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Determining the genetic basis that distinguishes HT from GD is key for a better understanding of the differences between these closely related diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objects<\/jats:title>\n                  <jats:p>To identify the susceptibility genes for HT in the Chinese cohort and compare susceptibility genes between GD and HT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>In the current study, 18 SNPs from 18 established GD risk loci were selected and then genotyped in 2682 patients with HT, 4980 patients with GD, and 3892 controls. The association analysis between HT and controls and heterogeneity analysis between HT and GD were performed on SPSS, with the logistic regression analysis adjusted for sex and age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 11 susceptibility loci for HT in the Chinese Han population, with 4 loci, including the rs1265883 in SLAMF6 locus, rs1024161 in CTLA4, rs1521 in HLA-B, and rs5912838 in GPR174\/ ITM2A at X chromosome, reaching genome-wide significance of 5 \u00d7 10\u20138. Five loci were reported to be associated with HT for the first time. We also identified 6 susceptibility loci with heterogeneity between GD and HT. Out of them, 4 loci were associated with GD but not with HT, including HLA-DPB1, CD40, TSHR, and TG; the association of HLA-B with GD was stronger than that with HT, but the association of SLAMF6 was reversed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our findings suggested that the pathogenesis of HT and GD was different.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa170","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T02:45:19Z","timestamp":1585968319000},"page":"e2600-e2608","source":"Crossref","is-referenced-by-count":22,"title":["Genetic Study in a Large Cohort Supported Different Pathogenesis of Graves\u2019 Disease and Hashimoto\u2019s Hypothyroidism"],"prefix":"10.1210","volume":"105","author":[{"given":"Qian-Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostic and Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostic and Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Endocrinology, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostic and Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hua","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Linyi People\u2019s Hospital, Linyi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Lin","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ping","family":"Ye","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostic and Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Jun","family":"Xie","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostic and Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Run","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostic and Endocrinology, Shanghai Ninth People\u2019s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Xia","family":"Ying","sequence":"additional","affiliation":[{"name":"The Core Laboratory in Medical Center of Clinical 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