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Insulin sensitivity was derived from oral glucose tolerance testing (ISOGTT). Androgen secretion was assessed from blood drawn fasting and 24, 48, and 72 h after human chorionic gonadotropin (HCG) administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In response to saturated fat ingestion, women with PCOS regardless of weight class exhibited lipid-induced increases in activated NF\u03baB, NF\u03baB, and TNF\u03b1 gene expression and plasma CRP and decreases in I\u03baB\u03b1 protein compared with lean control subjects. Both PCOS groups exhibited lower ISOGTT and greater HCG-stimulated androgen secretion compared with control subjects. Lipid-stimulated NF\u03baB activation was negatively correlated with ISOGTT, and positively correlated with HCG-stimulated androgen secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In PCOS, increases in NF\u03baB activation and circulating CRP and decreases in I\u03baB\u03b1 protein following saturated fat ingestion are independent of obesity. Circulating MNC and excess adipose tissue are separate and distinct contributors to inflammation in this disorder.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgaa108","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T06:55:06Z","timestamp":1583477706000},"page":"e2152-e2167","source":"Crossref","is-referenced-by-count":53,"title":["Inflammation Triggered by Saturated Fat Ingestion Is Linked to Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2647-957X","authenticated-orcid":false,"given":"Frank","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Illinois at Chicago College of Medicine, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V","family":"Considine","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola A","family":"Abdelhadi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Acton","sequence":"additional","affiliation":[{"name":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,3,6]]},"reference":[{"issue":"2","key":"2021122823062634200_CIT0001","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod."},{"issue":"1","key":"2021122823062634200_CIT0002","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil Steril."},{"issue":"2","key":"2021122823062634200_CIT0003","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1467-789X.2012.01053.x","article-title":"Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"14","author":"Lim","year":"2013","journal-title":"Obes Rev."},{"issue":"6","key":"2021122823062634200_CIT0004","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr Rev."},{"issue":"8","key":"2021122823062634200_CIT0005","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0002-9343(01)00948-2","article-title":"Prevalence and predictors of dyslipidemia in women with polycystic ovary syndrome","volume":"111","author":"Legro","year":"2001","journal-title":"Am J Med."},{"issue":"4","key":"2021122823062634200_CIT0006","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1172\/JCI110342","article-title":"Mechanism of the postreceptor defect in insulin action in human obesity. 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