{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:49:01Z","timestamp":1790470141540,"version":"4.1.0"},"reference-count":43,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006989","name":"Jackson State University","doi-asserted-by":"publisher","award":["HHSN268201800013I"],"award-info":[{"award-number":["HHSN268201800013I"]}],"id":[{"id":"10.13039\/100006989","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tougaloo College","award":["HHSN268201800014I"],"award-info":[{"award-number":["HHSN268201800014I"]}]},{"DOI":"10.13039\/100018098","name":"Mississippi State Department of Health","doi-asserted-by":"crossref","award":["HHSN268201800015I\/HHSN26800001"],"award-info":[{"award-number":["HHSN268201800015I\/HHSN26800001"]}],"id":[{"id":"10.13039\/100018098","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Mississippi Medical Center","award":["HHSN268201800010I"],"award-info":[{"award-number":["HHSN268201800010I"]}]},{"name":"University of Mississippi Medical Center","award":["HHSN268201800011I"],"award-info":[{"award-number":["HHSN268201800011I"]}]},{"name":"University of Mississippi Medical Center","award":["HHSN268201800012I"],"award-info":[{"award-number":["HHSN268201800012I"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute for Minority Health and Health Disparities","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK117041"],"award-info":[{"award-number":["K23DK117041"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Robert Wood Johnson Foundation Harold Amos Medical Faculty Development Program","award":["ID# 76236"],"award-info":[{"award-number":["ID# 76236"]}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Armadillo repeat containing 5 (ARMC5) on chromosome 16 is an adrenal gland tumor suppressor gene associated with primary aldosteronism, especially among African Americans (AAs). We examined the association of ARMC5 variants with aldosterone, plasma renin activity (PRA), blood pressure, glucose, and glycosylated hemoglobin A1c (HbA1c) in community-dwelling AAs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The Jackson Heart Study is a prospective cardiovascular cohort study in AAs with baseline data collection from 2000 to 2004. Kernel machine method was used to perform a single joint test to analyze for an overall association between the phenotypes of interest (aldosterone, PRA, systolic and diastolic blood pressure [SBP, DBP], glucose, and HbA1c) and the ARMC5 single nucleotide variants (SNVs) adjusted for age, sex, BMI, and medications; followed by Baysian Lasso methodology to identify sets of SNVs in terms of associated haplotypes with specific phenotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 3223 participants (62% female; mean age 55.6 (SD \u00b1 12.8) years), the average SBP and DBP were 127 and 76 mmHg, respectively. The average fasting plasma glucose and HbA1c were 101 mg\/dL and 6.0%, respectively. ARMC5 variants were associated with all 6 phenotypes. Haplotype TCGCC (ch16:31476015-31476093) was negatively associated, whereas haplotype CCCCTTGCG (ch16:31477195-31477460) was positively associated with SBP, DBP, and glucose. Haplotypes GGACG (ch16:31477790-31478013) and ACGCG (ch16:31477834-31478113) were negatively associated with aldosterone and positively associated with HbA1c and glucose, respectively. Haplotype GCGCGAGC (ch16:31471193-ch16:31473597(rs114871627) was positively associated with PRA and negatively associated with HbA1c.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ARMC5 variants are associated with aldosterone, PRA, blood pressure, fasting glucose, and HbA1c in community-dwelling AAs, suggesting that germline mutations in ARMC5 may underlie cardiometabolic disease in AAs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa290","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T14:38:10Z","timestamp":1590071890000},"page":"2625-2633","source":"Crossref","is-referenced-by-count":15,"title":["The Association of <i>ARMC5<\/i> with the Renin-Angiotensin-Aldosterone System, Blood Pressure, and Glycemia in African 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Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine A","family":"Stratakis","sequence":"additional","affiliation":[{"name":"Section on Endocrinology and Genetics, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-9842","authenticated-orcid":false,"given":"Fabio R","family":"Faucz","sequence":"additional","affiliation":[{"name":"Section on Endocrinology and Genetics, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya B","family":"Lodish","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetes, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Berthon","sequence":"additional","affiliation":[{"name":"Institut Cochin, Centre National de la Recherche Scientifique (CNRS), INSERM, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willa A","family":"Hsueh","sequence":"additional","affiliation":[{"name":"The Ohio State University, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherita H","family":"Golden","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University 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