{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:40:36Z","timestamp":1768268436520,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T00:00:00Z","timestamp":1536710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AAPS PharmSciTech"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1208\/s12249-018-1156-3","type":"journal-article","created":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T16:56:18Z","timestamp":1536771378000},"page":"3584-3598","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lipid Architectonics for Superior Oral Bioavailability of Nelfinavir Mesylate: Comparative in vitro and in vivo Assessment"],"prefix":"10.1208","volume":"19","author":[{"given":"Tejashree","family":"Belubbi","sequence":"first","affiliation":[]},{"given":"Sukhada","family":"Shevade","sequence":"additional","affiliation":[]},{"given":"Vivek","family":"Dhawan","sequence":"additional","affiliation":[]},{"given":"Vinay","family":"Sridhar","sequence":"additional","affiliation":[]},{"given":"Anuradha","family":"Majumdar","sequence":"additional","affiliation":[]},{"given":"Rute","family":"Nunes","sequence":"additional","affiliation":[]},{"given":"Francisca","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[]},{"given":"Kalpa","family":"Nagarsenker","sequence":"additional","affiliation":[]},{"given":"Frank","family":"Steiniger","sequence":"additional","affiliation":[]},{"given":"Alfred","family":"Fahr","sequence":"additional","affiliation":[]},{"given":"Aniket","family":"Magarkar","sequence":"additional","affiliation":[]},{"given":"Alex","family":"Bunker","sequence":"additional","affiliation":[]},{"given":"Mangal","family":"Nagarsenker","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,9,12]]},"reference":[{"key":"1156_CR1","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.colsurfb.2014.09.031","volume":"123","author":"MA Moretton","year":"2014","unstructured":"Moretton MA, Taira C, Flor S, Bernabeu E, Lucangioli S, H\u00f6cht C, et al. Novel nelfinavir mesylate loaded d-\u03b1-tocopheryl polyethylene glycol 1000 succinate micelles for enhanced pediatric anti HIV therapy: in vitro characterization and in vivo evaluation. Colloids Surf B: Biointerfaces. 2014;123:302\u201310.","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"4","key":"1156_CR2","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1208\/s12248-011-9290-9","volume":"13","author":"LZ Benet","year":"2011","unstructured":"Benet LZ, Broccatelli F. Oprea TI. BDDCS applied to over 900 drugs. AAPS J. 2011;13(4):519\u201347.","journal-title":"AAPS J"},{"issue":"2","key":"1156_CR3","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.ejpb.2011.04.005","volume":"79","author":"Y Shono","year":"2011","unstructured":"Shono Y, Jantratid E, Dressman JB. Precipitation in the small intestine may play a more important role in the in vivo performance of poorly soluble weak bases in the fasted state: case example nelfinavir. Eur J Pharm Biopharm. 2011;79(2):349\u201356.","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"1156_CR4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0169-409X(99)00027-7","volume":"39","author":"GC Williams","year":"1999","unstructured":"Williams GC, Sinko PJ. Oral absorption of the HIV protease inhibitors: a current update. Adv Drug Deliv Rev. 1999;39(1):211\u201338.","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"1156_CR5","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s13346-014-0191-1","volume":"4","author":"A Patel","year":"2014","unstructured":"Patel A, Shelat P, Lalwani A. Development and optimization of solid self-nanoemulsifying drug delivery system (S-SNEDDS) using Scheffe\u2019s design for improvement of oral bioavailability of nelfinavir mesylate. Drug Deliv Transl Res. 2014;4(2):171\u201386.","journal-title":"Drug Deliv Transl Res"},{"issue":"6","key":"1156_CR6","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.apsb.2013.10.001","volume":"3","author":"S Kalepu","year":"2013","unstructured":"Kalepu S, Manthina M, Padavala V. Oral lipid-based drug delivery systems-an overview. Acta Pharm Sin B. 2013;3(6):361\u201372.","journal-title":"Acta Pharm Sin B"},{"issue":"8","key":"1156_CR7","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s11095-010-0130-x","volume":"27","author":"G Fricker","year":"2010","unstructured":"Fricker G, Kromp T, Wendel A, Blume A, Zirkel J, Rebmann H, et al. Phospholipids and lipid-based formulations in oral drug delivery. Pharm Res. 2010;27(8):1469\u201386.","journal-title":"Pharm Res"},{"issue":"8","key":"1156_CR8","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.2217\/nnm.11.38","volume":"6","author":"AA Date","year":"2011","unstructured":"Date AA, Srivastava D, Nagarsenker MS, Mulherkar R, Panicker L, Aswal V, et al. Lecithin-based novel cationic nanocarriers (LeciPlex) I: fabrication, characterization and evaluation. Nanomedicine. 2011;6(8):1309\u201325.","journal-title":"Nanomedicine"},{"issue":"7","key":"1156_CR9","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1166\/jbn.2013.1636","volume":"9","author":"AS Jain","year":"2013","unstructured":"Jain AS, Shah SM, Nagarsenker MS, Nikam Y, Gude RP, Steiniger F, et al. Lipid colloidal carriers for improvement of anticancer activity of orally delivered quercetin: formulation, characterization and establishing in vitro-in vivo advantage. J Biomed Nanotechnol. 2013;9(7):1230\u201340.","journal-title":"J Biomed Nanotechnol"},{"issue":"3","key":"1156_CR10","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1021\/mp100305h","volume":"8","author":"AA Date","year":"2011","unstructured":"Date AA, Nagarsenker MS, Patere S, Dhawan V, Gude R, Hassan P, et al. Lecithin-based novel cationic nanocarriers (Leciplex) II: improving therapeutic efficacy of quercetin on oral administration. Mol Pharm. 2011;8(3):716\u201326.","journal-title":"Mol Pharm"},{"issue":"5","key":"1156_CR11","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s13402-014-0183-7","volume":"37","author":"VV Dhawan","year":"2014","unstructured":"Dhawan VV, Joshi GV, Jain AS, Nikam YP, Gude RP, Mulherkar R, et al. Apoptosis induction and anti-cancer activity of LeciPlex formulations. Cell Oncol. 2014;37(5):339\u201351.","journal-title":"Cell Oncol"},{"issue":"2","key":"1156_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ajps.2014.09.004","volume":"10","author":"J Li","year":"2015","unstructured":"Li J, Wang X, Zhang T, Wang C, Huang Z, Luo X, et al. A review on phospholipids and their main applications in drug delivery systems. Asian J Pharm Sci. 2015;10(2):81\u201398.","journal-title":"Asian J Pharm Sci"},{"issue":"6","key":"1156_CR13","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1128\/AAC.44.6.1463-1469.2000","volume":"44","author":"L Zarif","year":"2000","unstructured":"Zarif L, Graybill JR, Perlin D, Najvar L, Bocanegra R, Mannino RJ. Antifungal activity of amphotericin B cochleates against Candida albicans infection in a mouse model. Antimicrob Agents Chemother. 2000;44(6):1463\u20139.","journal-title":"Antimicrob Agents Chemother"},{"key":"1156_CR14","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","volume":"1","author":"MJ Abraham","year":"2015","unstructured":"Abraham MJ, Murtola T, Schulz R, P\u00e1ll S, Smith JC, Hess B, et al. GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers. SoftwareX. 2015;1:19\u201325.","journal-title":"SoftwareX"},{"issue":"11","key":"1156_CR15","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1002\/jcc.20945","volume":"29","author":"S Jo","year":"2008","unstructured":"Jo S, Kim T, Iyer VG, Im W. CHARMM-GUI: a web-based graphical user interface for CHARMM. J Comput Chem. 2008;29(11):1859\u201365.","journal-title":"J Comput Chem"},{"issue":"3","key":"1156_CR16","first-page":"156a","volume":"100","author":"S Jo","year":"2011","unstructured":"Jo S, Im W. CHARMM-GUI: brining advanced computational techniques to web interface. Biophys J. 2011;100(3):156a.","journal-title":"Biophys J"},{"issue":"23","key":"1156_CR17","doi-asserted-by":"publisher","first-page":"7830","DOI":"10.1021\/jp101759q","volume":"114","author":"JB Klauda","year":"2010","unstructured":"Klauda JB, Venable RM, Freites JA, O\u2019Connor JW, Tobias DJ, Mondragon-Ramirez C, et al. Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types. J Phys Chem B. 2010;114(23):7830\u201343.","journal-title":"J Phys Chem B"},{"issue":"2","key":"1156_CR18","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"WL Jorgensen","year":"1983","unstructured":"Jorgensen WL, Chandrasekhar J, Madura JD, Impey RW, Klein ML. Comparison of simple potential functions for simulating liquid water. J Chem Phys. 1983;79(2):926\u201335.","journal-title":"J Chem Phys"},{"issue":"1","key":"1156_CR19","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"W Humphrey","year":"1996","unstructured":"Humphrey W, Dalke A, Schulten K. VMD: visual molecular dynamics. J Mol Graph. 1996;14(1):33\u20138.","journal-title":"J Mol Graph"},{"issue":"19","key":"1156_CR20","doi-asserted-by":"publisher","first-page":"8577","DOI":"10.1063\/1.470117","volume":"103","author":"U Essmann","year":"1995","unstructured":"Essmann U, Perera L, Berkowitz ML, Darden T, Lee H, Pedersen LG. A smooth particle mesh Ewald method. J Chem Phys. 1995;103(19):8577\u201393.","journal-title":"J Chem Phys"},{"issue":"12","key":"1156_CR21","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","volume":"18","author":"B Hess","year":"1997","unstructured":"Hess B, Bekker H, Berendsen HJ, Fraaije JG. LINCS: a linear constraint solver for molecular simulations. J Comput Chem. 1997;18(12):1463\u201372.","journal-title":"J Comput Chem"},{"issue":"1","key":"1156_CR22","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1063\/1.447334","volume":"81","author":"S Nos\u00e9","year":"1984","unstructured":"Nos\u00e9 S. A unified formulation of the constant temperature molecular dynamics methods. J Chem Phys. 1984;81(1):511\u20139.","journal-title":"J Chem Phys"},{"issue":"3","key":"1156_CR23","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1103\/PhysRevA.31.1695","volume":"31","author":"WG Hoover","year":"1985","unstructured":"Hoover WG. Canonical dynamics: equilibrium phase-space distributions. Phys Rev A. 1985;31(3):1695\u20137.","journal-title":"Phys Rev A"},{"issue":"12","key":"1156_CR24","doi-asserted-by":"publisher","first-page":"7182","DOI":"10.1063\/1.328693","volume":"52","author":"M Parrinello","year":"1981","unstructured":"Parrinello M, Rahman A. Polymorphic transitions in single crystals: a new molecular dynamics method. J Appl Phys. 1981;52(12):7182\u201390.","journal-title":"J Appl Phys"},{"key":"1156_CR25","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.biomaterials.2015.03.054","volume":"56","author":"C Pereira","year":"2015","unstructured":"Pereira C, Ara\u00fajo F, Barrias CC, Granja PL, Sarmento B. Dissecting stromal-epithelial interactions in a 3D in vitro cellularized intestinal model for permeability studies. Biomaterials. 2015;56:36\u201345.","journal-title":"Biomaterials"},{"issue":"1","key":"1156_CR26","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ijpharm.2013.10.003","volume":"458","author":"F Ara\u00fajo","year":"2013","unstructured":"Ara\u00fajo F, Sarmento B. Towards the characterization of an in vitro triple co-culture intestine cell model for permeability studies. Int J Pharm. 2013;458(1):128\u201334.","journal-title":"Int J Pharm"},{"key":"1156_CR27","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.ejpb.2012.10.003","volume":"83","author":"F Antunes","year":"2013","unstructured":"Antunes F, Andrade F, Ara\u00fajo F, Ferreira D, Sarmento B. Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs. Eur J Pharm Biopharm. 2013;83:427\u201335.","journal-title":"Eur J Pharm Biopharm"},{"issue":"44","key":"1156_CR28","doi-asserted-by":"publisher","first-page":"13143","DOI":"10.1021\/la502775b","volume":"30","author":"K Nagarsekar","year":"2014","unstructured":"Nagarsekar K, Ashtikar M, Thamm J, Steiniger F, Schacher F, Fahr A, et al. Electron microscopy and theoretical modeling of cochleates. Langmuir. 2014;30(44):13143\u201351.","journal-title":"Langmuir"},{"issue":"1","key":"1156_CR29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ijpharm.2011.03.002","volume":"417","author":"AT Larsen","year":"2011","unstructured":"Larsen AT, Sassene P, M\u00fcllertz A. In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems. Int J Pharm. 2011;417(1):245\u201355.","journal-title":"Int J Pharm"},{"issue":"1","key":"1156_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2008.03.021","volume":"129","author":"A Dahan","year":"2008","unstructured":"Dahan A, Hoffman A. Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs. J Control Release. 2008;129(1):1\u201310.","journal-title":"J Control Release"},{"issue":"4","key":"1156_CR31","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1208\/s12248-012-9398-6","volume":"14","author":"N Thomas","year":"2012","unstructured":"Thomas N, Holm R, Rades T, M\u00fcllertz A. Characterising lipid lipolysis and its implication in lipid-based formulation development. AAPS J. 2012;14(4):860\u201371.","journal-title":"AAPS J"},{"issue":"15","key":"1156_CR32","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1016\/j.addr.2006.09.017","volume":"58","author":"W Abdelwahed","year":"2006","unstructured":"Abdelwahed W, Degobert G, Stainmesse S, Fessi H. Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev. 2006;58(15):1688\u2013713.","journal-title":"Adv Drug Deliv Rev"},{"issue":"114","key":"1156_CR33","doi-asserted-by":"publisher","first-page":"113538","DOI":"10.1039\/C6RA16432C","volume":"6","author":"V Dhawan","year":"2016","unstructured":"Dhawan V, Magarkar A, Joshi G, Makhija D, Jain A, Shah J, et al. Stearylated cycloarginine nanosystems for intracellular delivery-simulations, formulation and proof of concept. RSC Adv. 2016;6(114):113538\u201350.","journal-title":"RSC Adv"}],"container-title":["AAPS PharmSciTech"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1208\/s12249-018-1156-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-018-1156-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1208\/s12249-018-1156-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T09:06:41Z","timestamp":1573463201000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1208\/s12249-018-1156-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,12]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["1156"],"URL":"https:\/\/doi.org\/10.1208\/s12249-018-1156-3","relation":{},"ISSN":["1530-9932"],"issn-type":[{"value":"1530-9932","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,12]]},"assertion":[{"value":"4 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}