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however, sex-specific reference data on AGD and data on longitudinal changes in AGD in children is scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To create age-, sex-, and method-related reference ranges of AGD in healthy boys and girls aged 0\u201324 months, to assess the age-related changes in AGD and to evaluate the 2 predominantly used methods of AGD measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>The International AGD consortium comprising 4 centers compiled data from 1 cross-sectional and 3 longitudinal cohort studies (clinicaltrials.gov [NCT02497209]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>All data were collected from population-based studies, recruiting from 4 maternity or obstetric centers (United States, Cambridge [United Kingdom], Odense, and Copenhagen [Denmark]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects<\/jats:title>\n                    <jats:p>This study included a total of 3705 healthy, mainly Caucasian children aged 0\u201324 months on whom 7295 measurements were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>AGDAS (ano-scrotal), AGDAF (ano-fourchette), AGDAP (ano-penile), AGDAC (ano-clitoral), AGD body size indices (weight, body mass index [BMI], body surface area, and length), and intra- and interobserver biases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We created age-specific reference ranges by centers. We found that AGD increased from birth to 6 months of age and thereafter reached a plateau. Changes in AGD\/BMI during the first year of life were minor (0\u20136% and 0\u201311% in boys and girls, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Reference ranges for AGD can be used in future epidemiological research and may be utilized clinically to evaluate prenatal androgen action in differences-in-sex-development patients. The increase in AGD during the first year of life was age-related, while AGD\/BMI was fairly stable. The TIDES and Cambridge methods were equally reproducible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgaa393","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T14:43:48Z","timestamp":1592923428000},"page":"2996-3004","source":"Crossref","is-referenced-by-count":41,"title":["Anogenital Distance in Healthy Infants: Method-, Age- and Sex-related Reference Ranges"],"prefix":"10.1210","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-548X","authenticated-orcid":false,"given":"Margit Bistrup","family":"Fischer","sequence":"first","affiliation":[{"name":"Deptartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, 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