{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:06:04Z","timestamp":1768277164034,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,5,2]],"date-time":"2011-05-02T00:00:00Z","timestamp":1304294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1208\/s12249-011-9612-3","type":"journal-article","created":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T14:38:00Z","timestamp":1304260680000},"page":"553-563","source":"Crossref","is-referenced-by-count":38,"title":["Complexation and Full Characterization of the Tretinoin and Dimethyl-\u03b2eta-Cyclodextrin Complex"],"prefix":"10.1208","volume":"12","author":[{"given":"Andreia","family":"Ascenso","sequence":"first","affiliation":[]},{"given":"Rita","family":"Guedes","sequence":"additional","affiliation":[]},{"given":"Raul","family":"Bernardino","sequence":"additional","affiliation":[]},{"given":"Herminio","family":"Diogo","sequence":"additional","affiliation":[]},{"given":"Filomena A.","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Nuno C.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Aida M.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Helena Cabral","family":"Marques","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,5,2]]},"reference":[{"key":"9612_CR1","unstructured":"European Pharmacopoeia 6.0, edom, 2008. (electronic version)"},{"key":"9612_CR2","unstructured":"Tretinoin and Dimethyl-beta-cyclodextrin in: \n                    http:\/\/www.chemexper.com\n                    \n                   (accessed on Sept. 2008)"},{"key":"9612_CR3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/j.1468-3083.2004.00929.x","volume":"18","author":"RY Anadolu","year":"2004","unstructured":"Anadolu RY, Sen T, Tarimci N, Birol A, Erdem C. Improved efficacy and tolerability of retinoic acid in acne vulgaris: a new topical formulation with cyclodextrin complex psi. Eur J Acad Dermatol Venereol. 2004;18:416\u201321.","journal-title":"Eur. J. Acad. Dermatol. Venereol."},{"key":"9612_CR4","first-page":"1","volume":"XX","author":"SM Loveday","year":"2008","unstructured":"Loveday SM, Singh H. Recent advances in technologies for vitamin A protection in foods. Trends in Food Sci & Tech. 2008;XX:1\u201312.","journal-title":"Trends in Food Sci. & Tech"},{"key":"9612_CR5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF03258222","volume":"2","author":"J Szejtli","year":"1990","unstructured":"Szejtli J. Cyclodextrins properties and applications. Drug Invest. 1990;2:11\u201321.","journal-title":"Drug Invest."},{"key":"9612_CR6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1208\/pt060243","volume":"6","author":"R Challa","year":"2005","unstructured":"Challa R, Ahuja A, Ali J, Khar R. Cyclodextrins in drug delivery: an updated review. AAPS PharmSciTech. 2005;6:329\u201357.","journal-title":"AAPS PharmSciTech."},{"key":"9612_CR7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0734-9750(02)00020-4","volume":"20","author":"M Singh","year":"2002","unstructured":"Singh M. Biotechnological applications of cyclodextrins. Biot Adv. 2002;20:341\u201359.","journal-title":"Biot. Adv."},{"key":"9612_CR8","first-page":"85","volume":"44","author":"HC Marques","year":"1994","unstructured":"Marques HC. Applications of cyclodextrins. Thermodynamic aspects of cyclodextrin complexes. Rev Port Farm. 1994;44:85\u201396.","journal-title":"Rev. Port. Farm."},{"key":"9612_CR9","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1039\/a605235e","volume":"7","author":"J Szejtli","year":"1997","unstructured":"Szejtli J. Utilization of cyclodextrins in industrial products and processes. J Mat Chem. 1997;7:575\u201387.","journal-title":"J. Mat. Chem."},{"key":"9612_CR10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0169-409X(98)00056-8","volume":"36","author":"H Matsuda","year":"1999","unstructured":"Matsuda H, Arima H. Cyclodextrins in transdermal and rectal delivery. Adv Drug Deliv Rev. 1999;36:81\u201399.","journal-title":"Adv. Drug Deliv. Rev."},{"key":"9612_CR11","first-page":"49","volume-title":"Encyclopedia of pharmaceutical technology","author":"G Mosher","year":"2006","unstructured":"Mosher G, Thompson D. Complexation and cyclodextrins. In: Swarbrick J, Boylan JC, editors. Encyclopedia of pharmaceutical technology. New York, NY: Marcell Dekker; 2006. p. 49\u201388."},{"key":"9612_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0378-5173(97)00104-X","volume":"153","author":"P Montassier","year":"1997","unstructured":"Montassier P, Duch\u00eane D, Poelman M-C. Inclusion complexes of tretinoin with cyclodextrins. Int J Pharm. 1997;153:199\u2013209.","journal-title":"Int. J. Pharm."},{"key":"9612_CR13","first-page":"117","volume-title":"Advances in analytical chemistry and instrumentation","author":"T Higuchi","year":"1965","unstructured":"Higuchi T, Connors KA. Phase-solubility techniques. In: Reilly CN, editor. Advances in analytical chemistry and instrumentation, vol. 4. New York: Wiley; 1965. p. 117\u2013212."},{"key":"9612_CR14","doi-asserted-by":"publisher","first-page":"B864","DOI":"10.1103\/PhysRev.136.B864","volume":"136","author":"P Hohenberg","year":"1964","unstructured":"Hohenberg P, Kohn. Inhomogeneous electron gas. W Phys Rev. 1964;136:B864.","journal-title":"W Phys Rev"},{"key":"9612_CR15","doi-asserted-by":"publisher","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"AD Becke","year":"1993","unstructured":"Becke AD. Density-functional thermochemistry. III. The role of exact exchange. J Chem Phys. 1993;98:5648.","journal-title":"J Chem Phys"},{"key":"9612_CR16","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1021\/ja00523a008","volume":"102","author":"JS Binkley","year":"1980","unstructured":"Binkley JS, Pople JA, Hehre WJ. Self-consistent molecular orbital methods. 21. Small split-valence basis sets for first-row elements. J Am Chem Soc. 1980;102:939.","journal-title":"J. Am. Chem. Soc."},{"key":"9612_CR17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"B37","author":"C Lee","year":"1988","unstructured":"Lee C, Yang W, Parr RG. Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density. Phys Rev. 1988;B37:785.","journal-title":"Phys. Rev"},{"key":"9612_CR18","volume-title":"Gaussian 03, Revision C.02","author":"MJ Frisch","year":"2004","unstructured":"Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, et al. Gaussian 03, Revision C.02. Wallingford CT: Gaussian, Inc; 2004."},{"key":"9612_CR19","unstructured":"MOE\u2014the Molecular Operating Environment in: \n                    http:\/\/www.chemcomp.com\/\n                    \n                   (accessed on 2007\/08)"},{"key":"9612_CR20","unstructured":"http:\/\/pymol.sourceforge.net\/\n                    \n                   (accessed on 2007\/08)"},{"key":"9612_CR21","unstructured":"Molekel is an opensource (GPL) multiplatform molecular visualization program being developed by the Visualization and Data Analysis group at the Swiss National Supercomputing Centre (CSCS). The development website is hosted at \n                    http:\/\/bioinformatics.org\/molekel\n                    \n                   (accessed on 2007\/08)."},{"key":"9612_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0003-2670(02)00629-3","volume":"468","author":"S Mu\u00f1oz-Botella","year":"2002","unstructured":"Mu\u00f1oz-Botella S, Mart\u00edn MA, del Castillo B, Lerner DA, Men\u00e9ndez JC. Differentiating geometrical isomers of retinoids and controlling their photo-isomerization by complexation with cyclodextrins. Anal Chim Acta. 2002;468:161\u201370.","journal-title":"Anal Chim Acta"},{"key":"9612_CR23","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1248\/cpb.26.3477","volume":"26","author":"K Uekama","year":"1978","unstructured":"Uekama K, Ono N, Hirayama F, Arima H. Determination of the stability constants for inclusion complexes of cyclodextrins with various drug molecules by high performance liquid chromatography. Chem Pharm Bull. 1978;26:3477\u201384.","journal-title":"Chem Pharm Bull"},{"key":"9612_CR24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0939-6411(02)00166-2","volume":"55","author":"KJ Waleczek","year":"2003","unstructured":"Waleczek KJ, Cabral MH, Hempel B, Schmidt PC. Phase solubility studies of pure (\u2212)-alfa-bisabolol and camomile essencial oil with beta-cyclodextrin. Eur J Pharm Biopharm. 2003;55:247\u201351.","journal-title":"Eur J Pharm Biopharm"},{"key":"9612_CR25","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ijpharm.2005.05.042","volume":"302","author":"T Loftsson","year":"2005","unstructured":"Loftsson T, Hreinsd\u00f3ttir D, Masson M. Evaluation of cyclodextrin solubilization of drugs. Int J Pharm. 2005;302:18\u201328.","journal-title":"Int J Pharm"},{"key":"9612_CR26","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1248\/cpb.24.1155","volume":"24","author":"T Miyaji","year":"1976","unstructured":"Miyaji T, Kurono Y, Uekama K, Ikeda K. Simultaneous determination of complexation equilibrium constants for conjugated guest species by the extended potentiometric titration method on the barbiturate-\u03b2-cyclodextrin system. Chem Pharm Bull. 1976;24:1155\u20139.","journal-title":"Chem Pharm Bull"},{"key":"9612_CR27","first-page":"995","volume":"37","author":"M Cirri","year":"2004","unstructured":"Cirri M, Maestrelli F, Orlandini S, Furlanetto S, Pinzauti S, Mura P. Determination of stability constant values of flurbiprofen-cyclodextrin complexes using different techniques. J Pharm Sci. 2004;37:995\u20131002.","journal-title":"J Pharm Sci."},{"key":"9612_CR28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.ejps.2005.01.021","volume":"25","author":"KL Yap","year":"2005","unstructured":"Yap KL, Liu X, Thenmozhiyal JC, Ho PC. Characterization of the 13-cis-retinoic acid\/cyclodextrin inclusion complexes by phase solubility, photostability, physico-chemical and computational analysis. Eur J Pharm Sci. 2005;25:49\u201356.","journal-title":"Eur. J. Pharm. Sci."},{"key":"9612_CR29","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.cplett.2006.08.043","volume":"429","author":"GD Tavares","year":"2006","unstructured":"Tavares GD, Viana CM, Ara\u00fajo JGVC, Ramaldes GA, Carvalho WS, Pesquero JL, et al. Development and physico-chemical characterization of cyclodextrin\u2013DNA complexes loaded liposomes. Chem Phys Letters. 2006;429:507\u201312.","journal-title":"Chem Phys Letters"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-011-9612-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-011-9612-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-011-9612-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-011-9612-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T03:48:14Z","timestamp":1559620094000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-011-9612-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["9612"],"URL":"https:\/\/doi.org\/10.1208\/s12249-011-9612-3","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,2]]}}}