{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:12:57Z","timestamp":1790633577423,"version":"4.1.0"},"reference-count":77,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Charles Wolfson Trust"},{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"publisher","award":["GN2033"],"award-info":[{"award-number":["GN2033"]}],"id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000852","name":"Henry Smith Charity","doi-asserted-by":"publisher","award":["GN 2033"],"award-info":[{"award-number":["GN 2033"]}],"id":[{"id":"10.13039\/501100000852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002608","name":"American Thyroid Association","doi-asserted-by":"publisher","award":["ATA-2014-033.R1"],"award-info":[{"award-number":["ATA-2014-033.R1"]}],"id":[{"id":"10.13039\/100002608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context and Objectives<\/jats:title>\n                  <jats:p>The Controlled Antenatal Thyroid Screening Study I (CATS-I) was a randomized controlled trial investigating the effects of levothyroxine therapy for suboptimal gestational thyroid function (SGTF), comparing outcomes in children of treated (SGTF-T) with untreated (SGTF-U) women during pregnancy. This follow-up study, CATS-II, reports the long-term effects on anthropometric, bone, and cardiometabolic outcomes in mothers and offspring and includes a group with normal gestational thyroid function (NGTF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design &amp; Participants<\/jats:title>\n                  <jats:p>332 mothers (197 NGTF, 56 SGTF-U, 79 SGTF-T) aged 41.2\u00b15.3 years (mean\u00b1SD) and 326 paired children assessed 9.3\u00b11.0 years after birth for (i) body mass index (BMI); (ii) lean, fat, and bone mass by dual-energy X-ray absorptiometry; (iii) blood pressure, augmentation index, and aortic pulse-wave-velocity; and (iv) thyroid function, lipids, insulin, and adiponectin. The difference between group means was compared using linear regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Offspring\u2019s measurements were similar between groups. Although maternal BMI was similar between groups at CATS-I, after 9 years (at CATS-II) SGTF-U mothers showed higher BMI (median [interquartile ratio] 28.3 [24.6-32.6] kg\/m2) compared with NGTF (25.8 [22.9-30.0] kg\/m2; P = 0.029), driven by fat mass increase. At CATS-II SGTF-U mothers also had higher thyroid-stimulating hormone (TSH) values (2.45 [1.43-3.50] mU\/L) than NGTF (1.54 [1.12-2.07] mU\/L; P = 0.015), since 64% had never received levothyroxine. At CATS-II, SGTF-T mothers had BMI (25.8 [23.1-29.8] kg\/m2, P = 0.672) and TSH (1.68 [0.89-2.96] mU\/L; P = 0.474) values similar to NGTF mothers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Levothyroxine supplementation of women with SGTF did not affect long-term offspring anthropometric, bone, and cardiometabolic measurements. However, absence of treatment was associated with sustained long-term increase in BMI and fat mass in women with SGTF.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa129","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T16:40:47Z","timestamp":1590511247000},"page":"2150-2161","source":"Crossref","is-referenced-by-count":16,"title":["CATS II Long-term Anthropometric and Metabolic Effects of Maternal Sub-optimal Thyroid Function in Offspring and Mothers"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2926-0722","authenticated-orcid":false,"given":"Ilaria","family":"Muller","sequence":"first","affiliation":[{"name":"Thyroid Research Group, Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, UK"},{"name":"Department of Endocrinology, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter N","family":"Taylor","sequence":"additional","affiliation":[{"name":"Thyroid Research Group, Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhian M","family":"Daniel","sequence":"additional","affiliation":[{"name":"Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Hales","sequence":"additional","affiliation":[{"name":"Thyroid Research Group, Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Scholz","sequence":"additional","affiliation":[{"name":"Thyroid Research Group, Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Candler","sequence":"additional","affiliation":[{"name":"MRC The Gambia at the London School of Hygiene and Tropical Medicine, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J","family":"Pettit","sequence":"additional","affiliation":[{"name":"Radiology, Medical Physics and Clinical Engineering Directorate, University Hospital of Wales, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Evans","sequence":"additional","affiliation":[{"name":"Radiology, Medical Physics and Clinical Engineering Directorate, University Hospital of Wales, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionne","family":"Shillabeer","sequence":"additional","affiliation":[{"name":"Thyroid Research Group, Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff, 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