{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:18:20Z","timestamp":1769239100925,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1208\/pt0803076","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T15:47:21Z","timestamp":1191512841000},"page":"E195-E202","source":"Crossref","is-referenced-by-count":36,"title":["Compressed matrix core tablet as a quick\/slow dual-component delivery system containing ibuprofen"],"prefix":"10.1208","volume":"8","author":[{"given":"Carla Martins","family":"Lopes","sequence":"first","affiliation":[]},{"given":"Jos\u00e9 M.","family":"Sousa Lobo","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o F.","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Paulo C.","family":"Costa","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"83195_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0939-6411(99)00019-3","volume":"48","author":"L Maggi","year":"1999","unstructured":"Maggi L, Machiste EO, Torre ML, Conte U. Formulation of biphasic release tablets containing slightly soluble drugs.Eur J Pharm Biopharm. 1999;48:37\u201342.","journal-title":"Eur J Pharm Biopharm"},{"key":"83195_CR2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0378-5173(90)90099-P","volume":"63","author":"P Colombo","year":"1990","unstructured":"Colombo P, Conte U, Gazzaniga A, et al. Drug release modulation by physical restrictions of matrix swelling.Int J Pharm. 1990;63:43\u201348.","journal-title":"Int J Pharm."},{"key":"83195_CR3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0168-3659(97)00119-3","volume":"52","author":"Y Qiu","year":"1998","unstructured":"Qiu Y, Chidambaram N, Flood K. Design and evaluation of layered diffusional matrices for zero-order sustained release.J Control Release. 1998;52:123\u2013130.","journal-title":"J Control Release."},{"key":"83195_CR4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0168-3659(97)00207-1","volume":"52","author":"N Chidambaram","year":"1998","unstructured":"Chidambaram N, Porter W, Flood K, Qui Y. Formulation and characterization of new layered diffusional matrices for zero-order sustained release.J Control Release 1998;52:149\u2013158.","journal-title":"J Control Release"},{"key":"83195_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/S0168-3659(99)00147-9","volume":"64","author":"U Conte","year":"2000","unstructured":"Conte U, Maggi L. A flexible technology for the linear, pulsative and delayed release drugs, allowing for easy accommodation of difficult in vitro targets.J Control Release 2000;64:263\u2013268.","journal-title":"J Control Release"},{"key":"83195_CR6","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/jps.2600790314","volume":"79","author":"K Uekama","year":"1990","unstructured":"Uekama K, Matsubara K, Abe K, Horiuchi Y, Hirayamma F, Suzuki N. Design and in vitro evaluation of slow-release dosage form of piretanide: utility of beta-cyclodextrin: cellulose derivative combination as a modified-release drug carrier.J Pharm Sci. 1990;79:244\u2013248.","journal-title":"J Pharm Sci."},{"key":"83195_CR7","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jconrel.2003.11.023","volume":"95","author":"Y Li","year":"2004","unstructured":"Li Y, Zhu J. Modulation of combined-release behaviours from a novel \u201ctablets-in-capsule system.\u201dJ Control Release 2004;95:381\u2013389.","journal-title":"J Control Release"},{"key":"83195_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0378-5173(00)00549-4","volume":"208","author":"C Brabander De","year":"2000","unstructured":"De Brabander C, Vervaet C, G\u00f6rtz JP, Remon JP, Berlo JA. Bioavailability of ibuprofen from matrix mini-tablets based on a mixture of starch and microcrystallien wax.Int J Pharm. 2000;208:81\u201386.","journal-title":"Int J Pharm."},{"key":"83195_CR9","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S1461-5347(00)00269-8","volume":"3","author":"P Colombo","year":"2000","unstructured":"Colombo P, Bettini R, Santi P, Peppas NA. Swellable matrices for controlled drug delivery: gel-layer behavior, mechanisms and optimal performance.Pharm Sci Technol Today. 2000;3:198\u2013204.","journal-title":"Pharm Sci Technol Today."},{"key":"83195_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0168-3659(03)00122-6","volume":"90","author":"S Kiil","year":"2003","unstructured":"Kiil S, Dam-Johansen K. Controlled drug delivery from swellable hydroxypropylmethylcellulose matrices: model-based analysis of observed radial front movements.J Control Release. 2003;90:1\u201321.","journal-title":"J Control Release."},{"key":"83195_CR11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.2042-7158.1968.tb09832.x","volume":"20","author":"JT Fell","year":"1968","unstructured":"Fell JT, Newton JM. The tensile strength of lactose tablets.J Pharm Pharmacol. 1968;20:657\u2013659.","journal-title":"J Pharm Pharmacol."},{"key":"83195_CR12","first-page":"64","volume":"20","author":"JW Morre","year":"2007","unstructured":"Morre JW, Flanner HH. Mathematical comparison of dissolution profiles.Pharm Technol. 1996;20:64\u201374.","journal-title":"Pharm Technol."},{"key":"83195_CR13","unstructured":"CDER. Center for Drug Evaluation and Research, Guidance for Industry, Dissolution Testing of Immediate Release Solid Oral Dosage, 1997. Available at:http:\/\/www.fda.gov\/cder\/Guidance\/1713bpl.pdf. Accessed: September 19, 2006."},{"key":"83195_CR14","unstructured":"EMEA. European Agency for the Evaluation of Medicinal Products, Human Medicines Evaluation Unit, Note for Guidance on Quality of Modified Release Products: (A) Oral Dosage Forms; (B) Transdermal Dosage Forms; Section I (Quality), CPMP\/QWP\/604\/96 (1999). Available at: http:\/\/www.emea.eu.int\/pdfs\/human\/qwp\/060496en.pdf. Accessed: September 19, 2006."},{"key":"83195_CR15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0928-0987(01)00095-1","volume":"13","author":"P Costa","year":"2001","unstructured":"Costa P, Sousa Lobo JM. Modelling and comparison of dissolution profiles.Eur J Pharm Sci. 2001;13:123\u2013133.","journal-title":"Eur J Pharm Sci."},{"key":"83195_CR16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0168-3659(87)90034-4","volume":"5","author":"PL Ritger","year":"1987","unstructured":"Ritger PL, Peppas NA. A simple equation for description of solute release. I. Fickian and non-Fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs.J Control Release. 1987;5:23\u201336.","journal-title":"J Control Release"},{"key":"83195_CR17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.2042-7158.1980.tb12970.x","volume":"32","author":"M Donbrow","year":"1980","unstructured":"Donbrow M, Samuelov Y. Zero order drug delivery from double-layered porous films: release rate profiles from ethylcellulose, hydroxypropylcellulose and polyethylene glycol mixtures.J Pharm Pharmacol. 1980;32:463\u2013470.","journal-title":"J Pharm Pharmacol."},{"key":"83195_CR18","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1002\/jps.2600501018","volume":"50","author":"T Higuchi","year":"1961","unstructured":"Higuchi T. Rate of release of medicaments from ointment bases containing drugs in suspension.J Pharm Sci. 1961;50:874\u2013875.","journal-title":"J Pharm Sci."},{"key":"83195_CR19","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1002\/jps.2600521210","volume":"52","author":"T Higuchi","year":"1963","unstructured":"Higuchi T. Mechanism of sustained-action medication: theoretical analysis of rate of release of soild drugs dispersed in solid matrices.J Pharm Sci. 1963;52:1145\u20131149.","journal-title":"J Pharm Sci."},{"key":"83195_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","volume":"15","author":"RW Korsmeyer","year":"1983","unstructured":"Korsmeyer RW, Gurny R, Doelker EM, Buri P, Peppas NA. Mechanism of solute release from porous hydrophilic polymers.Int J Pharm. 1983;15:25\u201335.","journal-title":"Int J Pharm."},{"key":"83195_CR21","first-page":"110","volume":"60","author":"NA Peppas","year":"1985","unstructured":"Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers.Pharm Acta Helv. 1985;60:110\u2013111.","journal-title":"Pharm Acta Helv."},{"key":"83195_CR22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-4684-2877-3_6","volume-title":"Permeability of Plastic Films and Coatings to Gases, Vapors, and Liquids","author":"CHM Jacques","year":"1974","unstructured":"Jacques CHM, Hopfenberg HB, Stannett V. Super case II transport of organic vapors in glassy polymers. In: Hopfenberger HB, ed.Permeability of Plastic Films and Coatings to Gases, Vapors, and Liquids, New York, NY: Plenum Press; 1974:73\u201386."},{"key":"83195_CR23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0168-3659(03)00132-9","volume":"89","author":"KC Waterman","year":"2003","unstructured":"Waterman KC, Fergione MB. Press-coating of immediate release powders onto coated controlled release tablets with adhesives.J Control Release. 2003;89:387\u2013395.","journal-title":"J Control Release"},{"key":"83195_CR24","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0378-5173(94)00295-G","volume":"117","author":"B Johansson","year":"1995","unstructured":"Johansson B, Wikberg M, Ek R, Alderborn G. Compression behaviour and compactability of microcrystalline cellulose pellets in relationship to their pore structure and mechanical properties.Int. J. Pharm. 1995;117:57\u201373.","journal-title":"Int. J. Pharm."},{"key":"83195_CR25","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0378-5173(97)00355-4","volume":"163","author":"B Johansson","year":"1998","unstructured":"Johansson B, Nicklasson F, Alderborn G. Effect of pellet size on degree of deformation and densification during compression and on compactability of microcrystalline cellulose pellets.Int J Pharm. 1998;163:35\u201348.","journal-title":"Int J Pharm."},{"key":"83195_CR26","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0939-6411(01)00186-2","volume":"52","author":"B Johansson","year":"2001","unstructured":"Johansson B, Alderborn G. The effect of shape and porosity on the compression behaviour and tablet forming ability of granular materials formed from microcrystalline cellulose.Eur J Pharm Biopharm. 2001;52:347\u2013357.","journal-title":"Eur J Pharm Biopharm."},{"key":"83195_CR27","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ejps.2003.09.009","volume":"20","author":"A Tun\u00f3n","year":"2003","unstructured":"Tun\u00f3n A, Borjesson E, Frenning G, Alderborn G. Drug release from reservoir pellet compacted with some excipients of different physical properties.Eur J Pharm Sci. 2003;20:469\u2013479.","journal-title":"Eur J Pharm Sci."},{"key":"83195_CR28","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ijpharm.2006.05.063","volume":"323","author":"CM Lopes","year":"2006","unstructured":"Lopes CM, Sousa Lobo JM, Pinto JF, Costa P. Compressed mini-tablets as a biphasic delivery system.Int J Pharm. 2006;323:93\u2013100.","journal-title":"Int J Pharm."}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt0803076.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/pt0803076\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt0803076.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/pt0803076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T23:42:09Z","timestamp":1559605329000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/pt0803076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["83195"],"URL":"https:\/\/doi.org\/10.1208\/pt0803076","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}