{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:54:32Z","timestamp":1791536072334,"version":"4.3.4"},"reference-count":69,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011898","name":"Marianne and Marcus Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011898","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Fund raising for Congenital Adrenal Hyperplasia"},{"name":"European Society for Pediatric Endocrinology"},{"DOI":"10.13039\/501100004348","name":"Stockholm County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundations of Lisa and Johan Gr\u00f6nberg"},{"DOI":"10.13039\/501100006741","name":"Stiftelsen Frimurare Barnhuset i Stockholm","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006741","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Samariten, Jerringfonden, S\u00e4llskapet Barnav\u00e5rd"},{"name":"Wera Ekstr\u00f6ms stiftelse f\u00f6r Pediatrikforskning"},{"name":"Erik and Edith Fernstr\u00f6ms Stiftelse"},{"name":"Foundation for Research and Education in Pediatric Endocrinology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Prenatal treatment of human disease is rare. Dexamethasone (DEX) is used in pregnancies at risk for congenital adrenal hyperplasia (CAH) to prevent virilization in an affected female fetus. The safety and long-term consequences of prenatal DEX exposure on the brain are largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigate whether first-trimester prenatal DEX treatment is associated with alterations in brain structure at adult age, and if these alterations are associated with DNA methylation, mood, and cognitive abilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>T1-weighted and diffusion-weighted imaging scans, from a single research institute, are compared between 19 (9 women) first-trimester DEX-treated individuals, at risk of CAH but not having CAH, and 43 (26 women) controls (age range, 16.0-26.4 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DEX-treated participants showed bilateral enlargement of the amygdala, increased surface area and volume of the left superior frontal gyrus, and widespread increased radial, mean, and axial diffusivity of white matter, in particular in the superior longitudinal fasciculi and corticospinal tracts. In the DEX-treated group, increased mean and radial diffusivity correlated with increased methylation of the promotor region of the FKBP5 gene. There were no group differences in cognition or in scales assessing depression or anxiety, and the relationship between brain structure and cognition did not differ between DEX-treated and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>First-trimester prenatal DEX treatment is associated with structural alterations of the brain at adult age, with an accompanying change in gene methylation. The findings add to the safety concerns of prenatal DEX treatment in the context of CAH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa340","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:33:45Z","timestamp":1591317225000},"page":"2575-2586","source":"Crossref","is-referenced-by-count":28,"title":["First-Trimester Prenatal Dexamethasone Treatment Is Associated With Alterations in Brain Structure at Adult Age"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-3058","authenticated-orcid":false,"given":"Annelies","family":"van\u2019t Westeinde","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6274-9330","authenticated-orcid":false,"given":"Leif","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nordenstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Padilla","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, Division of Neonatology, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-0948","authenticated-orcid":false,"given":"Svetlana","family":"Lajic","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"issue":"3","key":"2022042611234258700_CIT0001","first-page":"245","article-title":"Congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"21","author":"White","year":"2000","journal-title":"Endocr Rev."},{"issue":"9","key":"2022042611234258700_CIT0002","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1210\/jc.2009-2631","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline","volume":"95","author":"Speiser","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2022042611234258700_CIT0003","doi-asserted-by":"crossref","first-page":"E346","DOI":"10.1210\/jc.2012-3343","article-title":"Genotype-phenotype correlation in 153 adult patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency: analysis of the United Kingdom Congenital adrenal Hyperplasia Adult Study Executive (CaHASE) cohort","volume":"98","author":"Krone","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2022042611234258700_CIT0004","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1001\/jamapediatrics.2013.5321","article-title":"Nationwide neonatal screening for congenital adrenal hyperplasia in Sweden: a 26-year longitudinal prospective population-based study","volume":"168","author":"Gidl\u00f6f","year":"2014","journal-title":"JAMA Pediatr."},{"issue":"11","key":"2022042611234258700_CIT0005","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1210\/jc.2001-011531","article-title":"Sex-typed toy play behavior correlates with the degree of prenatal androgen exposure assessed by CYP21 genotype in girls with congenital adrenal hyperplasia","volume":"87","author":"Nordenstr\u00f6m","year":"2002","journal-title":"J Clin Endocrinol Metab."},{"issue":"1-2","key":"2022042611234258700_CIT0006","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/07435808909039101","article-title":"Prenatal treatment in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: up-date 88 of the French Multicentric Study","volume":"15","author":"Forest","year":"1989","journal-title":"Endocr Res."},{"issue":"11","key":"2022042611234258700_CIT0007","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1210\/jc.2018-01865","article-title":"Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline","volume":"103","author":"Speiser","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"2022042611234258700_CIT0008","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.beem.2015.01.005","article-title":"Fetal endocrine therapy for congenital adrenal hyperplasia should not be done","volume":"29","author":"Miller","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"issue":"1","key":"2022042611234258700_CIT0009","first-page":"186","article-title":"Challenges in prenatal treatment with dexamethasone","volume":"16","author":"McCann-Crosby","year":"2018","journal-title":"Pediatr Endocrinol Rev."},{"issue":"5","key":"2022042611234258700_CIT0010","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1159\/000485100","article-title":"Prenatal treatment of congenital adrenal hyperplasia: long-term effects of excess glucocorticoid exposure","volume":"89","author":"Lajic","year":"2018","journal-title":"Horm Res Paediatr."},{"issue":"2","key":"2022042611234258700_CIT0011","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1210\/jc.2006-1340","article-title":"Cognitive functions in children at risk for congenital adrenal hyperplasia treated prenatally with dexamethasone","volume":"92","author":"Hirvikoski","year":"2007","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2022042611234258700_CIT0012","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1210\/jc.2016-1543","article-title":"Sex-dimorphic effects of prenatal treatment with dexamethasone","volume":"101","author":"Wallensteen","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"2022042611234258700_CIT0013","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.psyneuen.2018.02.033","article-title":"Prenatal dexamethasone treatment in the context of at risk CAH pregnancies: long-term behavioral and cognitive outcome","volume":"91","author":"Karlsson","year":"2018","journal-title":"Psychoneuroendocrinology."},{"issue":"1","key":"2022042611234258700_CIT0014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(73)90617-3","article-title":"Neuronal migration, with special reference to developing human brain: a review","volume":"62","author":"Sidman","year":"1973","journal-title":"Brain Res."},{"issue":"1","key":"2022042611234258700_CIT0015","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1210\/js.2018-00377","article-title":"Epigenetic alterations associated with early prenatal dexamethasone treatment","volume":"3","author":"Karlsson","year":"2019","journal-title":"J Endocr Soc."},{"issue":"5","key":"2022042611234258700_CIT0016","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/15592294.2015.1039221","article-title":"Maternal prenatal depressive symptoms predict infant NR3C1 1F and BDNF IV DNA methylation","volume":"10","author":"Braithwaite","year":"2015","journal-title":"Epigenetics."},{"issue":"2","key":"2022042611234258700_CIT0017","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S0954579418000056","article-title":"Associations of prenatal depressive symptoms with DNA methylation of HPA axis-related genes and diurnal cortisol profiles in primary school-aged children","volume":"31","author":"Stonawski","year":"2019","journal-title":"Dev Psychopathol."},{"key":"2022042611234258700_CIT0018","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.pscychresns.2018.12.012","article-title":"Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure","volume":"285","author":"Wrigglesworth","year":"2019","journal-title":"Psychiatry Res Neuroimaging."},{"key":"2022042611234258700_CIT0019","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jocn.2017.05.022","article-title":"A review of DNA methylation in depression","volume":"43","author":"Chen","year":"2017","journal-title":"J Clin Neurosci."},{"key":"2022042611234258700_CIT0020","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1016\/j.psyneuen.2009.05.021","article-title":"The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders","volume":"34","author":"Binder","year":"2009","journal-title":"Psychoneuroendocrinology."},{"issue":"3","key":"2022042611234258700_CIT0021","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1530\/JOE-18-0226","article-title":"Corticosteroids and the brain","volume":"238","author":"Jo\u00ebls","year":"2018","journal-title":"J Endocrinol."},{"issue":"9","key":"2022042611234258700_CIT0022","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.biopsych.2013.03.009","article-title":"Fetal glucocorticoid exposure is associated with preadolescent brain development","volume":"74","author":"Davis","year":"2013","journal-title":"Biol Psychiatry."},{"issue":"3","key":"2022042611234258700_CIT0023","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.neubiorev.2011.12.006","article-title":"Late gestational maternal serum cortisol is inversely associated with fetal brain growth","volume":"36","author":"Li","year":"2012","journal-title":"Neurosci Biobehav Rev."},{"issue":"20","key":"2022042611234258700_CIT0024","doi-asserted-by":"crossref","first-page":"E1312","DOI":"10.1073\/pnas.1201295109","article-title":"Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems","volume":"109","author":"Buss","year":"2012","journal-title":"Proc Nat Acad Sci."},{"issue":"1","key":"2022042611234258700_CIT0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.psyneuen.2009.07.010","article-title":"High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children","volume":"35","author":"Buss","year":"2010","journal-title":"Psychoneuroendocrinology."},{"issue":"11","key":"2022042611234258700_CIT0026","first-page":"5230","article-title":"Prenatal maternal cortisol has sex-specific associations with child brain network properties","volume":"27","author":"Kim","year":"2016","journal-title":"Cereb Cortex."},{"issue":"2","key":"2022042611234258700_CIT0027","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.biopsych.2018.06.023","article-title":"Maternal cortisol concentrations during pregnancy and sex-specific associations with neonatal amygdala connectivity and emerging internalizing behaviors","volume":"85","author":"Graham","year":"2019","journal-title":"Biol Psychiatry."},{"issue":"1","key":"2022042611234258700_CIT0028","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/cne.901320108","article-title":"The development of the human amygdala during early embryonic life","volume":"132","author":"Humphrey","year":"1968","journal-title":"J Comp Neurol."},{"issue":"3","key":"2022042611234258700_CIT0029","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00698785","article-title":"Development of the lateral amygdaloid nucleus in the human fetus: transient presence of discrete cytoarchitectonic units","volume":"174","author":"Nikoli\u0107","year":"1986","journal-title":"Anat Embryol."},{"issue":"6","key":"2022042611234258700_CIT0030","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/cen.13441","article-title":"Cognitive impairment in adolescents and adults with congenital adrenal hyperplasia","volume":"87","author":"Karlsson","year":"2017","journal-title":"Clin Endocrinol (Oxf)."},{"key":"2022042611234258700_CIT0031","volume-title":"WAIS-IV Administration and Scoring Manual.","author":"Wechsler"},{"key":"2022042611234258700_CIT0032","volume-title":"WMS-III: Wechsler Memory Scale. 3rd ed","author":"Wechsler"},{"key":"2022042611234258700_CIT0033","volume-title":"The Stroop Color and Word Test\u2014A Manual for Clinical and Experimental Uses.","author":"Golden"},{"key":"2022042611234258700_CIT0034","volume-title":"Barkley Deficits in Executive Functioning Scale (BDEFS for Adults).","author":"Barkley"},{"key":"2022042611234258700_CIT0035","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1477-7525-3-82","article-title":"Assessment of the structure of the Hospital Anxiety and Depression Scale in musculoskeletal patients","volume":"3","author":"Pallant","year":"2005","journal-title":"Health Qual Life Outcomes."},{"issue":"6","key":"2022042611234258700_CIT0036","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The Hospital Anxiety and Depression Scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand."},{"issue":"1","key":"2022042611234258700_CIT0037","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/da.20503","article-title":"Screening for social anxiety disorder with the self-report version of the Liebowitz Social Anxiety Scale","volume":"26","author":"Rytwinski","year":"2009","journal-title":"Depress Anxiety."},{"issue":"4","key":"2022042611234258700_CIT0038","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage."},{"issue":"2","key":"2022042611234258700_CIT0039","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/nimg.1998.0396","article-title":"Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system","volume":"9","author":"Fischl","year":"1999","journal-title":"Neuroimage."},{"issue":"2","key":"2022042611234258700_CIT0040","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","article-title":"Cortical surface-based analysis. I. Segmentation and surface reconstruction","volume":"9","author":"Dale","year":"1999","journal-title":"Neuroimage."},{"issue":"1 Pt 1","key":"2022042611234258700_CIT0041","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"Good","year":"2001","journal-title":"Neuroimage."},{"issue":"Pt 9","key":"2022042611234258700_CIT0042","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/brain\/awm184","article-title":"Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia","volume":"130","author":"Douaud","year":"2007","journal-title":"Brain."},{"key":"2022042611234258700_CIT0043","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage."},{"key":"2022042611234258700_CIT0044","article-title":"Non-linear optimisation","author":"Andersson","year":"2007"},{"key":"2022042611234258700_CIT0045","article-title":"Non-linear registration, aka Spatial normalisation FMRIB technical report TR07JA2","author":"Andersson","year":"2007"},{"key":"2022042611234258700_CIT0046","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"Neuroimage."},{"issue":"1","key":"2022042611234258700_CIT0047","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"Smith","year":"2009","journal-title":"Neuroimage."},{"key":"2022042611234258700_CIT0048","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuroimage.2016.06.058","article-title":"Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images","volume":"141","author":"Andersson","year":"2016","journal-title":"Neuroimage."},{"issue":"3","key":"2022042611234258700_CIT0049","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp."},{"issue":"8","key":"2022042611234258700_CIT0050","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1109\/42.796284","article-title":"Nonrigid registration using free-form deformations: application to breast MR images","volume":"18","author":"Rueckert","year":"1999","journal-title":"IEEE Trans Med Imaging."},{"key":"2022042611234258700_CIT0051","author":"van\u2019t Westeinde"},{"issue":"7370","key":"2022042611234258700_CIT0052","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature10523","article-title":"Spatio-temporal transcriptome of the human brain","volume":"478","author":"Kang","year":"2011","journal-title":"Nature."},{"issue":"6","key":"2022042611234258700_CIT0053","doi-asserted-by":"crossref","first-page":"e1153","DOI":"10.1038\/tp.2017.65","article-title":"Antenatal dexamethasone exposure differentially affects distinct cortical neural progenitor cells and triggers long-term changes in murine cerebral architecture and behavior","volume":"7","author":"Tsiarli","year":"2017","journal-title":"Transl Psychiatry."},{"issue":"1","key":"2022042611234258700_CIT0054","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1210\/me.2015-1258","article-title":"Research resource: the dexamethasone transcriptome in hypothalamic embryonic neural stem cells","volume":"30","author":"Frahm","year":"2016","journal-title":"Mol Endocrinol."},{"issue":"5","key":"2022042611234258700_CIT0055","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/npp.2012.253","article-title":"Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis","volume":"38","author":"Anacker","year":"2013","journal-title":"Neuropsychopharmacology."},{"issue":"6","key":"2022042611234258700_CIT0056","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1210\/endo-117-6-2505","article-title":"Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation","volume":"117","author":"Reul","year":"1985","journal-title":"Endocrinology."},{"issue":"5","key":"2022042611234258700_CIT0057","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00429-013-0589-4","article-title":"Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients","volume":"219","author":"Wang","year":"2014","journal-title":"Brain Struct Funct."},{"issue":"4","key":"2022042611234258700_CIT0058","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1210\/jc.2002-021730","article-title":"Children with classic congenital adrenal hyperplasia have decreased amygdala volume: potential prenatal and postnatal hormonal effects","volume":"88","author":"Merke","year":"2003","journal-title":"J Clin Endocrinol Metab."},{"key":"2022042611234258700_CIT0059","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-444-53860-4.00009-X","article-title":"Human prefrontal cortex: evolution, development, and pathology","volume":"195","author":"Teffer","year":"2012","journal-title":"Prog Brain Res."},{"issue":"4","key":"2022042611234258700_CIT0060","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11065-010-9148-4","article-title":"The basics of brain development","volume":"20","author":"Stiles","year":"2010","journal-title":"Neuropsychol Rev."},{"issue":"1","key":"2022042611234258700_CIT0061","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41598-018-37088-3","article-title":"Antenatal glucocorticoid exposure results in sex-specific and transgenerational changes in prefrontal cortex gene transcription that relate to behavioural outcomes","volume":"9","author":"Constantinof","year":"2019","journal-title":"Sci Rep."},{"issue":"12","key":"2022042611234258700_CIT0062","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.euroneuro.2012.03.008","article-title":"Detection of the acute effects of hydrocortisone in the hippocampus using pharmacological fMRI","volume":"22","author":"Symonds","year":"2012","journal-title":"Eur Neuropsychopharmacol."},{"issue":"3","key":"2022042611234258700_CIT0063","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1369\/0022155413517700","article-title":"Distribution of corticosteroid receptors in mature oligodendrocytes and oligodendrocyte progenitors of the adult mouse brain","volume":"62","author":"Matsusue","year":"2014","journal-title":"J Histochem Cytochem."},{"issue":"5","key":"2022042611234258700_CIT0064","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1242\/dev.120.5.1097","article-title":"A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development","volume":"120","author":"Barres","year":"1994","journal-title":"Development."},{"issue":"3","key":"2022042611234258700_CIT0065","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.jp.7211447","article-title":"Antenatal betamethasone treatment has a persisting influence on infant HPA axis regulation","volume":"26","author":"Davis","year":"2006","journal-title":"J Perinatol."},{"issue":"1","key":"2022042611234258700_CIT0066","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nn.3275","article-title":"Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions","volume":"16","author":"Klengel","year":"2013","journal-title":"Nat Neurosci."},{"issue":"2","key":"2022042611234258700_CIT0067","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1017\/S0954579415000073","article-title":"Brain adaptation and alternative developmental trajectories","volume":"27","author":"Johnson","year":"2015","journal-title":"Dev Psychopathol."},{"issue":"6","key":"2022042611234258700_CIT0068","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1186\/gb-2012-13-6-r43","article-title":"Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood","volume":"13","author":"Davies","year":"2012","journal-title":"Genome Biol."},{"issue":"1","key":"2022042611234258700_CIT0069","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/npp.2015.235","article-title":"Gene-stress-epigenetic regulation of FKBP5: clinical and translational implications","volume":"41","author":"Zannas","year":"2016","journal-title":"Neuropsychopharmacology."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgaa340\/33345431\/dgaa340.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/8\/2575\/43463868\/jcem_105_8_2575.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/105\/8\/2575\/43463868\/jcem_105_8_2575.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T09:16:37Z","timestamp":1650964597000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/105\/8\/2575\/5851472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":69,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,6,4]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgaa340","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738080999.793576523","asserted-by":"object"}]},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,6,4]]}}}