{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:06:54Z","timestamp":1781626014715,"version":"3.54.5"},"reference-count":45,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T00:00:00Z","timestamp":1587168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A030313837"],"award-info":[{"award-number":["2018A030313837"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Lysine-specific demethylase 1 (LSD1) stabilizes hypoxia-inducible factor 1\u03b1 (HIF1\u03b1) to advance tumor progression, while HIF1\u03b1 functions as a transcription factor to increase the expression of microRNA-146a (miR-146a).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aim to investigate whether LSD1 affects the development of papillary thyroid carcinoma (PTC) via HIF1\u03b1 and miR-146a.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>In vitro assays were performed with Nthy-ori 3-1, BHP5-16, BCPAP, K1, and BHP2-7 cell lines. In vivo assays were conducted with established xenograft tumors in nude mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>This study was conducted at our lab.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and Materials<\/jats:title>\n                  <jats:p>PTC tissues and corresponding adjacent normal tissues were obtained from 45 patients hospitalized in Sun Yat-Sen Memorial Hospital. Assays were conducted using Nthy-ori 3-1, BHP5-16, BCPAP, K1, and BHP2-7 cell lines, as well as 50 male BALB\/c nude mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>Cells were transfected with sh-LSD1, sh-GABPA, oe-LSD1, oe-HIF1\u03b1, miR-146a mimic, and miR-146a inhibitor. In addition, K1 cells expressing lv-oe-LSD1, lv-miR-146a inhibitor, lv-oe-LSD1 or miR-146a inhibitor were injected into the right side of the mice. LSD1 gene and protein expression patterns were analyzed in 45 clinical PTC tissue samples.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>Expression of LSD1, HIF1\u03b1, miR-146a, and GA-binding protein transcription factor alpha (GABPA), as well as their effects on PTC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>LSD1 was highly expressed in clinical PTC tissues. LSD1 stabilized HIF1\u03b1 and inhibited the degradation of its ubiquitin proteasome. HIF1\u03b1 was enriched in the promoter region of miR-146a, an upregulated miRNA in PTC. HIF1\u03b1 increased miR-146a expression to promote PTC progression in vitro, which was achieved by inhibiting GABPA, a target gene of miR-146a. LSD1 upregulated miR-146a to enhance the development and metastasis of PTC in nude mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results show that LSD1 functions as an oncogene in PTC by upregulating HIF1\u03b1 and miR-146a, elucidating an understanding of undefined mechanisms associated with tumor progression in PTC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa182","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T05:56:23Z","timestamp":1587189383000},"page":"2237-2251","source":"Crossref","is-referenced-by-count":15,"title":["Lysine-Specific Demethylase 1 Affects the Progression of Papillary Thyroid Carcinoma via HIF1\u03b1 and microRNA-146a"],"prefix":"10.1210","volume":"105","author":[{"given":"Miaoyun","family":"Long","sequence":"first","affiliation":[{"name":"Department of Thyroid Surgery, Sun Yat-Sen 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