{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:55:51Z","timestamp":1782896151725,"version":"3.54.5"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"DOI":"10.1208\/s12249-025-03314-1","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T22:56:33Z","timestamp":1769036193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Characterization of Eudragit Nanoparticle-Tailored \u03b2-Cyclodextrin\/Thiolated Sodium Alginate\/Polyethyleneglycol Polymer Hybrid as a Potential Bone Tissue Engineering Scaffold"],"prefix":"10.1208","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7086-4493","authenticated-orcid":false,"given":"Jiyaur","family":"Rahaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-5733","authenticated-orcid":false,"given":"Dhrubojyoti","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"issue":"3","key":"3314_CR1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1369-7021(11)70058-X","volume":"14","author":"FJ O\u2019Brien","year":"2011","unstructured":"O\u2019Brien FJ. Biomaterials & scaffolds for tissue engineering. Mater Today. 2011;14(3):88\u201395. https:\/\/doi.org\/10.1016\/S1369-7021(11)70058-X.","journal-title":"Mater Today"},{"issue":"5","key":"3314_CR2","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1080\/1061186x.2024.2445737","volume":"33","author":"J Rahaman","year":"2025","unstructured":"Rahaman J, Mukherjee D. Insulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold. J Drug Target. 2025;33(5):648\u201365. https:\/\/doi.org\/10.1080\/1061186x.2024.2445737.","journal-title":"J Drug Target"},{"key":"3314_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2025.102753","volume":"44","author":"J Rahaman","year":"2025","unstructured":"Rahaman J, Mukherjee D. Osteoimmunomodulatory biomaterials: engineering strategies, current progress, and future perspectives for bone regeneration. Appl Mater Today. 2025;44: 102753. https:\/\/doi.org\/10.1016\/j.apmt.2025.102753.","journal-title":"Appl Mater Today"},{"key":"3314_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041142","author":"A Froelich","year":"2023","unstructured":"Froelich A, Jakubowska E, Wojty\u0142ko M, Jadach B, Gackowski M, Gadzi\u0144ski P, et al. Alginate-based materials loaded with nanoparticles in wound healing. Pharmaceutics. 2023. https:\/\/doi.org\/10.3390\/pharmaceutics15041142.","journal-title":"Pharmaceutics"},{"key":"3314_CR5","doi-asserted-by":"publisher","DOI":"10.1557\/s43578-021-00405-0","author":"D Kamnoore","year":"2021","unstructured":"Kamnoore D, Mukherjee D, Nayak Ammunje D, Parasuraman P, Teja BV, Radhika M. Hydroxyapatite nanoparticle-enriched thiolated polymer-based biocompatible scaffold can improve skin tissue regeneration. J Mater Res. 2021. https:\/\/doi.org\/10.1557\/s43578-021-00405-0.","journal-title":"J Mater Res"},{"issue":"1","key":"3314_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/srep09806","volume":"5","author":"S Pramanik","year":"2015","unstructured":"Pramanik S, Ataollahi F, Pingguan-Murphy B, Oshkour AA, Osman NAA. In vitro study of surface modified poly(ethylene glycol)-impregnated sintered bovine bone scaffolds on human fibroblast cells. Sci Rep. 2015;5(1): 9806. https:\/\/doi.org\/10.1038\/srep09806.","journal-title":"Sci Rep"},{"issue":"28","key":"3314_CR7","doi-asserted-by":"publisher","first-page":"285105","DOI":"10.1088\/0957-4484\/21\/28\/285105","volume":"21","author":"TA Kelf","year":"2010","unstructured":"Kelf TA, Sreenivasan VK, Sun J, Kim EJ, Goldys EM, Zvyagin AV. Non-specific cellular uptake of surface-functionalized quantum dots. Nanotechnology. 2010;21(28):285105. https:\/\/doi.org\/10.1088\/0957-4484\/21\/28\/285105.","journal-title":"Nanotechnology"},{"key":"3314_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/polym11030459","author":"J Luk\u00e1\u0161ek","year":"2019","unstructured":"Luk\u00e1\u0161ek J, Hauzerov\u00e1 \u0160, Havl\u00ed\u010dkov\u00e1 K, Strnadov\u00e1 K, Ma\u0161ek K, Stuchl\u00edk M, et al. Cyclodextrin-polypyrrole coatings of scaffolds for tissue engineering. Polymers. 2019. https:\/\/doi.org\/10.3390\/polym11030459.","journal-title":"Polymers"},{"issue":"11","key":"3314_CR9","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1166\/jbt.2014.1267","volume":"4","author":"TGB Deluzio","year":"2014","unstructured":"Deluzio TGB, Penev KI, Mequanint K. Cyclodextrin inclusion complexes as potential oxygen delivery vehicles in tissue engineering. J Biomater Tissue Eng. 2014;4(11):957\u201366. https:\/\/doi.org\/10.1166\/jbt.2014.1267.","journal-title":"J Biomater Tissue Eng"},{"key":"3314_CR10","doi-asserted-by":"publisher","unstructured":"Majumdar S, Wang X, Sommerfeld SD, Chae JJ, Athanasopoulou EN, Shores LS, et al. Cyclodextrin Modulated Type I Collagen Self-Assembly to Engineer Biomimetic Cornea Implants. Adv Funct Mater. 2018;28(41).https:\/\/doi.org\/10.1002\/adfm.201804076.","DOI":"10.1002\/adfm.201804076"},{"key":"3314_CR11","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.ijbiomac.2020.04.019","volume":"156","author":"R Kamel","year":"2020","unstructured":"Kamel R, El-Wakil NA, Abdelkhalek AA, Elkasabgy NA. Nanofibrillated cellulose\/cyclodextrin based 3D scaffolds loaded with raloxifene hydrochloride for bone regeneration. Int J Biol Macromol. 2020;156:704\u201316. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.04.019.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"3314_CR12","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.fjps.2017.02.001","volume":"3","author":"CN Patra","year":"2017","unstructured":"Patra CN, Priya R, Swain S, Kumar Jena G, Panigrahi KC, Ghose D. Pharmaceutical significance of Eudragit: a review. Future J Pharm Sci. 2017;3(1):33\u201345. https:\/\/doi.org\/10.1016\/j.fjps.2017.02.001.","journal-title":"Future J Pharm Sci"},{"key":"3314_CR13","doi-asserted-by":"publisher","first-page":"105889","DOI":"10.1016\/j.jddst.2024.105889","volume":"98","author":"S Hulikal","year":"2024","unstructured":"Hulikal S, Teja BV, Mukherjee D. Thiolated eudragit\/\u03b2-cyclodextrin\/centella asiatica nanomaterial for bone tissue engineering construct. J Drug Deliv Sci Technol. 2024;98:105889. https:\/\/doi.org\/10.1016\/j.jddst.2024.105889.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"40","key":"3314_CR14","doi-asserted-by":"publisher","first-page":"17593","DOI":"10.1021\/acs.iecr.0c02195","volume":"59","author":"S Tandon","year":"2020","unstructured":"Tandon S, Kandasubramanian B, Ibrahim SM. Silk-based composite scaffolds for tissue engineering applications. Ind Eng Chem Res. 2020;59(40):17593\u2013611. https:\/\/doi.org\/10.1021\/acs.iecr.0c02195.","journal-title":"Ind Eng Chem Res"},{"issue":"5","key":"3314_CR15","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S1369-7021(04)00233-0","volume":"7","author":"PX Ma","year":"2004","unstructured":"Ma PX. Scaffolds for tissue fabrication. Mater Today. 2004;7(5):30\u201340. https:\/\/doi.org\/10.1016\/S1369-7021(04)00233-0.","journal-title":"Mater Today"},{"key":"3314_CR16","doi-asserted-by":"publisher","first-page":"113948","DOI":"10.1016\/j.mtcomm.2025.113948","volume":"49","author":"J Rahaman","year":"2025","unstructured":"Rahaman J, Reza A, Nasare D, Susanth J, Mukherjee D. Chitosan-based composite scaffolds for bone tissue engineering: design strategies, mechanisms, and emerging roles in osteoimmunomodulation. Mater Today Commun. 2025;49:113948. https:\/\/doi.org\/10.1016\/j.mtcomm.2025.113948.","journal-title":"Mater Today Commun"},{"issue":"3","key":"3314_CR17","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.compositesb.2006.06.014","volume":"38","author":"H-Y Cheung","year":"2007","unstructured":"Cheung H-Y, Lau K-T, Lu T-P, Hui D. A critical review on polymer-based bio-engineered materials for scaffold development. Compos Part B Eng. 2007;38(3):291\u2013300. https:\/\/doi.org\/10.1016\/j.compositesb.2006.06.014.","journal-title":"Compos Part B Eng"},{"issue":"5","key":"3314_CR18","doi-asserted-by":"publisher","first-page":"e10382","DOI":"10.1002\/btm2.10382","volume":"8","author":"TC Chen","year":"2023","unstructured":"Chen TC, Tang RC, Lin JN, Kuo WT, Yang IH, Liang YJ, et al. The synthesis and evaluation of thiolated alginate as the barrier to block nutrient absorption on small intestine for body-weight control. Bioengineering & translational medicine. 2023;8(5):e10382. https:\/\/doi.org\/10.1002\/btm2.10382.","journal-title":"Bioengineering & translational medicine"},{"key":"3314_CR19","doi-asserted-by":"publisher","first-page":"103813","DOI":"10.1016\/j.jddst.2022.103813","volume":"76","author":"K Bhagyasree","year":"2022","unstructured":"Bhagyasree K, Mukherjee D, Azamthulla M, Debnath S, Sundar LM, Hulikal S, et al. Thiolated sodium alginate\/polyethylene glycol\/hydroxyapatite nanohybrid for bone tissue engineering. J Drug Deliv Sci Technol. 2022;76:103813. https:\/\/doi.org\/10.1016\/j.jddst.2022.103813.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"11","key":"3314_CR20","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1211\/jpp.59.11.0005","volume":"59","author":"SU Schilling","year":"2007","unstructured":"Schilling SU, Shah NH, Malick AW, Infeld MH, McGinity JW. Citric acid as a solid-state plasticizer for Eudragit RS PO. J Pharm Pharmacol. 2007;59(11):1493\u2013500. https:\/\/doi.org\/10.1211\/jpp.59.11.0005.","journal-title":"J Pharm Pharmacol"},{"issue":"3","key":"3314_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2024.101864","volume":"28","author":"J Gao","year":"2024","unstructured":"Gao J, Sang Y, Han X, Zhao Y, Liang T, Chen T. Preparation of Eudragit L100 coated silica aerogel filled HPC\/CS pH-sensitive composites for sustained release of 5-fluorouracil. J Saudi Chem Soc. 2024;28(3): 101864. https:\/\/doi.org\/10.1016\/j.jscs.2024.101864.","journal-title":"J Saudi Chem Soc"},{"issue":"8","key":"3314_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-021-02131-6","volume":"22","author":"HB Haroon","year":"2021","unstructured":"Haroon HB, Mukherjee D, Anbu J, Teja BV. Thiolated Chitosan-Centella asiatica Nanocomposite: a potential brain targeting strategy through nasal route. AAPS PharmSciTech. 2021;22(8):1\u201316. https:\/\/doi.org\/10.1208\/s12249-021-02131-6.","journal-title":"AAPS PharmSciTech"},{"key":"3314_CR23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jddst.2017.02.004","volume":"38","author":"G Mohammadi","year":"2017","unstructured":"Mohammadi G, Namadi E, Mikaeili A, Mohammadi P, Adibkia K. Preparation, physicochemical characterization and anti-fungal evaluation of the Nystatin-loaded Eudragit RS100\/PLGA nanoparticles. J Drug Deliv Sci Technol. 2017;38:90\u20136. https:\/\/doi.org\/10.1016\/j.jddst.2017.02.004.","journal-title":"J Drug Deliv Sci Technol"},{"key":"3314_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212950","volume":"138","author":"\u0141 Paw\u0142owski","year":"2022","unstructured":"Paw\u0142owski \u0141, Wawrzyniak J, Banach-Kope\u0107 A, Cie\u015blik BM, Jurak K, Karczewski J, et al. Antibacterial properties of laser-encapsulated titanium oxide nanotubes decorated with nanosilver and covered with chitosan\/Eudragit polymers. Biomaterials Advances. 2022;138: 212950. https:\/\/doi.org\/10.1016\/j.bioadv.2022.212950.","journal-title":"Biomaterials Advances"},{"key":"3314_CR25","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jddst.2018.05.025","volume":"46","author":"PH Rajasree","year":"2018","unstructured":"Rajasree PH, Paul W, Sharma CP, Osmani RAM, Hani U, Srivastava A. Eudragit encapsulated cationic poly (lactic-co-glycolic acid) nanoparticles in targeted delivery of capecitabine for augmented colon carcinoma therapy. J Drug Deliv Sci Technol. 2018;46:302\u201311. https:\/\/doi.org\/10.1016\/j.jddst.2018.05.025.","journal-title":"J Drug Deliv Sci Technol"},{"key":"3314_CR26","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ijbiomac.2021.01.160","volume":"174","author":"L Ding","year":"2021","unstructured":"Ding L, Song S, Chen L, Shi J, Zhao B, Teng G, et al. A freeze-thawing method applied to the fabrication of 3-d curdlan\/polyvinyl alcohol hydrogels as scaffolds for cell culture. Int J Biol Macromol. 2021;174:101\u20139. https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.01.160.","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"3314_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2020.102924","volume":"14","author":"M Umar Aslam Khan","year":"2021","unstructured":"Umar Aslam Khan M, Haider S, Haider A, Izwan Abd Razak S, Rafiq Abdul Kadir M, Shah SA, et al. Development of porous, antibacterial and biocompatible GO\/n-HAp\/bacterial cellulose\/\u03b2-glucan biocomposite scaffold for bone tissue engineering. Arab J Chem. 2021;14(2): 102924. https:\/\/doi.org\/10.1016\/j.arabjc.2020.102924.","journal-title":"Arab J Chem"},{"key":"3314_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2022.132170","volume":"318","author":"M Rasoulianboroujeni","year":"2022","unstructured":"Rasoulianboroujeni M, Yadegari A, Tajik S, Tayebi L. Development of a modular reinforced bone tissue engineering scaffold with enhanced mechanical properties. Mater Lett. 2022;318: 132170. https:\/\/doi.org\/10.1016\/j.matlet.2022.132170.","journal-title":"Mater Lett"},{"key":"3314_CR29","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1016\/j.jmrt.2024.04.009","volume":"30","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, Li J, Qu Q, Pan S, Yu K, Liu Y. Graphene oxide modified sodium alginate\/polyethylene glycol phase change material hydrogel scaffold composite with photothermal temperature control for potential bone tissue regeneration. J Mater Res Technol. 2024;30:2446\u201357. https:\/\/doi.org\/10.1016\/j.jmrt.2024.04.009.","journal-title":"J Mater Res Technol"},{"issue":"9","key":"3314_CR30","doi-asserted-by":"publisher","first-page":"4349","DOI":"10.1007\/s10853-016-9747-4","volume":"51","author":"S Van Vlierberghe","year":"2016","unstructured":"Van Vlierberghe S. Crosslinking strategies for porous gelatin scaffolds. J Mater Sci. 2016;51(9):4349\u201357. https:\/\/doi.org\/10.1007\/s10853-016-9747-4.","journal-title":"J Mater Sci"},{"key":"3314_CR31","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.msec.2019.03.005","volume":"100","author":"LL Lima","year":"2019","unstructured":"Lima LL, Taketa TB, Beppu MM, Sousa IMdO, Foglio MA, Moraes \u00c2M. Coated electrospun bioactive wound dressings: mechanical properties and ability to control lesion microenvironment. Mater Sci Eng, C. 2019;100:493\u2013504. https:\/\/doi.org\/10.1016\/j.msec.2019.03.005.","journal-title":"Mater Sci Eng, C"},{"key":"3314_CR32","doi-asserted-by":"publisher","unstructured":"Samraj.S MD, Vadodaria K. Development and optimization of gelatin nanofibrous scaffold for tissue engineering applications. J Drug Deliv Sci Technol. 2022;71:103283. https:\/\/doi.org\/10.1016\/j.jddst.2022.103283.","DOI":"10.1016\/j.jddst.2022.103283"},{"key":"3314_CR33","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1016\/j.ijbiomac.2021.05.199","volume":"182","author":"O Iqbal","year":"2021","unstructured":"Iqbal O, Shah S, Abbas G, Rasul A, Hanif M, Ashfaq M, et al. Moxifloxacin loaded nanoparticles of disulfide bridged thiolated chitosan-eudragit RS100 for controlled drug delivery. Int J Biol Macromol. 2021;182:2087\u201396. https:\/\/doi.org\/10.1016\/j.ijbiomac.2021.05.199.","journal-title":"Int J Biol Macromol"},{"key":"3314_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138282","volume":"1310","author":"V Rudraradhya","year":"2024","unstructured":"Rudraradhya V, Teja BV, Mukherjee D. Hydroxypropyl methylcellulose\/sodium alginate\/hydroxyapatite nano biomaterial enriched with zinc to promote bone tissue augmentation. J Mol Struct. 2024;1310: 138282. https:\/\/doi.org\/10.1016\/j.molstruc.2024.138282.","journal-title":"J Mol Struct"},{"issue":"18","key":"3314_CR35","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1039\/C3SM52883A","volume":"10","author":"S Yashima","year":"2014","unstructured":"Yashima S, Takase N, Kurokawa T, Gong JP. Friction of hydrogels with controlled surface roughness on solid flat substrates. Soft Matter. 2014;10(18):3192\u20139. https:\/\/doi.org\/10.1039\/C3SM52883A.","journal-title":"Soft Matter"},{"key":"3314_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/polym15040907","author":"T Tolstova","year":"2023","unstructured":"Tolstova T, Drozdova M, Popyrina T, Matveeva D, Demina T, Akopova T, et al. Preparation and in vitro evaluation of chitosan-g-oligolactide based films and macroporous hydrogels for tissue engineering. Polymers. 2023. https:\/\/doi.org\/10.3390\/polym15040907.","journal-title":"Polymers"},{"key":"3314_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.chphi.2023.100441","volume":"8","author":"G Sabarees","year":"2024","unstructured":"Sabarees G, Velmurugan V, Solomon VR. Molecular docking and molecular dynamics simulations discover curcumin analogs as potential wound healing agents. Chemical Physics Impact. 2024;8: 100441. https:\/\/doi.org\/10.1016\/j.chphi.2023.100441.","journal-title":"Chemical Physics Impact"},{"key":"3314_CR38","unstructured":"RCSB Protein Data Bank [Internet]. 2025.\u00a0https:\/\/www.rcsb.org\/. Accessed 20 Aug 2025."},{"key":"3314_CR39","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1016\/j.ijbiomac.2020.08.116","volume":"164","author":"S Khalid","year":"2020","unstructured":"Khalid S, Abbas G, Hanif M, Shah S, Shah SNH, Jalil A, et al. Thiolated sodium alginate conjugates for mucoadhesive and controlled release behavior of metformin microspheres. Int J Biol Macromol. 2020;164:2691\u2013700. https:\/\/doi.org\/10.1016\/j.ijbiomac.2020.08.116.","journal-title":"Int J Biol Macromol"},{"issue":"4","key":"3314_CR40","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1208\/s12249-013-0023-5","volume":"14","author":"H Rachmawati","year":"2013","unstructured":"Rachmawati H, Edityaningrum CA, Mauludin R. Molecular inclusion complex of curcumin-\u03b2-cyclodextrin nanoparticle to enhance curcumin skin permeability from hydrophilic matrix gel. AAPS PharmSciTech. 2013;14(4):1303\u201312. https:\/\/doi.org\/10.1208\/s12249-013-0023-5.","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"3314_CR41","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1080\/15685551.2023.2205741","volume":"26","author":"YF Li","year":"2023","unstructured":"Li YF, Tian ZX, Shi B, He YB, Long MX. Synthesis and structural characterization of \u03b2 -cyclodextrin butenate. Des Monomers Polym. 2023;26(1):132\u20139. https:\/\/doi.org\/10.1080\/15685551.2023.2205741.","journal-title":"Des Monomers Polym"},{"issue":"4","key":"3314_CR42","doi-asserted-by":"publisher","DOI":"10.1208\/pt0804108","volume":"8","author":"D Leonardi","year":"2007","unstructured":"Leonardi D, Barrera MG, Lamas MC, Salom\u00f3n CJ. Development of prednisone:polyethylene glycol 6000 fast-release tablets from solid dispersions: solid-state characterization, dissolution behavior, and formulation parameters. AAPS PharmSciTech. 2007;8(4): E108. https:\/\/doi.org\/10.1208\/pt0804108.","journal-title":"AAPS PharmSciTech"},{"key":"3314_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/polym12030717","author":"AI Visan","year":"2020","unstructured":"Visan AI, Popescu-Pelin G, Gherasim O, Mihailescu A, Socol M, Zgura I, et al. Long-term evaluation of dip-coated PCL-blend-PEG coatings in simulated conditions. Polymers. 2020. https:\/\/doi.org\/10.3390\/polym12030717.","journal-title":"Polymers"},{"issue":"12","key":"3314_CR44","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.2138\/am-2023-9059","volume":"109","author":"RC Tacker","year":"2024","unstructured":"Tacker RC, Rakovan J, Harlov D, Hughes JM, Cichy SB. The OH-stretching region in infrared spectra of the apatite OH-Cl binary system. Am Mineral. 2024;109(12):2086\u201394. https:\/\/doi.org\/10.2138\/am-2023-9059.","journal-title":"Am Mineral"},{"issue":"1","key":"3314_CR45","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/2231-4040.107498","volume":"4","author":"R Mehta","year":"2013","unstructured":"Mehta R, Chawla A, Sharma P, Pawar P. Formulation and in vitro evaluation of Eudragit S-100 coated naproxen matrix tablets for colon-targeted drug delivery system. J Adv Pharm Technol Res. 2013;4(1):31\u201341. https:\/\/doi.org\/10.4103\/2231-4040.107498.","journal-title":"J Adv Pharm Technol Res"},{"key":"3314_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118278","volume":"269","author":"SN Kirmic Cosgun","year":"2021","unstructured":"Kirmic Cosgun SN, Ceylan Tuncaboylu D. Cyclodextrin-linked PVP\/PEG supramolecular hydrogels. Carbohydr Polym. 2021;269: 118278. https:\/\/doi.org\/10.1016\/j.carbpol.2021.118278.","journal-title":"Carbohydr Polym"},{"key":"3314_CR47","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.addr.2018.04.008","volume":"127","author":"S Saghazadeh","year":"2018","unstructured":"Saghazadeh S, Rinoldi C, Schot M, Kashaf SS, Sharifi F, Jalilian E, et al. Drug delivery systems and materials for wound healing applications. Adv Drug Deliv Rev. 2018;127:138\u201366. https:\/\/doi.org\/10.1016\/j.addr.2018.04.008.","journal-title":"Adv Drug Deliv Rev"},{"issue":"4","key":"3314_CR48","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s12633-017-9616-z","volume":"10","author":"Z Ahmadi","year":"2018","unstructured":"Ahmadi Z, Moztarzadeh F. Synthesizing and characterizing of gelatin-chitosan-bioactive glass (58s) scaffolds for bone tissue engineering. Silicon. 2018;10(4):1393\u2013402. https:\/\/doi.org\/10.1007\/s12633-017-9616-z.","journal-title":"Silicon"},{"key":"3314_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2024.113251","volume":"215","author":"M Selim","year":"2024","unstructured":"Selim M, Mousa HM, Abdel-Jaber GT, Barhoum A, Abdal-hay A. Innovative designs of 3D scaffolds for bone tissue regeneration: understanding principles and addressing challenges. Eur Polym J. 2024;215: 113251. https:\/\/doi.org\/10.1016\/j.eurpolymj.2024.113251.","journal-title":"Eur Polym J"},{"issue":"1","key":"3314_CR50","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1208\/s12249-025-03243-z","volume":"27","author":"E Abdelhakeem","year":"2025","unstructured":"Abdelhakeem E, Mohamed SA, Beherei HH, Moaness M, Hegazy D. Novel biocompatible hyaluronic acid (HA)\/polyvinylpyrrolidone (PVP) composites containing silver decorated-zinc MOF nanoparticles: antimicrobial activity, drug delivery and wound healing. AAPS PharmSciTech. 2025;27(1):5. https:\/\/doi.org\/10.1208\/s12249-025-03243-z.","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"3314_CR51","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1208\/s12249-025-03250-0","volume":"27","author":"MA Tawfik","year":"2025","unstructured":"Tawfik MA, Ahmed S, El-Dahmy RM, Aziz DE. Oleic acid enriched Leciplexes as novel mucoadhesive cationic nanocarriers of Agomelatine for glaucoma treatment. AAPS PharmSciTech. 2025;27(1):4. https:\/\/doi.org\/10.1208\/s12249-025-03250-0.","journal-title":"AAPS PharmSciTech"},{"key":"3314_CR52","doi-asserted-by":"publisher","first-page":"102806","DOI":"10.1016\/j.mtchem.2025.102806","volume":"47","author":"AS Mattos","year":"2025","unstructured":"Mattos AS, Bochanoski R, Inocente JM, De Pieri E, Raupp-Pereira F, Wermuth TB, et al. Bioactive LZSA glass\u2013ceramic scaffolds: bone regeneration and drug release for bone diseases. Mater Today Chem. 2025;47:102806. https:\/\/doi.org\/10.1016\/j.mtchem.2025.102806.","journal-title":"Mater Today Chem"},{"issue":"2","key":"3314_CR53","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/s0939-6411(02)00081-4","volume":"54","author":"A Gessner","year":"2002","unstructured":"Gessner A, Lieske A, Paulke B, M\u00fcller R. Influence of surface charge density on protein adsorption on polymeric nanoparticles: analysis by two-dimensional electrophoresis. Eur J Pharm Biopharm. 2002;54(2):165\u201370. https:\/\/doi.org\/10.1016\/s0939-6411(02)00081-4.","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"3314_CR54","doi-asserted-by":"publisher","first-page":"10","DOI":"10.5301\/jabfm.5000182","volume":"13","author":"B Cecen","year":"2015","unstructured":"Cecen B, Kozaci D, Yuksel M, Erdemli D, Bagriyanik A, Havitcioglu H. Biocompatibility of MG-63 cells on collagen, poly-L-lactic acid, hydroxyapatite scaffolds with different parameters. Journal of Applied Biomaterials & Functional Materials. 2015;13(1):10\u20136. https:\/\/doi.org\/10.5301\/jabfm.5000182.","journal-title":"Journal of Applied Biomaterials & Functional Materials"},{"key":"3314_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2020.146636","volume":"525","author":"Q Wang","year":"2020","unstructured":"Wang Q, Wang M, Wang K, Sun Y, Zhang H, Lu X, et al. Molecular mechanisms of interactions between BMP-2 and graphene: effects of functional groups and microscopic morphology. Appl Surf Sci. 2020;525: 146636. https:\/\/doi.org\/10.1016\/j.apsusc.2020.146636.","journal-title":"Appl Surf Sci"},{"issue":"5","key":"3314_CR56","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/03008207.2024.2396002","volume":"65","author":"M Tollabi","year":"2024","unstructured":"Tollabi M, Poursalehi Z, Mehrafshar P, Bakhtiari R, Hosseinpour Sarmadi V, Tayebi L, et al. Insight into the role of integrins and integrins-targeting biomaterials in bone regeneration. Connect Tissue Res. 2024;65(5):343\u201363. https:\/\/doi.org\/10.1080\/03008207.2024.2396002.","journal-title":"Connect Tissue Res"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-025-03314-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-025-03314-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-025-03314-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T21:46:59Z","timestamp":1772228819000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-025-03314-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["3314"],"URL":"https:\/\/doi.org\/10.1208\/s12249-025-03314-1","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"9 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report there are no competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"80"}}