{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:06:42Z","timestamp":1784308002406,"version":"3.55.0"},"reference-count":66,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["KL2RR025000"],"award-info":[{"award-number":["KL2RR025000"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Defense Peer Reviewed Medical Research Program","award":["W81XWH-07-2-0071"],"award-info":[{"award-number":["W81XWH-07-2-0071"]}]},{"name":"Department of Defense Peer Reviewed Medical Research Program","award":["P01 AG-11412"],"award-info":[{"award-number":["P01 AG-11412"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 HD057796"],"award-info":[{"award-number":["P50 HD057796"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG-11412"],"award-info":[{"award-number":["P01 AG-11412"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Chicago Institute for Translational Medicine","award":["UL1 RR024999"],"award-info":[{"award-number":["UL1 RR024999"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The endocannabinoid (eCB) system partly controls hedonic eating, a major cause of obesity. While some studies suggested an overactivation of the eCB system in obesity, peripheral levels of eCBs across the 24-hour cycle have not been characterized in obese individuals despite the fact that in lean adults, levels of the eCB 2-arachidonoylglycerol (2-AG) vary across the day.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We sought to examine 24-hour profiles of serum concentrations of 2-AG in healthy obese and nonobese adults, under well-controlled laboratory conditions. We also simultaneously assessed 24-hour profiles of 2-oleoylglycerol (2-OG), leptin, and cortisol in each participant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>With fixed light-dark and sleep-wake cycles, blood sampling was performed over an entire 24-hour period, including identical meals at 0900, 1400, and 1900.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Twelve obese (8 women, mean body mass index [BMI]: 39.1 kg\/m2) and 15 nonobese (6 women; mean BMI: 23.6 kg\/m2) healthy adults were studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We observed a 24-hour variation of 2-AG levels in obese individuals but, relative to nonobese adults, the amplitude was dampened and the timings of the nadir and peak were delayed by 4 to 5 hours. The profile of 2-OG was similarly misaligned. In contrast, when expressed relative to the 24-hour mean level, the 24-hour rhythm of cortisol and leptin were similar in obese and nonobese participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Obesity appears to be associated with a dampening and delay of the 24-hour variation of eCB activity relative to the central circadian signal as well as to the daily leptin rhythm. This misalignment may play a role in the pathophysiology of obesity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa028","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T08:52:19Z","timestamp":1579769539000},"page":"792-802","source":"Crossref","is-referenced-by-count":15,"title":["Circadian Misalignment of the 24-hour Profile of Endocannabinoid 2-Arachidonoylglycerol (2-AG) in Obese Adults"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-9724","authenticated-orcid":false,"given":"Erin C","family":"Hanlon","sequence":"first","affiliation":[{"name":"Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Leproult","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara L","family":"Stuhr","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M","family":"Doncheck","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia J","family":"Hillard","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Van Cauter","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Chicago, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,1,23]]},"reference":[{"key":"2021122018292309200_CIT0001","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3389\/fnins.2018.00271","article-title":"Hedonic eating and the \u201cDelicious Circle\u201d: from lipid-derived mediators to brain dopamine and back","volume":"12","author":"Coccurello","year":"2018","journal-title":"Front Neurosci."},{"key":"2021122018292309200_CIT0002","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1042\/bj2790129","article-title":"Molecular cloning of a human cannabinoid receptor which is also expressed in testis","volume":"279","author":"G\u00e9rard","year":"1991","journal-title":"Biochem J."},{"issue":"5090","key":"2021122018292309200_CIT0003","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science."},{"issue":"6441","key":"2021122018292309200_CIT0004","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/365061a0","article-title":"Molecular characterization of a peripheral receptor for cannabinoids","volume":"365","author":"Munro","year":"1993","journal-title":"Nature."},{"issue":"1","key":"2021122018292309200_CIT0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","article-title":"Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors","volume":"50","author":"Mechoulam","year":"1995","journal-title":"Biochem Pharmacol."},{"issue":"1","key":"2021122018292309200_CIT0006","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/bbrc.1995.2437","article-title":"2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain","volume":"215","author":"Sugiura","year":"1995","journal-title":"Biochem Biophys Res Commun."},{"issue":"1","key":"2021122018292309200_CIT0007","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/npp.2017.130","article-title":"Circulating endocannabinoids: from whence do they come and where are they going?","volume":"43","author":"Hillard","year":"2018","journal-title":"Neuropsychopharmacology."},{"issue":"11","key":"2021122018292309200_CIT0008","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1096\/fj.04-3177fje","article-title":"The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance","volume":"19","author":"Jbilo","year":"2005","journal-title":"Faseb J."},{"issue":"1","key":"2021122018292309200_CIT0009","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1463-1326.2004.00374.x","article-title":"The anti-obesity effect of rimonabant is associated with an improved serum lipid profile","volume":"7","author":"Poirier","year":"2005","journal-title":"Diabetes Obes Metab."},{"issue":"2","key":"2021122018292309200_CIT0010","doi-asserted-by":"crossref","first-page":"R345","DOI":"10.1152\/ajpregu.00545.2002","article-title":"Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice","volume":"284","author":"Ravinet Trillou","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"issue":"3","key":"2021122018292309200_CIT0011","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1124\/jpet.106.118737","article-title":"Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents","volume":"321","author":"Fong","year":"2007","journal-title":"J Pharmacol Exp Ther."},{"key":"2021122018292309200_CIT0012","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/B978-0-12-407766-9.00014-6","article-title":"Endocannabinoids and obesity","volume":"91","author":"Chen","year":"2013","journal-title":"Vitam Horm."},{"key":"2021122018292309200_CIT0013","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mam.2018.01.002","article-title":"The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite","volume":"64","author":"Witkamp","year":"2018","journal-title":"Mol Aspects Med."},{"issue":"8","key":"2021122018292309200_CIT0014","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2005-2679","article-title":"Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia","volume":"91","author":"Matias","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"2021122018292309200_CIT0015","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1007\/s00394-016-1153-9","article-title":"Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity","volume":"55","author":"Monteleone","year":"2016","journal-title":"Eur J Nutr."},{"issue":"6","key":"2021122018292309200_CIT0016","doi-asserted-by":"crossref","first-page":"E917","DOI":"10.1210\/jc.2011-3018","article-title":"Hedonic eating is associated with increased peripheral levels of ghrelin and the endocannabinoid 2-arachidonoyl-glycerol in healthy humans: a pilot study","volume":"97","author":"Monteleone","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2021122018292309200_CIT0017","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/ijo.2011.165","article-title":"Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity","volume":"36","author":"Gatta-Cherifi","year":"2012","journal-title":"Int J Obes."},{"issue":"9","key":"2021122018292309200_CIT0018","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3945\/jn.114.207704","article-title":"Food liking enhances the plasma response of 2-Arachidonoylglycerol and of pancreatic polypeptide upon modified sham feeding in humans","volume":"145","author":"Mennella","year":"2015","journal-title":"J Nutr."},{"issue":"2","key":"2021122018292309200_CIT0019","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0031-9384(98)00170-X","article-title":"Hyperphagia in pre-fed rats following oral delta9-THC","volume":"65","author":"Williams","year":"1998","journal-title":"Physiol Behav."},{"issue":"8","key":"2021122018292309200_CIT0020","doi-asserted-by":"crossref","first-page":"PL113","DOI":"10.1016\/S0024-3205(98)00322-1","article-title":"Appetite suppression and weight loss after the cannabinoid antagonist SR 141716","volume":"63","author":"Colombo","year":"1998","journal-title":"Life Sci."},{"key":"2021122018292309200_CIT0021","doi-asserted-by":"crossref","first-page":"432607","DOI":"10.1155\/2011\/432607","article-title":"Rimonabant: from RIO to Ban","volume":"2011","author":"Sam","year":"2011","journal-title":"J Obes."},{"issue":"20","key":"2021122018292309200_CIT0022","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa044537","article-title":"Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia","volume":"353","author":"Despr\u00e9s","year":"2005","journal-title":"N Engl J Med."},{"issue":"9548","key":"2021122018292309200_CIT0023","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/S0140-6736(06)69571-8","article-title":"Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study","volume":"368","author":"Scheen","year":"2006","journal-title":"Lancet."},{"issue":"14","key":"2021122018292309200_CIT0024","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1093\/eurheartj\/ehn076","article-title":"Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study","volume":"29","author":"Van Gaal","year":"2008","journal-title":"Eur Heart J."},{"issue":"9468","key":"2021122018292309200_CIT0025","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(05)66374-X","article-title":"Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study","volume":"365","author":"Van Gaal","year":"2005","journal-title":"Lancet."},{"issue":"10","key":"2021122018292309200_CIT0026","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11892-017-0924-x","article-title":"Re-visiting the endocannabinoid system and its therapeutic potential in obesity and associated diseases","volume":"17","author":"Richey","year":"2017","journal-title":"Curr Diab Rep."},{"issue":"4","key":"2021122018292309200_CIT0027","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/13543776.2019.1597851","article-title":"A patent update on cannabinoid receptor 1 antagonists (2015-2018)","volume":"29","author":"Amato","year":"2019","journal-title":"Expert Opin Ther Pat."},{"key":"2021122018292309200_CIT0028","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroscience.2011.11.020","article-title":"Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence","volume":"204","author":"Hillard","year":"2012","journal-title":"Neuroscience."},{"issue":"10","key":"2021122018292309200_CIT0029","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.2337\/diabetes.54.10.2838","article-title":"Activation of the peripheral endocannabinoid system in human obesity","volume":"54","author":"Engeli","year":"2005","journal-title":"Diabetes."},{"issue":"11","key":"2021122018292309200_CIT0030","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.2337\/db06-0812","article-title":"Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity","volume":"55","author":"Bl\u00fcher","year":"2006","journal-title":"Diabetes."},{"issue":"4","key":"2021122018292309200_CIT0031","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/sj.ijo.0803539","article-title":"Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men","volume":"31","author":"C\u00f4t\u00e9","year":"2007","journal-title":"Int J Obes."},{"issue":"4","key":"2021122018292309200_CIT0032","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s13679-012-0027-6","article-title":"Obesity and the endocannabinoid system: circulating endocannabinoids and obesity","volume":"1","author":"Matias","year":"2012","journal-title":"Current Obesity Reports"},{"issue":"1","key":"2021122018292309200_CIT0033","doi-asserted-by":"crossref","first-page":"e8792","DOI":"10.1371\/journal.pone.0008792","article-title":"Biomarkers of endocannabinoid system activation in severe obesity","volume":"5","author":"Sipe","year":"2010","journal-title":"Plos One."},{"issue":"2","key":"2021122018292309200_CIT0034","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00125-008-1178-6","article-title":"Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors","volume":"52","author":"Di Marzo","year":"2009","journal-title":"Diabetologia."},{"issue":"5","key":"2021122018292309200_CIT0035","doi-asserted-by":"crossref","first-page":"E70","DOI":"10.1002\/oby.20728","article-title":"Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects","volume":"22","author":"Engeli","year":"2014","journal-title":"Obesity."},{"issue":"1","key":"2021122018292309200_CIT0036","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41598-017-01562-1","article-title":"Participants with normal weight or with obesity show different relationships of 6-n-Propylthiouracil (PROP) taster status with BMI and plasma endocannabinoids","volume":"7","author":"Carta","year":"2017","journal-title":"Sci Rep."},{"key":"2021122018292309200_CIT0037","doi-asserted-by":"crossref","first-page":"29678","DOI":"10.3402\/fnr.v59.29678","article-title":"Anticipatory and consummatory effects of (hedonic) chocolate intake are associated with increased circulating levels of the orexigenic peptide ghrelin and endocannabinoids in obese adults","volume":"59","author":"Rigamonti","year":"2015","journal-title":"Food Nutr Res."},{"issue":"1","key":"2021122018292309200_CIT0038","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1210\/jc.2014-3455","article-title":"Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol","volume":"100","author":"Hanlon","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"key":"2021122018292309200_CIT0039","doi-asserted-by":"crossref","first-page":"15609","DOI":"10.1073\/pnas.1101338108","article-title":"Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism","volume":"108","author":"Hanlon","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2021122018292309200_CIT0040","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1196\/annals.1417.033","article-title":"Associations between sleep loss and increased risk of obesity and diabetes","volume":"1129","author":"Knutson","year":"2008","journal-title":"Ann N Y Acad Sci."},{"issue":"5","key":"2021122018292309200_CIT0041","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.beem.2010.07.001","article-title":"Sleep duration and cardiometabolic risk: a review of the epidemiologic evidence","volume":"24","author":"Knutson","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"issue":"6","key":"2021122018292309200_CIT0042","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.2337\/db13-1546","article-title":"Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss","volume":"63","author":"Leproult","year":"2014","journal-title":"Diabetes."},{"issue":"8","key":"2021122018292309200_CIT0043","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/oby.2008.298","article-title":"A longitudinal study on the effect of shift work on weight gain in male Japanese workers","volume":"16","author":"Suwazono","year":"2008","journal-title":"Obesity."},{"issue":"12","key":"2021122018292309200_CIT0044","doi-asserted-by":"crossref","first-page":"e1001138","DOI":"10.1371\/journal.pmed.1001138","article-title":"Shift work as a risk factor for future type 2 diabetes: evidence, mechanisms, implications, and future research directions","volume":"8","author":"Kivim\u00e4ki","year":"2011","journal-title":"Plos Med."},{"issue":"2","key":"2021122018292309200_CIT0045","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5271\/sjweh.2898","article-title":"Eating and shift work - effects on habits, metabolism and performance","volume":"36","author":"Lowden","year":"2010","journal-title":"Scand J Work Environ Health."},{"issue":"11","key":"2021122018292309200_CIT0046","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.nutres.2014.09.010","article-title":"Meal timing influences daily caloric intake in healthy adults","volume":"34","author":"Reid","year":"2014","journal-title":"Nutr Res."},{"issue":"7","key":"2021122018292309200_CIT0047","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/oby.2011.100","article-title":"Role of sleep timing in caloric intake and BMI","volume":"19","author":"Baron","year":"2011","journal-title":"Obesity (Silver Spring)."},{"issue":"6","key":"2021122018292309200_CIT0048","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1467-789X.2011.00975.x","article-title":"The night-eating syndrome and obesity","volume":"13","author":"Gallant","year":"2012","journal-title":"Obes Rev."},{"issue":"11","key":"2021122018292309200_CIT0049","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1038\/sj.ijo.0803664","article-title":"Night eating syndrome and nocturnal snacking: association with obesity, binge eating and psychological distress","volume":"31","author":"Colles","year":"2007","journal-title":"Int J Obes (Lond)."},{"issue":"9-10","key":"2021122018292309200_CIT0050","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.addr.2010.05.005","article-title":"Chronobiological aspects of nutrition, metabolic syndrome and obesity","volume":"62","author":"Garaulet","year":"2010","journal-title":"Adv Drug Deliv Rev."},{"issue":"6","key":"2021122018292309200_CIT0051","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.cmet.2018.04.010","article-title":"Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes","volume":"27","author":"Sutton","year":"2018","journal-title":"Cell Metab."},{"key":"2021122018292309200_CIT0052","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnins.2013.00020","article-title":"CNS control of glucose metabolism: response to environmental challenges","volume":"7","author":"Arble","year":"2013","journal-title":"Front Neurosci."},{"issue":"11","key":"2021122018292309200_CIT0053","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/oby.2009.264","article-title":"Circadian timing of food intake contributes to weight gain","volume":"17","author":"Arble","year":"2009","journal-title":"Obesity."},{"issue":"1","key":"2021122018292309200_CIT0054","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/er.2015-1080","article-title":"The functional and clinical significance of the 24-hour rhythm of circulating glucocorticoids","volume":"38","author":"Oster","year":"2017","journal-title":"Endocr Rev."},{"issue":"3","key":"2021122018292309200_CIT0055","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cmet.2015.06.005","article-title":"Circadian dysfunction induces leptin resistance in mice","volume":"22","author":"Kettner","year":"2015","journal-title":"Cell Metab."},{"issue":"6","key":"2021122018292309200_CIT0056","first-page":"1797","article-title":"Abnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity","volume":"79","author":"Van Cauter","year":"1994","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021122018292309200_CIT0057","doi-asserted-by":"crossref","first-page":"653","DOI":"10.5665\/sleep.5546","article-title":"Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol","volume":"39","author":"Hanlon","year":"2016","journal-title":"Sleep."},{"key":"2021122018292309200_CIT0058","first-page":"5","article-title":"Predicting basal metabolic rate, new standards and review of previous work","volume":"39","author":"Schofield","year":"1985","journal-title":"Hum Nutr Clin Nutr."},{"key":"2021122018292309200_CIT0059","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications","author":"Iber"},{"issue":"2","key":"2021122018292309200_CIT0060","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1055\/s-2007-993211","article-title":"Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report","volume":"41","author":"Hill","year":"2008","journal-title":"Pharmacopsychiatry."},{"issue":"2","key":"2021122018292309200_CIT0061","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1194\/jlr.M400377-JLR200","article-title":"The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity","volume":"46","author":"Patel","year":"2005","journal-title":"J Lipid Res."},{"issue":"368","key":"2021122018292309200_CIT0062","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1080\/01621459.1979.10481038","article-title":"Robust locally weighted regression and smoothing scatterplots","volume":"74","author":"Cleveland","year":"1979","journal-title":"J Am Stat Assoc"},{"issue":"4","key":"2021122018292309200_CIT0063","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/03610919508813281","article-title":"An expanded table of probability values for rao\u2019s spacing test","volume":"24","author":"Russell","year":"1995","journal-title":"Commun Stat Simul Comput"},{"key":"2021122018292309200_CIT0064","doi-asserted-by":"crossref","first-page":"104471","DOI":"10.1016\/j.psyneuen.2019.104471","article-title":"Impact of circadian rhythmicity and sleep restriction on circulating endocannabinoid (eCB) N-arachidonoylethanolamine (anandamide)","volume":"111","author":"Hanlon","year":"2020","journal-title":"Psychoneuroendocrinology."},{"issue":"7","key":"2021122018292309200_CIT0065","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1172\/JCI119717","article-title":"Entrainment of the diurnal rhythm of plasma leptin to meal timing","volume":"100","author":"Schoeller","year":"1997","journal-title":"J Clin Invest."},{"issue":"6","key":"2021122018292309200_CIT0066","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1210\/jcem.83.6.4864","article-title":"Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature","volume":"83","author":"Simon","year":"1998","journal-title":"J Clin Endocrinol Metab."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaa028\/31943768\/dgaa028.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/3\/792\/41824046\/jcem_105_3_792.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/3\/792\/41824046\/jcem_105_3_792.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T18:55:17Z","timestamp":1640026517000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/105\/3\/792\/5714353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,23]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,1,23]]},"published-print":{"date-parts":[[2020,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaa028","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3]]},"published":{"date-parts":[[2020,1,23]]}}}