{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:15:33Z","timestamp":1790309733786,"version":"4.1.0"},"reference-count":32,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.nationalarchives.gov.uk\/doc\/open-government-licence\/version\/3\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["SNF-162608"],"award-info":[{"award-number":["SNF-162608"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016015","name":"University Hospital Basel","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016015","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100016071","name":"Goldschmidt-Jacobson Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016071","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Arginine stimulates pituitary hormones, like growth hormone and vasopressin, but its effect on the hypothalamic\u2013pituitary\u2013adrenal (HPA) axis is unknown. Arginine may also stimulate the HPA axis, possibly through a mechanism involving vasopressin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the effect of arginine on adrenocorticotropic hormone (ACTH) and cortisol in subjects with and without vasopressin deficiency.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective study, University Hospital Basel.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>38 patients with central diabetes insipidus, 58 patients with primary polydipsia, and 50 healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>Arginine infusion with measurement of ACTH, cortisol and copeptin at baseline and 30, 45, 60, 90, and 120 minutes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found different response patterns to arginine: in patients with diabetes insipidus (and low stimulated copeptin levels) median (interquartile range [IQR]) ACTH and cortisol increased from 22.9 (16.8, 38.7) to 36.6 (26.2, 52.1) ng\/L and from 385 (266, 463) to 467 (349, 533) nmol\/L, respectively. In contrast, median (IQR) ACTH and cortisol levels decreased in patients with primary polydipsia (despite high stimulated copeptin levels): ACTH from 17.3 (12.3, 23) to 14.8 (10.9, 19.8) ng\/L and cortisol from 343 (262, 429) to 272 (220.8, 360.3) nmol\/L; likewise, in healthy controls: ACTH from 26.5 (17.6, 35.7) to 14.8 (12.1, 22.7) ng\/L and cortisol from 471 (393.3, 581.8) to 301.5 (206.5, 377.8) nmol\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Diabetes insipidus is associated with increased responsiveness of ACTH\/cortisol to arginine. In contrast, arginine does not stimulate the HPA axis in healthy controls or in primary polydipsia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa157","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T05:25:59Z","timestamp":1585718759000},"page":"e2327-e2336","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Arginine on the Hypothalamic\u2013Pituitary\u2013Adrenal Axis in Individuals With and Without Vasopressin Deficiency"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-5373","authenticated-orcid":false,"given":"Katja","family":"Bologna","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel, Basel, 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