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We hypothesized that eating a late dinner alters substrate metabolism during sleep in a manner that promotes obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this work is to examine the impact of late dinner on nocturnal metabolism in healthy volunteers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and Setting<\/jats:title>\n                    <jats:p>This is a randomized crossover trial of late dinner (LD, 22:00) vs routine dinner (RD, 18:00), with a fixed sleep period (23:00-07:00) in a laboratory setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Participants comprised 20 healthy volunteers (10 male, 10 female), age 26.0 \u00b1 0.6 years, body mass index 23.2\u2005\u00b1\u20050.7 kg\/m2, accustomed to a bedtime between 22:00 and 01:00.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>An isocaloric macronutrient diet was administered on both visits. Dinner (35% daily kcal, 50% carbohydrate, 35% fat) with an oral lipid tracer ([2H31] palmitate, 15 mg\/kg) was given at 18:00 with RD and 22:00 with LD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Measurements included nocturnal and next-morning hourly plasma glucose, insulin, triglycerides, free fatty acids (FFAs), cortisol, dietary fatty acid oxidation, and overnight polysomnography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LD caused a 4-hour shift in the postprandial period, overlapping with the sleep phase. Independent of this shift, the postprandial period following LD was characterized by higher glucose, a triglyceride peak delay, and lower FFA and dietary fatty acid oxidation. LD did not affect sleep architecture, but increased plasma cortisol. These metabolic changes were most pronounced in habitual earlier sleepers determined by actigraphy monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LD induces nocturnal glucose intolerance, and reduces fatty acid oxidation and mobilization, particularly in earlier sleepers. These effects might promote obesity if they recur chronically.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa354","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T09:16:53Z","timestamp":1591867013000},"page":"2789-2802","source":"Crossref","is-referenced-by-count":130,"title":["Metabolic Effects of Late Dinner in Healthy Volunteers\u2014A Randomized Crossover Clinical Trial"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9159-2109","authenticated-orcid":false,"given":"Chenjuan","family":"Gu","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University , Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nga","family":"Brereton","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Research, Johns Hopkins University , Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Schweitzer","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Research, Johns Hopkins University , Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Cotter","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Nutrition Center, Arkansas Children\u2019s Research Institute , Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Duan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University , Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"B\u00f8rsheim","sequence":"additional","affiliation":[{"name":"Arkansas Children\u2019s Nutrition Center, Arkansas Children\u2019s Research Institute , Little Rock, Arkansas"},{"name":"Department of Pediatrics, The University of Arkansas for Medical Sciences , Little Rock, Arkansas"},{"name":"Department of Geriatrics, Center for Translational Research in Aging and Longevity, The University of Arkansas for Medical Sciences , Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Arkansas for Medical Sciences , Little Rock, Arkansas"},{"name":"Department of Geriatrics, Center for Translational Research in Aging and Longevity, The University of Arkansas for Medical Sciences , Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luu V","family":"Pham","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University , Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vsevolod Y","family":"Polotsky","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University , Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5788-3535","authenticated-orcid":false,"given":"Jonathan C","family":"Jun","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Department of Medicine, Johns Hopkins University , Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"issue":"Pt B","key":"2026041420194596800_CIT0001","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.phrs.2017.09.005","article-title":"Timing of food intake: sounding the alarm about metabolic impairments? 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