373937.2021.1893330","volume":"39","author":"S Pardeshi","year":"2021","unstructured":"Pardeshi S, More M, Patil P, Pardeshi C, Deshmukh P, Mujumdar A, et al. A meticulous overview on drying-based (spray-, freeze-, and spray-freeze) particle engineering approaches for pharmaceutical technologies. Dry Technol. 2021;39:1447\u201391. https:\/\/doi.org\/10.1080\/07373937.2021.1893330.","journal-title":"Dry Technol"},{"key":"3208_CR23","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1208\/s12249-010-9489-6","volume":"11","author":"M Cetin","year":"2010","unstructured":"Cetin M, Atila A, Kadioglu Y. Formulation and in vitro characterization of Eudragit\u00ae L100 and Eudragit\u00ae L100-PLGA nanoparticles containing diclofenac sodium. AAPS PharmSciTech. 2010;11:1250\u20136. https:\/\/doi.org\/10.1208\/s12249-010-9489-6.","journal-title":"AAPS PharmSciTech"},{"key":"3208_CR24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/jphp.12319","volume":"67","author":"M Maniruzzaman","year":"2014","unstructured":"Maniruzzaman M, Douroumis D. An in-vitro-in-vivo taste assessment of bitter drug: comparative electronic tongues study. J Pharm Pharmacol. 2014;67:43\u201355. https:\/\/doi.org\/10.1111\/jphp.12319.","journal-title":"J Pharm Pharmacol"},{"issue":"9","key":"3208_CR25","doi-asserted-by":"publisher","first-page":"104","DOI":"10.9734\/bpi\/tipr\/v9\/11366d","volume":"5","author":"BM Raut","year":"2019","unstructured":"Raut BM, Bakade BV, Bompelwar SS. Design and development of taste masked formulations of model drug by using Eudragit L-100: a recent study. Technol Innov Pharm Res. 2019;5(9):104\u201313. https:\/\/doi.org\/10.9734\/bpi\/tipr\/v9\/11366d.","journal-title":"Technol Innov Pharm Res"},{"key":"3208_CR26","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.biopha.2014.10.010","volume":"68","author":"DJ Jang","year":"2014","unstructured":"Jang DJ, Bae SK, Oh E. Coated dextrin microcapsules of amlodipine incorporable into orally disintegrating tablets for geriatric patients. Biomed Pharmacother. 2014;68:1117\u201324. https:\/\/doi.org\/10.1016\/j.biopha.2014.10.010.","journal-title":"Biomed Pharmacother"},{"key":"3208_CR27","doi-asserted-by":"publisher","first-page":"118922","DOI":"10.1016\/j.ijpharm.2019.118922","volume":"574","author":"A Lopalco","year":"2020","unstructured":"Lopalco A, Denora N, Laquintana V, Cutrignelli A, Franco M, Robota M, et al. Taste masking of propranolol hydrochloride by microbeads of Eudragit\u00ae E PO obtained with prilling technique for paediatric oral administration. Int J Pharm. 2020;574:118922. https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118922.","journal-title":"Int J Pharm"},{"key":"3208_CR28","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1080\/03639045.2016.1220572","volume":"43","author":"M Dra\u0161kovi\u0107","year":"2017","unstructured":"Dra\u0161kovi\u0107 M, Medarevi\u0107 D, Aleksi\u0107 I, Paroj\u010di\u0107 J. In vitro and in vivo investigation of taste-masking effectiveness of Eudragit E PO as drug particle coating agent in orally disintegrating tablets. Drug Dev Ind Pharm. 2017;43:723\u201331. https:\/\/doi.org\/10.1080\/03639045.2016.1220572.","journal-title":"Drug Dev Ind Pharm"},{"key":"3208_CR29","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1691\/ph.2020.9123","volume":"75","author":"Y Georgieva","year":"2020","unstructured":"Georgieva Y, Kassarova M, Kokova V, Apostolova E, Pilicheva B. Taste masking of enalapril maleate by microencapsulation in Eudragit EPO\u00ae microparticles. Pharmazie. 2020;75:61\u20139. https:\/\/doi.org\/10.1691\/ph.2020.9123.","journal-title":"Pharmazie"},{"key":"3208_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104290","volume":"81","author":"FM Stavras","year":"2023","unstructured":"Stavras FM, Partheniadis I, Nikolakakis I. Formulation of taste-masked orodispersible famotidine tablets by sequential spray drying and direct compression \u2013 bitterness evaluation. J Drug Deliv Sci Technol. 2023;81: 104290. https:\/\/doi.org\/10.1016\/j.jddst.2023.104290.","journal-title":"J Drug Deliv Sci Technol"},{"key":"3208_CR31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejps.2013.09.001","volume":"51","author":"K Kondo","year":"2014","unstructured":"Kondo K, Niwa T, Danjo K. Preparation of sustained-release coated particles by novel microencapsulation method using three-fluid nozzle spray drying technique. Eur J Pharm Sci. 2014;51:11\u20139. https:\/\/doi.org\/10.1016\/j.ejps.2013.09.001.","journal-title":"Eur J Pharm Sci"},{"issue":"5","key":"3208_CR32","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1080\/03639045.2016.1200070","volume":"43","author":"M Taki","year":"2016","unstructured":"Taki M, Tagami T, Ozeki T. Preparation of polymer-blended quinine nanocomposite particles by spray drying and assessment of their instrumental bitterness-masking effect using a taste sensor. Drug Dev Ind Pharm. 2016;43(5):715\u201322. https:\/\/doi.org\/10.1080\/03639045.2016.1200070.","journal-title":"Drug Dev Ind Pharm"},{"key":"3208_CR33","doi-asserted-by":"publisher","first-page":"124191","DOI":"10.1016\/j.ijpharm.2024.124191","volume":"658","author":"LA Felton","year":"2024","unstructured":"Felton LA, Binzet G, Wiley C, McChesney D, McConville J, \u04aaelik M, et al. Spray drying Eudragit\u00ae E-PO with acetaminophen using 2- and 3-fluid nozzles for taste masking. Int J Pharm. 2024;658:124191. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.124191.","journal-title":"Int J Pharm"},{"key":"3208_CR34","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/jps.22291","volume":"100","author":"K Rizi","year":"2011","unstructured":"Rizi K, Green RJ, Donaldson M, Williams AC. Production of pH-responsive microparticles by spray drying: investigation of experimental parameter effects on morphological and release properties. J Pharm Sci. 2011;100:566\u201379. https:\/\/doi.org\/10.1002\/jps.22291.","journal-title":"J Pharm Sci"},{"key":"3208_CR35","first-page":"833","volume":"71","author":"A Jankowski","year":"2014","unstructured":"Jankowski A, Balwiarz R, Marciniak D, \u0141ukowiec D, Pluta J. Influence of spray drying manufacturing parameters on quality of losartan potassium microspheres. Acta Pol Pharm. 2014;71:833\u201341.","journal-title":"Acta Pol Pharm"},{"key":"3208_CR36","doi-asserted-by":"publisher","unstructured":"Pininnti A, Ponnoth DS, Dave R. Repurposing losartan as Dry Powder Inhalation (DPI) for asthma related cardiovascular complications. FASEB J. 2020;34. https:\/\/doi.org\/10.1096\/fasebj.2020.34.s1.06210.","DOI":"10.1096\/fasebj.2020.34.s1.06210"},{"key":"3208_CR37","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1080\/07373937.2016.1269807","volume":"35","author":"M Hamzehloo","year":"2017","unstructured":"Hamzehloo M, Karimi J, Eghbali N, Mirzakhani M, Aghapoor K, Darabi HR. A new blend of polymeric encapsulation of azithromycin by spray-drying with a pH responsive in drug release. Dry Technol. 2017;35:1688\u201395. https:\/\/doi.org\/10.1080\/07373937.2016.1269807.","journal-title":"Dry Technol"},{"key":"3208_CR38","doi-asserted-by":"publisher","unstructured":"Raffin Pohlmann A, Weiss V, Mertins O, Pesce da Silveira N, Stanis\u00e7uaski Guterres S. Spray-dried indomethacin-loaded polyester nanocapsules and nanospheres: development, stability evaluation and nanostructure models. Eur J Pharm Sci. 2002;16:305\u201312. https:\/\/doi.org\/10.1016\/S0928-0987(02)00127-6.","DOI":"10.1016\/S0928-0987(02)00127-6"},{"key":"3208_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/polym11030522","volume":"11","author":"K Wasilewska","year":"2019","unstructured":"Wasilewska K, Szekalska M, Ciosek-Skibinska P, Lenik J, Basa A, Jacyna J, et al. Ethylcellulose in organic solution or aqueous dispersion form in designing taste-masked microparticles by the spray drying technique with a model bitter drug: rupatadine fumarate. Polymers. 2019;11: 1\u201317. https:\/\/doi.org\/10.3390\/polym11030522.","journal-title":"Polymers"},{"key":"3208_CR40","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1080\/03639040802516491","volume":"35","author":"WL Hulse","year":"2009","unstructured":"Hulse WL, Forbes RT, Bonner MC, Getrost M. The characterization and comparison of spray-dried mannitol samples characterization of spray-dried mannitol. Drug Dev Ind Pharm. 2009;35:712\u20138. https:\/\/doi.org\/10.1080\/03639040802516491.","journal-title":"Drug Dev Ind Pharm"},{"key":"3208_CR41","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jpba.2011.05.008","volume":"56","author":"A Pom\u00e1zi","year":"2011","unstructured":"Pom\u00e1zi A, Ambrus R, Sipos P, Szab\u00f3-R\u00e9v\u00e9sz P. Analysis of co-spray-dried meloxicam-mannitol systems containing crystalline microcomposites. J Pharm Biomed Anal. 2011;56:183\u201390. https:\/\/doi.org\/10.1016\/j.jpba.2011.05.008.","journal-title":"J Pharm Biomed Anal"},{"key":"3208_CR42","volume-title":"USP 44 - NF 39","author":"The United States Pharmacopeia and National Formulary","year":"2021","unstructured":"The United States Pharmacopeia and National Formulary. USP 44 - NF 39. Rockville: The United States Pharmacopeial Convention, Inc.; 2021."},{"key":"3208_CR43","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.ijpharm.2014.03.001","volume":"466","author":"EJ Yi","year":"2014","unstructured":"Yi EJ, Kim JY, Rhee YS, Kim SH, Lee HJ, Park CW, et al. Preparation of sildenafil citrate microcapsules and in vitro\/in vivo evaluation of taste masking efficiency. Int J Pharm. 2014;466:286\u201395. https:\/\/doi.org\/10.1016\/j.ijpharm.2014.03.001.","journal-title":"Int J Pharm"},{"key":"3208_CR44","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jpba.2013.06.016","volume":"87","author":"R Chadha","year":"2014","unstructured":"Chadha R, Bhandari S. Drug-excipient compatibility screening - role of thermoanalytical and spectroscopic techniques. J Pharm Biomed Anal. 2014;87:82\u201397. https:\/\/doi.org\/10.1016\/j.jpba.2013.06.016.","journal-title":"J Pharm Biomed Anal"},{"key":"3208_CR45","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ijpharm.2012.05.045","volume":"440","author":"F Palazzo","year":"2013","unstructured":"Palazzo F, Giovagnoli S, Schoubben A, Blasi P, Rossi C, Ricci M. Development of a spray-drying method for the formulation of respirable microparticles containing ofloxacin-palladium complex. Int J Pharm. 2013;440:273\u201382. https:\/\/doi.org\/10.1016\/j.ijpharm.2012.05.045.","journal-title":"Int J Pharm"},{"key":"3208_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0178772","volume":"12","author":"H Alyami","year":"2017","unstructured":"Alyami H, Dahmash E, Bowen J, Mohammed AR. An investigation into the effects of excipient particle size, blending techniques & processing parameters on the homogeneity & content uniformity of a blend containing low-dose model drug. PLoS One. 2017;12:1\u201319. https:\/\/doi.org\/10.1371\/journal.pone.0178772.","journal-title":"PLoS One"},{"key":"3208_CR47","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1016\/j.jsps.2022.09.002","volume":"30","author":"AM Eisa","year":"2022","unstructured":"Eisa AM, El-Megrab NA, El-Nahas HM. Formulation and evaluation of fast dissolving tablets of haloperidol solid dispersion. Saudi Pharm J. 2022;30:1589\u2013602. https:\/\/doi.org\/10.1016\/j.jsps.2022.09.002.","journal-title":"Saudi Pharm J"},{"key":"3208_CR48","unstructured":"European Pharmacopoeia. 10th ed. Strasbourg, France: European directorate for the quality of medicines & healthcare, council of Europe; 2019."},{"key":"3208_CR49","unstructured":"Farmacopea Argentina, 7ma edici\u00f3n. ANMAT, Ministerio de Salud de la Naci\u00f3n. Ciudad Aut\u00f3noma de Buenos Aires; 2013. https:\/\/www.argentina.gob.ar\/sites\/default\/files. Accessed 20 Jan 2025."},{"key":"3208_CR50","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.2042-7158.1975.tb09378.x","volume":"27","author":"KA Khan","year":"1975","unstructured":"Khan KA. The concept of dissolution efficiency. J Pharm Pharmacol. 1975;27:48\u20139. https:\/\/doi.org\/10.1111\/j.2042-7158.1975.tb09378.x.","journal-title":"J Pharm Pharmacol"},{"key":"3208_CR51","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.drudis.2016.05.014","volume":"21","author":"AHA Mohamed-Ahmed","year":"2016","unstructured":"Mohamed-Ahmed AHA, Soto J, Ernest T, Tuleu C. Non-human tools for the evaluation of bitter taste in the design and development of medicines: A systematic review. Drug Discov Today. 2016;21:1170\u201380. https:\/\/doi.org\/10.1016\/j.drudis.2016.05.014.","journal-title":"Drug Discov Today"},{"key":"3208_CR52","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1080\/10837450.2019.1579228","volume":"24","author":"GM Mahrous","year":"2019","unstructured":"Mahrous GM, Ibrahim MA, Mostafa HF, Elzayat EM. Application of a quality-by-design approach for utilizing sodium stearyl fumarate as a taste-masking agent in dextromethorphan hydrobromide orally disintegrating tablets. Pharm Dev Technol. 2019;24:711\u20139. https:\/\/doi.org\/10.1080\/10837450.2019.1579228.","journal-title":"Pharm Dev Technol"},{"key":"3208_CR53","doi-asserted-by":"publisher","first-page":"797","DOI":"10.2165\/00003088-200544080-00003","volume":"44","author":"DA Sica","year":"2005","unstructured":"Sica DA, Gehr TW, Ghosh S. Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44:797\u2013814. https:\/\/doi.org\/10.2165\/00003088-200544080-00003.","journal-title":"Clin Pharmacokinet"},{"issue":"3","key":"3208_CR54","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/chemse\/bjl052","volume":"32","author":"RSJ Keast","year":"2007","unstructured":"Keast RSJ, Roper J. A complex relationship among chemical concentration, detection threshold, and suprathreshold intensity of bitter compounds. Chem Senses. 2007;32(3):245\u201353. https:\/\/doi.org\/10.1093\/chemse\/bjl052.","journal-title":"Chem Senses"},{"key":"3208_CR55","unstructured":"The World Medical Association. Declaration of Helsinki, 2013. https:\/\/www.wma.net\/policies-post\/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects\/. Accessed 27 Feb 2025."},{"key":"3208_CR56","doi-asserted-by":"publisher","unstructured":"Kulkarni AP, Khedkar AB, Lahotib SR, Dehghanb MHD. Development of oral disintegrating tablet of rizatriptan benzoate with inhibited bitter taste. AEJSR 2012;7(2):47\u201357. https:\/\/doi.org\/10.5829\/idosi.aejsr.2012.7.2.1507.","DOI":"10.5829\/idosi.aejsr.2012.7.2.1507"},{"key":"3208_CR57","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1248\/cpb.56.1395","volume":"56","author":"T Ishizaka","year":"2008","unstructured":"Ishizaka T, Okada S, Tokuyama E, Mukai J, Uchida T. Suppression of bitterness and improvement of palatability of commercial prednisolone powder. Chem Pharm Bull. 2008;56:1395\u20139. https:\/\/doi.org\/10.1248\/cpb.56.1395.","journal-title":"Chem Pharm Bull"},{"key":"3208_CR58","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.cis.2015.05.003","volume":"223","author":"A Sosnik","year":"2015","unstructured":"Sosnik A, Seremeta KP. Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers. Adv Colloid Interface Sci. 2015;223:40\u201354. https:\/\/doi.org\/10.1016\/j.cis.2015.05.003.","journal-title":"Adv Colloid Interface Sci"},{"key":"3208_CR59","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1080\/07373937.2015.1064947","volume":"34","author":"PS Wagh","year":"2016","unstructured":"Wagh PS, Naik JB. Development of mefenamic acid\u2013loaded polymeric microparticles using solvent evaporation and spray-drying technique. Dry Technol. 2016;34:608\u201317. https:\/\/doi.org\/10.1080\/07373937.2015.1064947.","journal-title":"Dry Technol"},{"key":"3208_CR60","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jopr.2013.04.015","volume":"6","author":"S Vidyadhara","year":"2013","unstructured":"Vidyadhara S, Babu JR, Balakrishna T, Trilochani P, Kumar MP. Design and evaluation of controlled release losartan potassium microcapsules. J Pharm Res. 2013;6:470\u20135. https:\/\/doi.org\/10.1016\/j.jopr.2013.04.015.","journal-title":"J Pharm Res"},{"key":"3208_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ma14237345","volume":"14","author":"A Ejsmont","year":"2021","unstructured":"Ejsmont A, Stasi\u0142owicz-Krzemie\u0144 A, Ludowicz D, Cielecka-Piontek J, Goscianska J. Synthesis and characterization of nanoporous carbon carriers for losartan potassium delivery. Materials. 2021;14:1\u201319. https:\/\/doi.org\/10.3390\/ma14237345.","journal-title":"Materials"},{"key":"3208_CR62","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jddst.2015.08.005","volume":"29","author":"AB Gangurde","year":"2015","unstructured":"Gangurde AB, Kundaikar HS, Javeer SD, Jaiswar DR, Degani MS, Amin PD. Enhanced solubility and dissolution of curcumin by a hydrophilic polymer solid dispersion and its in silico molecular modeling studies. J Drug Deliv Sci Technol. 2015;29:226\u201337. https:\/\/doi.org\/10.1016\/j.jddst.2015.08.005.","journal-title":"J Drug Deliv Sci Technol"},{"key":"3208_CR63","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.apt.2015.05.004","volume":"26","author":"TF Guimar\u00e3es","year":"2015","unstructured":"Guimar\u00e3es TF, Lanchote AD, Da Costa JS, Vi\u00e7osa AL, De Freitas LAP. A multivariate approach applied to quality on particle engineering of spray-dried mannitol. Adv Powder Technol. 2015;26:1094\u2013101. https:\/\/doi.org\/10.1016\/j.apt.2015.05.004.","journal-title":"Adv Powder Technol"},{"key":"3208_CR64","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.ijpharm.2015.03.029","volume":"486","author":"X Li","year":"2015","unstructured":"Li X, Peng H, Tian B, Gou J, Yao Q, Tao X, et al. Preparation and characterization of azithromycin - Aerosil 200 solid dispersions with enhanced physical stability. Int J Pharm. 2015;486:175\u201384. https:\/\/doi.org\/10.1016\/j.ijpharm.2015.03.029.","journal-title":"Int J Pharm"},{"key":"3208_CR65","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11090480","volume":"11","author":"M Vlachou","year":"2019","unstructured":"Vlachou M, Kikionis S, Siamidi A, Kyriakou S, Tsotinis A, Ioannou E, et al. Development and characterization of Eudragit\u00ae-based electrospun nanofibrous mats and their formulation into nanofiber tablets for the modified release of furosemide. Pharmaceutics. 2019;11: 1\u201313. https:\/\/doi.org\/10.3390\/pharmaceutics11090480.","journal-title":"Pharmaceutics"},{"key":"3208_CR66","unstructured":"Ponnaiah R, Desai S, Rathod D, Parikh C. Alembic limited. A process for preparation of losartan potassium form I. Patent WO 2010\/046804 A2. 29 April 2010."},{"key":"3208_CR67","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1007\/s11095-011-0655-7","volume":"29","author":"T Kojima","year":"2012","unstructured":"Kojima T, Higashi K, Suzuki T, Tomono K, Moribe K, Yamamoto K. Stabilization of a supersaturated solution of mefenamic acid from a solid dispersion with Eudragit\u00ae EPO. Pharm Res. 2012;29:2777\u201391. https:\/\/doi.org\/10.1007\/s11095-011-0655-7.","journal-title":"Pharm Res"},{"key":"3208_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pharmaceutics15020587","volume":"15","author":"A Nikam","year":"2023","unstructured":"Nikam A, Sahoo PR, Musale S, Pagar RR, Paiva-Santos AC, Giram PS. A systematic overview of Eudragit\u00ae based copolymer for smart healthcare. Pharmaceutics. 2023;15:1\u201331. https:\/\/doi.org\/10.3390\/pharmaceutics15020587.","journal-title":"Pharmaceutics"},{"key":"3208_CR69","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.ijpharm.2014.12.037","volume":"478","author":"SA El-Gizawy","year":"2015","unstructured":"El-Gizawy SA, Osman MA, Arafa MF, El Maghraby GM. Aerosil as a novel co-crystal co-former for improving the dissolution rate of hydrochlorothiazide. Int J Pharm. 2015;478:773\u20138. https:\/\/doi.org\/10.1016\/j.ijpharm.2014.12.037.","journal-title":"Int J Pharm"},{"issue":"10","key":"3208_CR70","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1007\/s11094-021-02316-0","volume":"54","author":"X Shi","year":"2021","unstructured":"Shi X, Ding Z, Bao J, Wang C. Preparation and in vitro\/vivo evaluation of new celecoxib solid dispersions with co-carrier containing Aerosil and Poloxamer 188. Pharm Chem J. 2021;54(10):1033\u20139. https:\/\/doi.org\/10.1007\/s11094-021-02316-0.","journal-title":"Pharm Chem J"},{"key":"3208_CR71","doi-asserted-by":"publisher","unstructured":"Ho TM, Truong T, Bhandari B. Spray-drying and non-equilibrium states\/glass transition. In: Bhandari B, Roos YH, editors. Non-equilibrium states and glass transitions in foods. Woodhead Publishing; 2017, p. 111\u2013136. https:\/\/doi.org\/10.1016\/B978-0-08-100309-1.00008-0.","DOI":"10.1016\/B978-0-08-100309-1.00008-0"},{"key":"3208_CR72","unstructured":"Kumar Y, Sharma TK, Bose P. Amorphous form of losartan potassium. WO 2004\/039352 A2, May 2004."},{"key":"3208_CR73","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1080\/07373937.2011.620726","volume":"30","author":"EM Littringer","year":"2012","unstructured":"Littringer EM, Mescher A, Eckhard S, Schr\u00f6ttner H, Langes C, Fries M, et al. Spray drying of mannitol as a drug carrier\u2014the impact of process parameters on product properties. Dry Technol. 2012;30:114\u201324. https:\/\/doi.org\/10.1080\/07373937.2011.620726.","journal-title":"Dry Technol"},{"key":"3208_CR74","doi-asserted-by":"publisher","first-page":"340","DOI":"10.2174\/1570163815666180801152918","volume":"16","author":"L Gallo","year":"2018","unstructured":"Gallo L, Bucal\u00e1 V. A review on influence of spray drying process parameters on the production of medicinal plant powders. Curr Drug Discov Technol. 2018;16:340\u201354. https:\/\/doi.org\/10.2174\/1570163815666180801152918.","journal-title":"Curr Drug Discov Technol"},{"key":"3208_CR75","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.apt.2019.10.004","volume":"31","author":"Y Kudo","year":"2020","unstructured":"Kudo Y, Yasuda M, Matsusaka S. Effect of particle size distribution on flowability of granulated lactose. Adv Powder Technol. 2020;31:121\u20137. https:\/\/doi.org\/10.1016\/j.apt.2019.10.004.","journal-title":"Adv Powder Technol"},{"key":"3208_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-024-02796-9","volume":"25","author":"C Juan","year":"2024","unstructured":"Juan C, Gallo L, Gonzalez VN. Development of losartan orally disintegrating tablets by direct compression: a cost - effective approach to improve paediatric patient\u2019s compliance. AAPS PharmSciTech. 2024;25:1\u201315. https:\/\/doi.org\/10.1208\/s12249-024-02796-9.","journal-title":"AAPS PharmSciTech"},{"key":"3208_CR77","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.ejpb.2020.08.014","volume":"156","author":"L Freerks","year":"2020","unstructured":"Freerks L, Sommerfeldt J, L\u00f6per PC, Klein S. Safe, swallowable and palatable paediatric mini-tablet formulations for a WHO model list of essential medicines for children compound \u2013 a promising starting point for future PUMA applications. Eur J Pharm Biopharm. 2020;156:11\u20139. https:\/\/doi.org\/10.1016\/j.ejpb.2020.08.014.","journal-title":"Eur J Pharm Biopharm"},{"key":"3208_CR78","unstructured":"Rowe R, Sheskey PJ, Quinn ME. Handbook of pharmaceutical excipients, 6th ed. London: Pharmaceutical Press, Washington: American Pharmacists Association; 2009."},{"key":"3208_CR79","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.arcped.2019.09.008","volume":"26","author":"KA Nakama","year":"2019","unstructured":"Nakama KA, Dos Santos RB, Serpa P, Maciel TR, Haas SE. Organoleptic excipients used in pediatric antibiotics. Arch Pediatr. 2019;26:431\u20136. https:\/\/doi.org\/10.1016\/j.arcped.2019.09.008.","journal-title":"Arch Pediatr"},{"key":"3208_CR80","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.addr.2014.02.012","volume":"73","author":"J Walsh","year":"2014","unstructured":"Walsh J, Cram A, Woertz K, Breitkreutz J, Winzenburg G, Turner R, et al. Playing hide and seek with poorly tasting paediatric medicines: Do not forget the excipients. Adv Drug Deliv Rev. 2014;73:14\u201333. https:\/\/doi.org\/10.1016\/j.addr.2014.02.012.","journal-title":"Adv Drug Deliv Rev"},{"key":"3208_CR81","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/s12247-020-09511-8","volume":"17","author":"RF Naqvi","year":"2020","unstructured":"Naqvi RF, Khan A, Umer MF, Malik O, Shahwani NA. Design and optimization of novel taste-masked medicated chocolates of dextromethorphan with in vitro and in vivo taste evaluation. J Pharm Innov. 2020;17:376\u201390. https:\/\/doi.org\/10.1007\/s12247-020-09511-8.","journal-title":"J Pharm Innov"},{"key":"3208_CR82","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s13346-017-0367-6","volume":"7","author":"MY Moutasim","year":"2017","unstructured":"Moutasim MY, ElMeshad AN, El-Nabarawi MA. A pharmaceutical study on lornoxicam fast disintegrating tablets: formulation and in vitro and in vivo evaluation. Drug Deliv Transl Res. 2017;7:450\u20139. https:\/\/doi.org\/10.1007\/s13346-017-0367-6.","journal-title":"Drug Deliv Transl Res"},{"key":"3208_CR83","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/S0308-8146(99)00254-X","volume":"69","author":"C Nofre","year":"2000","unstructured":"Nofre C, Tinti JM. Neotame: discovery, properties, utility. Food Chem. 2000;69:245\u201357. https:\/\/doi.org\/10.1016\/S0308-8146(99)00254-X.","journal-title":"Food Chem"},{"issue":"111853","key":"3208_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.foodres.2022.111853","volume":"162","author":"MA Farag","year":"2022","unstructured":"Farag MA, Rezk MM, Elashal MH, El-Araby M, Khalifa SAM, El-Seedi HR. An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety. Food Res Int. 2022;162(111853):1\u201319. https:\/\/doi.org\/10.1016\/j.foodres.2022.111853.","journal-title":"Food Res Int"},{"key":"3208_CR85","doi-asserted-by":"publisher","unstructured":"European Food Safety Authority (EFSA). Neotame as a sweetener and flavour enhancer - Scientific Opinion of the Panel on food additives, flavourings, processing aids and materials in contact with food. EFSA J. 2007;581:1\u201343. https:\/\/doi.org\/10.2903\/j.efsa.2007.581. Accessed 23 Feb 2025.","DOI":"10.2903\/j.efsa.2007.581"},{"key":"3208_CR86","unstructured":"Food and Drug Administration (FDA). Guidance for industry: Orally disintegrating tablets. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER). 2008. https:\/\/www.fda.gov\/media\/70877\/download. Accessed 7 Dec 2024."},{"key":"3208_CR87","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.ijpharm.2009.09.003","volume":"383","author":"H Liu","year":"2010","unstructured":"Liu H, Wang P, Zhang X, Shen F, Gogos CG. Effects of extrusion process parameters on the dissolution behavior of indomethacin in Eudragit\u00ae E PO solid dispersions. Int J Pharm. 2010;383:161\u20139. https:\/\/doi.org\/10.1016\/j.ijpharm.2009.09.003.","journal-title":"Int J Pharm"},{"key":"3208_CR88","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3109\/10837450.2015.1086370","volume":"21","author":"M Fujii","year":"2015","unstructured":"Fujii M, Kawakami A, Saito A, Tuchiya H, Koizumi N, Watanabe Y. Preparation and characterization of a powder containing an oily liquid drug with Eudragit EPO or L100 copolymer. Pharm Dev Technol. 2015;21:1023\u20138. https:\/\/doi.org\/10.3109\/10837450.2015.1086370.","journal-title":"Pharm Dev Technol"},{"key":"3208_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pharmaceutics15082050","volume":"15","author":"G Bedogni","year":"2023","unstructured":"Bedogni G, Garcia P, Seremeta K, Okulik N, Salomon C. Preformulation and long-term stability studies of an optimized palatable praziquantel ethanol-free solution for pediatric delivery. Pharmaceutics. 2023;15:1\u201316. https:\/\/doi.org\/10.3390\/pharmaceutics15082050.","journal-title":"Pharmaceutics"},{"key":"3208_CR90","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.jsps.2017.06.001","volume":"25","author":"A Amelian","year":"2017","unstructured":"Amelian A, Wasilewska K, Weso\u0142y M, Ciosek-Skibi\u0144ska P, Winnicka K. Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine dihydrochloride microparticles. Saudi Pharm J. 2017;25:1144\u201350. https:\/\/doi.org\/10.1016\/j.jsps.2017.06.001.","journal-title":"Saudi Pharm J"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-025-03208-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-025-03208-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-025-03208-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T14:53:44Z","timestamp":1758725624000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-025-03208-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,13]]},"references-count":90,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["3208"],"URL":"https:\/\/doi.org\/10.1208\/s12249-025-03208-2","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,13]]},"assertion":[{"value":"30 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A written informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare that they have no conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"212"}}