{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:48Z","timestamp":1792788528729,"version":"4.5.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universidade Estadual De Campinas","id":[{"id":"https:\/\/ror.org\/04wffgt70","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"DOI":"10.1208\/s12249-026-03472-w","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:48:13Z","timestamp":1781038093000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oil-in-water Emulsion as a Strategy for Taste Masking of Cannabinoid Extract"],"prefix":"10.1208","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3711-7282","authenticated-orcid":false,"given":"Juliana","family":"Feitoza Brasil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7004-6253","authenticated-orcid":false,"given":"Luiza Aparecida","family":"Luna Silv\u00e9rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-1808","authenticated-orcid":false,"given":"Claudete","family":"da Costa-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9961-5659","authenticated-orcid":false,"given":"Leonardo","family":"Costalonga Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Helena","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-1013","authenticated-orcid":false,"given":"Leonardo Mathias","family":"Leidens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-7341","authenticated-orcid":false,"given":"Carla Daniela","family":"Boeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-3391","authenticated-orcid":false,"given":"Jose Luiz","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9760-1851","authenticated-orcid":false,"given":"Antonio Riul","family":"Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-8189","authenticated-orcid":false,"given":"Priscila Gava","family":"Mazzola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"3472_CR1","unstructured":"Sciences NAo, Medicine, Division M, Health BoP, Practice PH, Marijuana CotHEo, et al. The health effects of cannabis and cannabinoids: the current state of evidence and recommendations for research. Washington (DC): National Academies Press (US); 2017."},{"key":"3472_CR2","doi-asserted-by":"publisher","unstructured":"Grotenhermen F, M\u00fcller-Vahl K. The therapeutic potential of cannabis and cannabinoids. DEUTSCHES \u00c4RZTEBLATT INTERNATIONAL. 2012;109(1866-0452 (Electronic)):2. https:\/\/doi.org\/10.3238\/arztebl.2012.0495.","DOI":"10.3238\/arztebl.2012.0495"},{"issue":"12","key":"3472_CR3","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1016\/j.mayocp.2018.09.005","volume":"93","author":"JO Ebbert","year":"2018","unstructured":"Ebbert JO, Scharf EL, Hurt RT. Medical cannabis. Mayo Clin Proc. 2018;93(12):1842\u20137. https:\/\/doi.org\/10.1016\/j.mayocp.2018.09.005.","journal-title":"Mayo Clin Proc"},{"key":"3472_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23102478","author":"N Bruni","year":"2018","unstructured":"Bruni N, Della Pepa C, Oliaro-Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid delivery systems for pain and inflammation treatment. Molecules. 2018. https:\/\/doi.org\/10.3390\/molecules23102478.","journal-title":"Molecules"},{"key":"3472_CR5","unstructured":"Langan JP, SONI BK, Clark AJ, Schmidt L. Methods for reduction of bitterness in cannabinoids using mycelial materials. US Patent US20220339183A1. Google Patents; 2022."},{"key":"3472_CR6","unstructured":"BRASIL. Conselho Federal de Medicina. Resolu\u00e7\u00e3o CFM n\u00ba 2.324, de 11 de outubro de 2022: aprova o uso do canabidiol para o tratamento de epilepsias da crian\u00e7a e do adolescente refrat\u00e1rias \u00e0s terapias convencionais na S\u00edndrome de Dravet e Lennox-Gastaut e no Complexo de Esclerose Tuberosa. Di\u00e1rio Oficial da Uni\u00e3o. Conselho Federal de Medicina; 2022. p. 189."},{"issue":"6","key":"3472_CR7","doi-asserted-by":"publisher","DOI":"10.5014\/ajot.2015.019273","volume":"69","author":"K Tanner","year":"2015","unstructured":"Tanner K, Case-Smith J, Nahikian-Nelms M, Ratliff-Schaub K, Spees C, Darragh AR. Behavioral and physiological factors associated with selective eating in children with Autism Spectrum Disorder. Am J Occup Ther. 2015;69(6):8. https:\/\/doi.org\/10.5014\/ajot.2015.019273.","journal-title":"Am J Occup Ther"},{"key":"3472_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1392478","volume":"12","author":"RdCS Soares","year":"2024","unstructured":"Soares RdCS, C\u00e2ndido FG, Filgueiras MDS, Rosa CdOB, Novaes JFd, Araujo RMA. Problematic behaviors at mealtimes and the nutritional status of Brazilian children with Autism Spectrum Disorder. Front Public Health. 2024;12:1392478. https:\/\/doi.org\/10.3389\/fpubh.2024.1392478.","journal-title":"Front Public Health"},{"issue":"1","key":"3472_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2008.09.015","volume":"365","author":"A Cram","year":"2009","unstructured":"Cram A, Breitkreutz J, Desset-Br\u00e8thes S, Nunn T, Tuleu C. Challenges of developing palatable oral paediatric formulations. Int J Pharm. 2009;365(1):1\u20133. https:\/\/doi.org\/10.1016\/j.ijpharm.2008.09.015.","journal-title":"Int J Pharm"},{"key":"3472_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030513","author":"F Baratta","year":"2022","unstructured":"Baratta F, Peira E, Maza C, Gallarate M, Brusa P. Cannabis-based oral emulsion for medical purposes to meet the needs of patients: formulation, quality and stability. Pharmaceutics. 2022. https:\/\/doi.org\/10.3390\/pharmaceutics14030513.","journal-title":"Pharmaceutics"},{"issue":"1","key":"3472_CR11","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1089\/can.2017.0018","volume":"2","author":"SEM de Bruijn","year":"2017","unstructured":"de Bruijn SEM, de Graaf C, Witkamp RF, Jager G. Explorative placebo-controlled double-blind intervention study with low doses of inhaled \u03949-Tetrahydrocannabinol and Cannabidiol reveals no effect on sweet taste intensity perception and liking in humans. Cannabis Cannabinoid Res. 2017;2(1):114\u201322. https:\/\/doi.org\/10.1089\/can.2017.0018.","journal-title":"Cannabis Cannabinoid Res"},{"issue":"1","key":"3472_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1682-2","volume":"18","author":"AK Bhardwaj","year":"2018","unstructured":"Bhardwaj AK, Allsop DJ, Copeland J, McGregor IS, Dunlop A, Shanahan M, et al. Randomised controlled trial (RCT) of cannabinoid replacement therapy (Nabiximols) for the management of treatment-resistant cannabis dependent patients: a study protocol. BMC Psychiatry. 2018;18(1):140. https:\/\/doi.org\/10.1186\/s12888-018-1682-2.","journal-title":"BMC Psychiatry"},{"issue":"10","key":"3472_CR13","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1093\/pm\/pnaa303","volume":"21","author":"C Chaves","year":"2020","unstructured":"Chaves C, Bittencourt PCT, Pelegrini A. Ingestion of a THC-rich cannabis oil in people with Fibromyalgia: a randomized, double-blind, placebo-controlled clinical trial. Pain Med. 2020;21(10):2212\u20138. https:\/\/doi.org\/10.1093\/pm\/pnaa303.","journal-title":"Pain Med"},{"issue":"1","key":"3472_CR14","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.ijpharm.2010.11.028","volume":"417","author":"K Woertz","year":"2011","unstructured":"Woertz K, Tissen C, Kleinebudde P, Breitkreutz J. Taste sensing systems (electronic tongues) for pharmaceutical applications. Int J Pharm. 2011;417(1):256\u201371. https:\/\/doi.org\/10.1016\/j.ijpharm.2010.11.028.","journal-title":"Int J Pharm"},{"issue":"5","key":"3472_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16050658","volume":"16","author":"D Steiner","year":"2024","unstructured":"Steiner D, Meyer A, Immohr LI, Pein-Hackelbusch M. Critical view on the qualification of electronic tongues regarding their performance in the development of peroral drug formulations with bitter ingredients. Pharmaceutics. 2024;16(5):658. https:\/\/doi.org\/10.3390\/pharmaceutics16050658.","journal-title":"Pharmaceutics"},{"issue":"6","key":"3472_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ma15062126","volume":"15","author":"K Olechno","year":"2022","unstructured":"Olechno K, Maciejewski B, G\u0142owacz K, Lenik J, Ciosek-Skibi\u0144ska P, Basa A, et al. Orodispersible films with Rupatadine Fumarate enclosed in Ethylcellulose microparticles as drug delivery platform with taste-masking effect. Materials Basel. 2022;15(6):2126. https:\/\/doi.org\/10.3390\/ma15062126.","journal-title":"Materials Basel"},{"key":"3472_CR17","first-page":"146","volume-title":"Resolu\u00e7\u00e3o da Diretoria Colegiada - RDC n\u00ba 318, de 6 de novembro de 2019. RDC N\u00ba 318, DE 6 DE NOVEMBRO DE 2019","author":"BRASIL","year":"2019","unstructured":"BRASIL. Resolu\u00e7\u00e3o da Diretoria Colegiada - RDC n\u00ba 318, de 6 de novembro de 2019. RDC N\u00ba 318, DE 6 DE NOVEMBRO DE 2019. ANVISA; 2019. p. 146."},{"key":"3472_CR18","volume-title":"Potency analysis in hemp and cannabis products using a single-dilution combined LC-UV-MS\/MS approach [Application Note]","author":"SC Roberts","year":"2019","unstructured":"Roberts SC, Winkler P, Krepich S, Garber T, Hyland KC, Borton C. Potency analysis in hemp and cannabis products using a single-dilution combined LC-UV-MS\/MS approach [Application Note]. United States of America: Sciex. SCIEX; Phenomenex; Phenova; 2019."},{"key":"3472_CR19","unstructured":"World Health Organization. Annex 2: stability testing of active pharmaceutical ingredients and finished pharmaceutical products. In: WHO Technical Report Series, No. 953, Annex 2. World Health Organization; 2009."},{"issue":"31","key":"3472_CR20","doi-asserted-by":"publisher","first-page":"33949","DOI":"10.1021\/acsomega.4c04452","volume":"9","author":"ML Braunger","year":"2024","unstructured":"Braunger ML, Neto MP, Kirsanov D, Fier I, Amaral LR, Shimizu FM, et al. Analysis of macronutrients in soil using impedimetric multisensor arrays. ACS Omega. 2024;9(31):33949\u201358. https:\/\/doi.org\/10.1021\/acsomega.4c04452.","journal-title":"ACS Omega"},{"issue":"12","key":"3472_CR21","doi-asserted-by":"publisher","first-page":"5537","DOI":"10.1021\/acsaelm.5c00489","volume":"7","author":"LM Leidens","year":"2025","unstructured":"Leidens LM, Boeira CD, Gon\u00e7alves MH, Costa EEC, Marchi MC, Zanatta AR, et al. Microfluidic electronic tongues based on high-entropy nitride films. ACS Appl Electron Mater. 2025;7(12):5537\u201348. https:\/\/doi.org\/10.1021\/acsaelm.5c00489.","journal-title":"ACS Appl Electron Mater"},{"issue":"8","key":"3472_CR22","doi-asserted-by":"publisher","first-page":"5760","DOI":"10.1021\/acssensors.5c00921","volume":"10","author":"CD Boeira","year":"2025","unstructured":"Boeira CD, Leidens LM, Carvalho Costa EE, Gon\u00e7alves MH, Perillo AS, Ferraz FA, et al. Metallic nitride microfluidic e-Tongue: a novel selective approach for the detection of macronutrients in soil. ACS Sens. 2025;10(8):5760\u201371. https:\/\/doi.org\/10.1021\/acssensors.5c00921.","journal-title":"ACS Sens"},{"key":"3472_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/s20216194","author":"ML Braunger","year":"2020","unstructured":"Braunger ML, Fier I, Shimizu FM, de Barros A, Rodrigues V, Riul A. Influence of the flow rate in an automated microfluidic electronic tongue tested for sucralose differentiation. Sensors. 2020. https:\/\/doi.org\/10.3390\/s20216194.","journal-title":"Sensors"},{"issue":"47","key":"3472_CR24","doi-asserted-by":"publisher","first-page":"55073","DOI":"10.1021\/acsami.3c11590","volume":"15","author":"A Riul Jr.","year":"2023","unstructured":"Riul A Jr., de Barros A, Ga\u00e1l G, Braunger ML, Martinez Jimenez MJ, Avila-Avendano C, et al. Self-healing E-tongue. ACS Appl Mater Interfaces. 2023;15(47):55073\u201381. https:\/\/doi.org\/10.1021\/acsami.3c11590.","journal-title":"ACS Appl Mater Interfaces"},{"key":"3472_CR25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0922-3487(08)70032-7","volume":"5","author":"K Varmuza","year":"1990","unstructured":"Varmuza K, Lohninger H. 3 principal component analysis of chemical data. Data Handl Sci Technol. 1990;5:43\u201364. https:\/\/doi.org\/10.1016\/S0922-3487(08)70032-7.","journal-title":"Data Handl Sci Technol"},{"issue":"4","key":"3472_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v001.i04","volume":"1","author":"A Struyf","year":"1997","unstructured":"Struyf A, Hubert M, Rousseeuw P. Clustering in an object-oriented environment. J Stat Softw. 1997;1(4):1\u201330. https:\/\/doi.org\/10.18637\/jss.v001.i04.","journal-title":"J Stat Softw"},{"issue":"1","key":"3472_CR27","doi-asserted-by":"publisher","DOI":"10.1186\/s13638-021-01910-w","volume":"2021","author":"C Shi","year":"2021","unstructured":"Shi C, Wei B, Wei S, Wang W, Liu H, Liu J. A quantitative discriminant method of elbow point for the optimal number of clusters in clustering algorithm. EURASIP J Wirel Commun Netw. 2021;2021(1):31. https:\/\/doi.org\/10.1186\/s13638-021-01910-w.","journal-title":"EURASIP J Wirel Commun Netw"},{"key":"3472_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2025.104906","volume":"143","author":"H Scattone","year":"2025","unstructured":"Scattone H, Gauer LE, Pezzini JV, T\u00f3foli LF. Patterns of cannabis use for medical reasons in Brazil: an exploratory latent class analysis study. Int J Drug Policy. 2025;143:104906. https:\/\/doi.org\/10.1016\/j.drugpo.2025.104906.","journal-title":"Int J Drug Policy"},{"issue":"16","key":"3472_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/nu15163625","volume":"15","author":"A Isaakidis","year":"2023","unstructured":"Isaakidis A, Maghariki JE, Carvalho-Barros S, Gomes AM, Correia M. Is there more to olive oil than healthy lipids? Nutrients. 2023;15(16):3625. https:\/\/doi.org\/10.3390\/nu15163625.","journal-title":"Nutrients"},{"key":"3472_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1218538","volume":"10","author":"A Fazlollahi","year":"2023","unstructured":"Fazlollahi A, Motlagh Asghari K, Aslan C, Noori M, Nejadghaderi SA, Araj-Khodaei M, et al. The effects of olive oil consumption on cognitive performance: a systematic review. Front Nutr. 2023;10:1218538. https:\/\/doi.org\/10.3389\/fnut.2023.1218538.","journal-title":"Front Nutr"},{"issue":"3","key":"3472_CR31","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1089\/can.2022.0076","volume":"8","author":"JG Gouv\u00eaa-Silva","year":"2023","unstructured":"Gouv\u00eaa-Silva JG, Costa-Oliveira C, Ramos YJ, Mantovanelli DF, Cardoso MS, Viana-Oliveira LD, et al. Is there enough knowledge to standardize a Cannabis sativa L. medicinal oil preparation with a high content of cannabinoids? Cannabis Cannabinoid Res. 2023;8(3):476\u201386. https:\/\/doi.org\/10.1089\/can.2022.0076.","journal-title":"Cannabis Cannabinoid Res"},{"key":"3472_CR32","unstructured":"ANVISA. Guia de Estabilidade de Produtos Cosm\u00e9ticos. Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria; 2004. p. 52."},{"issue":"5","key":"3472_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/foods11050681","volume":"11","author":"J Kampa","year":"2022","unstructured":"Kampa J, Frazier R, Rodriguez-Garcia J. Physical and chemical characterisation of conventional and nano\/emulsions: influence of vegetable oils from different origins. Foods. 2022;11(5):681. https:\/\/doi.org\/10.3390\/foods11050681.","journal-title":"Foods"},{"issue":"6","key":"3472_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/foods10061354","volume":"10","author":"L Deng","year":"2021","unstructured":"Deng L. Current progress in the utilization of Soy-based emulsifiers in food applications\u2014a review. Foods. 2021;10(6):1354. https:\/\/doi.org\/10.3390\/foods10061354.","journal-title":"Foods"},{"key":"3472_CR35","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cis.2017.12.001","volume":"251","author":"DJ McClements","year":"2018","unstructured":"McClements DJ, Jafari SM. Improving emulsion formation, stability and performance using mixed emulsifiers: a review. Adv Colloid Interface Sci. 2018;251:55\u201379. https:\/\/doi.org\/10.1016\/j.cis.2017.12.001.","journal-title":"Adv Colloid Interface Sci"},{"issue":"12","key":"3472_CR36","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1007\/s11095-006-9104-4","volume":"23","author":"G Dumortier","year":"2006","unstructured":"Dumortier G, Grossiord JL, Agnely F, Chaumeil JC. A review of Poloxamer 407 pharmaceutical and pharmacological characteristics. Pharm Res. 2006;23(12):2709\u201328. https:\/\/doi.org\/10.1007\/s11095-006-9104-4.","journal-title":"Pharm Res"},{"issue":"8","key":"3472_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2017.e00390","volume":"3","author":"A Fakhari","year":"2017","unstructured":"Fakhari A, Corcoran M, Schwarz A. Thermogelling properties of purified poloxamer 407. Heliyon. 2017;3(8):e00390. https:\/\/doi.org\/10.1016\/j.heliyon.2017.e00390.","journal-title":"Heliyon"},{"issue":"1","key":"3472_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ijpharm.2018.08.021","volume":"551","author":"FL Lopez","year":"2018","unstructured":"Lopez FL, Ernest TB, Orlu M, Tuleu C. The effect of administration media on palatability and ease of swallowing of multiparticulate formulations. Int J Pharm. 2018;551(1):67\u201375. https:\/\/doi.org\/10.1016\/j.ijpharm.2018.08.021.","journal-title":"Int J Pharm"},{"issue":"4","key":"3472_CR39","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3390\/foods2040521","volume":"2","author":"S Zahn","year":"2013","unstructured":"Zahn S, Hoppert K, Ullrich F, Rohm H. Dairy-based emulsions: viscosity affects fat difference thresholds and sweetness perception. Foods. 2013;2(4):521\u201333. https:\/\/doi.org\/10.3390\/foods2040521.","journal-title":"Foods"},{"issue":"29","key":"3472_CR40","doi-asserted-by":"publisher","first-page":"8199","DOI":"10.1080\/10408398.2021.1926903","volume":"62","author":"K Light","year":"2022","unstructured":"Light K, Karboune S. Emulsion, hydrogel and emulgel systems and novel applications in cannabinoid delivery: a review. Crit Rev Food Sci Nutr. 2022;62(29):8199\u2013229. https:\/\/doi.org\/10.1080\/10408398.2021.1926903.","journal-title":"Crit Rev Food Sci Nutr"},{"key":"3472_CR41","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-3-030-84977-1_6","volume-title":"Essentials of Industrial Pharmacy","author":"SA Khan","year":"2022","unstructured":"Khan SA, Uddin S. Oral Emulsions. In: Khan SA, editor. Essentials of Industrial Pharmacy. Cham: Springer International Publishing; 2022. p. 67\u201379."},{"issue":"11","key":"3472_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112324","volume":"14","author":"O Gonz\u00e1lez-Gonz\u00e1lez","year":"2022","unstructured":"Gonz\u00e1lez-Gonz\u00e1lez O, Ramirez IO, Ramirez BI, O\u2019Connell P, Ballesteros MP, Torrado JJ, et al. Drug stability: ICH versus accelerated predictive stability studies. Pharmaceutics. 2022;14(11):2324. https:\/\/doi.org\/10.3390\/pharmaceutics14112324.","journal-title":"Pharmaceutics"},{"key":"3472_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2025.107399","volume":"113","author":"JC Coco","year":"2025","unstructured":"Coco JC, Dias CG, dos Santos \u00c9M, Silv\u00e9rio LAL, Paiva-Santos A-C, Ataide JA, et al. Optimizing topical antifungal liposomal delivery using plant by-product functional adjuvants. J Drug Deliv Sci Technol. 2025;113:107399. https:\/\/doi.org\/10.1016\/j.jddst.2025.107399.","journal-title":"J Drug Deliv Sci Technol"},{"issue":"1","key":"3472_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s44147-023-00322-5","volume":"70","author":"JSU Tabaniag","year":"2023","unstructured":"Tabaniag JSU, Abad MQD, Morcelos CJR, Geraldino GVB, Alvarado JLM, Lopez ECR. Stabilization of oil\/water emulsions using soybean lecithin as a biobased surfactant for enhanced oil recovery. J Eng Appl Sci. 2023;70(1):154. https:\/\/doi.org\/10.1186\/s44147-023-00322-5.","journal-title":"J Eng Appl Sci"},{"issue":"6","key":"3472_CR45","doi-asserted-by":"publisher","first-page":"221","DOI":"10.7399\/fh.10932","volume":"42","author":"S V\u00e1zquez-BlamilyName","year":"2018","unstructured":"V\u00e1zquez-BlamilyName S, Gonz\u00e1lez-Freire L, D\u00e1vila-Pousa MC, Crespo-Diz C. pH determination as a quality standard for the elaboration of oral liquid compounding formula. Farm Hosp. 2018;42(6):221\u20137. https:\/\/doi.org\/10.7399\/fh.10932.","journal-title":"Farm Hosp"},{"issue":"1","key":"3472_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.103414","volume":"28","author":"S Abdella","year":"2023","unstructured":"Abdella S, Abid F, Youssef SH, Kim S, Afinjuomo F, Malinga C, et al. pH and its applications in targeted drug delivery. Drug Discov Today. 2023;28(1):103414. https:\/\/doi.org\/10.1016\/j.drudis.2022.103414.","journal-title":"Drug Discov Today"},{"issue":"6","key":"3472_CR47","doi-asserted-by":"publisher","first-page":"11767","DOI":"10.3390\/ijms140611767","volume":"14","author":"R Pichot","year":"2013","unstructured":"Pichot R, Watson RL, Norton IT. Phospholipids at the interface: current trends and challenges. Int J Mol Sci. 2013;14(6):11767\u201394. https:\/\/doi.org\/10.3390\/ijms140611767.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3472_CR48","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.ijpharm.2017.06.040","volume":"528","author":"I Haidar","year":"2017","unstructured":"Haidar I, Harding IH, Bowater IC, Eldridge DS, Charman WN. The role of lecithin degradation on the pH dependent stability of halofantrine encapsulated fat nano-emulsions. Int J Pharm. 2017;528(1):524\u201335. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.06.040.","journal-title":"Int J Pharm"},{"issue":"7","key":"3472_CR49","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s11746-998-0239-9","volume":"75","author":"S Bhattacharya","year":"1998","unstructured":"Bhattacharya S, Shylaja MH, Manjunath MS, Sankar U. Rheology of lecithin dispersions. J Am Oil Chem Soc. 1998;75(7):871\u20134. https:\/\/doi.org\/10.1007\/s11746-998-0239-9.","journal-title":"J Am Oil Chem Soc"},{"issue":"5","key":"3472_CR50","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1111\/ics.12723","volume":"43","author":"JM Crowther","year":"2021","unstructured":"Crowther JM. Understanding humectant behaviour through their water-holding properties. Int J Cosmet Sci. 2021;43(5):601\u20139. https:\/\/doi.org\/10.1111\/ics.12723.","journal-title":"Int J Cosmet Sci"},{"issue":"1","key":"3472_CR51","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40543-022-00317-6","volume":"13","author":"D Bhangare","year":"2022","unstructured":"Bhangare D, Rajput N, Jadav T, Sahu AK, Tekade RK, Sengupta P. Systematic strategies for degradation kinetic study of pharmaceuticals: an issue of utmost importance concerning current stability analysis practices. J Anal Sci Technol. 2022;13(1):7. https:\/\/doi.org\/10.1186\/s40543-022-00317-6.","journal-title":"J Anal Sci Technol"},{"issue":"23","key":"3472_CR52","doi-asserted-by":"publisher","first-page":"3923","DOI":"10.3390\/foods11233923","volume":"11","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Shi Y, Tu Z, Hu Y, He C. Emulsion properties during microencapsulation of cannabis oil based on protein and sucrose esters as emulsifiers: stability and rheological behavior. Foods. 2022;11(23):3923. https:\/\/doi.org\/10.3390\/foods11233923.","journal-title":"Foods"},{"key":"3472_CR53","doi-asserted-by":"publisher","first-page":"138633","DOI":"10.1016\/j.foodchem.2024.138633","volume":"444","author":"N Wang","year":"2024","unstructured":"Wang N, Liu B, Wang D, Xing K, Wang W, Wang T, et al. Oil-in-water and oleogel-in-water emulsion encapsulate with hemp seed oil containing \u03949-tetrahydrocannabinol and cannabinol: stability, degradation and in vitro simulation characteristics. Food Chem. 2024;444:138633. https:\/\/doi.org\/10.1016\/j.foodchem.2024.138633.","journal-title":"Food Chem"},{"key":"3472_CR54","doi-asserted-by":"publisher","first-page":"122188","DOI":"10.1016\/j.jchromb.2020.122188","volume":"1150","author":"AI Fraguas-S\u00e1nchez","year":"2020","unstructured":"Fraguas-S\u00e1nchez AI, Fern\u00e1ndez-Carballido A, Martin-Sabroso C, Torres-Su\u00e1rez AI. Stability characteristics of cannabidiol for the design of pharmacological, biochemical and pharmaceutical studies. J Chromatogr B. 2020;1150:122188. https:\/\/doi.org\/10.1016\/j.jchromb.2020.122188.","journal-title":"J Chromatogr B"},{"key":"3472_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13030412","author":"E Kosovi\u0107","year":"2021","unstructured":"Kosovi\u0107 E, S\u00fdkora D, Kucha\u0159 M. Stability study of cannabidiol in the form of solid powder and sunflower oil solution. Pharmaceutics. 2021. https:\/\/doi.org\/10.3390\/pharmaceutics13030412.","journal-title":"Pharmaceutics"},{"issue":"1","key":"3472_CR56","doi-asserted-by":"publisher","first-page":"8951","DOI":"10.1038\/s41598-021-88389-z","volume":"11","author":"Z Cz\u00e9g\u00e9ny","year":"2021","unstructured":"Cz\u00e9g\u00e9ny Z, Nagy G, Babinszki B, Bajtel \u00c1, Sebesty\u00e9n Z, Kiss T, et al. CBD, a precursor of THC in e-cigarettes. Sci Rep. 2021;11(1):8951. https:\/\/doi.org\/10.1038\/s41598-021-88389-z.","journal-title":"Sci Rep"},{"key":"3472_CR57","doi-asserted-by":"publisher","first-page":"1038729","DOI":"10.3389\/fchem.2022.1038729","volume":"10","author":"MT Garc\u00eda-Valverde","year":"2022","unstructured":"Garc\u00eda-Valverde MT, S\u00e1nchez-CarnereroCallado C, D\u00edaz-Li\u00f1\u00e1n MC, S\u00e1nchez de Medina V, Hidalgo-Garc\u00eda J, Nadal X, et al. Effect of temperature in the degradation of cannabinoids: from a brief residence in the gas chromatography inlet port to a longer period in thermal treatments. Front Chem. 2022;10:1038729. https:\/\/doi.org\/10.3389\/fchem.2022.1038729.","journal-title":"Front Chem"},{"issue":"1","key":"3472_CR58","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s42238-024-00239-7","volume":"7","author":"A Henriques","year":"2025","unstructured":"Henriques A. Cannabinoid spoilage, metabolism and cannabidiol(CBD) conversion to Tetrahydrocannabinol(THC) mechanisms with energetic parameters. J Cannabis Res. 2025;7(1):11. https:\/\/doi.org\/10.1186\/s42238-024-00239-7.","journal-title":"J Cannabis Res"},{"key":"3472_CR59","doi-asserted-by":"publisher","unstructured":"Ramalho VC, Jorge N. Antioxidants used in oils, fats and fatty foods. Qu\u00edmica Nova. 2006;29. https:\/\/doi.org\/10.1590\/S0100-40422006000400023.","DOI":"10.1590\/S0100-40422006000400023"},{"issue":"4","key":"3472_CR60","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s11746-012-2194-8","volume":"90","author":"A Szterk","year":"2013","unstructured":"Szterk A, Roszko M, G\u00f3rnicka E. Chemical Stability of the Lipid Phase in Concentrated Beverage Emulsions Colored with Natural \u03b2-Carotene. J Am Oil Chem Soc. 2013;90(4):483\u201391. https:\/\/doi.org\/10.1007\/s11746-012-2194-8.","journal-title":"J Am Oil Chem Soc"},{"key":"3472_CR61","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.jcis.2020.04.001","volume":"574","author":"CEP Silva","year":"2020","unstructured":"Silva CEP, Tam KC, Bernardes JS, Loh W. Double stabilization mechanism of O\/W Pickering emulsions using cationic nanofibrillated cellulose. J Colloid Interface Sci. 2020;574:207\u201316. https:\/\/doi.org\/10.1016\/j.jcis.2020.04.001.","journal-title":"J Colloid Interface Sci"},{"key":"3472_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/gels8120807","author":"A Abbasi Moud","year":"2022","unstructured":"Abbasi Moud A. Colloidal and sedimentation behavior of kaolinite suspension in presence of non-ionic polyacrylamide (PAM). Gels. 2022. https:\/\/doi.org\/10.3390\/gels8120807.","journal-title":"Gels"},{"key":"3472_CR63","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.cis.2015.06.005","volume":"233","author":"M Kawaguchi","year":"2016","unstructured":"Kawaguchi M. Silicone oil emulsions stabilized by polymers and solid particles. Adv Coll Interface Sci. 2016;233:186\u201399. https:\/\/doi.org\/10.1016\/j.cis.2015.06.005.","journal-title":"Adv Coll Interface Sci"},{"issue":"8","key":"3472_CR64","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.jsps.2017.07.004","volume":"25","author":"AR Fernandes","year":"2017","unstructured":"Fernandes AR, Ferreira NR, Fangueiro JF, Santos AC, Veiga FJ, Cabral C, et al. Ibuprofen nanocrystals developed by 22 factorial design experiment: A new approach for poorly water-soluble drugs. Saudi Pharmaceutical Journal. 2017;25(8):1117\u201324. https:\/\/doi.org\/10.1016\/j.jsps.2017.07.004.","journal-title":"Saudi Pharmaceutical Journal"},{"issue":"1","key":"3472_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0169-7439(99)00047-7","volume":"50","author":"R De Maesschalck","year":"2000","unstructured":"De Maesschalck R, Jouan-Rimbaud D, Massart DL. The Mahalanobis distance. Chemom Intell Lab Syst. 2000;50(1):1\u201318. https:\/\/doi.org\/10.1016\/S0169-7439(99)00047-7.","journal-title":"Chemom Intell Lab Syst"},{"issue":"2","key":"3472_CR66","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1208\/s12249-018-1277-8","volume":"20","author":"MRP Rao","year":"2019","unstructured":"Rao MRP, Bhutada K, Kaushal P. Taste Evaluation by Electronic Tongue and Bioavailability Enhancement of Efavirenz. AAPS PharmSciTech. 2019;20(2):56. https:\/\/doi.org\/10.1208\/s12249-018-1277-8.","journal-title":"AAPS PharmSciTech"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-026-03472-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1208\/s12249-026-03472-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-026-03472-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:04:24Z","timestamp":1790276664000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1208\/s12249-026-03472-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["3472"],"URL":"https:\/\/doi.org\/10.1208\/s12249-026-03472-w","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"assertion":[{"value":"11 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"232"}}