{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:43:37Z","timestamp":1790279017898,"version":"4.1.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Vertebral fractures (VFs) are a frequent complication of acromegaly, but no studies have been so far published on effectiveness of antiosteoporotic drugs in this clinical setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate whether in real-life clinical practice bone active drugs may reduce the risk of VFs in patients with active or controlled acromegaly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study design<\/jats:title>\n                  <jats:p>Retrospective, longitudinal study including 9 tertiary care endocrine units.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and Methods<\/jats:title>\n                  <jats:p>Two hundred and forty-eight patients with acromegaly (104 males; mean age 56.00\u2005\u00b1\u200513.60 years) were evaluated for prevalent and incident VFs by quantitative morphometric approach. Bone active agents were used in 52 patients (20.97%) and the median period of follow-up was 48 months (range 12-132).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the follow-up, 65 patients (26.21%) developed incident VFs in relationship with pre-existing VFs (odds ratio [OR] 3.75; P\u2005&amp;lt;\u2005.001), duration of active acromegaly (OR 1.01; P\u2005=\u2005.04), active acromegaly at the study entry (OR 2.48; P\u2005=\u2005.007), and treated hypoadrenalism (OR 2.50; P\u2005=\u2005.005). In the entire population, treatment with bone active drugs did not have a significant effect on incident VFs (P\u2005=\u2005.82). However, in a sensitive analysis restricted to patients with active acromegaly at study entry (111 cases), treatment with bone active drugs was associated with a lower risk of incident VFs (OR 0.11; P\u2005=\u2005.004), independently of prevalent VFs (OR 7.65; P\u2005&amp;lt;\u2005.001) and treated hypoadrenalism (OR 3.86; P\u2005=\u2005.007).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Bone active drugs may prevent VFs in patients with active acromegaly.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa363","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T18:04:34Z","timestamp":1591639474000},"page":"e3285-e3292","source":"Crossref","is-referenced-by-count":38,"title":["Treatment of Acromegalic Osteopathy in Real-life Clinical Practice: The BAAC (Bone Active Drugs in Acromegaly) Study"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5458-701X","authenticated-orcid":false,"given":"Gherardo","family":"Mazziotti","sequence":"first","affiliation":[{"name":"Endocrinology, Diabetology and Medical Andrology Unit, Osteoporosis and Metabolic Bone Disease Section, Humanitas Clinical and Research Center, IRCCS, Rozzano-Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Battista","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology, \u201cCasa Sollievo della Sofferenza\u201d Hospital, IRCCS, San Giovanni Rotondo (FG), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Maffezzoni","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism, Department of Medicine, ASST Spedali Civili Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-2392","authenticated-orcid":false,"given":"Sabrina","family":"Chiloiro","sequence":"additional","affiliation":[{"name":"Pituitary Unit, Department of Endocrinology and Metabolism, Fondazione Policlinico \u201cA. 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