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Hood Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001680","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The management of youth with delayed puberty is hampered by difficulty in predicting who will eventually progress through puberty and who will fail to attain adult reproductive endocrine function. The neuropeptide kisspeptin, which stimulates gonadotropin-releasing hormone (GnRH) release, can be used to probe the integrity of the reproductive endocrine axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to determine whether responses to kisspeptin can predict outcomes for individuals with pubertal delay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>We conducted a longitudinal cohort study in an academic medical center of 16 children (3 girls and 13 boys) with delayed or stalled puberty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention and Outcome Measures<\/jats:title>\n                    <jats:p>Children who had undergone kisspeptin- and GnRH-stimulation tests were followed every 6 months for clinical evidence of progression through puberty. Inhibin B was measured in boys. A subset of participants underwent exome sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All participants who had responded to kisspeptin with a rise in luteinizing hormone (LH) of 0.8 mIU\/mL or greater subsequently progressed through puberty (n\u2005=\u20058). In contrast, all participants who had exhibited LH responses to kisspeptin\u2005\u2264\u20050.4 mIU\/mL reached age 18 years without developing physical signs of puberty (n\u2005=\u20058). Thus, responses to kisspeptin accurately predicted later pubertal outcomes (P\u2005=\u2005.0002). Moreover, the kisspeptin-stimulation test outperformed GnRH-stimulated LH, inhibin B, and genetic testing in predicting pubertal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The kisspeptin-stimulation can assess future reproductive endocrine potential in prepubertal children and is a promising novel tool for predicting pubertal outcomes for children with delayed puberty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa162","type":"journal-article","created":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T08:15:15Z","timestamp":1585642515000},"page":"e2717-e2725","source":"Crossref","is-referenced-by-count":49,"title":["Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-8502","authenticated-orcid":false,"given":"Yee-Ming","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret F","family":"Lippincott","sequence":"additional","affiliation":[{"name":"Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Sales Barroso","sequence":"additional","affiliation":[{"name":"Unidade de Endocrinologia do Desenvolvimento, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM42, Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cielo","family":"Alleyn","sequence":"additional","affiliation":[{"name":"Ochsner Health Center for Children, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Brodsky","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Caremount Medical, Poughkeepsie, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Granados","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Texas Tech University Health Sciences Center, El Paso, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A","family":"Roberts","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Sandler","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinash","family":"Srivatsa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Pediatrics, Boston Children\u2019s Hospital, Boston, Massachusetts"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie B","family":"Seminara","sequence":"additional","affiliation":[{"name":"Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,3,31]]},"reference":[{"issue":"5","key":"2021122109312624100_CIT0001","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMcp1109290","article-title":"Clinical practice. 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