{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:12:13Z","timestamp":1790874733587,"version":"4.1.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"French Agence Nationale pour la Recherche","award":["ANR-10-LABX-46 and ANR-16-RHUS-0006"],"award-info":[{"award-number":["ANR-10-LABX-46 and ANR-16-RHUS-0006"]}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["LSHM-CT-2005\u2013018734"],"award-info":[{"award-number":["LSHM-CT-2005\u2013018734"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7-305707"],"award-info":[{"award-number":["FP7-305707"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERC Advanced","award":["694717"],"award-info":[{"award-number":["694717"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Plasma branched chain amino acid (BCAA) concentrations correlate positively with body mass index (BMI), measures of insulin resistance (IR), and severity of nonalcoholic fatty liver disease (NAFLD). Moreover, plasma BCAA concentrations also differ between the sexes, which display different susceptibilities to cardio-metabolic diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Assess whether plasma BCAA concentrations associate with NAFLD severity independently of BMI, IR, and sex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Patients visiting the obesity clinic of the Antwerp University Hospital were consecutively recruited from 2006 to 2014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting<\/jats:title>\n                  <jats:p>A cross-sectional study cohort of 112 obese patients (59 women and 53 men) was divided into 4 groups according to NAFLD severity. Groups were matched for sex, age, BMI, homeostatic model assessment of IR, and hemoglobin A1c.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Fasting plasma BCAA concentrations were measured by tandem mass spectrometry using the aTRAQ\u2122 method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the study cohort, a modest positive correlation was observed between plasma BCAA concentrations and NAFLD severity, as well as a strong effect of sex on plasma BCAA levels. Subgroup analysis by sex revealed that while plasma BCAA concentrations increased with severity of NAFLD in women, they tended to decrease in men. Additionally, only women displayed significantly increased plasma BCAAs with increasing fibrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Plasma BCAA concentrations display sex-dimorphic changes with increasing severity of NAFLD, independently of BMI, IR, and age. Additionally, plasma BCAA are associated with significant fibrosis in women, but not in men. These results highlight the importance of a careful consideration of sex as a major confounding factor in cross-sectional studies of NAFLD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa175","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T14:35:21Z","timestamp":1586442921000},"page":"2311-2321","source":"Crossref","is-referenced-by-count":63,"title":["Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-0109","authenticated-orcid":false,"given":"Guillaume","family":"Grzych","sequence":"first","affiliation":[{"name":"University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France"},{"name":"CHU Lille, Service d\u2019Hormonologie, M\u00e9tabolisme, Nutrition, Oncologie, Lille, 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Curt","sequence":"additional","affiliation":[{"name":"CHU Lille, Service d\u2019Hormonologie, M\u00e9tabolisme, Nutrition, Oncologie, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Gaal","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Medicine and Pediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk\/Antwerp, Belgium"},{"name":"Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Edegem\/Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9jane","family":"Paumelle","sequence":"additional","affiliation":[{"name":"University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Francque","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Antwerp University 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