{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:22:45Z","timestamp":1787858565309,"version":"build-2784847793"},"reference-count":29,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Efficacy and Mechanism Evaluation program","award":["09\/100\/10"],"award-info":[{"award-number":["09\/100\/10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Observational cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>A total of 49 hospitals across the United Kingdom between 2011 and 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Women aged 16 to 41years with history of miscarriage or subfertility trying for a pregnancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Prevalences and 95% confidence intervals (CIs) were estimated using the binomial exact method. Multivariate logistic regression analyses were conducted to identify risk factors for thyroid disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention<\/jats:title>\n                  <jats:p>None.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>Rates of thyroid dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thyroid function and thyroid peroxidase antibody (TPOAb) data were available for 19213 and 19237 women, respectively. The prevalence of abnormal thyroid function was 4.8% (95% CI, 4.5-5.1); euthyroidism was defined as levels of thyroid-stimulating hormone (TSH) of 0.44 to 4.50 mIU\/L and free thyroxine (fT4) of 10 to 21 pmol\/L. Overt hypothyroidism (TSH &amp;gt; 4.50 mIU\/L, fT4 &amp;lt; 10 pmol\/L) was present in 0.2% of women (95% CI, 0.1-0.3) and overt hyperthyroidism (TSH &amp;lt; 0.44 mIU\/L, fT4 &amp;gt; 21 pmol\/L) was present in 0.3% (95% CI, 0.2-0.3). The prevalence of subclinical hypothyroidism (SCH) using an upper TSH concentration of 4.50 mIU\/L was 2.4% (95% CI, 2.1-2.6). Lowering the upper TSH to 2.50 mIU\/L resulted in higher rates of SCH, 19.9% (95% CI, 19.3-20.5). Multiple regression analyses showed increased odds of SCH (TSH &amp;gt; 4.50 mIU\/L) with body mass index (BMI) \u2265 35.0 kg\/m2 (adjusted odds ratio [aOR] 1.71; 95% CI, 1.13-2.57; P = 0.01) and Asian ethnicity (aOR 1.76; 95% CI, 1.31-2.37; P &amp;lt; 0.001), and increased odds of SCH (TSH \u2265 2.50 mIU\/L) with subfertility (aOR 1.16; 95% CI, 1.04-1.29; P = 0.008). TPOAb positivity was prevalent in 9.5% of women (95% CI, 9.1-9.9).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The prevalence of undiagnosed overt thyroid disease is low. SCH and TPOAb are common, particularly in women with higher BMI or of Asian ethnicity. A TSH cutoff of 2.50 mIU\/L to define SCH results in a significant proportion of women potentially requiring levothyroxine treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa302","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T13:03:29Z","timestamp":1592399009000},"page":"2667-2677","source":"Crossref","is-referenced-by-count":56,"title":["The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6142-5350","authenticated-orcid":false,"given":"Rima K","family":"Dhillon-Smith","sequence":"first","affiliation":[{"name":"Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Tommy\u2019s Centre for Miscarriage Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Birmingham Women\u2019s and Children\u2019s Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelio","family":"Tobias","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P","family":"Smith","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Tommy\u2019s Centre for Miscarriage Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Birmingham Women\u2019s and Children\u2019s Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee J","family":"Middleton","sequence":"additional","affiliation":[{"name":"Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirandeep K","family":"Sunner","sequence":"additional","affiliation":[{"name":"Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Baker","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Farrell-Carver","sequence":"additional","affiliation":[{"name":"Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Bender-Atik","sequence":"additional","affiliation":[{"name":"The Miscarriage Association, Wakefield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Agrawal","sequence":"additional","affiliation":[{"name":"University Hospital Coventry, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalsang","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Burnley General Hospital, East Lancashire Hospitals NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin J","family":"Chu","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Tommy\u2019s Centre for Miscarriage Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Birmingham Women\u2019s and Children\u2019s Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond","family":"Edi-Osagie","sequence":"additional","affiliation":[{"name":"St Mary\u2019s Hospital, Central Manchester University Hospital Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Ewies","sequence":"additional","affiliation":[{"name":"City Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Ghobara","sequence":"additional","affiliation":[{"name":"University Hospital Coventry, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratima","family":"Gupta","sequence":"additional","affiliation":[{"name":"University Hospital Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davor","family":"Jurkovic","sequence":"additional","affiliation":[{"name":"University College Hospital, University College Hospitals NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacoub","family":"Khalaf","sequence":"additional","affiliation":[{"name":"Assisted Conception Unit, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khashia","family":"Mulbagal","sequence":"additional","affiliation":[{"name":"Royal Bolton Hospital, Bolton NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Nunes","sequence":"additional","affiliation":[{"name":"West Middlesex Hospital, Chelsea and Westminster NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Overton","sequence":"additional","affiliation":[{"name":"St Michaels Hospital, University Hospitals Bristol NHS Foundation Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-5471","authenticated-orcid":false,"given":"Siobhan","family":"Quenby","sequence":"additional","affiliation":[{"name":"University Hospital Coventry, University Hospitals Coventry & Warwickshire NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Rai","sequence":"additional","affiliation":[{"name":"St Mary\u2019s Hospital, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Raine-Fenning","sequence":"additional","affiliation":[{"name":"Queens Medical Centre, Nottingham University Hospitals NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Robinson","sequence":"additional","affiliation":[{"name":"Birmingham Women\u2019s and Children\u2019s Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Ross","sequence":"additional","affiliation":[{"name":"Early Pregnancy and Gynaecology Assessment Unit, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Sizer","sequence":"additional","affiliation":[{"name":"The Princess Royal Hospital, The Shrewsbury and Telford NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Small","sequence":"additional","affiliation":[{"name":"City Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyn","family":"Underwood","sequence":"additional","affiliation":[{"name":"The Princess Royal Hospital, The Shrewsbury and Telford NHS Trust, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D","family":"Kilby","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Birmingham Women\u2019s and Children\u2019s Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Daniels","sequence":"additional","affiliation":[{"name":"Nottingham Clinical Trials Unit, University of Nottingham, School of Medicine, Nottingham Health Sciences Partners, Queens Medical Centre, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakila","family":"Thangaratinam","sequence":"additional","affiliation":[{"name":"Barts Research Centre for Women\u2019s Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiao","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristien","family":"Boelaert","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arri","family":"Coomarasamy","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Tommy\u2019s Centre for Miscarriage Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK"},{"name":"Birmingham Women\u2019s and Children\u2019s Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"issue":"7","key":"2021122110120876300_CIT0001","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1089\/thy.1999.9.727","article-title":"Fetal and neonatal hyperthyroidism","volume":"9","author":"Zimmerman","year":"1999","journal-title":"Thyroid."},{"issue":"9","key":"2021122110120876300_CIT0002","first-page":"CD008633","article-title":"Interventions for preventing and treating hyperthyroidism in pregnancy","author":"Earl","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"2021122110120876300_CIT0003","first-page":"387","article-title":"Thyroid dysfunction and pregnancy outcomes","volume":"13","author":"Nazarpour","year":"2015","journal-title":"Iran J Reprod Med."},{"issue":"2","key":"2021122110120876300_CIT0004","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1001\/jama.291.2.228","article-title":"Subclinical thyroid disease: scientific review and guidelines for diagnosis and management","volume":"291","author":"Surks","year":"2004","journal-title":"JAMA."},{"issue":"5","key":"2021122110120876300_CIT0005","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/humupd\/dmr024","article-title":"Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review","volume":"17","author":"van den Boogaard","year":"2011","journal-title":"Hum Reprod Update."},{"issue":"2","key":"2021122110120876300_CIT0006","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/jcem-73-2-421","article-title":"Pregnancy in patients with mild thyroid abnormalities: maternal and neonatal repercussions","volume":"73","author":"Glinoer","year":"1991","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2021122110120876300_CIT0007","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/thy.2000.10.871","article-title":"The potential repercussions of maternal, fetal, and neonatal hypothyroxinemia on the progeny","volume":"10","author":"Glinoer","year":"2000","journal-title":"Thyroid."},{"issue":"7","key":"2021122110120876300_CIT0008","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1210\/jc.2005-1603","article-title":"Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications","volume":"91","author":"Negro","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2021122110120876300_CIT0009","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF03347388","article-title":"Euthyroid women with autoimmune disease undergoing assisted reproduction technologies: the role of autoimmunity and thyroid function","volume":"30","author":"Negro","year":"2007","journal-title":"J Endocrinol Invest."},{"issue":"2","key":"2021122110120876300_CIT0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000362597","article-title":"2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children","volume":"3","author":"Lazarus","year":"2014","journal-title":"Eur Thyroid J."},{"issue":"3","key":"2021122110120876300_CIT0011","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid."},{"key":"2021122110120876300_CIT0012","doi-asserted-by":"crossref","first-page":"i6865","DOI":"10.1136\/bmj.i6865","article-title":"Thyroid hormone treatment among pregnant women with subclinical hypothyroidism: US national assessment","volume":"356","author":"Maraka","year":"2017","journal-title":"BMJ."},{"issue":"8","key":"2021122110120876300_CIT0013","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/jc.2011-2803","article-title":"Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline","volume":"97","author":"De Groot","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2021122110120876300_CIT0014","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.fertnstert.2015.05.028","article-title":"Subclinical hypothyroidism in the infertile female population: a guideline","volume":"104","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2015","journal-title":"Fertil Steril"},{"key":"2021122110120876300_CIT0015"},{"key":"2021122110120876300_CIT0016","article-title":"ESHRE guideline: recurrent pregnancy loss","author":"Bender Atik","journal-title":"Hum Reprod Open."},{"issue":"4","key":"2021122110120876300_CIT0017","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000356507","article-title":"2013 ETA guideline: management of subclinical hypothyroidism","volume":"2","author":"Pearce","year":"2013","journal-title":"Eur Thyroid J."},{"issue":"6","key":"2021122110120876300_CIT0018","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/cen.12824","article-title":"Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee","volume":"84","author":"Okosieme","year":"2016","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"6","key":"2021122110120876300_CIT0019","doi-asserted-by":"crossref","first-page":"988","DOI":"10.4158\/EP12280.GL","article-title":"Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association","volume":"18","author":"Garber","year":"2012","journal-title":"Endocr Pract."},{"key":"2021122110120876300_CIT0020","article-title":"Data from: The prevalence of thyroid dysfunction and autoimmunity in women with history of miscarriage or subfertility across the United Kingdom","author":"Dhillon-Smith","journal-title":"Figshare"},{"key":"2021122110120876300_CIT0021"},{"key":"2021122110120876300_CIT0022"},{"issue":"4","key":"2021122110120876300_CIT0023","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10653-015-9682-3","article-title":"A review of the iodine status of UK pregnant women and its implications for the offspring","volume":"37","author":"Bath","year":"2015","journal-title":"Environ Geochem Health."},{"issue":"5","key":"2021122110120876300_CIT0024","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/09513590701259542","article-title":"Subclinical hypothyroidism and thyroid autoimmunity in women with infertility","volume":"23","author":"Abalovich","year":"2007","journal-title":"Gynecol Endocrinol."},{"key":"2021122110120876300_CIT0025","doi-asserted-by":"crossref","first-page":"132718","DOI":"10.1155\/2015\/132718","article-title":"Impaired fertility associated with subclinical hypothyroidism and thyroid autoimmunity: the Danish General Suburban Population Study","volume":"2015","author":"Feldthusen","year":"2015","journal-title":"J Pregnancy."},{"issue":"2","key":"2021122110120876300_CIT0026","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1210\/jc.2009-1845","article-title":"Age- and race-based serum thyrotropin reference limits","volume":"95","author":"Surks","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"issue":"9","key":"2021122110120876300_CIT0027","doi-asserted-by":"crossref","first-page":"3678","DOI":"10.1210\/jc.2013-2005","article-title":"Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R study","volume":"98","author":"Korevaar","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"key":"2021122110120876300_CIT0028","doi-asserted-by":"crossref","first-page":"d2616","DOI":"10.1136\/bmj.d2616","article-title":"Association between thyroid autoantibodies and miscarriage and preterm birth: meta-analysis of evidence","volume":"342","author":"Thangaratinam","year":"2011","journal-title":"BMJ."},{"issue":"14","key":"2021122110120876300_CIT0029","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1056\/NEJMoa1812537","article-title":"Levothyroxine in women with thyroid peroxidase antibodies before conception","volume":"380","author":"Dhillon-Smith","year":"2019","journal-title":"N Engl J Med."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaa302\/33375967\/dgaa302.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/8\/2667\/41830498\/jcem_105_8_2667.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/8\/2667\/41830498\/jcem_105_8_2667.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T10:12:34Z","timestamp":1640081554000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/105\/8\/2667\/5855667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,6,17]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaa302","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,6,17]]}}}