{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:58:53Z","timestamp":1778907533281,"version":"3.51.4"},"reference-count":60,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Lundquist Institute","award":["HHSN27520130024I"],"award-info":[{"award-number":["HHSN27520130024I"]}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","award":["HHSN275201300025I"],"award-info":[{"award-number":["HHSN275201300025I"]}],"id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Decisions","award":["HHSN2752012002"],"award-info":[{"award-number":["HHSN2752012002"]}]},{"name":"Robert McMillen Professorship in Lipid Research"},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K24HL138632"],"award-info":[{"award-number":["K24HL138632"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>11\u03b2-methyl-19-nortestosterone (11\u03b2-MNT) is a modified testosterone (T) with androgenic and progestational activity. A single oral dose of the prodrug, 11\u03b2-MNT dodecylcarbonate (11\u03b2-MNTDC), was well tolerated in healthy men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a randomized, double-blind study at 2 academic medical centers. 42 healthy men (18\u201350 years) were randomized to receive oral placebo or 11\u03b2-MNTDC, 200 or 400 mg daily, for 28 consecutive days. Primary outcome (safety and tolerability) measures were assessed twice per week. Subjects underwent serial blood sampling over 24 hours on days 1 and 28 to assess secondary outcomes: pharmacokinetics (serum drug concentrations); pharmacodynamics of 11\u03b2-MNTDC (serum sex steroids and gonadotropins); and mood and sexual function (via validated questionnaires).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no serious adverse events. No participants discontinued because of an adverse event or laboratory test abnormality. 11\u03b2-MNTDC resulted in a dose-related increase in serum 11\u03b2-MNTDC and 11\u03b2-MNT concentrations sustained over 24 hours. Administration of 11\u03b2-MNTDC resulted in a marked suppression of serum gonadotropins, T, calculated free T, estradiol, and SHBG over the treatment period (P\u2005&amp;lt;\u20050.01). Adverse effects that may be related to 11\u03b2-MNTDC included weight gain, acne, headaches, fatigue, and mild mood changes, with 5 men reporting decreased libido and 3 decreased erectile\/ejaculatory function. Serum low-density lipoprotein cholesterol, weight (~2 kg), hematocrit, and hemoglobin increased and serum high-density lipoprotein cholesterol decreased in both 11\u03b2-MNTDC groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Daily oral 11\u03b2-MNTDC for 28 days in healthy men markedly suppressed serum gonadotropin and T concentrations without serious adverse effects. These results warrant further evaluation of 11\u03b2-MNTDC as a potential male oral contraceptive.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgaa032","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T10:36:53Z","timestamp":1579862213000},"page":"e835-e847","source":"Crossref","is-referenced-by-count":37,"title":["Daily Oral Administration of the Novel Androgen 11\u03b2-MNTDC Markedly Suppresses Serum Gonadotropins in Healthy Men"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8200-2311","authenticated-orcid":false,"given":"Fiona","family":"Yuen","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthi","family":"Thirumalai","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington, 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The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana L","family":"Blithe","sequence":"additional","affiliation":[{"name":"Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Long","sequence":"additional","affiliation":[{"name":"Contraceptive Development Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, 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