{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:14:14Z","timestamp":1791825254870,"version":"4.3.4"},"reference-count":256,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"DOI":"10.1208\/s12249-026-03411-9","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T21:45:51Z","timestamp":1775166351000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polymer Drug Conjugate: A Revolution in Drug Delivery"],"prefix":"10.1208","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6598-5355","authenticated-orcid":false,"given":"Chandan Kumar","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-2874","authenticated-orcid":false,"given":"Pran Kishore","family":"Deb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"3411_CR1","unstructured":"Moeller M, Matyjaszewski K. Polymer science: a comprehensive reference. Newnes; 2012 Dec 5. https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780444533494090063. Accessed 30 Jul 2025."},{"key":"3411_CR2","doi-asserted-by":"crossref","unstructured":"Tebaldi ML, Belardi RM, Montoro SR. Chapter 9 - Polymers with Nano-Encapsulated Functional Polymers: Encapsulated Nanoparticles for Treatment of Cancer Cells. In: Thomas S, Shanks R, Chandrasekharakurup S, editors. Design and Applications of Nanostructured Polymer Blends and Nanocomposite Systems [Internet]. Boston: William Andrew Publishing; 2016 [cited 2025 Jul 30]. p. 171\u201386. (Micro and Nano Technologies). Available from: \nhttps:\/\/www.sciencedirect.com\/science\/article\/pii\/B978032339408600008X.\u00a0Accessed 30 Jul 2025.","DOI":"10.1016\/B978-0-323-39408-6.00008-X"},{"issue":"6","key":"3411_CR3","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e17488","volume":"9","author":"TC Ezike","year":"2023","unstructured":"Ezike TC, Okpala US, Onoja UL, Nwike CP, Ezeako EC, Okpara OJ, et al. Advances in drug delivery systems, challenges and future directions. Heliyon. 2023Jun 1;9(6):e17488.","journal-title":"Heliyon"},{"key":"3411_CR4","doi-asserted-by":"crossref","unstructured":"Rajendran S, Anand SC, Rigby AJ. 5 - Textiles for healthcare and medical applications. In: Horrocks AR, Anand SC, editors. Handbook of Technical Textiles (Second Edition) [Internet]. Woodhead Publishing; 2016 [cited 2025 Jul 30]. p. 135\u201368. Available from: \nhttps:\/\/www.sciencedirect.com\/science\/article\/pii\/B9781782424659000057.\u00a0Accessed 30 Jul 2025.","DOI":"10.1016\/B978-1-78242-465-9.00005-7"},{"issue":"23","key":"3411_CR5","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.drudis.2013.09.007","volume":"18","author":"X Pang","year":"2013","unstructured":"Pang X, Du HL, Zhang HQ, Zhai YJ, Zhai GX. Polymer\u2013drug conjugates: present state of play and future perspectives. Drug Discov Today. 2013Dec 1;18(23):1316\u201322.","journal-title":"Drug Discov Today"},{"issue":"4","key":"3411_CR6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41573-018-0005-0","volume":"18","author":"I Ekladious","year":"2019","unstructured":"Ekladious I, Colson YL, Grinstaff MW. Polymer\u2013drug conjugate therapeutics: advances, insights and prospects. Nat Rev Drug Discov. 2019;18(4):273\u201394.","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"3411_CR7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.addr.2021.03.022","volume":"173","author":"S Borandeh","year":"2021","unstructured":"Borandeh S, van Bochove B, Teotia A, Sepp\u00e4l\u00e4 J. Polymeric drug delivery systems by additive manufacturing. Adv Drug Deliv Rev. 2021;173(1):349\u201373.","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"3411_CR8","volume":"48","author":"X Yao","year":"2023","unstructured":"Yao X, Qi C, Sun C, Huo F, Jiang X. Poly(ethylene glycol) alternatives in biomedical applications. Nano Today. 2023;48(1):101738.","journal-title":"Nano Today"},{"key":"3411_CR9","doi-asserted-by":"crossref","unstructured":"Pharmaceutical and Biomedical Applications of Polymers. In: Basic fundamentals of drug delivery [Internet]. Academic Press; 2019 [cited 2026 Feb 15]. pp. 203\u201367. Available from: \nhttps:\/\/www.sciencedirect.com\/science\/chapter\/edited-volume\/abs\/pii\/B9780128179093000066. Accessed\u00a015 Feb 2026.","DOI":"10.1016\/B978-0-12-817909-3.00006-6"},{"issue":"10","key":"3411_CR10","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.drudis.2017.05.011","volume":"22","author":"S Sau","year":"2017","unstructured":"Sau S, Alsaab HO, Kashaw SK, Tatiparti K, Iyer AK. Advances in antibody\u2013drug conjugates: A new era of targeted cancer therapy. Drug Discov Today. 2017Oct 1;22(10):1547\u201356.","journal-title":"Drug Discov Today"},{"issue":"3","key":"3411_CR11","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1866","volume":"15","author":"H Takahashi","year":"2023","unstructured":"Takahashi H, Sovadinova I, Yasuhara K, Vemparala S, Caputo GA, Kuroda K. Biomimetic antimicrobial polymers\u2014design, characterization, antimicrobial, and novel applications. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023;15(3):e1866.","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"issue":"1","key":"3411_CR12","volume":"162","author":"Z Vinarov","year":"2021","unstructured":"Vinarov Z, Abdallah M, Agundez JAG, Allegaert K, Basit AW, Braeckmans M, et al. Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP review. Eur J Pharm Sci. 2021;162(1):105812.","journal-title":"Eur J Pharm Sci"},{"issue":"6","key":"3411_CR13","doi-asserted-by":"crossref","DOI":"10.3390\/polym16060843","volume":"16","author":"L Ding","year":"2024","unstructured":"Ding L, Agrawal P, Singh SK, Chhonker YS, Sun J, Murry DJ. Polymer-based drug delivery systems for cancer therapeutics. Polymers. 2024;16(6):843.","journal-title":"Polymers"},{"issue":"1","key":"3411_CR14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biomaterials.2015.03.021","volume":"54","author":"W Xu","year":"2015","unstructured":"Xu W, Ding J, Xiao C, Li L, Zhuang X, Chen X. Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic. Biomaterials. 2015;54(1):72\u201386.","journal-title":"Biomaterials"},{"issue":"20","key":"3411_CR15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/IJN.S429279","volume":"4","author":"A Ullah","year":"2025","unstructured":"Ullah A, Khan M, Zhang Y, Shafiq M, Ullah M, Abbas A, et al. Advancing Therapeutic Strategies with Polymeric Drug Conjugates for Nucleic Acid Delivery and Treatment. Int J Nanomedicine. 2025Jan;4(20):25\u201352.","journal-title":"Int J Nanomedicine"},{"key":"3411_CR16","doi-asserted-by":"crossref","unstructured":"Sharma P, Jain V, Tailang M, Sharma P, Jain V, Tailang M. Selection and role of polymers for designing of a drug carrier. In: Drug carriers [Internet]. IntechOpen; 2022 [cited 2025 Jul 30]. Available from: \nhttps:\/\/www.intechopen.com\/chapters\/80892. Accessed 30 Jun 2025.","DOI":"10.5772\/intechopen.103125"},{"issue":"5","key":"3411_CR17","volume":"1","author":"A Fattah-alhosseini","year":"2024","unstructured":"Fattah-alhosseini A, Chaharmahali R, Alizad S, Kaseem M, Dikici B. A review of smart polymeric materials: Recent developments and prospects for medicine applications. Hybrid Adv. 2024Apr;1(5):100178.","journal-title":"Hybrid Adv"},{"issue":"276","key":"3411_CR18","volume":"5","author":"A Nazli","year":"2024","unstructured":"Nazli A, Irshad Khan MZ, R\u00e1cz \u00c1, B\u00e9ni S. Acid-sensitive prodrugs; a promising approach for site-specific and targeted drug release. Eur J Med Chem. 2024Oct;5(276):116699.","journal-title":"Eur J Med Chem"},{"issue":"15","key":"3411_CR19","doi-asserted-by":"crossref","first-page":"10358","DOI":"10.1021\/acs.chemrev.7b00090","volume":"117","author":"DK K\u00f6lmel","year":"2017","unstructured":"K\u00f6lmel DK, Kool ET. Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis. Chem Rev. 2017Aug 9;117(15):10358\u201376.","journal-title":"Chem Rev"},{"issue":"22","key":"3411_CR20","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1039\/D2PY00414C","volume":"13","author":"AG Gavriel","year":"2022","unstructured":"Gavriel AG, Sambrook MR, Russell AT, Hayes W. Recent advances in self-immolative linkers and their applications in polymeric reporting systems. Polym Chem. 2022Jun 7;13(22):3188\u2013269.","journal-title":"Polym Chem"},{"issue":"22","key":"3411_CR21","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1002\/pol.20230403","volume":"61","author":"J Singh","year":"2023","unstructured":"Singh J, Nayak P. pH-responsive polymers for drug delivery: trends and opportunities. J Polym Sci. 2023;61(22):2828\u201350.","journal-title":"J Polym Sci"},{"issue":"9","key":"3411_CR22","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1039\/C5SM02693H","volume":"12","author":"T Swift","year":"2016","unstructured":"Swift T, Swanson L, Geoghegan M, Rimmer S. The pH-responsive behaviour of poly(acrylic acid) in aqueous solution is dependent on molar mass. Soft Matter. 2016Feb 23;12(9):2542\u20139.","journal-title":"Soft Matter"},{"issue":"19","key":"3411_CR23","doi-asserted-by":"crossref","DOI":"10.3390\/polym13193256","volume":"13","author":"I Aranaz","year":"2021","unstructured":"Aranaz I, Alc\u00e1ntara AR, Civera MC, Arias C, Elorza B, Heras Caballero A, et al. Chitosan: an overview of its properties and applications. Polymers. 2021;13(19):3256.","journal-title":"Polymers"},{"issue":"16","key":"3411_CR24","doi-asserted-by":"crossref","DOI":"10.3390\/polym14163318","volume":"14","author":"A Salawi","year":"2022","unstructured":"Salawi A. Pharmaceutical coating and its different approaches, a review. Polymers. 2022;14(16):3318.","journal-title":"Polymers"},{"key":"3411_CR25","doi-asserted-by":"publisher","unstructured":"Modarresi-Saryazdi SM, Haddadi-Asl V, Salami-Kalajahi M. N,N\u2019\u2010methylenebis(acrylamide)\u2010crosslinked poly(acrylic acid) particles as doxorubicin carriers: A comparison between release behavior of physically loaded drug and conjugated drug via acid\u2010labile hydrazone linkage. [cited 2026 Feb 12]; Available from: https:\/\/doi.org\/10.1002\/jbm.a.36240.","DOI":"10.1002\/jbm.a.36240"},{"issue":"293","key":"3411_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2018.10.033","volume":"10","author":"C Song","year":"2019","unstructured":"Song C, Lin T, Zhang Q, Thayumanavan S, Ren L. pH-Sensitive morphological transitions in polymeric tadpole assemblies for programmed tumor therapy. J Controlled Release. 2019Jan;10(293):1\u20139.","journal-title":"J Controlled Release"},{"issue":"6","key":"3411_CR27","volume":"12","author":"SS Das","year":"2020","unstructured":"Das SS, Bharadwaj P, Bilal M, Barani M, Rahdar A, Taboada P, et al. Stimuli-responsive polymeric nanocarriers for drug delivery, imaging, and theragnosis. Polymers. 2020;12(6):1397.","journal-title":"Polymers"},{"issue":"6","key":"3411_CR28","doi-asserted-by":"crossref","DOI":"10.3390\/polym14061259","volume":"14","author":"H Arkaban","year":"2022","unstructured":"Arkaban H, Barani M, Akbarizadeh MR, Pal Singh Chauhan N, Jadoun S, Dehghani Soltani M, et al. Polyacrylic acid nanoplatforms: antimicrobial, tissue engineering, and cancer theranostic applications. Polymers. 2022;14(6):1259.","journal-title":"Polymers"},{"issue":"11","key":"3411_CR29","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.7150\/thno.23459","volume":"8","author":"W Wu","year":"2018","unstructured":"Wu W, Luo L, Wang Y, Wu Q, Dai HB, Li JS, et al. Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications. Theranostics. 2018Apr 30;8(11):3038.","journal-title":"Theranostics"},{"issue":"349","key":"3411_CR30","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jconrel.2022.08.005","volume":"1","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Kim I, Lu Y, Xu Y, Yu DG, Song W. Intelligent poly(l-histidine)-based nanovehicles for controlled drug delivery. J Controlled Release. 2022Sep;1(349):963\u201382.","journal-title":"J Controlled Release"},{"issue":"1","key":"3411_CR31","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e08674","volume":"8","author":"Y Herdiana","year":"2022","unstructured":"Herdiana Y, Wathoni N, Shamsuddin S, Muchtaridi M. Drug release study of the chitosan-based nanoparticles. Heliyon. 2022Jan 1;8(1):e08674.","journal-title":"Heliyon"},{"issue":"11","key":"3411_CR32","doi-asserted-by":"crossref","DOI":"10.3390\/polym12112499","volume":"12","author":"FC Barbosa","year":"2020","unstructured":"Barbosa FC, Silva M, Silva H, Albuquerque D, Gomes AAR, Silva S, et al. Progress in the development of chitosan based insulin delivery systems: a systematic literature review. Polymers. 2020;12(11):2499.","journal-title":"Polymers"},{"issue":"3","key":"3411_CR33","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0168-3659(03)00205-0","volume":"90","author":"ES Lee","year":"2003","unstructured":"Lee ES, Shin HJ, Na K, Bae YH. Poly(l-histidine)\u2013PEG block copolymer micelles and pH-induced destabilization. J Controlled Release. 2003Jul 31;90(3):363\u201374.","journal-title":"J Controlled Release"},{"issue":"48","key":"3411_CR34","doi-asserted-by":"crossref","first-page":"30242","DOI":"10.1039\/C7RA04254J","volume":"7","author":"B Li","year":"2017","unstructured":"Li B, Shan M, Di X, Gong C, Zhang L, Wang Y, et al. A dual pH- and reduction-responsive anticancer drug delivery system based on PEG\u2013SS\u2013poly(amino acid) block copolymer. RSC Adv. 2017Jun 8;7(48):30242\u20139.","journal-title":"RSC Adv"},{"issue":"10","key":"3411_CR35","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1080\/17425247.2020.1796628","volume":"17","author":"J Karlsson","year":"2020","unstructured":"Karlsson J, Rhodes KR, Green JJ, Tzeng SY. Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities. Expert Opin Drug Deliv. 2020Oct 2;17(10):1395\u2013410.","journal-title":"Expert Opin Drug Deliv"},{"issue":"8","key":"3411_CR36","volume":"1","author":"I Fatima","year":"2025","unstructured":"Fatima I, Khan A, Rahdar A, Karkan SF, Kharaba Z, Baino F. Optimized mesalamine-loaded polyelectrolyte complex nanoparticles for targeted colon delivery in inflammatory bowel disease treatment: A central composite design approach. Mater. 2025Jul;1(8):100530.","journal-title":"Mater"},{"issue":"4","key":"3411_CR37","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.nantod.2012.06.013","volume":"7","author":"M Creixell","year":"2012","unstructured":"Creixell M, Peppas NA. Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance. Nano Today. 2012Aug 1;7(4):367\u201379.","journal-title":"Nano Today"},{"issue":"5","key":"3411_CR38","first-page":"605","volume":"15","author":"X Zhang","year":"2020","unstructured":"Zhang X, Zhang T, Ma X, Wang Y, Lu Y, Jia D, et al. The design and synthesis of dextran-doxorubicin prodrug-based pH-sensitive drug delivery system for improving chemotherapy efficacy. Asian J Pharm Sci. 2020Sep 1;15(5):605\u201316.","journal-title":"Asian J Pharm Sci"},{"issue":"5","key":"3411_CR39","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1039\/C8BM01643G","volume":"7","author":"JJ Baljon","year":"2019","unstructured":"Baljon JJ, Dandy A, Wang-Bishop L, Wehbe M, Jacobson ME, Wilson JT. The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome. Biomater Sci. 2019Apr 23;7(5):1888\u201397.","journal-title":"Biomater Sci"},{"issue":"20","key":"3411_CR40","doi-asserted-by":"crossref","first-page":"12458","DOI":"10.1021\/la202616u","volume":"27","author":"HS Lee","year":"2011","unstructured":"Lee HS, Eckmann DM, Lee D, Hickok NJ, Composto RJ. Symmetric pH-Dependent Swelling and Antibacterial Properties of Chitosan Brushes. Langmuir. 2011Oct 18;27(20):12458\u201365.","journal-title":"Langmuir"},{"issue":"3","key":"3411_CR41","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10030150","volume":"10","author":"E Mazzotta","year":"2018","unstructured":"Mazzotta E, Tavano L, Muzzalupo R. Thermo-sensitive vesicles in controlled drug delivery for chemotherapy. Pharmaceutics. 2018;10(3):150.","journal-title":"Pharmaceutics"},{"issue":"24","key":"3411_CR42","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.2174\/1381612823666170516144914","volume":"23","author":"A Vashist","year":"2017","unstructured":"Vashist A, Kaushik A, Alexis K, Jayant RD, Sagar V, Vashist A, et al. Bioresponsive injectable hydrogels for on-demand drug release and tissue engineering. Curr Pharm Des. 2017;23(24):3595\u2013602.","journal-title":"Curr Pharm Des"},{"key":"#cr-split#-3411_CR43.1","doi-asserted-by":"crossref","unstructured":"Yaramiri A, Asalh RA, Asalh MA, AlSawaftah N, Abuwatfa WH, Husseini GA. A Comprehensive Review of Smart Thermosensitive Nanocarriers for Precision Cancer Therapy [Internet]. [cited 2025 Aug 6]. Available from:","DOI":"10.3390\/ijms26157322"},{"key":"#cr-split#-3411_CR43.2","doi-asserted-by":"crossref","unstructured":"https:\/\/www.mdpi.com\/1422-0067\/26\/15\/7322.\u00a0 Accessed 06 Aug 2025.","DOI":"10.3390\/ijms26157322"},{"issue":"11","key":"3411_CR44","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/j.apsb.2020.05.011","volume":"10","author":"Y Luo","year":"2020","unstructured":"Luo Y, Li J, Hu Y, Gao F, Pak-Heng Leung G, Geng F, et al. Injectable thermo-responsive nano-hydrogel loading triptolide for the anti-breast cancer enhancement via localized treatment based on \u201ctwo strikes\u201d effects. Acta Pharm Sin B. 2020Nov 1;10(11):2227\u201345.","journal-title":"Acta Pharm Sin B"},{"issue":"2","key":"3411_CR45","volume":"15","author":"Z Wang","year":"2023","unstructured":"Wang Z, Liu B, Tu J, Xiang J, Xiong H, Wu Y, et al. PLGA nanoparticles loaded with sorafenib combined with thermosensitive hydrogel system and microwave hyperthermia for multiple sensitized radiotherapy. Pharmaceutics. 2023;15(2):487.","journal-title":"Pharmaceutics"},{"issue":"1","key":"3411_CR46","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12951-018-0398-2","volume":"16","author":"X Guo","year":"2018","unstructured":"Guo X, Cheng Y, Zhao X, Luo Y, Chen J, Yuan WE. Advances in redox-responsive drug delivery systems of tumor microenvironment. J Nanobiotechnology. 2018Sep 22;16(1):74.","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"3411_CR47","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/1444990","volume":"2024","author":"S Throat","year":"2024","unstructured":"Throat S, Bhattacharya S. Macromolecular poly(N-isopropylacrylamide) (PNIPAM) in cancer treatment and beyond. Adv Polym Technol. 2024;2024(1):1444990.","journal-title":"Adv Polym Technol"},{"key":"3411_CR48","unstructured":"Cheemalakonda LD. Development and evaluation of Plga-S-S-Peg micelles coencapsulating curcumin difluorinated and paclitaxel for synergistic therapeutic efficacy."},{"issue":"3","key":"3411_CR49","doi-asserted-by":"crossref","DOI":"10.3390\/gels6030020","volume":"6","author":"S Ghaeini-Hesaroeiye","year":"2020","unstructured":"Ghaeini-Hesaroeiye S, Razmi Bagtash H, Boddohi S, Vasheghani-Farahani E, Jabbari E. Thermoresponsive nanogels based on different polymeric moieties for biomedical applications. Gels. 2020;6(3):20.","journal-title":"Gels"},{"issue":"6","key":"3411_CR50","doi-asserted-by":"crossref","DOI":"10.3390\/polym13060987","volume":"13","author":"G Kasza","year":"2021","unstructured":"Kasza G, Stumphauser T, Bisztr\u00e1n M, Szarka G, Heged\u00fcs I, Nagy E, Iv\u00e1n B. Thermoresponsive poly (N, N-diethylacrylamide-co-glycidyl methacrylate) copolymers and its catalytically active \u03b1-chymotrypsin bioconjugate with enhanced enzyme stability. Polymers. 2021 Mar 23;13(6):987.","journal-title":"Polymers"},{"issue":"240","key":"3411_CR51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2015.11.010","volume":"28","author":"J Despanie","year":"2016","unstructured":"Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Controlled Release. 2016Oct;28(240):93\u2013108.","journal-title":"J Controlled Release"},{"key":"3411_CR52","doi-asserted-by":"crossref","unstructured":"Release of 5-fluorouracil from poly(acrylamide-co-monopropyl itaconate) hydrogels. J Chromatogr B Biomed Sci App. 1996 May 17;680(1\u20132):243\u201353.","DOI":"10.1016\/0378-4347(95)00401-7"},{"issue":"32","key":"3411_CR53","doi-asserted-by":"crossref","first-page":"20450","DOI":"10.1021\/acsomega.0c02548","volume":"5","author":"A Ahsan","year":"2020","unstructured":"Ahsan A, Farooq MA, Parveen A. Thermosensitive Chitosan-Based Injectable Hydrogel as an Efficient Anticancer Drug Carrier. ACS Omega. 2020Aug 18;5(32):20450\u201360.","journal-title":"ACS Omega"},{"issue":"7","key":"3411_CR54","doi-asserted-by":"crossref","DOI":"10.3390\/polym15071697","volume":"15","author":"LM Gradinaru","year":"2023","unstructured":"Gradinaru LM, Bercea M, Lupu A, Gradinaru VR. Development of polyurethane\/peptide-based carriers with self-healing properties. Polymers. 2023;15(7):1697.","journal-title":"Polymers"},{"issue":"11","key":"3411_CR55","volume":"12","author":"X Liu","year":"2020","unstructured":"Liu X, Hou Y, Zhang Y, Zhang W. Thermoresponsive polymers of poly(2-(N-alkylacrylamide)ethyl acetate)s. Polymers. 2020;12(11):2464.","journal-title":"Polymers"},{"issue":"11","key":"3411_CR56","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26113332","volume":"26","author":"DM Beaupre","year":"2021","unstructured":"Beaupre DM, Weiss RG. Thiol- and disulfide-based stimulus-responsive soft materials and self-assembling systems. Molecules. 2021;26(11):3332.","journal-title":"Molecules"},{"issue":"14","key":"3411_CR57","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/marc.200400062","volume":"25","author":"Y Maeda","year":"2004","unstructured":"Maeda Y, Mochiduki H, Ikeda I. Hydration changes during thermosensitive association of a block copolymer consisting of LCST and UCST blocks. Macromol Rapid Commun. 2004;25(14):1330\u20134.","journal-title":"Macromol Rapid Commun"},{"issue":"8","key":"3411_CR58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23084421","volume":"23","author":"M Sobczak","year":"2022","unstructured":"Sobczak M. Enzyme-responsive hydrogels as potential drug delivery systems\u2014state of knowledge and future prospects. Int J Mol Sci. 2022;23(8):4421.","journal-title":"Int J Mol Sci"},{"issue":"21","key":"3411_CR59","doi-asserted-by":"crossref","first-page":"12273","DOI":"10.1039\/C4NR04249B","volume":"6","author":"Q Hu","year":"2014","unstructured":"Hu Q, Katti PS, Gu Z. Enzyme-responsive nanomaterials for controlled drug delivery. Nanoscale. 2014Oct 10;6(21):12273\u201386.","journal-title":"Nanoscale"},{"issue":"118","key":"3411_CR60","volume":"1","author":"Z Cao","year":"2019","unstructured":"Cao Z, Li W, Liu R, Li X, Li H, Liu L, et al. pH- and enzyme-triggered drug release as an important process in the design of anti-tumor drug delivery systems. Biomed Pharmacother. 2019Oct;1(118):109340.","journal-title":"Biomed Pharmacother"},{"issue":"257","key":"3411_CR61","volume":"1","author":"F Guo","year":"2024","unstructured":"Guo F, Du Y, Wang Y, Wang M, Wang L, Yu N, et al. Targeted drug delivery systems for matrix metalloproteinase-responsive anoparticles in tumor cells: A review. Int J Biol Macromol. 2024Feb;1(257):128658.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"3411_CR62","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12645-023-00169-8","volume":"14","author":"A Askarizadeh","year":"2023","unstructured":"Askarizadeh A, Mashreghi M, Mirhadi E, Mirzavi F, Shargh VH, Badiee A, et al. Doxorubicin-loaded liposomes surface engineered with the matrix metalloproteinase-2 cleavable polyethylene glycol conjugate for cancer therapy. Cancer Nanotechnol. 2023Mar 7;14(1):18.","journal-title":"Cancer Nanotechnol"},{"issue":"151\u2013152","key":"3411_CR63","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.addr.2019.01.010","volume":"1","author":"D Dheer","year":"2019","unstructured":"Dheer D, Nicolas J, Shankar R. Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases. Adv Drug Deliv Rev. 2019Nov;1(151\u2013152):130\u201351.","journal-title":"Adv Drug Deliv Rev"},{"issue":"5","key":"3411_CR64","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17050606","volume":"17","author":"KB Narayanan","year":"2025","unstructured":"Narayanan KB. Enzyme-based anti-inflammatory therapeutics for inflammatory diseases. Pharmaceutics. 2025;17(5):606.","journal-title":"Pharmaceutics"},{"key":"3411_CR65","doi-asserted-by":"crossref","unstructured":"Sikder A, Bagasariya D, Shah S, Famta P, Kashikar R, Kotha AK, et al. Chapter 8 - Polymers in advanced drug and gene delivery. In: Patravale V, Disouza J, Shahiwala A, editors. Polymers for Pharmaceutical and Biomedical Applications [Internet]. Elsevier; 2024 [cited 2025 Aug 9]. p. 291\u2013332. Available from: \nhttps:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780323954969000089. Accessed\u00a009 Aug 2025.","DOI":"10.1016\/B978-0-323-95496-9.00008-9"},{"issue":"8","key":"3411_CR66","doi-asserted-by":"crossref","DOI":"10.3390\/polym16081163","volume":"16","author":"K Filipek","year":"2024","unstructured":"Filipek K, Otulakowski \u0141, Jelonek K, Utrata-Weso\u0142ek A. Degradable nanogels based poly[oligo(ethylene glycol) methacrylate] (POEGMA) derivatives through thermo-induced aggregation of polymer chain and subsequent chemical crosslinking. Polymers. 2024;16(8):1163.","journal-title":"Polymers"},{"issue":"11","key":"3411_CR67","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1021\/acsbiomaterials.7b00397","volume":"4","author":"E Bakaic","year":"2018","unstructured":"Bakaic E, Smeets NMB, Badv M, Dodd M, Barrigar O, Siebers E, et al. Injectable and Degradable Poly(Oligoethylene glycol methacrylate) Hydrogels with Tunable Charge Densities as Adhesive Peptide-Free Cell Scaffolds. ACS Biomater Sci Eng. 2018Nov 12;4(11):3713\u201325.","journal-title":"ACS Biomater Sci Eng"},{"issue":"3","key":"3411_CR68","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ejpb.2007.03.023","volume":"67","author":"GY Lee","year":"2007","unstructured":"Lee GY, Park K, Kim SY, Byun Y. MMPs-specific PEGylated peptide\u2013DOX conjugate micelles that can contain free doxorubicin. Eur J Pharm Biopharm. 2007Nov 1;67(3):646\u201354.","journal-title":"Eur J Pharm Biopharm"},{"key":"3411_CR69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biomaterials.2018.09.023","volume":"1;186","author":"JJ Arroyo-Crespo","year":"2018","unstructured":"Arroyo-Crespo JJ, Armi\u00f1\u00e1n A, Charbonnier D, Balzano-Nogueira L, Huertas-L\u00f3pez F, Mart\u00ed C, et al. Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment. Biomaterials. 2018;1;186:8\u201321.","journal-title":"Biomaterials"},{"issue":"5","key":"3411_CR70","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/10611860701349141","volume":"15","author":"M Werle","year":"2007","unstructured":"Werle M, Loretz B, Entstrasser D, F\u00f6ger F. Design and evaluation of a chitosan\u2013aprotinin conjugate for the peroral delivery of therapeutic peptides and proteins susceptible to enzymatic degradation. J Drug Target. 2007Jan 1;15(5):327\u201333.","journal-title":"J Drug Target"},{"issue":"24","key":"3411_CR71","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.1158\/0008-5472.CAN-16-1681","volume":"76","author":"M Zhang","year":"2016","unstructured":"Zhang M, Xu C, Wen L, Han MK, Xiao B, Zhou J, et al. A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells. Cancer Res. 2016Dec 15;76(24):7208\u201318.","journal-title":"Cancer Res"},{"key":"3411_CR72","volume":"30;585","author":"DL Priwitaningrum","year":"2020","unstructured":"Priwitaningrum DL, Jentsch J, Bansal R, Rahimian S, Storm G, Hennink WE, et al. Apoptosis-inducing peptide loaded in PLGA nanoparticles induces anti-tumor effects in vivo. Int J Pharm. 2020;30;585:119535.","journal-title":"Int J Pharm"},{"issue":"4","key":"3411_CR73","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1039\/C7PY01492A","volume":"9","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Zhou Y, Zhou Z, Piao Y, Kalva N, Liu X, et al. Synthesis of enzyme-responsive phosphoramidate dendrimers for cancer drug delivery. Polym Chem. 2018Jan 23;9(4):438\u201349.","journal-title":"Polym Chem"},{"issue":"6","key":"3411_CR74","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1021\/acs.biomac.4c00221","volume":"25","author":"P Rathee","year":"2024","unstructured":"Rathee P, Edelstein-Pardo N, Koren G, Beck R, Amir RJ. Cascade Mesophase Transitions of Multi-enzyme Responsive Polymeric Formulations. Biomacromol. 2024Jun 10;25(6):3607\u201319.","journal-title":"Biomacromol"},{"issue":"2","key":"3411_CR75","doi-asserted-by":"crossref","first-page":"89","DOI":"10.4155\/tde-2016-0060","volume":"8","author":"CS Linsley","year":"2017","unstructured":"Linsley CS, Wu BM. Recent advances in light-responsive on-demand drug-delivery systems. Ther Deliv. 2017;8(2):89\u2013107.","journal-title":"Ther Deliv"},{"key":"3411_CR76","doi-asserted-by":"publisher","unstructured":"Tao Y, Chan HF, Shi B, Li M, Leong KW. Light: A Magical Tool for Controlled Drug Delivery. [cited 2025 Aug 9]; Available from: https:\/\/doi.org\/10.1002\/adfm.202005029.","DOI":"10.1002\/adfm.202005029"},{"issue":"12","key":"3411_CR77","doi-asserted-by":"crossref","DOI":"10.3390\/ma13122777","volume":"13","author":"A Romano","year":"2020","unstructured":"Romano A, Roppolo I, Rossegger E, Schl\u00f6gl S, Sangermano M. Recent trends in applying ortho-nitrobenzyl esters for the design of photo-responsive polymer networks. Materials. 2020;13(12):2777.","journal-title":"Materials"},{"issue":"9","key":"3411_CR78","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1021\/acs.chemmater.8b00357","volume":"30","author":"S Jia","year":"2018","unstructured":"Jia S, Fong WK, Graham B, Boyd BJ. Photoswitchable Molecules in Long-Wavelength Light-Responsive Drug Delivery: From Molecular Design to Applications. Chem Mater. 2018May 8;30(9):2873\u201387.","journal-title":"Chem Mater"},{"issue":"17","key":"3411_CR79","volume":"198","author":"SA Safavi-Mirmahalleh","year":"2023","unstructured":"Safavi-Mirmahalleh SA, Golshan M, Gheitarani B, Salami Hosseini M, Salami-Kalajahi M. A review on applications of coumarin and its derivatives in preparation of photo-responsive polymers. Eur Polym J. 2023;198(17):112430.","journal-title":"Eur Polym J"},{"issue":"1","key":"3411_CR80","volume":"59","author":"NS Thakur","year":"2024","unstructured":"Thakur NS, Saleh N, Khan AF, Chakrabarty B, Agrahari V. Progress and promise of photoresponsive nanocarriers for precision drug delivery in cancer. J Photochem Photobiol C Photochem Rev. 2024;59(1):100665.","journal-title":"J Photochem Photobiol C Photochem Rev"},{"issue":"9","key":"3411_CR81","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1002\/smll.201000028","volume":"6","author":"J You","year":"2010","unstructured":"You J, Shao R, Wei X, Gupta S, Li C. Near-infrared light triggers release of Paclitaxel from biodegradable microspheres: photothermal effect and enhanced antitumor activity. Small. 2010;6(9):1022\u201331.","journal-title":"Small"},{"issue":"1","key":"3411_CR82","volume":"3","author":"M Gao","year":"2023","unstructured":"Gao M, Kwaria D, Norikane Y, Yue Y. Visible-light-switchable azobenzenes: molecular design, supramolecular systems, and applications. Nat Sci. 2023;3(1):e220020.","journal-title":"Nat Sci"},{"issue":"7","key":"3411_CR83","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.603","volume":"5","author":"W Zhao","year":"2024","unstructured":"Zhao W, Wang L, Zhang M, Liu Z, Wu C, Pan X, et al. Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies. MedComm. 2024;5(7):e603.","journal-title":"MedComm"},{"issue":"4","key":"3411_CR84","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1021\/acsabm.0c01621","volume":"4","author":"MF Tsai","year":"2021","unstructured":"Tsai MF, Lo YL, Soorni Y, Su CH, Sivasoorian SS, Yang JY, et al. Near-Infrared Light-Triggered Drug Release from Ultraviolet- and Redox-Responsive Polymersome Encapsulated with Core-Shell Upconversion Nanoparticles for Cancer Therapy. ACS Appl Bio Mater. 2021Apr 19;4(4):3264\u201375.","journal-title":"ACS Appl Bio Mater"},{"issue":"4","key":"3411_CR85","volume":"3","author":"B Xia","year":"2016","unstructured":"Xia B, Wang B, Chen Z, Zhang Q, Shi J. Near-infrared light-triggered intracellular delivery of anticancer drugs using porous silicon nanoparticles conjugated with IR820 dyes. Adv Mater Interfaces. 2016;3(4):1500715.","journal-title":"Adv Mater Interfaces"},{"issue":"9","key":"3411_CR86","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/j.chempr.2018.07.002","volume":"4","author":"X Fu","year":"2018","unstructured":"Fu X, Hosta-Rigau L, Chandrawati R, Cui J. Multi-Stimuli-Responsive Polymer Particles, Films, and Hydrogels for Drug Delivery. Chem. 2018Sep 13;4(9):2084\u2013107.","journal-title":"Chem"},{"key":"3411_CR87","doi-asserted-by":"publisher","unstructured":"Xing Y, Zeng B, Yang W. Light responsive hydrogels for controlled drug delivery. Front Bioeng Biotechnol [Internet]. 2022 Dec 16 [cited 2026 Feb 15];10. Available from: https:\/\/doi.org\/10.3389\/fbioe.2022.1075670.","DOI":"10.3389\/fbioe.2022.1075670"},{"key":"3411_CR88","doi-asserted-by":"crossref","unstructured":"Rinaldi A, Caraffi R, Grazioli MV, Oddone N, Giardino L, Tosi G, et al. Applications of the ROS-Responsive Thioketal Linker for the Production of Smart Nanomedicines. Polymers [Internet]. 2022 Feb 11 [cited 2026 Feb 12];14(4). Available from: \nhttps:\/\/www.mdpi.com\/2073-4360\/14\/4\/687.","DOI":"10.3390\/polym14040687"},{"issue":"1","key":"3411_CR89","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1021\/acsomega.6b00018","volume":"1","author":"S Bhattacharya","year":"2016","unstructured":"Bhattacharya S, Ganivada MN, Dinda H, Das Sarma J, Shunmugam R. Biodegradable Copolymer for Stimuli-Responsive Sustained Release of Doxorubicin. ACS Omega. 2016Jul 31;1(1):108\u201317.","journal-title":"ACS Omega"},{"issue":"3","key":"3411_CR90","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11095-020-2759-4","volume":"37","author":"NB Mutlu-Agardan","year":"2020","unstructured":"Mutlu-Agardan NB, Sarisozen C, Torchilin VP. Cytotoxicity of Novel Redox Sensitive PEG2000-S-S-PTX Micelles against Drug-Resistant Ovarian and Breast Cancer Cells. Pharm Res. 2020Mar 12;37(3):65. Accessed 12 Feb 2026.","journal-title":"Pharm Res"},{"issue":"7","key":"3411_CR91","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.1021\/acs.nanolett.8b01924","volume":"18","author":"X Ling","year":"2018","unstructured":"Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, et al. Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. Nano Lett. 2018Jul 11;18(7):4618\u201325.","journal-title":"Nano Lett"},{"issue":"194","key":"3411_CR92","volume":"1","author":"Q Pan","year":"2020","unstructured":"Pan Q, Deng X, Gao W, Chang J, Pu Y, He B. ROS triggered cleavage of thioketal moiety to dissociate prodrug nanoparticles for chemotherapy. Colloids Surf B Biointerfaces. 2020Oct;1(194):111223.","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"567","key":"3411_CR93","volume":"15","author":"YS Birhan","year":"2019","unstructured":"Birhan YS, Hailemeskel BZ, Mekonnen TW, Hanurry EY, Darge HF, Andrgie AT, et al. Fabrication of redox-responsive Bi(mPEG-PLGA)-Se2 micelles for doxorubicin delivery. Int J Pharm. 2019Aug;15(567):118486.","journal-title":"Int J Pharm"},{"issue":"5","key":"3411_CR94","first-page":"1013","volume":"28","author":"P Vader","year":"2011","unstructured":"Vader P, van der Aa LJ, Engbersen JFJ, Storm G, Schiffelers RM. Disulfide-Based Poly(amido amine)s for siRNA Delivery: Effects of Structure on siRNA Complexation, Cellular Uptake. Gene Silencing and Toxicity Pharm Res. 2011May 1;28(5):1013\u201322.","journal-title":"Gene Silencing and Toxicity Pharm Res"},{"issue":"207","key":"3411_CR95","volume":"1","author":"H Maslah","year":"2020","unstructured":"Maslah H, Skarbek C, Pethe S, Labru\u00e8re R. Anticancer boron-containing prodrugs responsive to oxidative stress from the tumor microenvironment. Eur J Med Chem. 2020Dec;1(207):112670.","journal-title":"Eur J Med Chem"},{"issue":"9","key":"3411_CR96","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15092216","volume":"15","author":"VB Junyaprasert","year":"2023","unstructured":"Junyaprasert VB, Thummarati P. Innovative design of targeted nanoparticles: polymer\u2013drug conjugates for enhanced cancer therapy. Pharmaceutics. 2023;15(9):2216.","journal-title":"Pharmaceutics"},{"key":"3411_CR97","doi-asserted-by":"crossref","unstructured":"Alven S, Nqoro X, Buyana B, Aderibigbe BA. Polymer-Drug Conjugate, a Potential Therapeutic to Combat Breast and Lung Cancer. Pharmaceutics [Internet]. 2020 Apr 29 [cited 2026 Feb 12];12(5). Available from: \nhttps:\/\/www.mdpi.com\/1999-4923\/12\/5\/406.","DOI":"10.3390\/pharmaceutics12050406"},{"issue":"623","key":"3411_CR98","volume":"25","author":"A Javia","year":"2022","unstructured":"Javia A, Vanza J, Bardoliwala D, Ghosh S, Misra LA, Patel M, et al. Polymer-drug conjugates: Design principles, emerging synthetic strategies and clinical overview. Int J Pharm. 2022Jul;25(623):121863.","journal-title":"Int J Pharm"},{"issue":"1","key":"3411_CR99","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/jnt2010005","volume":"2","author":"S Manandhar","year":"2021","unstructured":"Manandhar S, Sj\u00f6holm E, Bobacka J, Rosenholm JM, Bansal KK. Polymer-drug conjugates as nanotheranostic agents. J Nanotheranostics. 2021;2(1):63\u201381. Accessed 13 Aug 2025.","journal-title":"J Nanotheranostics"},{"key":"3411_CR100","doi-asserted-by":"publisher","unstructured":"Li K, Oderinde O, Liu S, Yao F, Fu G. Polymer synthesis: copper-catalyzed azide alkyne cycloaddition. In: Encyclopedia of polymer science and technology [Internet]. John Wiley & Sons, Ltd; 2017 [cited 2025 Aug 13]. pp. 1\u201340. Available from:\u00a0 https:\/\/doi.org\/10.1002\/0471440264.pst662.","DOI":"10.1002\/0471440264.pst662"},{"issue":"12","key":"3411_CR101","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1021\/ma2005102","volume":"44","author":"Y Yu","year":"2011","unstructured":"Yu Y, Zou J, Yu L, Ji W, Li Y, Law WC, et al. Functional Polylactide-g-Paclitaxel\u2013Poly(ethylene glycol) by Azide-Alkyne Click Chemistry. Macromolecules. 2011Jun 28;44(12):4793\u2013800.","journal-title":"Macromolecules"},{"issue":"1","key":"3411_CR102","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1021\/bc5005262","volume":"26","author":"SD Fontaine","year":"2015","unstructured":"Fontaine SD, Reid R, Robinson L, Ashley GW, Santi DV. Long-Term Stabilization of Maleimide-Thiol Conjugates. Bioconjug Chem. 2015Jan 21;26(1):145\u201352.","journal-title":"Bioconjug Chem"},{"issue":"16","key":"3411_CR103","volume":"24","author":"J Xu","year":"2019","unstructured":"Xu J, Liu Y, HuiHsu S. Hydrogels based on schiff base linkages for biomedical applications. Molecules. 2019;24(16):3005.","journal-title":"Molecules"},{"issue":"4","key":"3411_CR104","doi-asserted-by":"crossref","DOI":"10.3390\/polym15040823","volume":"15","author":"D Berraaouan","year":"2023","unstructured":"Berraaouan D, Essifi K, Addi M, Hano C, Fauconnier ML, Tahani A. Hybrid microcapsules for encapsulation and controlled release of rosemary essential oil. Polymers. 2023;15(4):823.","journal-title":"Polymers"},{"issue":"3","key":"3411_CR105","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ijrobp.2013.02.009","volume":"86","author":"ME Werner","year":"2013","unstructured":"Werner ME, Cummings ND, Sethi M, Wang EC, Sukumar R, Moore DT, et al. Preclinical Evaluation of Genexol-PM, a Nanoparticle Formulation of Paclitaxel, as a Novel Radiosensitizer for the Treatment of Non-Small Cell Lung Cancer. Int J Radiat Oncol. 2013Jul 1;86(3):463\u20138.","journal-title":"Int J Radiat Oncol"},{"key":"3411_CR106","doi-asserted-by":"crossref","unstructured":"Ma P, Mumper RJ. Paclitaxel Nano-Delivery Systems: A Comprehensive Review. 2013;4(2).","DOI":"10.4172\/2157-7439.1000164"},{"issue":"2","key":"3411_CR107","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1208\/s12249-025-03319-w","volume":"27","author":"CK Singh","year":"2026","unstructured":"Singh CK, Bania R, Deka S, Dwivedi M, Nair AB, Bal T, et al. Recent Trends in the Development and Clinical Translation of Polymer-based Targeted Therapeutic Nanoparticle. AAPS PharmSciTech. 2026Feb 4;27(2):93.","journal-title":"AAPS PharmSciTech"},{"issue":"4","key":"3411_CR108","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.apsb.2022.07.011","volume":"13","author":"K Butowska","year":"2023","unstructured":"Butowska K, Han X, Gong N, El-Mayta R, Haley RM, Xue L, Zhong W, Guo W, Wang K, Mitchell MJ. Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy. Acta Pharmaceutica Sinica B. 2023 Apr 1;13(4):1429-37.","journal-title":"Acta Pharm Sin B"},{"issue":"10","key":"3411_CR109","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1021\/mp500399j","volume":"11","author":"X Chuan","year":"2014","unstructured":"Chuan X, Song Q, Lin J, Chen X, Zhang H, Dai W, et al. Novel Free-Paclitaxel-Loaded Redox-Responsive Nanoparticles Based on a Disulfide-Linked Poly(ethylene glycol)\u2013Drug Conjugate for Intracellular Drug Delivery: Synthesis, Characterization, and Antitumor Activity in Vitro and in Vivo. Mol Pharm. 2014Oct 6;11(10):3656\u201370.","journal-title":"Mol Pharm"},{"issue":"2","key":"3411_CR110","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3892\/ijo.2012.1754","volume":"42","author":"YJ Zhong","year":"2013","unstructured":"Zhong YJ, Shao LH, Li Y. Cathepsin B-cleavable doxorubicin prodrugs for targeted cancer therapy (Review). Int J Oncol. 2013Feb 1;42(2):373\u201383.","journal-title":"Int J Oncol"},{"issue":"1","key":"3411_CR111","first-page":"1530","volume":"2","author":"D Barnard","year":"2000","unstructured":"Barnard D. Pegasys. Pegasys. 2000;2(1):1530\u20138.","journal-title":"Pegasys"},{"issue":"8","key":"3411_CR112","doi-asserted-by":"crossref","DOI":"10.3390\/polym13081272","volume":"13","author":"AI Visan","year":"2021","unstructured":"Visan AI, Popescu-Pelin G, Socol G. Degradation behavior of polymers used as coating materials for drug delivery\u2014a basic review. Polymers. 2021;13(8):1272.","journal-title":"Polymers"},{"issue":"6","key":"3411_CR113","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1002\/med.21720","volume":"40","author":"X Yang","year":"2020","unstructured":"Yang X, Pan Z, Choudhury MR, Yuan Z, Anifowose A, Yu B, et al. Making smart drugs smarter: the importance of linker chemistry in targeted drug delivery. Med Res Rev. 2020;40(6):2682\u2013713.","journal-title":"Med Res Rev"},{"issue":"1","key":"3411_CR114","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/1567201819666220408095510","volume":"20","author":"C Gupta","year":"2023","unstructured":"Gupta C, Naik I, Menon M, Ambre P, Coutinho E. A review on exploring the opportunities of polymer drug conjugated systems for targeted cancer treatment. Curr Drug Deliv. 2023;20(1):8\u201330.","journal-title":"Curr Drug Deliv"},{"issue":"1","key":"3411_CR115","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1038\/s41467-018-05381-4","volume":"9","author":"A Creamer","year":"2018","unstructured":"Creamer A, Wood CS, Howes PD, Casey A, Cong S, Marsh AV, et al. Post-polymerisation functionalisation of conjugated polymer backbones and its application in multi-functional emissive nanoparticles. Nat Commun. 2018Aug 13;9(1):3237.","journal-title":"Nat Commun"},{"issue":"1","key":"3411_CR116","doi-asserted-by":"crossref","first-page":"3","DOI":"10.7150\/thno.3463","volume":"2","author":"MK Yu","year":"2012","unstructured":"Yu MK, Park J, Jon S. Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy. Theranostics. 2012Jan 1;2(1):3\u201344.","journal-title":"Theranostics"},{"key":"3411_CR117","doi-asserted-by":"publisher","unstructured":"Kunjiappan S, Pavadai P, Vellaichamy S, Pandian SRK, Ravishankar V, Palanisamy P, et al. Surface receptor\u2010mediated targeted drug delivery systems for enhanced cancer treatment: A state\u2010of\u2010the\u2010art review. [cited 2025 Aug 13]; Available from: https:\/\/doi.org\/10.1002\/ddr.21758.","DOI":"10.1002\/ddr.21758"},{"issue":"1","key":"3411_CR118","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.breast.2022.10.016","volume":"66","author":"E Rassy","year":"2022","unstructured":"Rassy E, Rached L, Pistilli B. Antibody drug conjugates targeting HER2: clinical development in metastatic breast cancer. Breast. 2022;66(1):217\u201326.","journal-title":"Breast"},{"key":"3411_CR119","doi-asserted-by":"publisher","unstructured":"Javid H, Oryani MA, Rezagholinejad N, Esparham A, Tajaldini M, Karimi-Shahri M. RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin\u2013RGD interactions. [cited 2025 Aug 13]; Available from: https:\/\/doi.org\/10.1002\/cam4.6800.","DOI":"10.1002\/cam4.6800"},{"issue":"23","key":"3411_CR120","doi-asserted-by":"crossref","first-page":"13216","DOI":"10.1021\/acs.chemrev.4c00251","volume":"124","author":"K Ghosal","year":"2024","unstructured":"Ghosal K, Bhattacharyya SK, Mishra V, Zuilhof H. Click Chemistry for Biofunctional Polymers: From Observing to Steering Cell Behavior. Chem Rev. 2024Dec 11;124(23):13216\u2013300.","journal-title":"Chem Rev"},{"issue":"1","key":"3411_CR121","first-page":"1","volume":"15","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Li C, Chen X, Zhao Y, Liao Y, Huang P, et al. Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteins. Nat Commun. 2024Oct 8;15(1):1\u201314.","journal-title":"Nat Commun"},{"issue":"203","key":"3411_CR122","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jconrel.2015.02.022","volume":"10","author":"AA D\u2019Souza","year":"2015","unstructured":"D\u2019Souza AA, Devarajan PV. Asialoglycoprotein receptor mediated hepatocyte targeting \u2014 Strategies and applications. J Controlled Release. 2015Apr;10(203):126\u201339.","journal-title":"J Controlled Release"},{"issue":"9","key":"3411_CR123","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1021\/acs.biochem.8b00006","volume":"57","author":"MD Kleven","year":"2018","unstructured":"Kleven MD, Jue S, Enns CA. Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms. Biochemistry. 2018Mar 6;57(9):1552\u20139.","journal-title":"Biochemistry"},{"issue":"4","key":"3411_CR124","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.addr.2007.10.008","volume":"60","author":"VP Torchilin","year":"2008","unstructured":"Torchilin VP. Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers. Adv Drug Deliv Rev. 2008Mar 1;60(4):548\u201358.","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"3411_CR125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-022-00579-0","volume":"22","author":"SM Swain","year":"2023","unstructured":"Swain SM, Shastry M, Hamilton E. Targeting HER2-positive breast cancer: advances and future directions. Nat Rev Drug Discov. 2023;22(2):101\u201326.","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"3411_CR126","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.clinthera.2005.06.003","volume":"27","author":"SF Wong","year":"2005","unstructured":"Wong SF. Cetuximab: An epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer. Clin Ther. 2005Jun 1;27(6):684\u201394.","journal-title":"Clin Ther"},{"key":"3411_CR127","doi-asserted-by":"crossref","unstructured":"Herbst RS, Hong WK. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer. Semin Oncol. 2002 Oct 1;29(5, Supplement 14):18\u201330.","DOI":"10.1053\/sonc.2002.35644"},{"issue":"3","key":"3411_CR128","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3892\/mco.2014.255","volume":"2","author":"X Pei","year":"2014","unstructured":"Pei X, Zhang J, Liu J. Clinical applications of nucleic acid aptamers in cancer (Review). Mol Clin Oncol. 2014May 1;2(3):341\u20138.","journal-title":"Mol Clin Oncol"},{"issue":"3","key":"3411_CR129","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25031370","volume":"25","author":"M Paurevi\u0107","year":"2024","unstructured":"Paurevi\u0107 M, \u0160rajer Gajdo\u0161ik M, Ribi\u0107 R. Mannose ligands for mannose receptor targeting. Int J Mol Sci. 2024;25(3):1370.","journal-title":"Int J Mol Sci"},{"issue":"111","key":"3411_CR130","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biopha.2018.12.118","volume":"1","author":"WA Mohamed","year":"2019","unstructured":"Mohamed WA, Salama RM, Schaalan MF. A pilot study on the effect of lactoferrin on Alzheimer\u2019s disease pathological sequelae: Impact of the p-Akt\/PTEN pathway. Biomed Pharmacother. 2019Mar;1(111):714\u201323.","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"3411_CR131","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27061775","volume":"27","author":"A Speciale","year":"2022","unstructured":"Speciale A, Muscar\u00e0 C, Molonia MS, Cristani M, Cimino F, Saija A. Recent advances in glycyrrhetinic acid-functionalized biomaterials for liver cancer-targeting therapy. Molecules. 2022;27(6):1775.","journal-title":"Molecules"},{"key":"3411_CR132","doi-asserted-by":"crossref","unstructured":"Muller YA, Chen Y, Christinger HW, Li B, Cunningham BC, Lowman HB, et al. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 \u00e5 resolution and mutational analysis of the interface. Structure. 1998 Sep 15;6(9):1153\u201367.","DOI":"10.1016\/S0969-2126(98)00116-6"},{"issue":"3","key":"3411_CR133","volume":"8","author":"X Yang","year":"2013","unstructured":"Yang X, Sarvestani SK, Moeinzadeh S, He X, Jabbari E. Effect of CD44 Binding Peptide Conjugated to an Engineered Inert Matrix on Maintenance of Breast Cancer Stem Cells and Tumorsphere Formation. PLoS ONE. 2013Mar 18;8(3):e59147.","journal-title":"PLoS ONE"},{"issue":"40","key":"3411_CR134","doi-asserted-by":"crossref","first-page":"24487","DOI":"10.1039\/D1RA03322K","volume":"11","author":"AD Capua","year":"2021","unstructured":"Capua AD, Palladino A, Chino M, Attanasio C, Lombardi A, Vecchione R, et al. Active targeting of cancer cells by CD44 binding peptide-functionalized oil core-based nanocapsules. RSC Adv. 2021Jul 13;11(40):24487\u201399.","journal-title":"RSC Adv"},{"issue":"1","key":"3411_CR135","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12931-017-0546-5","volume":"18","author":"L Cortes-Dericks","year":"2017","unstructured":"Cortes-Dericks L, Schmid RA. CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives. Respir Res. 2017Apr 12;18(1):58.","journal-title":"Respir Res"},{"issue":"1","key":"3411_CR136","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10010002","volume":"10","author":"I Genta","year":"2018","unstructured":"Genta I, Chiesa E, Colzani B, Modena T, Conti B, Dorati R. GE11 peptide as an active targeting agent in antitumor therapy: a minireview. Pharmaceutics. 2018;10(1):2.","journal-title":"Pharmaceutics"},{"key":"3411_CR137","doi-asserted-by":"publisher","unstructured":"Ahmad ZA, Yeap SK, Ali AM, Ho WY, Alitheen NBM, Hamid M. scFv Antibody: Principles and clinical application. [cited 2025 Aug 13]; Available from: https:\/\/doi.org\/10.1155\/2012\/980250.","DOI":"10.1155\/2012\/980250"},{"issue":"6","key":"3411_CR138","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.omtn.2016.12.003","volume":"17","author":"Y Huang","year":"2017","unstructured":"Huang Y. Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics. Mol Ther - Nucleic Acids. 2017Mar;17(6):116\u201332.","journal-title":"Mol Ther - Nucleic Acids"},{"key":"3411_CR139","doi-asserted-by":"crossref","unstructured":"Khan N, Ruchika, Dhritlahre RK, Saneja A. Recent advances in dual-ligand targeted nanocarriers for cancer therapy. Drug Discov Today. 2022 Aug 1;27(8):2288\u201399.","DOI":"10.1016\/j.drudis.2022.04.011"},{"issue":"5","key":"3411_CR140","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1208\/s12249-014-0143-6","volume":"15","author":"JT Duskey","year":"2014","unstructured":"Duskey JT, Rice KG. Nanoparticle Ligand Presentation for Targeting Solid Tumors. AAPS PharmSciTech. 2014Oct 1;15(5):1345\u201354.","journal-title":"AAPS PharmSciTech"},{"issue":"42","key":"3411_CR141","doi-asserted-by":"crossref","first-page":"14488","DOI":"10.1039\/C7DT02634J","volume":"46","author":"BL Oliveira","year":"2017","unstructured":"Oliveira BL, Caravan P. Peptide-based fibrin-targeting probes for thrombus imaging. Dalton Trans. 2017Oct 31;46(42):14488\u2013508.","journal-title":"Dalton Trans"},{"issue":"6","key":"3411_CR142","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.stem.2020.04.008","volume":"26","author":"P Vora","year":"2020","unstructured":"Vora P, Venugopal C, Salim SK, Tatari N, Bakhshinyan D, Singh M, et al. The Rational Development of CD133-Targeting Immunotherapies for Glioblastoma. Cell Stem Cell. 2020Jun 4;26(6):832\u2013844.e6.","journal-title":"Cell Stem Cell"},{"key":"3411_CR143","doi-asserted-by":"publisher","unstructured":"Comparison of prostate\u2010specific membrane antigen ligands in clinical translation research for diagnosis of prostate cancer. [cited 2025 Aug 13]; Available from: https:\/\/doi.org\/10.1002\/cnr2.1169.","DOI":"10.1002\/cnr2.1169"},{"key":"3411_CR144","doi-asserted-by":"crossref","unstructured":"Dall\u2019Olmo L, Papa N, Surdo NC, Marigo I, Mocellin S. Alpha-melanocyte stimulating hormone (\u03b1-MSH): biology, clinical relevance and implication in melanoma. J Transl Med. 2023 Aug 22;21(1):562.","DOI":"10.1186\/s12967-023-04405-y"},{"issue":"2","key":"3411_CR145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10549-012-2289-9","volume":"136","author":"H Masuda","year":"2012","unstructured":"Masuda H, Zhang D, Bartholomeusz C, Doihara H, Hortobagyi GN, Ueno NT. Role of epidermal growth factor receptor in breast cancer. Breast Cancer Res Treat. 2012Nov 1;136(2):331\u201345.","journal-title":"Breast Cancer Res Treat"},{"issue":"10","key":"3411_CR146","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s13346-021-01103-4","volume":"12","author":"AK Bakshi","year":"2022","unstructured":"Bakshi AK, Haider T, Tiwari R, Soni V. Critical parameters for design and development of multivalent nanoconstructs: recent trends. Drug Deliv Transl Res. 2022Oct 1;12(10):2335\u201358.","journal-title":"Drug Deliv Transl Res"},{"issue":"95","key":"3411_CR147","doi-asserted-by":"crossref","first-page":"53352","DOI":"10.1039\/C4RA10631H","volume":"4","author":"VA Ganesh","year":"2014","unstructured":"Ganesh VA, Baji A, Ramakrishna S. Smart functional polymers \u2013 a new route towards creating a sustainable environment. RSC Adv. 2014Oct 20;4(95):53352\u201364.","journal-title":"RSC Adv"},{"issue":"1","key":"3411_CR148","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s13167-010-0001-x","volume":"1","author":"JF Coelho","year":"2010","unstructured":"Coelho JF, Ferreira PC, Alves P, Cordeiro R, Fonseca AC, G\u00f3is JR, et al. Drug delivery systems: advanced technologies potentially applicable in personalized treatments. EPMA J. 2010;1(1):164\u2013209.","journal-title":"EPMA J"},{"issue":"5","key":"3411_CR149","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/cm2031569","volume":"24","author":"N Larson","year":"2012","unstructured":"Larson N, Ghandehari H. Polymeric Conjugates for Drug Delivery. Chem Mater. 2012Mar 13;24(5):840\u201353.","journal-title":"Chem Mater"},{"issue":"623","key":"3411_CR150","volume":"25","author":"A Javia","year":"2022","unstructured":"Javia A, Vanza J, Bardoliwala D, Ghosh S, Misra LA, Patel M, et al. Polymer-drug conjugates: Design principles, emerging synthetic strategies and clinical overview. Int J Pharm. 2022Jul;25(623):121863.","journal-title":"Int J Pharm"},{"issue":"3","key":"3411_CR151","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jsps.2020.01.004","volume":"28","author":"M Alsehli","year":"2020","unstructured":"Alsehli M. Polymeric nanocarriers as stimuli-responsive systems for targeted tumor (cancer) therapy: Recent advances in drug delivery. Saudi Pharm J. 2020Mar 1;28(3):255\u201365.","journal-title":"Saudi Pharm J"},{"key":"3411_CR152","doi-asserted-by":"crossref","unstructured":"Santhanakrishnan KR, Koilpillai J, Narayanasamy D, Santhanakrishnan K, Koilpillai J, Narayanasamy D. PEGylation in Pharmaceutical Development: Current Status and Emerging Trends in Macromolecular and Immunotherapeutic Drugs. Cureus [Internet]. 2024 Aug 12 [cited 2025 Aug 20];16(8). Available from: \nhttps:\/\/cureus.com\/articles\/276399-pegylation-in-pharmaceutical-development-current-status-and-emerging-trends-in-macromolecular-and-immunotherapeutic-drugs.","DOI":"10.7759\/cureus.66669"},{"issue":"6","key":"3411_CR153","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2217\/nnm.16.5","volume":"11","author":"N Hoshyar","year":"2016","unstructured":"Hoshyar N, Gray S, Han H, Bao G. The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction. Nanomed. 2016Mar 1;11(6):673\u201392.","journal-title":"Nanomed"},{"issue":"1","key":"3411_CR154","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1080\/10717544.2022.2089296","volume":"29","author":"R Bajracharya","year":"2022","unstructured":"Bajracharya R, Song JG, Patil BR, Lee SH, Noh HM, Kim DH, et al. Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems. Drug Deliv. 2022Dec 31;29(1):1959\u201370.","journal-title":"Drug Deliv"},{"issue":"569","key":"3411_CR155","volume":"5","author":"M Mackiewicz","year":"2019","unstructured":"Mackiewicz M, Romanski J, Drabczyk K, Waleka E, Stojek Z, Karbarz M. Degradable, thermo-, pH- and redox-sensitive hydrogel microcapsules for burst and sustained release of drugs. Int J Pharm. 2019Oct;5(569):118589. Accessed 20 Aug 2025.","journal-title":"Int J Pharm"},{"issue":"12","key":"3411_CR156","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1007\/s11095-008-9787-9","volume":"25","author":"S Sahin","year":"2008","unstructured":"Sahin S, Benet LZ. The Operational Multiple Dosing Half-life: A Key to Defining Drug Accumulation in Patients and to Designing Extended Release Dosage Forms. Pharm Res. 2008Dec 1;25(12):2869\u201377.","journal-title":"Pharm Res"},{"issue":"9","key":"3411_CR157","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10092055","volume":"10","author":"DV Bhalani","year":"2022","unstructured":"Bhalani DV, Nutan B, Kumar A, Singh Chandel AK. Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics. Biomedicines. 2022;10(9):2055.","journal-title":"Biomedicines"},{"issue":"180","key":"3411_CR158","volume":"1","author":"D Shi","year":"2022","unstructured":"Shi D, Beasock D, Fessler A, Szebeni J, Ljubimova JY, Afonin KA, et al. To PEGylate or not to PEGylate: Immunological properties of nanomedicine\u2019s most popular component, polyethylene glycol and its alternatives. Adv Drug Deliv Rev. 2022Jan;1(180):114079.","journal-title":"Adv Drug Deliv Rev"},{"issue":"194","key":"3411_CR159","volume":"1","author":"C Pacheco","year":"2023","unstructured":"Pacheco C, Bai\u00e3o A, Ding T, Cui W, Sarmento B. Recent advances in long-acting drug delivery systems for anticancer drug. Adv Drug Deliv Rev. 2023Mar;1(194):114724.","journal-title":"Adv Drug Deliv Rev"},{"issue":"12","key":"3411_CR160","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.2147\/IJN.S132780","volume":"31","author":"S Shen","year":"2017","unstructured":"Shen S, Wu Y, Liu Y, Wu D. High drug-loading nanomedicines: progress, current status, and prospects. Int J Nanomedicine. 2017May;31(12):4085\u2013109.","journal-title":"Int J Nanomedicine"},{"issue":"9","key":"3411_CR161","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1021\/bm500921q","volume":"15","author":"MA van Dongen","year":"2014","unstructured":"van Dongen MA, Dougherty CA, Banaszak Holl MM. Multivalent Polymers for Drug Delivery and Imaging: The Challenges of Conjugation. Biomacromol. 2014Sep 8;15(9):3215\u201334.","journal-title":"Biomacromol"},{"issue":"10","key":"3411_CR162","volume":"13","author":"X Bai","year":"2022","unstructured":"Bai X, Smith ZL, Wang Y, Butterworth S, Tirella A. Sustained drug release from smart nanoparticles in cancer therapy: a comprehensive review. Micromachines. 2022;13(10):1623.","journal-title":"Micromachines"},{"issue":"4","key":"3411_CR163","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1089\/adt.2022.102","volume":"21","author":"P Sandal","year":"2023","unstructured":"Sandal P, Kumari L, Patel P, Singh A, Singh D, Gupta GD, et al. Doxorubicin Conjugates: An Efficient Approach for Enhanced Therapeutic Efficacy with Reduced Side Effects. ASSAY Drug Dev Technol. 2023Jun 1;21(4):137\u201356.","journal-title":"ASSAY Drug Dev Technol"},{"issue":"9","key":"3411_CR164","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrc1958","volume":"6","author":"R Duncan","year":"2006","unstructured":"Duncan R. Polymer conjugates as anticancer nanomedicines. Nat Rev Cancer. 2006;6(9):688\u2013701.","journal-title":"Nat Rev Cancer"},{"issue":"7","key":"3411_CR165","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.2741\/2882","volume":"13","author":"F Greco","year":"2008","unstructured":"Greco F, Vicent MJ. Polymer-drug conjugates: current status and future trends. Front Biosci-Landmark. 2008Jan 1;13(7):2744\u201356.","journal-title":"Front Biosci-Landmark"},{"issue":"5","key":"3411_CR166","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1517\/17425247.5.5.593","volume":"5","author":"MJ Vicent","year":"2008","unstructured":"Vicent MJ, Dieudonn\u00e9 L, Carbajo RJ, Pineda-Lucena A. Polymer conjugates as therapeutics: future trends, challenges and opportunities. Expert Opin Drug Deliv. 2008May 1;5(5):593\u2013614.","journal-title":"Expert Opin Drug Deliv"},{"issue":"1","key":"3411_CR167","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13046-024-03028-5","volume":"43","author":"A Tosi","year":"2024","unstructured":"Tosi A, Parisatto B, Gaffo E, Bortoluzzi S, Rosato A. A paclitaxel-hyaluronan conjugate (ONCOFID-P-B\u2122) in patients with BCG-unresponsive carcinoma in situ of the bladder: a dynamic assessment of the tumor microenvironment. J Exp Clin Cancer Res. 2024Apr 10;43(1):109.","journal-title":"J Exp Clin Cancer Res"},{"key":"3411_CR168","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1021\/bm4003199","volume":"13;14(5)","author":"HY Cho","year":"2013","unstructured":"Cho HY, Averick SE, Paredes E, Wegner K, Averick A, Jurga S, et al. Star polymers with a cationic core prepared by ATRP for cellular nucleic acids delivery. Biomacromolecules. 2013;13;14(5):1262\u20137.","journal-title":"Biomacromolecules"},{"key":"3411_CR169","doi-asserted-by":"publisher","DOI":"10.1186\/s13036-022-00298-5","author":"J Wang","year":"2022","unstructured":"Wang J, Li B, Qiu L, Qiao X, Yang H. Dendrimer-based drug delivery systems: history, challenges, and latest developments. J Biol Eng. 2022. https:\/\/doi.org\/10.1186\/s13036-022-00298-5.","journal-title":"J Biol Eng"},{"key":"3411_CR170","doi-asserted-by":"publisher","unstructured":"S\u00e1nchez-Trasvi\u00f1a C, Flores-Gatica M, Enriquez-Ochoa D, Rito-Palomares M, Mayolo-Deloisa K. Purification of modified therapeutic proteins available on the market: an analysis of chromatography-based strategies. Front Bioeng Biotechnol [Internet]. 2021 Aug 20 [cited 2025 Aug 21];9. Available from: https:\/\/doi.org\/10.3389\/fbioe.2021.717326.","DOI":"10.3389\/fbioe.2021.717326"},{"issue":"8","key":"3411_CR171","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15082068","volume":"15","author":"C Wilhelmy","year":"2023","unstructured":"Wilhelmy C, Keil IS, Uebbing L, Schroer MA, Franke D, Nawroth T, et al. Polysarcosine-functionalized mRNA lipid nanoparticles tailored for immunotherapy. Pharmaceutics. 2023;15(8):2068.","journal-title":"Pharmaceutics"},{"issue":"9","key":"3411_CR172","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/emmm.201201290","volume":"4","author":"I Teo","year":"2012","unstructured":"Teo I, Toms SM, Marteyn B, Barata TS, Simpson P, Johnston KA, et al. Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers. EMBO Mol Med. 2012;4(9):866\u201381.","journal-title":"EMBO Mol Med"},{"key":"3411_CR173","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1021\/mp500108p","volume":"7;11(7)","author":"PS Kulkarni","year":"2014","unstructured":"Kulkarni PS, Haldar MK, Nahire RR, Katti P, Ambre AH, Muhonen WW, et al. MMP-9 responsive PEG cleavable nanovesicles for efficient delivery of chemotherapeutics to pancreatic cancer. Mol Pharm. 2014;7;11(7):2390\u20139.","journal-title":"Mol Pharm"},{"key":"3411_CR174","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.addr.2009.11.027","volume":"17;62(2)","author":"DB Pike","year":"2010","unstructured":"Pike DB, Ghandehari H. HPMA copolymer\u2013cyclic RGD conjugates for tumor targeting. Adv Drug Deliv Rev. 2010;17;62(2):167\u201383.","journal-title":"Adv Drug Deliv Rev"},{"key":"3411_CR175","unstructured":"FDA\/CDER\/Yeaton A. Drug Products, Including Biological Products, that Contain Nanomaterials - Guidance for Industry. 2017."},{"issue":"147","key":"3411_CR176","volume":"1","author":"N Bayliss","year":"2023","unstructured":"Bayliss N, Schmidt BVKJ. Hydrophilic polymers: Current trends and visions for the future. Prog Polym Sci. 2023Dec;1(147):101753.","journal-title":"Prog Polym Sci"},{"key":"3411_CR177","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2217\/nnm.09.21","volume":"1;4(4)","author":"R Goel","year":"2009","unstructured":"Goel R, Shah N, Visaria R, Paciotti GF, Bischof JC. Biodistribution of TNF-\u03b1-coated gold nanoparticles in an in vivo model system. Nanomed. 2009;1;4(4):401\u201310.","journal-title":"Nanomed"},{"issue":"8","key":"3411_CR178","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.3390\/polym6082186","volume":"6","author":"AK Rajora","year":"2014","unstructured":"Rajora AK, Ravishankar D, Osborn HM, Greco F. Impact of the enhanced permeability and retention (EPR) effect and cathepsins levels on the activity of polymer-drug conjugates. Polymers. 2014 Aug 20;6(8):2186-220.","journal-title":"Polymers"},{"issue":"3","key":"3411_CR179","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics11030412","volume":"11","author":"M Skwarczynski","year":"2022","unstructured":"Skwarczynski M, Bashiri S, Yuan Y, Ziora ZM, Nabil O, Masuda K, et al. Antimicrobial activity enhancers: towards smart delivery of antimicrobial agents. Antibiotics. 2022;11(3):412.","journal-title":"Antibiotics"},{"issue":"8","key":"3411_CR180","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16081037","volume":"16","author":"I Alradwan","year":"2024","unstructured":"Alradwan I, AL Fayez N, Alomary MN, Alshehri AA, Aodah AH, Almughem FA, et al. Emerging trends and innovations in the treatment and diagnosis of atherosclerosis and cardiovascular disease: a comprehensive review towards healthier aging. Pharmaceutics. 2024;16(8):1037.","journal-title":"Pharmaceutics"},{"issue":"1","key":"3411_CR181","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","volume":"8","author":"D Wu","year":"2023","unstructured":"Wu D, Chen Q, Chen X, Han F, Chen Z, Wang Y. The blood\u2013brain barrier: Structure, regulation and drug delivery. Signal Transduct Target Ther. 2023May 25;8(1):217.","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"3411_CR182","volume":"8","author":"W Zhang","year":"2021","unstructured":"Zhang W, Mehta A, Tong Z, Esser L, Voelcker NH. Development of polymeric nanoparticles for blood\u2013brain barrier transfer\u2014strategies and challenges. Adv Sci. 2021;8(10):2003937.","journal-title":"Adv Sci"},{"issue":"1","key":"3411_CR183","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5869676","volume":"2013","author":"N Mishra","year":"2013","unstructured":"Mishra N, Yadav NP, Rai VK, Sinha P, Yadav KS, Jain S, et al. Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance. BioMed Res Int. 2013;2013(1):382184.","journal-title":"BioMed Res Int"},{"issue":"1","key":"3411_CR184","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s12672-024-01509-9","volume":"15","author":"AK Parashar","year":"2024","unstructured":"Parashar AK, Saraogi GK, Jain PK, Kurmi B, Shrivastava V, Arora V. Polymer-drug conjugates: revolutionizing nanotheranostic agents for diagnosis and therapy. Discov Oncol. 2024Nov 11;15(1):641.","journal-title":"Discov Oncol"},{"key":"3411_CR185","doi-asserted-by":"publisher","unstructured":"PEGylated PLGA nanoparticles: unlocking advanced strategies for cancer therapy | Molecular Cancer | Full Text [Internet]. [cited 2025 Jul 30]. https:\/\/doi.org\/10.1186\/s12943-025-02410-x.","DOI":"10.1186\/s12943-025-02410-x"},{"issue":"4","key":"3411_CR186","volume":"15","author":"Y Li","year":"2025","unstructured":"Li Y, Xing L, Zhu M, Li X, Wei F, Sun W, Jia Y. HPMA copolymers: a versatile platform for targeted peptide drug delivery. Biomolecules. 2025 Apr 17;15(4):596.","journal-title":"Biomolecules"},{"issue":"2","key":"3411_CR187","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0169-409X(91)90040-J","volume":"6","author":"H Maeda","year":"1991","unstructured":"Maeda H. SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv Drug Deliv Rev. 1991Mar 1;6(2):181\u2013202.","journal-title":"Adv Drug Deliv Rev"},{"issue":"241","key":"3411_CR188","volume":"1","author":"HT Gebrie","year":"2024","unstructured":"Gebrie HT, Thankachan D, Tsai HC, Lai JY, Chang HM, Wu SY. Doxorubicin-loaded Polymeric Biotin-PEG-SeSe-PBLA Micelles with surface Binding of Biotin-Mediated Cancer Cell Targeting and Redox-Responsive Drug release for enhanced anticancer efficacy. Colloids Surf B Biointerfaces. 2024Sep;1(241):114028.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"3411_CR189","doi-asserted-by":"crossref","unstructured":"Zong H, Thomas TP, Lee KH, Desai AM, Li M hsin, Kotlyar A, et al. Bifunctional PAMAM Dendrimer Conjugates of Folic Acid and Methotrexate with Defined Ratio. Biomacromolecules. 2012 Apr 9;13(4):982\u201391.","DOI":"10.1021\/bm201639c"},{"issue":"17","key":"3411_CR190","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.2217\/nnm-2019-0099","volume":"14","author":"Q Li","year":"2019","unstructured":"Li Q, Hou M, Ren J, Lu S, Xu Z, Li CM, et al. Co-delivery of Chlorin e6 and Doxorubicin Using PEGylated Hollow Nanocapsules for \u2018all-in-one\u2019 Tumor Theranostics. Nanomed. 2019Sep 1;14(17):2273\u201392.","journal-title":"Nanomed"},{"issue":"5","key":"3411_CR191","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1128\/AAC.45.5.1487-1492.2001","volume":"45","author":"IAJM Bakker-Woudenberg","year":"2001","unstructured":"Bakker-Woudenberg IAJM, ten Kate MT, Guo L, Working P, Mouton JW. Improved efficacy of ciprofloxacin administered in polyethylene glycol-coated liposomes for treatment of Klebsiella pneumoniae pneumonia in rats. Antimicrob Agents Chemother. 2001;45(5):1487\u201392.","journal-title":"Antimicrob Agents Chemother"},{"key":"3411_CR192","doi-asserted-by":"crossref","unstructured":"Boles LR, Awais R, Beenken KE, Smeltzer MS, Haggard WO, Jessica AJ. Local Delivery of Amikacin and Vancomycin from Chitosan Sponges Prevent Polymicrobial Implant-Associated Biofilm. Mil Med. 2018 Mar 1;183(suppl_1):459\u201365.","DOI":"10.1093\/milmed\/usx161"},{"issue":"671","key":"3411_CR193","volume":"25","author":"J Movellan","year":"2025","unstructured":"Movellan J, Murgia X, Gracia R, Marradi M, Miranda JI, Aizpurua JM, et al. Tobramycin nanoformulation for chronic pulmonary infections: From drug product definition to scale-up for preclinical evaluation. Int J Pharm. 2025Feb;25(671):125241.","journal-title":"Int J Pharm"},{"issue":"17","key":"3411_CR194","doi-asserted-by":"crossref","first-page":"9541","DOI":"10.1039\/D0NR00308E","volume":"12","author":"SH Nasr","year":"2020","unstructured":"Nasr SH, Rashidijahanabad Z, Ramadan S, Kauffman N, Parameswaran N, Zinn KR, et al. Effective atherosclerotic plaque inflammation inhibition with targeted drug delivery by hyaluronan conjugated atorvastatin nanoparticles. Nanoscale. 2020May 7;12(17):9541\u201356.","journal-title":"Nanoscale"},{"issue":"2","key":"3411_CR195","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/adfm.201101707","volume":"22","author":"MC Jen","year":"2012","unstructured":"Jen MC, Serrano MC, van Lith R, Ameer GA. Polymer-based nitric oxide therapies: recent insights for biomedical applications. Adv Funct Mater. 2012;22(2):239\u201360.","journal-title":"Adv Funct Mater"},{"issue":"10","key":"3411_CR196","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1177\/0885328219832984","volume":"33","author":"AA Shitole","year":"2019","unstructured":"Shitole AA, Giram PS, Raut PW, Rade PP, Khandwekar AP, Sharma N, et al. Clopidogrel eluting electrospun polyurethane\/polyethylene glycol thromboresistant, hemocompatible nanofibrous scaffolds. J Biomater Appl. 2019May 1;33(10):1327\u201347.","journal-title":"J Biomater Appl"},{"issue":"2","key":"3411_CR197","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/1570159X19666210823103020","volume":"20","author":"SK Shahbaz","year":"2022","unstructured":"Shahbaz SK, Koushki K, Sathyapalan T, Majeed M, Sahebkar A. PLGA-based curcumin delivery system: an interesting therapeutic approach in the treatment of Alzheimer\u2019s disease. Curr Neuropharmacol. 2022;20(2):309\u201323.","journal-title":"Curr Neuropharmacol"},{"key":"3411_CR198","doi-asserted-by":"publisher","unstructured":"Trapani A, Carbone A, Gioia SD, Fracchiolla G, Soccio P, Perna FM, et al. Synthesis and characterization of chitosan-grafted-dopamine based micelles as multifunctional nanomedicines for Parkinson\u2019s disease treatment by intranasal administration. Drug Deliv Transl Res [Internet]. 2025 Sep 1 [cited 2025 Sep 2]; Available from: \nhttps:\/\/doi.org\/10.1007\/s13346-025-01963-0.","DOI":"10.1007\/s13346-025-01963-0"},{"issue":"17","key":"3411_CR199","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1016\/j.biomaterials.2010.02.042","volume":"31","author":"Q Tian","year":"2010","unstructured":"Tian Q, Zhang CN, Wang XH, Wang W, Huang W, Cha RT, et al. Glycyrrhetinic acid-modified chitosan\/poly(ethylene glycol) nanoparticles for liver-targeted delivery. Biomaterials. 2010Jun 1;31(17):4748\u201356.","journal-title":"Biomaterials"},{"issue":"9","key":"3411_CR200","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1177\/08853282241304396","volume":"39","author":"G Chen","year":"2025","unstructured":"Chen G. Investigation of polyvinylpyrrolidone-catechol-derived chitosan nanoconjugates allowed for kidney-targeted treatment of cisplatin-induced acute kidney injury and nursing care management. J Biomater Appl. 2025Apr 1;39(9):1084\u201396.","journal-title":"J Biomater Appl"},{"key":"3411_CR201","unstructured":"Meijer D. Drug Targeting Organ-Specific Strategies. 1991."},{"issue":"17","key":"3411_CR202","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179181","volume":"22","author":"M de la Fuente","year":"2021","unstructured":"de la Fuente M, Lombardero L, G\u00f3mez-Gonz\u00e1lez A, Solari C, Angulo-Barturen I, Acera A, et al. Enzyme Therapy: Current Challenges and Future Perspectives. Int J Mol Sci. 2021;22(17):9181.","journal-title":"Int J Mol Sci"},{"issue":"7","key":"3411_CR203","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00210-022-02245-z","volume":"395","author":"S Hamimed","year":"2022","unstructured":"Hamimed S, Jabberi M, Chatti A. Nanotechnology in drug and gene delivery. Naunyn Schmiedebergs Arch Pharmacol. 2022Jul 1;395(7):769\u201387.","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"10","key":"3411_CR204","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.7150\/thno.38069","volume":"10","author":"P Mi","year":"2020","unstructured":"Mi P. Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics. Theranostics. 2020Mar 15;10(10):4557\u201388.","journal-title":"Theranostics"},{"issue":"1","key":"3411_CR205","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1039\/C4BM00272E","volume":"3","author":"W Scarano","year":"2014","unstructured":"Scarano W, de Souza P, Stenzel MH. Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer. Biomater Sci. 2014Dec 2;3(1):163\u201374.","journal-title":"Biomater Sci"},{"key":"3411_CR206","doi-asserted-by":"publisher","unstructured":"Gupta N, Mishra A, Deb PK, Tekade M. PEGylated Nanocarriers for Diagnostic Applications. In: Tekade RK, Jain NK, editors. PEGylated Nanocarriers in Medicine and Pharmacy [Internet]. Singapore: Springer Nature; 2025 [cited 2026 Feb 15]. pp. 345\u201365. Available from: \nhttps:\/\/doi.org\/10.1007\/978-981-97-7316-9_12.","DOI":"10.1007\/978-981-97-7316-9_12"},{"key":"3411_CR207","doi-asserted-by":"publisher","unstructured":"Bird RE, Lemmel SA, Yu X, Zhou QA. Bioorthogonal Chemistry and Its Applications. Bioconjug Chem [Internet]. 2021 Nov 30 [cited 2025 Sep 7]; Available from: https:\/\/doi.org\/10.1021\/acs.bioconjchem.1c00461.","DOI":"10.1021\/acs.bioconjchem.1c00461"},{"issue":"1","key":"3411_CR208","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12859-020-03633-z","volume":"21","author":"Y Kim","year":"2020","unstructured":"Kim Y, Kim D, Cao B, Carvajal R, Kim M. PDXGEM: patient-derived tumor xenograft-based gene expression model for predicting clinical response to anticancer therapy in cancer patients. BMC Bioinformatics. 2020Jul 6;21(1):288.","journal-title":"BMC Bioinformatics"},{"key":"3411_CR209","doi-asserted-by":"publisher","unstructured":"Waldman SA, Terzic A. Companion Diagnostics at the Intersection of Personalized Medicine and Healthcare Delivery. Biomark Med [Internet]. 2015 Jan 1 [cited 2025 Sep 7]; Available from: https:\/\/doi.org\/10.2217\/bmm.14.99.","DOI":"10.2217\/bmm.14.99"},{"issue":"12","key":"3411_CR210","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12122750","volume":"12","author":"G Molla","year":"2024","unstructured":"Molla G, Bitew M. Revolutionizing personalized medicine: synergy with multi-omics data generation, main hurdles, and future perspectives. Biomedicines. 2024;12(12):2750.","journal-title":"Biomedicines"},{"key":"3411_CR211","unstructured":"Agrawal N, Rohini, Joseph A, Mukerjee A. Polymeric Prodrugs: Recent Achievements and General Strategies. J Antivir Antiretrovir. 0(0):1\u201312."},{"issue":"9","key":"3411_CR212","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.drudis.2020.06.028","volume":"25","author":"P Thakor","year":"2020","unstructured":"Thakor P, Bhavana V, Sharma R, Srivastava S, Singh SB, Mehra NK. Polymer\u2013drug conjugates: recent advances and future perspectives. Drug Discov Today. 2020Sep 1;25(9):1718\u201326.","journal-title":"Drug Discov Today"},{"issue":"11","key":"3411_CR213","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1002\/jps.24594","volume":"104","author":"J Rantanen","year":"2015","unstructured":"Rantanen J, Khinast J. The Future of Pharmaceutical Manufacturing Sciences. J Pharm Sci. 2015Nov 1;104(11):3612\u201338.","journal-title":"J Pharm Sci"},{"key":"3411_CR214","doi-asserted-by":"crossref","unstructured":"Peptide and Protein Bioconjugation: A Useful Tool to Improve the Biological Performance of Biotech Drugs. In: Peptide and Protein Delivery [Internet]. Academic Press; 2011 [cited 2025 Nov 20]. pp. 247\u201390. Available from: \nhttps:\/\/www.sciencedirect.com\/science\/chapter\/edited-volume\/abs\/pii\/B9780123849359100112.","DOI":"10.1016\/B978-0-12-384935-9.10011-2"},{"key":"3411_CR215","doi-asserted-by":"crossref","unstructured":"Seymour. Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer. Int J Oncol [Internet]. 2009 May 7 [cited 2025 Nov 20];34(6). Available from: \nhttp:\/\/www.spandidos-publications.com\/ijo\/34\/6\/1629.","DOI":"10.3892\/ijo_00000293"},{"issue":"3","key":"3411_CR216","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0168-3659(98)00124-2","volume":"57","author":"PJ Julyan","year":"1999","unstructured":"Julyan PJ, Seymour LW, Ferry DR, Daryani S, Boivin CM, Doran J, et al. Preliminary clinical study of the distribution of HPMA copolymers bearing doxorubicin and galactosamine. J Controlled Release. 1999Feb 22;57(3):281\u201390.","journal-title":"J Controlled Release"},{"issue":"1","key":"3411_CR217","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jconrel.2005.09.033","volume":"109","author":"JW Singer","year":"2005","unstructured":"Singer JW. Paclitaxel poliglumex (XYOTAX\u2122, CT-2103): A macromolecular taxane. J Controlled Release. 2005Dec 5;109(1):120\u20136. Accessed 20 Nov 2025.","journal-title":"J Controlled Release"},{"issue":"13","key":"3411_CR218","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.addr.2009.06.004","volume":"61","author":"DP Nowotnik","year":"2009","unstructured":"Nowotnik DP, Cvitkovic E. ProLindac\u2122 (AP5346): A review of the development of an HPMA DACH platinum Polymer Therapeutic. Adv Drug Deliv Rev. 2009Nov 12;61(13):1214\u20139. Accessed\u00a020 Nov 2025.","journal-title":"Adv Drug Deliv Rev"},{"issue":"13","key":"3411_CR219","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.addr.2009.05.005","volume":"61","author":"ME Davis","year":"2009","unstructured":"Davis ME. Design and development of IT-101, a cyclodextrin-containing polymer conjugate of camptothecin. Adv Drug Deliv Rev. 2009Nov 12;61(13):1189\u201392.","journal-title":"Adv Drug Deliv Rev"},{"issue":"16","key":"3411_CR220","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1021\/acs.jcim.3c00554","volume":"63","author":"SSS Ng","year":"2023","unstructured":"Ng SSS, Lu Y. Evaluating the Use of Graph Neural Networks and Transfer Learning for Oral Bioavailability Prediction. J Chem Inf Model. 2023Aug 28;63(16):5035\u201344.","journal-title":"J Chem Inf Model"},{"issue":"4","key":"3411_CR221","volume":"17","author":"I Malashin","year":"2025","unstructured":"Malashin I, Tynchenko V, Gantimurov A, Nelyub V, Borodulin A. Support vector machines in polymer science: a review. Polymers. 2025;17(4):491.","journal-title":"Polymers"},{"issue":"02","key":"3411_CR222","doi-asserted-by":"crossref","first-page":"138","DOI":"10.5414\/CP203800","volume":"59","author":"X Liu","year":"2021","unstructured":"Liu X, Liu C, Huang R, Zhu H, Liu Q, Mitra S, et al. Long short-term memory recurrent neural network for pharmacokinetic-pharmacodynamic modeling. Int J Clin Pharmacol Ther. 2021Feb 1;59(02):138\u201346.","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"9","key":"3411_CR223","volume":"13","author":"R Shen","year":"2025","unstructured":"Shen R, Luo G, Su A. Bayesian optimization for chemical synthesis in the era of artificial intelligence: advances and applications. Processes. 2025;13(9):2687.","journal-title":"Processes"},{"issue":"10","key":"3411_CR224","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1039\/D2RE00406B","volume":"8","author":"C Zhang","year":"2023","unstructured":"Zhang C, Lapkin AA. Reinforcement learning optimization of reaction routes on the basis of large, hybrid organic chemistry\u2013synthetic biological, reaction network data. React Chem Eng. 2023Sep 26;8(10):2491\u2013504.","journal-title":"React Chem Eng"},{"issue":"3","key":"3411_CR225","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.5599\/admet.2772","volume":"13","author":"M Venkataraman","year":"2025","unstructured":"Venkataraman M, Rao GC, Madavareddi JK, Maddi SR. Leveraging machine learning models in evaluating ADMET properties for drug discovery and development: review article. ADMET DMPK. 2025;13(3):2772\u20132772.","journal-title":"ADMET DMPK"},{"issue":"5","key":"3411_CR226","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.xphs.2023.01.010","volume":"112","author":"A Tang","year":"2023","unstructured":"Tang A. Machine Learning for Pharmacokinetic\/Pharmacodynamic Modeling. J Pharm Sci. 2023May 1;112(5):1460\u201375.","journal-title":"J Pharm Sci"},{"issue":"W1","key":"3411_CR227","doi-asserted-by":"crossref","first-page":"W469","DOI":"10.1093\/nar\/gkae254","volume":"52","author":"Y Myung","year":"2024","unstructured":"Myung Y, de S\u00e1 AGC, Ascher DB. Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction. Nucleic Acids Res. 2024Jul 5;52(W1):W469\u201375.","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"3411_CR228","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1021\/acs.jcim.4c01907","volume":"65","author":"J Michels","year":"2025","unstructured":"Michels J, Bandarupalli R, Ahangar Akbari A, Le T, Xiao H, Li J, et al. Natural Language Processing Methods for the Study of Protein-Ligand Interactions. J Chem Inf Model. 2025Mar 10;65(5):2191\u2013213.","journal-title":"J Chem Inf Model"},{"key":"3411_CR229","doi-asserted-by":"publisher","unstructured":"Zhao L, Wang J, Pang L, Liu Y, Zhang J. GANsDTA: Predicting Drug-Target Binding Affinity Using GANs. Front Genet [Internet]. 2020 Jan 9 [cited 2025 Sep 8];10. Available from: https:\/\/doi.org\/10.3389\/fgene.2019.01243.","DOI":"10.3389\/fgene.2019.01243"},{"issue":"4","key":"3411_CR230","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18041919","volume":"18","author":"M Nedyalkova","year":"2021","unstructured":"Nedyalkova M, Madurga S, Simeonov V. Combinatorial K-means clustering as a machine learning tool applied to diabetes mellitus type 2. Int J Environ Res Public Health. 2021;18(4):1919.","journal-title":"Int J Environ Res Public Health"},{"key":"3411_CR231","unstructured":"Mccall A. AutoML Solutions in the Cloud: Automated Model Training and Hyperparameter Optimization with Google Vertex AI and SageMaker; 2025."},{"key":"3411_CR232","doi-asserted-by":"crossref","unstructured":"Saba L, Maindarkar M, Khanna NN, Johri AM, Mantella L, Laird JR, et al. A Pharmaceutical Paradigm for Cardiovascular Composite Risk Assessment Using Novel Radiogenomics Risk Predictors in Precision Explainable Artificial Intelligence Framework: Clinical Trial Tool. 2023 [cited 2025 Sep 8]; Available from: \nhttps:\/\/iris.unica.it\/handle\/11584\/388283.","DOI":"10.31083\/j.fbl2810248"},{"key":"3411_CR233","doi-asserted-by":"crossref","unstructured":"Calvo E, Hoch U, Maslyar DJ, Tolcher AW. Dose-escalation phase I study of NKTR-105, a novel pegylated form of docetaxel. J Clin Oncol. 2010 May 20;28(15_suppl):TPS160\u2013TPS160.","DOI":"10.1200\/jco.2010.28.15_suppl.tps160"},{"issue":"9","key":"3411_CR234","volume":"16","author":"R Han","year":"2023","unstructured":"Han R, Yoon H, Kim G, Lee H, Lee Y. Revolutionizing medicinal chemistry: the application of artificial intelligence (AI) in early drug discovery. Pharmaceuticals. 2023;16(9):1259.","journal-title":"Pharmaceuticals"},{"issue":"9","key":"3411_CR235","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17091165","volume":"17","author":"M El-Tanani","year":"2025","unstructured":"El-Tanani M, Satyam SM, Rabbani SA, El-Tanani Y, Aljabali AAA, Al Faouri I, et al. Correction: El-Tanani et al. Revolutionizing Drug Delivery: The Impact of Advanced Materials Science and Technology on Precision Medicine. Pharmaceutics 2025, 17, 375. Pharmaceutics. 2025;17(9):1165.","journal-title":"Pharmaceutics"},{"key":"3411_CR236","doi-asserted-by":"crossref","unstructured":"Constable DJC. Green and sustainable chemistry \u2013 The case for a systems-based, interdisciplinary approach. iScience. 2021 Dec 17;24(12):103489.","DOI":"10.1016\/j.isci.2021.103489"},{"issue":"4","key":"3411_CR237","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0318167","volume":"20","author":"TG Baidoo","year":"2025","unstructured":"Baidoo TG, Rodrigo H. Data-driven survival modeling for breast cancer prognostics: A comparative study with machine learning and traditional survival modeling methods. PLoS ONE. 2025Apr 22;20(4):e0318167.","journal-title":"PLoS ONE"},{"issue":"6","key":"3411_CR238","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/mame.200700395","volume":"293","author":"JM Raquez","year":"2008","unstructured":"Raquez JM, Narayan R, Dubois P. Recent advances in reactive extrusion processing of biodegradable polymer-based compositions. Macromol Mater Eng. 2008;293(6):447\u201370.","journal-title":"Macromol Mater Eng"},{"issue":"01","key":"3411_CR239","doi-asserted-by":"crossref","first-page":"544","DOI":"10.63125\/n6esv923","volume":"1","author":"NH Sajal","year":"2025","unstructured":"Sajal NH, Sutar R. Supercritical co\u2082 as a green solvent: a comprehensive review of its applications in industrial processes. Am J Adv Technol Eng Solut. 2025Apr 21;1(01):544\u201378.","journal-title":"Am J Adv Technol Eng Solut"},{"issue":"1","key":"3411_CR240","doi-asserted-by":"crossref","DOI":"10.3390\/analytica6010010","volume":"6","author":"AK Meher","year":"2025","unstructured":"Meher AK, Zarouri A. Green analytical chemistry\u2014recent innovations. Analytica. 2025 Mar 11;6(1):10.","journal-title":"Analytica"},{"key":"3411_CR241","doi-asserted-by":"crossref","unstructured":"Ramon Tom\u00e9 Oliveira A, da Silva Aires FI, Nascimento Dari D, de Matos Filho JR, dos Santos KM, Sim\u00e3o Neto F, et al. Review on Lipase-Catalyzed Flavor Synthesis: Global Trends and Advances. J Agric Food Chem. 2025 Jul 16;73(28):17315\u201330. Accessed 08 Sep 2025.","DOI":"10.1021\/acs.jafc.5c00386"},{"issue":"14","key":"3411_CR242","volume":"17","author":"R Dallaev","year":"2025","unstructured":"Dallaev R, Pape\u017e N, Allaham MM, Holcman V. Biodegradable polymers: properties, applications, and environmental impact. Polymers. 2025;17(14):1981.","journal-title":"Polymers"},{"issue":"12","key":"3411_CR243","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/cbic.201100117","volume":"12","author":"NE Mbua","year":"2011","unstructured":"Mbua NE, Guo J, Wolfert MA, Steet R, Boons GJ. Strain-promoted alkyne\u2013azide cycloadditions (SPAAC) reveal new features of glycoconjugate biosynthesis. Chembiochem. 2011;12(12):1912\u201321.","journal-title":"Chembiochem"},{"key":"3411_CR244","doi-asserted-by":"crossref","unstructured":"Ma X, Zhang W. Recent developments in one-pot stepwise synthesis (OPSS) of small molecules. iScience. 2022 Sep 16;25(9):105005.","DOI":"10.1016\/j.isci.2022.105005"},{"issue":"5","key":"3411_CR245","volume":"14","author":"KB Feng","year":"2025","unstructured":"Feng KB, Zhu YY, Gu SX, Long J, Wang HF. Typical cases of continuous flow chemistry in pharmaceutical synthesis in 2023\u20132024. Asian J Org Chem. 2025;14(5):e202500132.","journal-title":"Asian J Org Chem"},{"issue":"107","key":"3411_CR246","volume":"1","author":"N Zaquen","year":"2020","unstructured":"Zaquen N, Rubens M, Corrigan N, Xu J, Zetterlund PB, Boyer C, et al. Polymer Synthesis in Continuous Flow Reactors. Prog Polym Sci. 2020Aug;1(107):101256.","journal-title":"Prog Polym Sci"},{"issue":"1","key":"3411_CR247","first-page":"49","volume":"38","author":"L Zong","year":"2003","unstructured":"Zong L, Zhou S, Sgriccia N, Hawley MC, Kempel LC. A Review of Microwave-Assist Polymer Chemistry (MAPC). J Microw Power Electromagn Energy. 2003Jan 1;38(1):49\u201374.","journal-title":"J Microw Power Electromagn Energy"},{"issue":"29","key":"3411_CR248","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.drup.2016.10.003","volume":"1","author":"AA Gabizon","year":"2016","unstructured":"Gabizon AA, Patil Y, La-Beck NM. New insights and evolving role of pegylated liposomal doxorubicin in cancer therapy. Drug Resist Updat. 2016Nov;1(29):90\u2013106.","journal-title":"Drug Resist Updat"},{"issue":"22","key":"3411_CR249","volume":"14","author":"GW Jin","year":"2022","unstructured":"Jin GW, Rejinold NS, Choy JH. Multifunctional polymeric micelles for cancer therapy. Polymers. 2022;14(22):4839.","journal-title":"Polymers"},{"issue":"117","key":"3411_CR250","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.eurpolymj.2019.04.050","volume":"1","author":"X Pan","year":"2019","unstructured":"Pan X, Chen J, Yang M, Wu J, He G, Yin Y, et al. Enzyme\/pH dual-responsive polymer prodrug nanoparticles based on 10-hydroxycamptothecin-carboxymethylchitosan for enhanced drug stability and anticancer efficacy. Eur Polym J. 2019Aug;1(117):372\u201381.","journal-title":"Eur Polym J"},{"issue":"13","key":"3411_CR251","volume":"1","author":"H Majidzadeh","year":"2024","unstructured":"Majidzadeh H, Araj-Khodaei M, Aghanejad A, Ghaffari M, Jafari A, Jenanifard F, et al. PAMAM dendrimers based co-delivery of methotrexate and berberine for targeting of Hela cancer cells. Toxicol Rep. 2024Dec;1(13):101765.","journal-title":"Toxicol Rep"},{"issue":"203","key":"3411_CR252","volume":"1","author":"L Cunha Silva","year":"2024","unstructured":"Cunha Silva L, Branco F, Cunha J, Vitorino C, Gomes C, Carrascal MA, et al. The potential of exosomes as a new therapeutic strategy for glioblastoma. Eur J Pharm Biopharm. 2024Oct;1(203):114460.","journal-title":"Eur J Pharm Biopharm"},{"issue":"192","key":"3411_CR253","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.10.032","volume":"1","author":"X Wan","year":"2019","unstructured":"Wan X, Beaudoin JJ, Vinod N, Min Y, Makita N, Bludau H, et al. Co-delivery of paclitaxel and cisplatin in poly(2-oxazoline) polymeric micelles: Implications for drug loading, release, pharmacokinetics and outcome of ovarian and breast cancer treatments. Biomaterials. 2019Feb;1(192):1\u201314.","journal-title":"Biomaterials"},{"issue":"1","key":"3411_CR254","doi-asserted-by":"crossref","first-page":"2400476","DOI":"10.1080\/10717544.2024.2400476","volume":"31","author":"Z Wang","year":"2024","unstructured":"Wang Z, Zhai B, Sun J, Zhang X, Zou J, Shi Y, et al. Recent advances of injectable in situ-forming hydrogels for preventing postoperative tumor recurrence. Drug Deliv. 2024Dec 31;31(1):2400476.","journal-title":"Drug Deliv"},{"issue":"13","key":"3411_CR255","doi-asserted-by":"crossref","DOI":"10.3390\/polym16131769","volume":"16","author":"A Beena Unni","year":"2024","unstructured":"Beena Unni A, Muringayil Joseph T. Enhancing polymer sustainability: eco-conscious strategies. Polymers. 2024;16(13):1769.","journal-title":"Polymers"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-026-03411-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-026-03411-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-026-03411-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:53:05Z","timestamp":1780390385000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-026-03411-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":256,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["3411"],"URL":"https:\/\/doi.org\/10.1208\/s12249-026-03411-9","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"28 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interest"}}],"article-number":"168"}}