{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:02:06Z","timestamp":1783519326045,"version":"3.55.0"},"reference-count":58,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Research Support Foundation of the State of Rio de Janeiro","award":["E-26\/202.700\/2019 - 244480"],"award-info":[{"award-number":["E-26\/202.700\/2019 - 244480"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["312413\/2019-0"],"award-info":[{"award-number":["312413\/2019-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Data regarding high-resolution peripheral quantitative computed tomography (HR-pQCT) in patients with adrenal incidentaloma (AI) are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate the areal bone mineral density (aBMD), microstructure, and fractures in patients with nonfunctioning AI (NFAI) and autonomous cortisol secretion (ACS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 45 patients with NFAI (1 mg dexamethasone suppression test [DST] \u22641.8 \u00b5g\/dL) and 30 patients with ACS (1 mg DST 1.9-5.0 \u00b5g\/dL). aBMD was measured using dual-energy X-ray absorptiometry; vertebral fracture by spine X-ray; and bone geometry, volumetric bone mineral density (vBMD), and microstructure by HR-pQCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with ACS showed lower aBMD values at the spine, femoral neck, and radius 33% than those with NFAI. Osteoporosis was frequent in both groups: NFAI (64.9%) and ACS (75%). Parameters at the distal radius by HR-pQCT were decreased in patients with ACS compared to those with NFAI: trabecular vBMD (Tb.vBMD, P = 0.03), inner zone of the trabecular region (Inn.Tb.vBMD, P = 0.01), the bone volume\/tissue volume ratio (BV\/TV, P = 0.03) and trabecular thickness (P = 0.04). As consequence, a higher ratio of the outer zone of the trabecular region\/inner zone vBMD (Meta\/Inn.vBMD, P = 0.003) was observed. A correlation between the cortisol levels after 1 mg DST and Meta\/Inn.vBMD ratio was found (r = 0.29; P = 0.01). The fracture frequency was 73.7% in patients with ACS vs 55.6% in patients with NFAI (P = 0.24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings point to an association between trabecular bone microarchitectural derangement at the distal radius and ACS. Our data suggest that AI have a negative impact on bone when assessed by HR-pQCT, probably associated to subclinical hypercortisolism.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgaa263","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T18:15:49Z","timestamp":1591726549000},"page":"e2726-e2737","source":"Crossref","is-referenced-by-count":30,"title":["Bone Evaluation by High-Resolution Peripheral Quantitative Computed Tomography in Patients With Adrenal Incidentaloma"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7533-7458","authenticated-orcid":false,"given":"Aline Barbosa","family":"Moraes","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Endocrine Unit, Federal University of Rio de Janeiro, School of Medicine, Clementino Fraga Filho University Hospital, Rio de Janeiro, RJ, 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School of Medicine, Clementino Fraga Filho University Hospital, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-1090","authenticated-orcid":false,"given":"Luis Felipe Cardoso","family":"Lima","sequence":"additional","affiliation":[{"name":"Nuclear Instrumentation Laboratory, COPPE-PEN, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2129-3546","authenticated-orcid":false,"given":"Laura Maria Carvalho","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology Unit, Federal University of Rio de Janeiro, Clementino Fraga Filho University Hospital, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-3250","authenticated-orcid":false,"given":"Maria Lucia 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