{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:17:17Z","timestamp":1777421837799,"version":"3.51.4"},"reference-count":59,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSA-INV\/0003\/2015"],"award-info":[{"award-number":["NMRC\/CSA-INV\/0003\/2015"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671775"],"award-info":[{"award-number":["81671775"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Adipocyte-derived hormones play a role in insulin sensitivity and energy homeostasis. However, the relationship between circulating fibroblast growth factor 21 (FGF21), adipocytokines and cold-induced supraclavicular brown adipose tissue (sBAT) activation is underexplored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Our study aimed to investigate the relationships between cold-induced sBAT activity and plasma FGF21 and adipocytokines levels in healthy adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Nineteen healthy participants underwent energy expenditure (EE) and supraclavicular infrared thermography (IRT) within a whole-body calorimeter at baseline and at 2 hours post-cold exposure. 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography\/magnetic resonance (PET\/MR) imaging scans were performed post-cold exposure. PET sBAT mean standardized uptake value (SUV mean), MR supraclavicular fat fraction (sFF), anterior supraclavicular maximum temperature (Tscv max) and EE change (%) after cold exposure were used to quantify sBAT activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Plasma FGF21, leptin, adiponectin, and tumor necrosis factor alpha (TNF\u03b1) at baseline and 2 hours post-cold exposure. Body composition at baseline by dual-energy x-ray absorptiometry (DXA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Plasma FGF21 and adiponectin levels were significantly reduced after cold exposure in BAT-positive subjects but not in BAT-negative subjects. Leptin concentration was significantly reduced in both BAT-positive and BAT-negative participants after cold exposure. Adiponectin concentration at baseline was positively strongly associated with sBAT PET SUV mean (coefficient,\u20053269; P\u2005=\u20050.01) and IRT Tscv max (coefficient,\u20056801; P \u2005=\u20050.03), and inversely correlated with MR sFF (coefficient,\u2005\u2212404; P \u2005=\u20050.02) after cold exposure in BAT-positive subjects but not in BAT-negative subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Higher adiponectin concentrations at baseline indicate a greater cold-induced sBAT activity, which may be a novel predictor for sBAT activity in healthy BAT-positive adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:p>A higher adiponectin concentration at baseline was associated with higher cold-induced supraclavicular BAT PET SUV mean and IRT Tscv max, and lower MR supraclavicular FF. Adiponectin levels maybe a novel predictor for cold-induced sBAT activity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa005","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T12:28:15Z","timestamp":1578486495000},"page":"e520-e531","source":"Crossref","is-referenced-by-count":30,"title":["Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7650-3400","authenticated-orcid":false,"given":"Lijuan","family":"Sun","sequence":"first","affiliation":[{"name":"Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR) and National University Health System (NUHS), Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Yan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"},{"name":"Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China"},{"name":"Molecular Imaging Precision Medicine Collaborative Innovation Centre, Shanxi Medical University, Taiyuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Jen","family":"Goh","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR) and National University Health System (NUHS), Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priya","family":"Govindharajulu","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR) and National University Health System (NUHS), Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Verma","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navin","family":"Michael","sequence":"additional","affiliation":[{"name":"Singapore Institute of Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh Anand","family":"Sadananthan","sequence":"additional","affiliation":[{"name":"Singapore Institute of Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiani Jeyakumar","family":"Henry","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR) and National University Health System (NUHS), Singapore"},{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Sendhil","family":"Velan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Agency for Science Technology and Research (A*STAR), Singapore"},{"name":"Singapore Institute of Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore"},{"name":"Departments of Physiology & Medicine, National University of Singapore (NUS), Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melvin Khee-Shing","family":"Leow","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research 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